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John E. Gerich, M.D.

John E. Gerich, M.D.

About Me

Dr. Gerich received his B.A. from Cornell University and his M.D. from Georgetown University. Dr. Gerich has been productive as both a clinical investigator (over 500 publications) and as a teacher (nearly 50 clinical research fellows) for nearly 35 years. His research examines hormone-substrate con...
Dr. Gerich received his B.A. from Cornell University and his M.D. from Georgetown University. Dr. Gerich has been productive as both a clinical investigator (over 500 publications) and as a teacher (nearly 50 clinical research fellows) for nearly 35 years. His research examines hormone-substrate control of glucose homeostasis and of hypoglycemia counter regulation by evaluating the role of the kidney. Dr Gerich has also served as Program Director of the NIH funded Clinical Research Center (CRC). He is also an active faculty member of the University's Clinical and Translational Science Institute (CTSI).

Faculty Appointments

Professor Emeritus - Department of Medicine, Endocrine/Metabolism (SMD)

Credentials

Education

MD | Georgetown Univ Sch Medicine. Medicine. 1969

BA | Cornell University. Not Classifiable. 1965

Research

Dr. Gerich received his B.A. from Cornell University and his M.D. from Georgetown University. Dr. Gerich has been productive as both a clinical investigator (over 500 publications) and as a teacher (nearly 50 clinical research fellows) for nearly 35 years. His research examines hormone-substrate con...
Dr. Gerich received his B.A. from Cornell University and his M.D. from Georgetown University. Dr. Gerich has been productive as both a clinical investigator (over 500 publications) and as a teacher (nearly 50 clinical research fellows) for nearly 35 years. His research examines hormone-substrate control of glucose homeostasis and of hypoglycemia counter regulation by evaluating the role of the kidney. Dr Gerich has also served as Program Director of the NIH funded Clinical Research Center (CRC). He is also an active faculty member of the University's Clinical and Translational Science Institute (CTSI).

Publications

Journal Articles

DPP-4 inhibitors: what may be the clinical differentiators?

Gerich J

Diabetes research and clinical practice.. 2010 November 90 (2):131-40. Epub 08/13/2010.

Type 2 diabetes: postprandial hyperglycemia and increased cardiovascular risk.

Aryangat AV, Gerich JE

Vascular health and risk management.. 2010 March 246 :145-55. Epub 03/24/2010.

Diabetes mellitus and gastric emptying: questions and issues in clinical practice.

Samsom M, Bharucha A, Gerich JE, Herrmann K, Limmer J, Linke R, Maggs D, Schirra J, Vella A, Wörle HJ, Göke B

Diabetes/metabolism research and reviews.. 2009 September 25 (6):502-14. Epub 1900 01 01.

Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD).

Zinman B, Gerich J, Buse JB, Lewin A, Schwartz S, Raskin P, Hale PM, Zdravkovic M, Blonde L,

Diabetes care.. 2009 July 32 (7):1224-30. Epub 03/16/2009.

Is a history of gestational diabetes related to risk factors for coronary heart disease?

King KB, Gerich JE, Guzick DS, King KU, McDermott MP

Research in nursing & health.. 2009 June 32 (3):298-306. Epub 1900 01 01.

Different pathophysiology of impaired glucose tolerance in first-degree relatives of individuals with type 2 diabetes mellitus.

Emerson P, Van Haeften TW, Pimenta W, Plummer E, Woerle HJ, Mitrakou A, Szoke E, Gerich J, Meyer C

Metabolism: clinical and experimental.. 2009 May 58 (5):602-7. Epub 1900 01 01.

Impaired hyperglycemia-induced delay in gastric emptying in patients with type 1 diabetes deficient for islet amyloid polypeptide.

Woerle HJ, Albrecht M, Linke R, Zschau S, Neumann C, Nicolaus M, Gerich JE, Göke B, Schirra J

Diabetes care.. 2008 December 31 (12):2325-31. Epub 1900 01 01.

Guideline for management of postmeal glucose.

