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Michael A. O'Reilly, Ph.D.

Michael A. O'Reilly, Ph.D.

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About Me

I grew up on Long Island and became interested in biological sciences when my 7th grade biology teacher brought clams from the Sound to school for us to dissect. I earned my undergraduate degree in Biology from the State University of New York at Stony Brook in 1984 and my doctoral degree at the Uni...
I grew up on Long Island and became interested in biological sciences when my 7th grade biology teacher brought clams from the Sound to school for us to dissect. I earned my undergraduate degree in Biology from the State University of New York at Stony Brook in 1984 and my doctoral degree at the University of Cincinnati in 1989. My thesis research under the mentorship of Dr. Jeffrey Whitsett showed how the collagen domain was responsible for proper folding and secretion of surfactant protein A and how glucocorticoids regulate transcription of surfactant proteins A and B. As a postdoctoral fellow at the NIH, I sequenced and studied transcriptional regulation of transforming growth factor-beta2 with Drs. Michael Sporn and Anita Roberts, and learned how to created transgenic mice working with Drs. Heiner Westphal and Kathleen Mahon. I joined the Department of Pediatrics at the University of Rochester in 1995 where I began to use my research training to investigate how high levels of oxygen (hyperoxia) inhibit cell proliferation via transforming growth factor-beta and p53 signaling. The preterm birth of my son in 2006 heavily motivated me to refocus my research towards understanding how early-life oxygen exposure reprograms lung development and cardiopulmonary health.

Faculty Appointments

Professor - Department of Pediatrics, Neonatology (SMD)

Professor - Department of Environmental Medicine (SMD) - Joint

Credentials

Post-doctoral Training & Residency

NRC Fellow, Lab. Mamm. Genes and Develop., NICHD, NIH
Dr. Heiner Westphal 1993 - 1995

Senior Staff Fellow, Laboratory of Chemoprevention, NCI, NIH 1992 - 1993

Staff Fellow, Laboratory of Chemoprevention, NCI, NIH
Drs. Michael B. Sporn and Anita B. Roberts 1989 - 1992

Education

PhD | University of Cincinnati. Developmental Biology. 1989

BS | SUNY at Stony Brook. Biology. 1984

Awards

Ruth A. Lawrence Academic Faculty Service Award. 2005

Dean's Incentive Award. 2004 - 2008

National Research Council. 1993 - 1995

Albert B. Ryan. 1988 - 1989

NIH Training Grant. 1986 - 1988

Research

Research from my lab has shown how mitochondrial superoxide produced during hyperoxia damages DNA, thereby activating SMG1 and ATM kinases controlling p53-dependent expression of the cyclin-dependent kinase inhibitor p21. Although p21 is best known for its ability to inhibit proliferation, my lab w...
Research from my lab has shown how mitochondrial superoxide produced during hyperoxia damages DNA, thereby activating SMG1 and ATM kinases controlling p53-dependent expression of the cyclin-dependent kinase inhibitor p21. Although p21 is best known for its ability to inhibit proliferation, my lab was the first to show that it protects against oxidative stress independent of cell cycle arrest through maintenance of anti-apoptotic proteins of the Bcl-2 family. P21 has now emerged to be one of the most abundantly expressed genes in many forms of lung injury.

The preterm birth of my son reminded me of my graduate training experience where I contributed to the understanding of surfactant biology and witnessed the excitement of a Neonatology fellow who used it to successfully treat a preterm infant for the first time. Using mice and human tissues as a model system, I have spent the past 15 years investigating how the oxygen environment at birth influences cardiopulmonary health later in life. My lab has shown how early-life oxygen exposure alters differentiation of alveolar epithelial cells, the host response to influenza A virus infection, reduces cognitive performance, and promotes age-dependent pulmonary hypertension and heart failure that can shorten lifespan. RNA-seq studies, genetic lineage mapping in mice, and investigation of human tissues are currently being used to understand how neonatal oxygen causes disease via metabolic reprogramming of stem/progenitor cells.

Publications

Journal Articles

PPAR? drives mitochondrial stress signaling and the loss of atrial cardiomyocytes in newborn mice exposed to hyperoxia.

Cohen ED, Roethlin K, Yee M, Woeller CF, Brookes PS, Porter GA, O'Reilly MA

Redox biology.. 2024 September 1276 :103351. Epub 09/12/2024.

Cyclophilin D inhibition rescues cardiac function in neonatal hypoxia.

