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Gary D. Paige, M.D., Ph.D.

Gary D. Paige, M.D., Ph.D.

Contact

Call Center (585) 276-3000

About Me

Faculty Appointments

Professor Emeritus - Department of Neurology (SMD)

Credentials

Post-doctoral Training & Residency

Resident
University of California-san Francisco
San Francisco, California
94143 1982 - 1985

Clinical Internship
Dept. of Anesthesiology
Michael Reese Hospital
Chicago, Illinois 1981 - 1982

Education

MD | Pritzker School of Medicine, University of Chicago. Medicine. 1981

PhD | University of Chicago. Neurophysiology. 1980

BS | University of California Irvine. Biological Sciences. 1974

Secondary Education | Interlochen Arts Academy. Major in music, minor in broadcasting. 1970

Awards

Commencement Address. 2013

President. 2010

Vice President and Program Director. 2007 - 2010

President. 2002 - 2004

Stadium Generale (keynote) Presentation. 1999

Arthur Kornberg Research Award. 1997

Honory Life Member. 1995

Traveling Fellowship. 1991

Michael J. Hogan Award. 1984

Medical Scientist Training Program (MD, PhD). 1975 - 1981

J. Franks Fund Scholarship Award. 1974 - 1975

B.S. Cum Laude and With Honors. 1974

National Science Foundation Research Participation Award. 1972

Academic Honors Award. 1970

Dow Foundation Scholarship. 1966 - 1970

Research

Multisensory Interaction and Adaptive Plasticity in Spatial Localization and Orientation.

The sensori-neural processes underlying our abilities to localize, track, and interact with a cluttered environment are crucial attributes of daily life, and are among the most fundamental tasks of the n...
Multisensory Interaction and Adaptive Plasticity in Spatial Localization and Orientation.

The sensori-neural processes underlying our abilities to localize, track, and interact with a cluttered environment are crucial attributes of daily life, and are among the most fundamental tasks of the nervous system. The integration of multiple sensory inputs are required to guide spatial behaviors, ranging from mundane tasks such as reaching for objects to complex ones such as navigating to and from the workplace. These functions are also among the first (and often most subtle) to register problems after head trauma, neurological disease, and aging. The goal of our research is to understand how the brain integrates sensory inputs from the outside world (location and motion of visual and auditory targets) with those of the internal senses (vestibular and somatosensory depictions of orientation and motion of the body and its parts,) to achieve meaningful spatial perceptions and behaviors (eye, head and postural movements and reflexes). An equally important interest is how plastic neural mechanisms register errors and adaptively adjust performance in order to maintain proper spatial calibration across sensory modalities, or analogously, recover normal function after suffering pathologic loss. Finally, an important translational concern is how the neural degeneration of natural aging affects spatial behavior and plasticity. Recent experiments have addressed two intriguing areas of interest. One is understanding how the brain utilizes auditory and visual information about target location and motion in order to maintain accurate and congruent spatial calibration across modalities, as assessed through different forms of orienting movements ("pointing"). These include visually-guided manual pointing by laser joystick, and more natural gaze (eye and head) pointing. Since gaze shifts activate vestibular reflexes (vestibulo-ocular and –collic reflexes: VOR and VCR) as well as somatosensory feedback from the neck, we have addressed how the senses interact with each other and with volitional and reflex motor control. We also investigated the important challenges of spatial memory when targets are transient, as occurs frequently in nature. Finally, we maintain interest in how spatial sensory modalities are plastically co-calibrated by cross-sensory experience--an essential feature normal spatial behavior over a lifetime.


A second focus has addressed vestibular inputs during both angular (from the semicircular canals) and linear (from the otoliths) head motion and how they interact with each other, despite an intriguing limitation in the physics of the linear form (Einstein's "equivalency principle"). As biological linear accelerometers, the otolith organs cannot readily distinguish accelerations due to head tilt (relative to gravity) from those arising during translational (as opposed to angular) motion, and yet relevant behaviors and perceptions associated with these two forms of motion differ greatly.


The lab has completed a set of studies related to the above topics, and witnessed several graduate students through completion of PhD requirements. I have returned to largely a clinical role related to disorders of balance and equilibrium--a cross between neuro-otology and neuro-ophthalmology--and serve in an advisory role for students and others at all levels.

Publications

Journal Articles

Multiple time scales of the ventriloquism aftereffect.

Bosen AK, Fleming JT, Allen PD, O'Neill WE, Paige GD

PloS one.. 2018 13 (8):e0200930. Epub 08/01/2018.

Accumulation and decay of visual capture and the ventriloquism aftereffect caused by brief audio-visual disparities.

Bosen AK, Fleming JT, Allen PD, O'Neill WE, Paige GD

Experimental brain research.. 2017 February 235 (2):585-595. Epub 11/11/2016.