Ceriello A, Colagiuri S, Gerich J, Tuomilehto J,

Nutrition, metabolism, and cardiovascular diseases : NMCD.. 2008 May 18 (4):S17-33. Epub 1900 01 01.

Effect of aging on glucose homeostasis: accelerated deterioration of beta-cell function in individuals with impaired glucose tolerance.

Szoke E, Shrayyef MZ, Messing S, Woerle HJ, van Haeften TW, Meyer C, Mitrakou A, Pimenta W, Gerich JE

Diabetes care.. 2008 March 31 (3):539-43. Epub 12/14/2007.

Impact of fasting and postprandial glycemia on overall glycemic control in type 2 diabetes Importance of postprandial glycemia to achieve target HbA1c levels.

Woerle HJ, Neumann C, Zschau S, Tenner S, Irsigler A, Schirra J, Gerich JE, Göke B

Diabetes research and clinical practice.. 2007 August 77 (2):280-5. Epub 01/22/2007.

The rationale for paired pre- and postprandial self-monitoring of blood glucose: the role of glycemic variability in micro- and macrovascular risk.

Gerich JE, Odawara M, Terauchi Y

Current medical research and opinion.. 2007 August 23 (8):1791-8. Epub 1900 01 01.

The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications.

Dunning BE, Gerich JE

Endocrine reviews.. 2007 May 28 (3):253-83. Epub 04/04/2007.

Type 2 diabetes mellitus is associated with multiple cardiometabolic risk factors.

Gerich JE

Clinical cornerstone. 2007 8 (3):53-68. Epub 1900 01 01.

Insulin's actions on plasma free fatty acids are normal in patients with stage 2 to 3 chronic kidney disease.

Gadegbeku CA, Dhandayuthapani A, Taylor TP, Shrayyef Z, Gerich J, Garvey WT, Egan BM

Journal of the American Society of Hypertension : JASH.. 2007 1 (6):414-22. Epub 1900 01 01.

Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans.

Meyer C, Pimenta W, Woerle HJ, Van Haeften T, Szoke E, Mitrakou A, Gerich J

Diabetes care.. 2006 August 29 (8):1909-14. Epub 1900 01 01.

Multiple defects in counterregulation of hypoglycemia in modestly advanced type 2 diabetes mellitus.

Israelian Z, Szoke E, Woerle J, Bokhari S, Schorr M, Schwenke DC, Cryer PE, Gerich JE, Meyer C

Metabolism: clinical and experimental.. 2006 May 55 (5):593-8. Epub 1900 01 01.

Fluctuation of serum basal insulin levels following single and multiple dosing of insulin glargine.

Gerich J, Becker RH, Zhu R, Bolli GB

Diabetes technology & therapeutics.. 2006 April 8 (2):237-43. Epub 1900 01 01.

Mechanisms for abnormal postprandial glucose metabolism in type 2 diabetes.

Woerle HJ, Szoke E, Meyer C, Dostou JM, Wittlin SD, Gosmanov NR, Welle SL, Gerich JE

American journal of physiology. Endocrinology and metabolism.. 2006 January 290 (1):E67-E77. Epub 08/16/2005.

Effects of glimepiride and glyburide on glucose counterregulation and recovery from hypoglycemia.

Szoke E, Gosmanov NR, Sinkin JC, Nihalani A, Fender AB, Cryer PE, Meyer C, Gerich JE

Metabolism: clinical and experimental.. 2006 January 55 (1):78-83. Epub 1900 01 01.

Postprandial hyperglycemia and cardiovascular disease.

Gerich JE

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.. 2006 12 Suppl 1 :47-51. Epub 1900 01 01.

Clinicians can help their patients control postprandial hyperglycemia as a means of reducing cardiovascular risk.

Gerich JE

The Diabetes educator.. 2006 32 (4):513-4, 520-2. Epub 1900 01 01.

Glycemic control in the metabolic syndrome and implications in preventing cardiovascular disease.