Burris J, Beutner G, Cohen ED, Yee M, O'Reilly MA, Porter GA

Biophysical journal.. 2023 February 10122 (3S1):96a. Epub 1900 01 01.

Diacetyl inhalation impairs airway epithelial repair in mice infected with influenza A virus.

McGraw MD, Yee M, Kim SY, Dylag AM, Lawrence BP, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2022 November 1323 (5):L578-L592. Epub 09/06/2022.

Ataxia telangiectasia mutated is required for efficient proximal airway epithelial cell regeneration following influenza A virus infection.

Warren R, Dylag AM, Behan M, Domm W, Yee M, Mayer-Proschel M, Martinez L, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2022 April 1322 (4):L581-L592. Epub 02/23/2022.

Neonatal Hyperoxia Activates Activating Transcription Factor 4 to Stimulate Folate Metabolism and Alveolar Epithelial Type 2 Cell Proliferation.

Yee M, McDavid AN, Cohen ED, Huyck HL, Poole C, Altman BJ, Maniscalco WM, Deutsch GH, Pryhuber GS, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2022 April 66 (4):402-414. Epub 1900 01 01.

Low-dose hyperoxia primes airways for fibrosis in mice after influenza A infection.

Dylag AM, Haak J, Warren R, Yee M, Pryhuber GS, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2021 October 1321 (4):L750-L763. Epub 07/29/2021.

Neonatal hyperoxia impairs adipogenesis of bone marrow-derived mesenchymal stem cells and fat accumulation in adult mice.

Woeller CF, Lim SA, Roztocil E, Yee M, Beier EE, Puzas JE, O'Reilly MA

Free radical biology & medicine.. 2021 May 1167 :287-298. Epub 03/21/2021.

Neonatal hyperoxia inhibits proliferation and survival of atrial cardiomyocytes by suppressing fatty acid synthesis.

Cohen ED, Yee M, Porter GA, Ritzer EE, McDavid AN, Brookes PS, Pryhuber GS, O'Reilly MA

JCI insight.. 2021 March 86 (5)Epub 03/08/2021.

Neonatal hyperoxia enhances age-dependent expression of SARS-CoV-2 receptors in mice.

Yee M, David Cohen E, Haak J, Dylag AM, O'Reilly MA

Scientific reports.. 2020 December 2810 (1):22401. Epub 12/28/2020.

Tumor Necrosis Factor Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease-Associated Pulmonary Arterial Hypertension.

Bell RD, White RJ, Garcia-Hernandez ML, Wu E, Rahimi H, Marangoni RG, Slattery P, Duemmel S, Nuzzo M, Huertas N, Yee M, O'Reilly MA, Morrell C, Ritchlin CT, Schwarz EM, Korman BD

Arthritis & rheumatology.. 2020 October 72 (10):1759-1770. Epub 08/20/2020.

Lung SOD3 limits neurovascular reperfusion injury and systemic immune activation following transient global cerebral ischemia.

Mai N, Prifti V, Lim K, O'Reilly MA, Kim M, Halterman MW

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2020 September 29 (9):104942. Epub 05/14/2020.

Early Neonatal Oxygen Exposure Predicts Pulmonary Morbidity and Functional Deficits at 1 Year.

Dylag AM, Kopin HG, O'Reilly MA, Wang H, Davis SD, Ren CL, Pryhuber GS

The Journal of pediatrics.. 2020 August 223 :20-28.e2. Epub 1900 01 01.

Pulmonary mechanics and structural lung development after neonatal hyperoxia in mice.

Dylag AM, Haak J, Yee M, O'Reilly MA

Pediatric research.. 2020 June 87 (7):1201-1210. Epub 12/13/2019.

Swapping mitochondria: a key to understanding susceptibility to neonatal chronic lung disease.

Dylag AM, Brookes PS, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2019 December 1317 (6):L737-L739. Epub 10/09/2019.

Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection.

Warren R, Domm W, Yee M, Campbell A, Malone J, Wright T, Mayer-Proschel M, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2019 November 1317 (5):L591-L601. Epub 09/11/2019.

An Elusive Fox that Suppresses Scgb1a1 in Asthma Has Been Found.

Warren R, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2019 June 60 (6):615-617. Epub 1900 01 01.

Lung-Derived SOD3 Attenuates Neurovascular Injury After Transient Global Cerebral Ischemia.

Mai N, Miller-Rhodes K, Prifti V, Kim M, O'Reilly MA, Halterman MW

Journal of the American Heart Association.. 2019 May 78 (9):e011801. Epub 1900 01 01.