Comparison of congruence judgment and auditory localization tasks for assessing the spatial limits of visual capture.

Bosen AK, Fleming JT, Brown SE, Allen PD, O'Neill WE, Paige GD

Biological cybernetics.. 2016 December 110 (6):455-471. Epub 11/04/2016.

Influence of age, spatial memory, and ocular fixation on localization of auditory, visual, and bimodal targets by human subjects.

Dobreva MS, O'Neill WE, Paige GD

Experimental brain research.. 2012 December 223 (4):441-55. Epub 10/14/2012.

Influence of sound source width on human sound localization.

Greene NT, Paige GD

Annual International Conference of the IEEE Engineering in Medicine and Biology Society.. 2012 2012 :6455-8. Epub 1900 01 01.

Influence of aging on human sound localization.

Dobreva MS, O'Neill WE, Paige GD

Journal of neurophysiology.. 2011 May 105 (5):2471-86. Epub 03/02/2011.

Advancing age alters the influence of eye position on sound localization.

Cui QN, O'Neill WE, Paige GD

Experimental brain research.. 2010 October 206 (4):371-9. Epub 09/21/2010.

Perception of auditory, visual, and egocentric spatial alignment adapts differently to changes in eye position.

Cui QN, Razavi B, O'Neill WE, Paige GD

Journal of neurophysiology.. 2010 February 103 (2):1020-35. Epub 10/21/2009.

The perception of translational motion: what is vestibular and what is not.

Seidman SH, Au Yong N, Paige GD

Annals of the New York Academy of Sciences.. 2009 May 1164 :222-8. Epub 1900 01 01.

Eye position and cross-sensory learning both contribute to prism adaptation of auditory space.

Cui QN, Bachus L, Knoth E, O'Neill WE, Paige GD

Progress in brain research.. 2008 171 :265-70. Epub 1900 01 01.

Auditory spatial perception dynamically realigns with changing eye position.

Razavi B, O'Neill WE, Paige GD

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2007 September 1927 (38):10249-58. Epub 1900 01 01.

Multiple sensory cues underlying the perception of translation and path.

Yong NA, Paige GD, Seidman SH

Journal of neurophysiology.. 2007 February 97 (2):1100-13. Epub 11/22/2006.

Anticipatory VOR suppression induced by visual and nonvisual stimuli in humans.

Barnes GR, Paige GD

Journal of neurophysiology.. 2004 September 92 (3):1501-11. Epub 12/03/2003.

Plasticity in human sound localization induced by compressed spatial vision.

Zwiers MP, Van Opstal AJ, Paige GD

Nature neuroscience.. 2003 February 6 (2):175-81. Epub 1900 01 01.

Linearity of canal-otolith interaction during eccentric rotation in humans.

Seidman SH, Paige GD, Tomlinson RD, Schmitt N

Experimental brain research.. 2002 November 147 (1):29-37. Epub 09/13/2002.

Otolith function: basis for modern testing.

Paige GD

Annals of the New York Academy of Sciences.. 2002 April 956 :314-23. Epub 1900 01 01.

Characteristics of the VOR in response to linear acceleration.

Paige GD, Seidman SH

Annals of the New York Academy of Sciences.. 1999 May 28871 :123-35. Epub 1900 01 01.

Adaptive plasticity in the naso-occipital linear vestibulo-ocular reflex.

Seidman SH, Paige GD, Tomko DL

Experimental brain research.. 1999 April 125 (4):485-94. Epub 1900 01 01.

Human vestibuloocular reflex and its interactions with vision and fixation distance during linear and angular head movement.

Paige GD, Telford L, Seidman SH, Barnes GR

Journal of neurophysiology.. 1998 November 80 (5):2391-404. Epub 1900 01 01.

Tilt perception during dynamic linear acceleration.

Seidman SH, Telford L, Paige GD

Experimental brain research.. 1998 April 119 (3):307-14. Epub 1900 01 01.

Canal-otolith interactions in the squirrel monkey vestibulo-ocular reflex and the influence of fixation distance.

Telford L, Seidman SH, Paige GD

Experimental brain research.. 1998 January 118 (1):115-25. Epub 1900 01 01.

Dynamics of squirrel monkey linear vestibuloocular reflex and interactions with fixation distance.

Telford L, Seidman SH, Paige GD

Journal of neurophysiology.. 1997 October 78 (4):1775-90. Epub 1900 01 01.

Influence of sensorimotor context on the linear vestibulo-ocular reflex.

Paige GD, Barnes GR, Telford L, Seidman SH

Annals of the New York Academy of Sciences.. 1996 June 19781 :322-31. Epub 1900 01 01.