Gerich JE

Metabolic syndrome and related disorders.. 2006 4 (4):315-27. Epub 1900 01 01.

A potential important role of skeletal muscle in human counterregulation of hypoglycemia.

Meyer C, Saar P, Soydan N, Eckhard M, Bretzel RG, Gerich J, Linn T

The Journal of clinical endocrinology and metabolism.. 2005 November 90 (11):6244-50. Epub 09/06/2005.

Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes.

Israelian Z, Gosmanov NR, Szoke E, Schorr M, Bokhari S, Cryer PE, Gerich JE, Meyer C

Diabetes care.. 2005 November 28 (11):2691-6. Epub 1900 01 01.

PRESERVE-beta: two-year efficacy and safety of initial combination therapy with nateglinide or glyburide plus metformin.

Gerich J, Raskin P, Jean-Louis L, Purkayastha D, Baron MA

Diabetes care.. 2005 September 28 (9):2093-9. Epub 1900 01 01.

The importance of tight glycemic control.

Gerich JE

The American journal of medicine.. 2005 September 118 (Suppl 9A):7S-11S. Epub 1900 01 01.

Use of inhaled insulin in a basal/bolus insulin regimen in type 1 diabetic subjects: a 6-month, randomized, comparative trial.

Skyler JS, Weinstock RS, Raskin P, Yale JF, Barrett E, Gerich JE, Gerstein HC,

Diabetes care.. 2005 July 28 (7):1630-5. Epub 1900 01 01.

Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans.

Gosmanov NR, Szoke E, Israelian Z, Smith T, Cryer PE, Gerich JE, Meyer C

Diabetes care.. 2005 May 28 (5):1124-31. Epub 1900 01 01.

Role of impaired insulin secretion and insulin resistance in the pathogenesis of type 2 diabetes mellitus.

Szoke E, Gerich JE

Comprehensive therapy.. 2005 31 (2):106-12. Epub 1900 01 01.

Abnormal renal, hepatic, and muscle glucose metabolism following glucose ingestion in type 2 diabetes.

Meyer C, Woerle HJ, Dostou JM, Welle SL, Gerich JE

American journal of physiology. Endocrinology and metabolism.. 2004 December 287 (6):E1049-56. Epub 08/10/2004.

Paradoxical changes of muscle glutamine release during hyperinsulinemia euglycemia and hypoglycemia in humans: further evidence for the glucose-glutamine cycle.

Meyer C, Woerle HJ, Gerich J

Metabolism: clinical and experimental.. 2004 September 53 (9):1208-14. Epub 1900 01 01.

Advances in diabetes for the millennium: understanding insulin resistance.

Gerich JE, Dailey G

MedGenMed : Medscape general medicine. 2004 August 266 (3 Suppl):11. Epub 08/26/2004.

Insulin glargine: long-acting basal insulin analog for improved metabolic control.

Gerich JE

Current medical research and opinion.. 2004 January 20 (1):31-7. Epub 1900 01 01.

Diagnostic and therapeutic implications of relationships between fasting, 2-hour postchallenge plasma glucose and hemoglobin a1c values.

Woerle HJ, Pimenta WP, Meyer C, Gosmanov NR, Szoke E, Szombathy T, Mitrakou A, Gerich JE

Archives of internal medicine.. 2004 164 (15):1627-32. Epub 1900 01 01.

The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients.

Riddle MC, Rosenstock J, Gerich J,

Diabetes care.. 2003 November 26 (11):3080-6. Epub 1900 01 01.

Relative importance of liver, kidney, and substrates in epinephrine-induced increased gluconeogenesis in humans.

Meyer C, Stumvoll M, Welle S, Woerle HJ, Haymond M, Gerich J

American journal of physiology. Endocrinology and metabolism.. 2003 October 285 (4):E819-26. Epub 1900 01 01.

Clinical significance, pathogenesis, and management of postprandial hyperglycemia.

Gerich JE

Archives of internal medicine.. 2003 June 9163 (11):1306-16. Epub 1900 01 01.