Effect of neonatal hyperoxia followed by concentrated ambient ultrafine particle exposure on cumulative learning in C57Bl/6J mice.

Morris-Schaffer K, Sobolewski M, Allen JL, Marvin E, Yee M, Arora M, O'Reilly MA, Cory-Slechta DA

Neurotoxicology.. 2018 July 67 :234-244. Epub 06/18/2018.

Neonatal hyperoxia depletes pulmonary vein cardiomyocytes in adult mice via mitochondrial oxidation.

Yee M, Cohen ED, Domm W, Porter GA, McDavid AN, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2018 May 1314 (5):L846-L859. Epub 01/18/2018.

Cognitive flexibility deficits in male mice exposed to neonatal hyperoxia followed by concentrated ambient ultrafine particles.

Morris-Schaffer K, Sobolewski M, Welle K, Conrad K, Yee M, O'Reilly MA, Cory-Slechta DA

Neurotoxicology and teratology.. 2018 70 :51-59. Epub 10/11/2018.

Inflammation and transcriptional responses of peripheral blood mononuclear cells in classic ataxia telangiectasia.

McGrath-Morrow SA, Ndeh R, Collaco JM, Rothblum-Oviatt C, Wright J, O'Reilly MA, Singer BD, Lederman HM

PloS one.. 2018 13 (12):e0209496. Epub 12/26/2018.

Lung-Specific Extracellular Superoxide Dismutase Improves Cognition of Adult Mice Exposed to Neonatal Hyperoxia.

Buczynski BW, Mai N, Yee M, Allen JL, Prifti L, Cory-Slechta DA, Halterman MW, O'Reilly MA

Frontiers in medicine.. 2018 5 :334. Epub 12/10/2018.

Oxygen-dependent changes in lung development do not affect epithelial infection with influenza A virus.

Domm W, Yee M, Misra RS, Gelein R, Nogales A, Martinez Sobrido L, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2017 November 1313 (5):L940-L949. Epub 08/10/2017.

Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells.

Yee M, Domm W, Gelein R, Bentley KL, Kottmann RM, Sime PJ, Lawrence BP, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2017 April 56 (4):453-464. Epub 1900 01 01.

Giving New Identities to Alveolar Epithelial Type I Cells.

O'Reilly MA

American journal of respiratory cell and molecular biology.. 2017 March 56 (3):277-278. Epub 1900 01 01.

SMG-1 kinase attenuates mitochondrial ROS production but not cell respiration deficits during hyperoxia.

Resseguie EA, Brookes PS, O'Reilly MA

Experimental lung research.. 2017 43 (6-7):229-239. Epub 07/27/2017.

The Oxygen Environment at Birth Specifies the Population of Alveolar Epithelial Stem Cells in the Adult Lung.

Yee M, Gelein R, Mariani TJ, Lawrence BP, O'Reilly MA

Stem cells.. 2016 May 34 (5):1396-406. Epub 03/07/2016.

Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction.

Resseguie EA, Staversky RJ, Brookes PS, O'Reilly MA

Redox biology.. 2015 August 5 :176-185. Epub 05/02/2015.

Cumulative neonatal oxygen exposure predicts response of adult mice infected with influenza A virus.

Maduekwe ET, Buczynski BW, Yee M, Rangasamy T, Stevens TP, Lawrence BP, O'Reilly MA

Pediatric pulmonology.. 2015 March 50 (3):222-230. Epub 05/22/2014.

Neonatal hyperoxia leads to persistent alterations in NK responses to influenza A virus infection.

Reilly EC, Martin KC, Jin GB, Yee M, O'Reilly MA, Lawrence BP

American journal of physiology. Lung cellular and molecular physiology.. 2015 January 1308 (1):L76-85. Epub 11/07/2014.

Bronchopulmonary dysplasia early changes leading to long-term consequences.

Hilgendorff A, O'Reilly MA

Frontiers in medicine.. 2015 2 :2. Epub 02/12/2015.

Affect of Early Life Oxygen Exposure on Proper Lung Development and Response to Respiratory Viral Infections.

Domm W, Misra RS, O'Reilly MA

Frontiers in medicine.. 2015 2 :55. Epub 08/10/2015.

The genome-wide transcriptional response to neonatal hyperoxia identifies Ahr as a key regulator.

Bhattacharya S, Zhou Z, Yee M, Chu CY, Lopez AM, Lunger VA, Solleti SK, Resseguie E, Buczynski BW, Mariani TJ, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2014 October 1307 (7):L516-23. Epub 08/22/2014.

DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells.

Kalifa L, Gewandter JS, Staversky RJ, Sia EA, Brookes PS, O'Reilly MA

Free radical biology & medicine.. 2014 October 75 :30-9. Epub 07/15/2014.

Neonatal hyperoxia stimulates the expansion of alveolar epithelial type II cells.

Yee M, Buczynski BW, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2014 April 50 (4):757-66. Epub 1900 01 01.

Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis.

Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW

The Journal of immunology : official journal of the American Association of Immunologists.. 2013 November 1191 (9):4720-30. Epub 09/27/2013.

Transdifferentiation of alveolar epithelial type II to type I cells is controlled by opposing TGF-? and BMP signaling.

Zhao L, Yee M, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2013 September 15305 (6):L409-18. Epub 07/05/2013.

Neonatal hyperoxia alters the host response to influenza A virus infection in adult mice through multiple pathways.

Buczynski BW, Yee M, Martin KC, Lawrence BP, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2013 August 15305 (4):L282-90. Epub 06/07/2013.

Neonatal hyperoxia increases sensitivity of adult mice to bleomycin-induced lung fibrosis.

Yee M, Buczynski BW, Lawrence BP, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2013 February 48 (2):258-66. Epub 12/20/2012.

Angiotensin II: tapping the cell cycle machinery to kill endothelial cells.

O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2012 October 1303 (7):L575-6. Epub 08/10/2012.

Memory CD8+ T cells are sufficient to alleviate impaired host resistance to influenza A virus infection caused by neonatal oxygen supplementation.

Giannandrea M, Yee M, O'Reilly MA, Lawrence BP

Clinical and vaccine immunology : CVI.. 2012 September 19 (9):1432-41. Epub 07/11/2012.

Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1.

O'Reilly MA, Yee M, Buczynski BW, Vitiello PF, Keng PC, Welle SL, Finkelstein N, Dean DA, Lawrence BP

The American journal of pathology.. 2012 August 181 (2):441-51. Epub 06/05/2012.

Lung development and the host response to influenza A virus are altered by different doses of neonatal oxygen in mice.

Buczynski BW, Yee M, Lawrence BP, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2012 May 15302 (10):L1078-87. Epub 03/09/2012.

Neonatal hyperoxia contributes additively to cigarette smoke-induced chronic obstructive pulmonary disease changes in adult mice.

McGrath-Morrow SA, Lauer T, Collaco JM, Yee M, O'Reilly M, Mitzner W, Neptune E, Wise R, Biswal S

American journal of respiratory cell and molecular biology.. 2011 September 45 (3):610-6. Epub 01/14/2011.

The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA.

Gewandter JS, Bambara RA, O'Reilly MA

Cell cycle.. 2011 August 110 (15):2561-7. Epub 08/01/2011.

Neonatal hyperoxia causes pulmonary vascular disease and shortens life span in aging mice.

Yee M, White RJ, Awad HA, Bates WA, McGrath-Morrow SA, O'Reilly MA

The American journal of pathology.. 2011 June 178 (6):2601-10. Epub 05/06/2011.

Bcl-X(L) is the primary mediator of p21 protection against hyperoxia-induced cell death.

Wu YC, O'Reilly MA

Experimental lung research.. 2011 March 37 (2):82-91. Epub 12/04/2010.

Epithelial ablation of Bcl-XL increases sensitivity to oxygen without disrupting lung development.

Staversky RJ, Vitiello PF, Yee M, Callahan LM, Dean DA, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2010 September 43 (3):376-85. Epub 10/30/2009.

Murine mechanical ventilation stimulates alveolar epithelial cell proliferation.

Chess PR, Benson RP, Maniscalco WM, Wright TW, O'Reilly MA, Johnston CJ

Experimental lung research.. 2010 August 36 (6):331-41. Epub 1900 01 01.

Hyperoxia augments ER-stress-induced cell death independent of BiP loss.

Gewandter JS, Staversky RJ, O'Reilly MA

Free radical biology & medicine.. 2009 December 1547 (12):1742-52. Epub 09/26/2009.

Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity.

Yee M, Chess PR, McGrath-Morrow SA, Wang Z, Gelein R, Zhou R, Dean DA, Notter RH, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2009 October 297 (4):L641-9. Epub 07/17/2009.

Activation of the aryl hydrocarbon receptor during different critical windows in pregnancy alters mammary epithelial cell proliferation and differentiation.

