MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.
DeRollo RE, Cazarin J, Ahmad Shahidan SNAB, Burchett JB, Mwangi D, Krishnaiah S, Hsieh AL, Walton ZE, Brooks R, Mello SS, Weljie AM, Dang CV, Altman BJ
bioRxiv : the preprint server for biology.. 2023 August 8 Epub 08/08/2023.
MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.
Cazarin J, DeRollo RE, Shahidan SNABA, Burchett JB, Mwangi D, Krishnaiah S, Hsieh AL, Walton ZE, Brooks R, Mello SS, Weljie AM, Dang CV, Altman BJ
PLoS genetics.. 2023 August 19 (8):e1010904. Epub 08/28/2023.
A PERK-miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival.
Bu Y, Yoshida A, Chitnis N, Altman BJ, Tameire F, Oran A, Gennaro V, Armeson KE, McMahon SB, Wertheim GB, Dang CV, Ruggero D, Koumenis C, Fuchs SY, Diehl JA
Nature cell biology.. 2018 January 20 (1):104-115. Epub 12/11/2017.
Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism.
Krishnaiah SY, Wu G, Altman BJ, Growe J, Rhoades SD, Coldren F, Venkataraman A, Olarerin-George AO, Francey LJ, Mukherjee S, Girish S, Selby CP, Cal S, Er U, Sianati B, Sengupta A, Anafi RC, Kavakli IH, Sancar A, Baur JA, Dang CV, Hogenesch JB, Weljie AM
Cell metabolism.. 2017 April 425 (4):961-974.e4. Epub 1900 01 01.
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.
Altman BJ, Hsieh AL, Sengupta A, Krishnanaiah SY, Stine ZE, Walton ZE, Gouw AM, Venkataraman A, Li B, Goraksha-Hicks P, Diskin SJ, Bellovin DI, Simon MC, Rathmell JC, Lazar MA, Maris JM, Felsher DW, Hogenesch JB, Weljie AM, Dang CV
Cell metabolism.. 2015 December 122 (6):1009-19. Epub 09/17/2015.
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.
Xiang Y, Stine ZE, Xia J, Lu Y, O'Connor RS, Altman BJ, Hsieh AL, Gouw AM, Thomas AG, Gao P, Sun L, Song L, Yan B, Slusher BS, Zhuo J, Ooi LL, Lee CG, Mancuso A, McCallion AS, Le A, Milone MC, Rayport S, Felsher DW, Dang CV
The Journal of clinical investigation.. 2015 June 125 (6):2293-306. Epub 04/27/2015.
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.
Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC
The Journal of biological chemistry.. 2011 February 18286 (7):5921-33. Epub 12/15/2010.
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.
Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC
Molecular and cellular biology.. 2007 June 27 (12):4328-39. Epub 03/19/2007.