Renal compensation for impaired hepatic glucose release during hypoglycemia in type 2 diabetes: further evidence for hepatorenal reciprocity.

Woerle HJ, Meyer C, Popa EM, Cryer PE, Gerich JE

Diabetes.. 2003 June 52 (6):1386-92. Epub 1900 01 01.

Pathways for glucose disposal after meal ingestion in humans.

Woerle HJ, Meyer C, Dostou JM, Gosmanov NR, Islam N, Popa E, Wittlin SD, Welle SL, Gerich JE

American journal of physiology. Endocrinology and metabolism.. 2003 April 284 (4):E716-25. Epub 12/10/2002.

Mechanisms for the deterioration in glucose tolerance associated with HIV protease inhibitor regimens.

Woerle HJ, Mariuz PR, Meyer C, Reichman RC, Popa EM, Dostou JM, Welle SL, Gerich JE

Diabetes.. 2003 April 52 (4):918-25. Epub 1900 01 01.

Contributions of insulin-resistance and insulin-secretory defects to the pathogenesis of type 2 diabetes mellitus.

Gerich JE

Mayo Clinic proceedings.. 2003 April 78 (4):447-56. Epub 1900 01 01.

Exogenous insulin replacement in type 2 diabetes reverses excessive hepatic glucose release, but not excessive renal glucose release and impaired free fatty acid clearance.

Woerle HJ, Popa E, Dostou J, Welle S, Gerich J, Meyer C

Metabolism: clinical and experimental.. 2002 November 51 (11):1494-500. Epub 1900 01 01.

Glimepiride improves both first and second phases of insulin secretion in type 2 diabetes.

Korytkowski M, Thomas A, Reid L, Tedesco MB, Gooding WE, Gerich J

Diabetes care.. 2002 September 25 (9):1607-11. Epub 1900 01 01.

Autoregulation of endogenous glucose production during hyperglucagonemia.

Toft I, Gerich JE, Jenssen T

Metabolism: clinical and experimental.. 2002 September 51 (9):1128-34. Epub 1900 01 01.

Novel insulins: expanding options in diabetes management.

Gerich JE

The American journal of medicine.. 2002 September 113 (4):308-16. Epub 1900 01 01.

Role of the kidney in hyperglycemia in type 2 diabetes.

Meyer C, Gerich JE

Current diabetes reports.. 2002 June 2 (3):237-41. Epub 1900 01 01.

Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis.

Meyer C, Dostou JM, Welle SL, Gerich JE

American journal of physiology. Endocrinology and metabolism.. 2002 February 282 (2):E419-27. Epub 1900 01 01.

Renal substrate exchange and gluconeogenesis in normal postabsorptive humans.

Meyer C, Stumvoll M, Dostou J, Welle S, Haymond M, Gerich J

American journal of physiology. Endocrinology and metabolism.. 2002 February 282 (2):E428-34. Epub 1900 01 01.

Is reduced first-phase insulin release the earliest detectable abnormality in individuals destined to develop type 2 diabetes?

Gerich JE

Diabetes.. 2002 February 51 Suppl 1 :S117-21. Epub 1900 01 01.

Disturbances in beta-cell function in impaired fasting glycemia.

van Haeften TW, Pimenta W, Mitrakou A, Korytkowski M, Jenssen T, Yki-Jarvinen H, Gerich JE

Diabetes.. 2002 February 51 Suppl 1 :S265-70. Epub 1900 01 01.

Steady-state and non-steady-state measurements of plasma glutamine turnover in humans.

Kreider ME, Stumvoll M, Meyer C, Overkamp D, Welle S, Gerich J

The American journal of physiology.. 1997 April 272 (4 Pt 1):E621-7. Epub 1900 01 01.

Impact of obesity on insulin action in volunteers with normal glucose tolerance: demonstration of a threshold for the adverse effect of obesity.

Campbell PJ, Gerich JE

The Journal of clinical endocrinology and metabolism.. 1990 April 70 (4):1114-8. Epub 1900 01 01.