Lew BJ, Collins LL, O'Reilly MA, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2009 September 111 (1):151-62. Epub 06/05/2009.

Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia.

McGrath-Morrow S, Lauer T, Yee M, Neptune E, Podowski M, Thimmulappa RK, O'Reilly M, Biswal S

American journal of physiology. Lung cellular and molecular physiology.. 2009 April 296 (4):L565-73. Epub 01/16/2009.

p21(Cip1) protects against oxidative stress by suppressing ER-dependent activation of mitochondrial death pathways.

Vitiello PF, Wu YC, Staversky RJ, O'Reilly MA

Free radical biology & medicine.. 2009 January 146 (1):33-41. Epub 10/07/2008.

Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia.

Pryhuber GS, Huyck HL, Bhagwat S, O'Reilly MA, Finkelstein JN, Gigliotti F, Wright TW

The Journal of immunology : official journal of the American Association of Immunologists.. 2008 July 15181 (2):1409-19. Epub 1900 01 01.

hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress.

Gehen SC, Staversky RJ, Bambara RA, Keng PC, O'Reilly MA

Oncogene.. 2008 July 327 (29):4065-74. Epub 03/10/2008.

Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice.

Yao H, Yang SR, Edirisinghe I, Rajendrasozhan S, Caito S, Adenuga D, O'Reilly MA, Rahman I

American journal of respiratory cell and molecular biology.. 2008 July 39 (1):7-18. Epub 01/31/2008.

Neonatal hyperoxia enhances the inflammatory response in adult mice infected with influenza A virus.

O'Reilly MA, Marr SH, Yee M, McGrath-Morrow SA, Lawrence BP

American journal of respiratory and critical care medicine.. 2008 May 15177 (10):1103-10. Epub 02/21/2008.

PUMA inactivation protects against oxidative stress through p21/Bcl-XL inhibition of bax death.

Vitiello PF, Staversky RJ, Keng PC, O'Reilly MA

Free radical biology & medicine.. 2008 February 144 (3):367-74. Epub 10/10/2007.

Downregulation of PCNA potentiates p21-mediated growth inhibition in response to hyperoxia.

Gehen SC, Vitiello PF, Bambara RA, Keng PC, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2007 March 292 (3):L716-24. Epub 11/03/2006.

c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells.

Bijli KM, Minhajuddin M, Fazal F, O'Reilly MA, Platanias LC, Rahman A

American journal of physiology. Lung cellular and molecular physiology.. 2007 February 292 (2):L396-404. Epub 09/29/2006.

Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development.

Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2006 November 291 (5):L1101-11. Epub 07/21/2006.

p21(Cip1/Waf1/Sdi1) protects against hyperoxia by maintaining expression of Bcl-X(L).

Staversky RJ, Vitiello PF, Gehen SC, Helt CE, Rahman A, Keng PC, O'Reilly MA

Free radical biology & medicine.. 2006 August 1541 (4):601-9. Epub 05/23/2006.

p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth.

Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA

The American journal of pathology.. 2006 June 168 (6):1838-47. Epub 1900 01 01.

Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia.

Auten RL, O'Reilly MA, Oury TD, Nozik-Grayck E, Whorton MH

American journal of physiology. Lung cellular and molecular physiology.. 2006 January 290 (1):L32-40. Epub 08/12/2005.

Reactive oxidant and p42/44 MAP kinase signaling is necessary for mechanical strain-induced proliferation in pulmonary epithelial cells.

Chess PR, O'Reilly MA, Sachs F, Finkelstein JN

Journal of applied physiology.. 2005 September 99 (3):1226-32. Epub 05/12/2005.

Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expression.

Maniscalco WM, Watkins RH, Roper JM, Staversky R, O'Reilly MA

Pediatric research.. 2005 September 58 (3):549-56. Epub 1900 01 01.

High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation.

Boo LM, Lin HH, Chung V, Zhou B, Louie SG, O'Reilly MA, Yen Y, Ann DK

Cancer research.. 2005 August 165 (15):6622-30. Epub 1900 01 01.

Acute tumor necrosis factor-alpha-induced liver injury in the absence of tumor necrosis factor receptor-associated factor 1 gene expression.

Pryhuber GS, Huyck HL, Roper JM, Cornejo J, O'Reilly MA, Pierce RH, Tsitsikov EN

The American journal of pathology.. 2005 June 166 (6):1637-45. Epub 1900 01 01.

Loss of Gadd45a does not modify the pulmonary response to oxidative stress.