Perception and eye movement during low-frequency centripetal acceleration.

Seidman SH, Paige GD

Annals of the New York Academy of Sciences.. 1996 June 19781 :693-5. Epub 1900 01 01.

Canal-otolith interactions driving vertical and horizontal eye movements in the squirrel monkey.

Telford L, Seidman SH, Paige GD

Experimental brain research.. 1996 June 109 (3):407-18. Epub 1900 01 01.

Nystagmus and postural instability after headshake in patients with vestibular dysfunction.

Panosian MS, Paige GD

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 1995 March 112 (3):399-404. Epub 1900 01 01.

Vertical, horizontal, and torsional eye movement responses to head roll in the squirrel monkey.

Seidman SH, Telford L, Paige GD

Experimental brain research.. 1995 104 (2):218-26. Epub 1900 01 01.

Eye position signals in the abducens and oculomotor nuclei of monkeys during ocular convergence.

King WM, Zhou W, Tomlinson RD, McConville KM, Page WK, Paige GD, Maxwell JS

Journal of vestibular research : equilibrium & orientation.. 1994 4 (5):401-8. Epub 1900 01 01.

Senescence of human visual-vestibular interactions: smooth pursuit, optokinetic, and vestibular control of eye movements with aging.

Paige GD

Experimental brain research.. 1994 98 (2):355-72. Epub 1900 01 01.

Three dimensional eye movements of squirrel monkeys following postrotatory tilt.

Merfeld DM, Young LR, Paige GD, Tomko DL

Journal of vestibular research : equilibrium & orientation.. 1993 3 (2):123-39. Epub 1900 01 01.

Linear vestibuloocular reflex during motion along axes between nasooccipital and interaural.

Tomko DL, Paige GD

Annals of the New York Academy of Sciences.. 1992 May 22656 :233-41. Epub 1900 01 01.

Senescence of human visual-vestibular interactions. 1. Vestibulo-ocular reflex and adaptive plasticity with aging.

Paige GD

Journal of vestibular research : equilibrium & orientation.. 1992 2 (2):133-51. Epub 1900 01 01.

Ocular motor abnormalities in human immunodeficiency virus infection.

Merrill PT, Paige GD, Abrams RA, Jacoby RG, Clifford DB

Annals of neurology.. 1991 August 30 (2):130-8. Epub 1900 01 01.

Headshake versus whole-body rotation testing of the vestibulo-ocular reflex.

Goebel JA, Fortin M, Paige GD

The Laryngoscope.. 1991 July 101 (7 Pt 1):695-8. Epub 1900 01 01.

Eye movement responses to linear head motion in the squirrel monkey. I. Basic characteristics.

Paige GD, Tomko DL

Journal of neurophysiology.. 1991 May 65 (5):1170-82. Epub 1900 01 01.

Eye movement responses to linear head motion in the squirrel monkey. II. Visual-vestibular interactions and kinematic considerations.

Paige GD, Tomko DL

Journal of neurophysiology.. 1991 May 65 (5):1183-96. Epub 1900 01 01.

Falls in the elderly: reliability of a classification system.

Lach HW, Reed AT, Arfken CL, Miller JP, Paige GD, Birge SJ, Peck WA

Journal of the American Geriatrics Society.. 1991 February 39 (2):197-202. Epub 1900 01 01.

The squirrel monkey vestibulo-ocular reflex and adaptive plasticity in yaw, pitch, and roll.

Bello S, Paige GD, Highstein SM

Experimental brain research.. 1991 87 (1):57-66. Epub 1900 01 01.

The primate vestibulo-ocular reflex during combined linear and angular head motion.

Sargent EW, Paige GD

Experimental brain research.. 1991 87 (1):75-84. Epub 1900 01 01.

Visually-induced adaptive plasticity in the human vestibulo-ocular reflex.

Paige GD, Sargent EW

Experimental brain research.. 1991 84 (1):25-34. Epub 1900 01 01.

Linear vestibulo-ocular reflex (LVOR) and modulation by vergence.

Paige GD

Acta oto-laryngologica. Supplementum.. 1991 481 :282-6. Epub 1900 01 01.

Spatial orientation of VOR to combined vestibular stimuli in squirrel monkeys.

Merfeld DM, Young LR, Tomko DL, Paige GD

Acta oto-laryngologica. Supplementum.. 1991 481 :287-92. Epub 1900 01 01.

The aging vestibulo-ocular reflex (VOR) and adaptive plasticity.

Paige GD

Acta oto-laryngologica. Supplementum.. 1991 481 :297-300. Epub 1900 01 01.

Posturography following rotation: a model of posture control during vestibular dysfunction.

Goebel JA, Paige GD

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 1990 June 102 (6):722-6. Epub 1900 01 01.