Roper JM, Gehen SC, Staversky RJ, Hollander MC, Fornace AJ, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2005 April 288 (4):L663-71. Epub 01/14/2005.

p53 modulates radiation sensitivity independent of p21 transcriptional activation.

Mazzatti DJ, Lee YJ, Helt CE, O'Reilly MA, Keng PC

American journal of clinical oncology.. 2005 February 28 (1):43-50. Epub 1900 01 01.

Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.

Helt CE, Cliby WA, Keng PC, Bambara RA, O'Reilly MA

The Journal of biological chemistry.. 2005 January 14280 (2):1186-92. Epub 11/08/2004.

p21(Cip1/WAF1/Sdi1) does not affect expression of base excision DNA repair enzymes during chronic oxidative stress.

O'reilly MA, Vitiello PF, Gehen SC, Staversky RJ

Antioxidants & redox signaling.. 2005 7 (5-6):719-25. Epub 1900 01 01.

Macroarray analysis reveals a strain-induced oxidant response in pulmonary epithelial cells.

Chess PR, O'Reilly MA, Toia L

Experimental lung research.. 2004 December 30 (8):739-53. Epub 1900 01 01.

In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cells.

Roper JM, Mazzatti DJ, Watkins RH, Maniscalco WM, Keng PC, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2004 May 286 (5):L1045-54. Epub 01/16/2004.

DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway.

Su C, Gao G, Schneider S, Helt C, Weiss C, O'Reilly MA, Bohmann D, Zhao J

The EMBO journal.. 2004 March 1023 (5):1133-43. Epub 02/19/2004.

The Cdk and PCNA domains on p21Cip1 both function to inhibit G1/S progression during hyperoxia.

Helt CE, Staversky RJ, Lee YJ, Bambara RA, Keng PC, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2004 March 286 (3):L506-13. Epub 08/22/2003.

Induced p21Cip1 in premature baboons with CLD: implications for alveolar hypoplasia.

O'Reilly MA, Watkins RH, Staversky RJ, Maniscalco WM

American journal of physiology. Lung cellular and molecular physiology.. 2003 October 285 (4):L964-71. Epub 07/18/2003.

Identification and isolation of mouse type II cells on the basis of intrinsic expression of enhanced green fluorescent protein.

Roper JM, Staversky RJ, Finkelstein JN, Keng PC, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2003 September 285 (3):L691-700. Epub 05/09/2003.

Activation of the G2 cell cycle checkpoint enhances survival of epithelial cells exposed to hyperoxia.

O'Reilly MA, Staversky RJ, Finkelstein JN, Keng PC

American journal of physiology. Lung cellular and molecular physiology.. 2003 February 284 (2):L368-75. Epub 10/11/2002.

Carbonic anhydrase XII mRNA encodes a hydratase that is differentially expressed along the rabbit nephron.

Schwartz GJ, Kittelberger AM, Watkins RH, O'Reilly MA

American journal of physiology. Renal physiology.. 2003 February 284 (2):F399-410. Epub 10/08/2002.

Effects of hyperoxia on tumor necrosis factor alpha and Grobeta expression in newborn rabbit lungs.

Varughese R, Nayak JL, LoMonaco M, O'Reilly MA, Ryan RM, D'Angio CT

Lung.. 2003 181 (6):335-46. Epub 1900 01 01.

Increased epithelial cell proliferation in very premature baboons with chronic lung disease.

Maniscalco WM, Watkins RH, O'Reilly MA, Shea CP

American journal of physiology. Lung cellular and molecular physiology.. 2002 November 283 (5):L991-L1001. Epub 1900 01 01.

Growth arrest in G1 protects against oxygen-induced DNA damage and cell death.

Rancourt RC, Hayes DD, Chess PR, Keng PC, O'Reilly MA

Journal of cellular physiology.. 2002 October 193 (1):26-36. Epub 1900 01 01.

Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1).

Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA

The American journal of pathology.. 2002 October 161 (4):1383-93. Epub 1900 01 01.

p53-dependent induction of p21(Cip1/WAF1/Sdi1) protects against oxygen-induced toxicity.

Helt CE, Rancourt RC, Staversky RJ, O'Reilly MA

Toxicological sciences : an official journal of the Society of Toxicology.. 2001 October 63 (2):214-22. Epub 1900 01 01.

The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress.

O'Reilly MA, Staversky RJ, Watkins RH, Reed CK, de Mesy Jensen KL, Finkelstein JN, Keng PC

American journal of respiratory cell and molecular biology.. 2001 June 24 (6):703-10. Epub 1900 01 01.

The role of p21(CIP1/WAF1) in growth of epithelial cells exposed to hyperoxia.

Rancourt RC, Keng PC, Helt CE, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2001 April 280 (4):L617-26. Epub 1900 01 01.

Bcl-2 family gene expression during severe hyperoxia induced lung injury.

O'Reilly MA, Staversky RJ, Huyck HL, Watkins RH, LoMonaco MB, D'Angio CT, Baggs RB, Maniscalco WM, Pryhuber GS

Laboratory investigation; a journal of technical methods and pathology.. 2000 December 80 (12):1845-54. Epub 1900 01 01.

Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica.

Johnston CJ, Driscoll KE, Finkelstein JN, Baggs R, O'Reilly MA, Carter J, Gelein R, Oberdörster G

Toxicological sciences : an official journal of the Society of Toxicology.. 2000 August 56 (2):405-13. Epub 1900 01 01.

p53-independent induction of GADD45 and GADD153 in mouse lungs exposed to hyperoxia.

O'Reilly MA, Staversky RJ, Watkins RH, Maniscalco WM, Keng PC

American journal of physiology. Lung cellular and molecular physiology.. 2000 March 278 (3):L552-9. Epub 1900 01 01.

Tumor necrosis factor-alpha-induced lung cell expression of antiapoptotic genes TRAF1 and cIAP2.

Pryhuber GS, Huyck HL, Staversky RJ, Finkelstein JN, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2000 February 22 (2):150-6. Epub 1900 01 01.

Hyperoxia inhibits proliferation of Mv1Lu epithelial cells independent of TGF-? signaling.

Rancourt RC, Staversky RJ, Keng PC, O'reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 1999 December 1277 (6):L1172-L1178. Epub 1900 01 01.

Hyperoxia inhibits proliferation of Mv1Lu epithelial cells independent of TGF-beta signaling.

Rancourt RC, Staversky RJ, Keng PC, O'Reilly MA

The American journal of physiology.. 1999 December 277 (6):L1172-8. Epub 1900 01 01.

Accumulation of p21(Cip1/WAF1) during hyperoxic lung injury in mice.

O'Reilly MA, Staversky RJ, Watkins RH, Maniscalco WM

American journal of respiratory cell and molecular biology.. 1998 November 19 (5):777-85. Epub 1900 01 01.

TGF-beta1 up-regulates the mRNA for the Na+/Ca2+ exchanger in neonatal rat cardiac myocytes.

Carrillo C, Cafferata EG, Genovese J, O'Reilly M, Roberts AB, Santa-Coloma TA

Cellular and molecular biology.. 1998 May 44 (3):543-51. Epub 1900 01 01.

Exposure to hyperoxia induces p53 expression in mouse lung epithelium.

O'Reilly MA, Staversky RJ, Stripp BR, Finkelstein JN

American journal of respiratory cell and molecular biology.. 1998 January 18 (1):43-50. Epub 1900 01 01.

Temporal changes in expression of TGF-beta isoforms in mouse lung exposed to oxygen.

O'Reilly MA, Staversky RJ, Flanders KC, Johnston CJ, Finkelstein JN

The American journal of physiology.. 1997 January 272 (1 Pt 1):L60-7. Epub 1900 01 01.

Regulation of the transforming growth factor-beta 1 and -beta 3 promoters by transcription factor Sp1.

Geiser AG, Busam KJ, Kim SJ, Lafyatis R, O'Reilly MA, Webbink R, Roberts AB, Sporn MB

Gene.. 1993 July 30129 (2):223-8. Epub 1900 01 01.

Loss of expression of transforming growth factor beta in skin and skin tumors is associated with hyperproliferation and a high risk for malignant conversion.

Glick AB, Kulkarni AB, Tennenbaum T, Hennings H, Flanders KC, O'Reilly M, Sporn MB, Karlsson S, Yuspa SH

Proceedings of the National Academy of Sciences of the United States of America.. 1993 July 190 (13):6076-80. Epub 1900 01 01.

Identification of an activating transcription factor (ATF) binding site in the human transforming growth factor-beta 2 promoter.

O'Reilly MA, Geiser AG, Kim SJ, Bruggeman LA, Luu AX, Roberts AB, Sporn MB

The Journal of biological chemistry.. 1992 October 5267 (28):19938-43. Epub 1900 01 01.

Differential regulation of the transforming growth factor type-beta 2 gene promoter in embryonal carcinoma cells and their differentiated cells.