Effect of head orientation on human postural stability following unilateral vestibular ablation.

Fox CR, Paige GD

Journal of vestibular research : equilibrium & orientation.. 1990 1 (2):153-60. Epub 1900 01 01.

Dynamic posturography and caloric test results in patients with and without vertigo.

Goebel JA, Paige GD

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 1989 June 100 (6):553-8. Epub 1900 01 01.

Central adaptation models of the vestibulo-ocular and optokinetic systems.

Furman JM, Hain TC, Paige GD

Biological cybernetics.. 1989 61 (4):255-64. Epub 1900 01 01.

Nonlinearity and asymmetry in the human vestibulo-ocular reflex.

Paige GD

Acta oto-laryngologica.. 1989 108 (1-2):1-8. Epub 1900 01 01.

The influence of target distance on eye movement responses during vertical linear motion.

Paige GD

Experimental brain research.. 1989 77 (3):585-93. Epub 1900 01 01.

Closed chamber iris suture for intraocular lens fixation.

Paige GD

Ophthalmic surgery. 1985 September 16 (9):566-7. Epub 1900 01 01.

Plasticity in the vestibulo-ocular and optokinetic reflexes following modification of canal input.

Paige GD

Reviews of oculomotor research. 1985 1 :145-53. Epub 1900 01 01.

Caloric responses after horizontal canal inactivation.

Paige GD

Acta oto-laryngologica.. 1985 100 (5-6):321-7. Epub 1900 01 01.

Vestibuloocular reflex and its interactions with visual following mechanisms in the squirrel monkey. I. Response characteristics in normal animals.

Paige GD

Journal of neurophysiology.. 1983 January 49 (1):134-51. Epub 1900 01 01.

Vestibuloocular reflex and its interactions with visual following mechanisms in the squirrel monkey. II. Response characteristics and plasticity following unilateral inactivation of horizontal canal.

Paige GD

Journal of neurophysiology.. 1983 January 49 (1):152-68. Epub 1900 01 01.

Evoked potential decrements in auditory cortex. I. Discrete-trial and continual stimulation.

Westenberg IS, Paige G, Golub B, Weinberger NM

Electroencephalography and clinical neurophysiology.. 1976 April 40 (4):337-55. Epub 1900 01 01.

Books

Brain Res. (2008)

Chapter: Eye Position and Cross-Sensory Learning both Contribute to Prism Adaptation of Auditory Space.

Authors: Cui, Q.N., O'Neill, Bachus, L, Knoth, E., W.E. and Paige, G.D.

Publisher: Elsevier 2008

Three-Dimensional Kinematic Principles of Eye, Head, and Limb Movements (1997)

Chapter: Torsional Eye Movements Evoked by Unilateral Galvanic Polarization in the Squirrel Monkey

Authors: Minor, L.B., Tomko, D.L., Paige, G.D.

Publisher: Harwood Academic Publishers GNBH, Chur, Switzerland 1997

Three-Dimensional Kinematic Principles of Eye, Head, and Limb Movements (1997)

Chapter: The VOR During Head Roll: Distinctive Properties Related to Visual Demands

Authors: Seidman, S.H., Paige, G.D., Leigh, R.J.

Publisher: Harwood Academic Publishing GNBH, Chur, Switzerland 1997

Disorders of the Vestibular System (1996)

Chapter: How Does the Linear VOR Compare with the Angular VOR

Authors: Paige, G.D.

Publisher: Oxford University Press, New York 1996

The Vestibulo-Ocular Reflex and Vertigo (1993)

Chapter: Aging and Equilibrium: The Vestibulo-Ocular Reflex and Posture.

Authors: Paige, G.D.

Publisher: Raven, New York 1993

Second Symposium on Head Movement Control; The Head-Neck Sensory-Motor System (1992)

Chapter: Eye movements and visual-vestibular interactions during linear head motion.

Authors: Paige, G.D. and Tomko, D.L.

Publisher: Oxford, New York 1992

From Neuron to Action. An Appraisal of Fundamental and Clinical Research. (1991)

Chapter: Optokinetic and Smooth Pursuit Response After Adaptive Modification of the Vestibulo-Ocular Reflex.

Authors: Paige, G.D. and Fredrickson, J.M.

Publisher: Springer Verlag, Berlin 1991

Reviews in Oculomotor Research. I. Adaptive Mechanisms in Gaze Control. (1985)

Chapter: Plasticity in the vestibulo-ocular and optokinetic reflexes following modification of canal input.

Authors: Paige, G.

Publisher: Elsevier: Amsterdam 1985

Locations

Strong Memorial Hospital

601 Elmwood Ave
Rochester, NY 14642-0001

(585) 275-6395 Get Directions