Kelly D, O'Reilly MA, Rizzino A

Developmental biology.. 1992 September 153 (1):172-5. Epub 1900 01 01.

Retinoblastoma gene product activates expression of the human TGF-beta 2 gene through transcription factor ATF-2.

Kim SJ, Wagner S, Liu F, O'Reilly MA, Robbins PD, Green MR

Nature.. 1992 July 23358 (6384):331-4. Epub 1900 01 01.

Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.

Bang YJ, Kim SJ, Danielpour D, O'Reilly MA, Kim KY, Myers CE, Trepel JB

Proceedings of the National Academy of Sciences of the United States of America.. 1992 April 1589 (8):3556-60. Epub 1900 01 01.

Transforming growth factor-beta inhibits surfactant protein A expression in vitro.

Whitsett JA, Budden A, Hull WM, Clark JC, O'Reilly MA

Biochimica et biophysica acta.. 1992 February 121123 (3):257-62. Epub 1900 01 01.

Regulation of expression of transforming growth factor-beta 2 by transforming growth factor-beta isoforms is dependent upon cell type.

O'Reilly MA, Danielpour D, Roberts AB, Sporn MB

Growth factors.. 1992 6 (3):193-201. Epub 1900 01 01.

Glucocorticoid enhances pulmonary surfactant protein B gene transcription.

O'Reilly MA, Clark JC, Whitsett JA

The American journal of physiology.. 1991 February 260 (2 Pt 1):L37-43. Epub 1900 01 01.

Molecular cloning and structure of the human transforming growth factor-beta 2 gene promoter.

Noma T, Glick AB, Geiser AG, O'Reilly MA, Miller J, Roberts AB, Sporn MB

Growth factors.. 1991 4 (4):247-55. Epub 1900 01 01.

Multiple forms of TGF-beta: distinct promoters and differential expression.

Roberts AB, Kim SJ, Noma T, Glick AB, Lafyatis R, Lechleider R, Jakowlew SB, Geiser A, O'Reilly MA, Danielpour D

Ciba Foundation symposium.. 1991 157 :7-15; discussion 15-28. Epub 1900 01 01.

Phorbol ester inhibits surfactant protein SP-A and SP-B expression.

Pryhuber GS, O'Reilly MA, Clark JC, Hull WM, Fink I, Whitsett JA

The Journal of biological chemistry.. 1990 December 5265 (34):20822-8. Epub 1900 01 01.

Glucocorticoids regulate surfactant protein synthesis in a pulmonary adenocarcinoma cell line.

O'Reilly MA, Gazdar AF, Clark JC, Pilot-Matias TJ, Wert SE, Hull WM, Whitsett JA

The American journal of physiology.. 1989 December 257 (6 Pt 1):L385-92. Epub 1900 01 01.

In vitro translation, post-translational processing and secretion of pulmonary surfactant protein B precursors.

O'Reilly MA, Weaver TE, Pilot-Matias TJ, Sarin VK, Gazdar AF, Whitsett JA

Biochimica et biophysica acta.. 1989 May 101011 (2-3):140-8. Epub 1900 01 01.

Differential effects of glucocorticoid on expression of surfactant proteins in a human lung adenocarcinoma cell line.

O'Reilly MA, Gazdar AF, Morris RE, Whitsett JA

Biochimica et biophysica acta.. 1988 June 30970 (2):194-204. Epub 1900 01 01.

Requirement of the collagenous domain for carbohydrate processing and secretion of a surfactant protein, SP-A.

O'Reilly MA, Nogee L, Whitsett JA

Biochimica et biophysica acta.. 1988 April 25969 (2):176-84. Epub 1900 01 01.

Books

Lung Development, Clinical Correlates and Technologies for the Future (2015)

Chapter: Perinatal disruptions of lung development: Mechanisms and implications for chronic lung diseases.

Authors: O'Reilly, MA.

Publisher: New York, Cambridge University Press 2015

Mitochondrial Function in Lung Health and Disease. (2014)

Chapter: The impact of DNA damage on epithelial cell maintenance of the lung.

Authors: Kalifa L and O'Reilly MA.

Publisher: Springer Science+Business Media 2014

Lung Injury: Mechanisms, Pathophysiology, and Therapy (2005)

Chapter: Cell and Animal Models of Lung Injury

Authors: Finkelstein JN, O'Reilly MA, Holm BA, Chess PC, Notter RH

Publisher: Marcel Dekker, New York, NY 2005