Professor
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Department of Pediatrics, Neonatology (SMD)
Professor
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Department of Pharmacology and Physiology (SMD) - Joint
Credentials
Post-doctoral Training & Residency
Senior Research Associate, Department of Pharmacology, Rush Medical Center, Chicago, IL 1993 - 1995
Research Associate, Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, IL 1992 - 1993
Education
PhD | AM University.Biochemistry.1988
MSc | AM University.Biochemistry.1984
BSc | AM University.Chemistry.1981
Research
My laboratory has a long-standing interest in endothelial cell biology and lung physiology especially as it relates to molecular analysis of signal transduction and gene regulation, and in vivo gene delivery to the lung endothelium. Specifically, we want to know how the otherwise "antiadhesive, anti...
My laboratory has a long-standing interest in endothelial cell biology and lung physiology especially as it relates to molecular analysis of signal transduction and gene regulation, and in vivo gene delivery to the lung endothelium. Specifically, we want to know how the otherwise "antiadhesive, anticoagulant, and relatively restrictive (semipermeable)" microvasculature is rendered into a "proadhesive, procoagulant, and leaky" one during acute lung injury (ALI). We have made contributions to the understanding of regulation of nuclear factor-kappaB (NF-?B), a master regulator of inflammation that is implicated in regulating these phenotypes of microvasculature during ALI and other inflammatory conditions. Another area of my research focuses on understanding the regulation and function of endothelial cells (EC) autophagy and its relationship with EC inflammation in the context of ALI. Our novel and exciting findings that autophagy and inflammation are linked in the lung endothelium and collaborate in causing lung injury form the basis of our ongoing research to identify the mechanistic link between these two fundamental processes (autophagy and inflammation), and address the relevance of this linkage in the pathogenesis of ALI.
More recently, we have been focusing on Spleen Tyrosine Kinase (Syk) and Mechanistic/Mammalian Target of Rapamycin (MTOR) as critical mechanistic targets for modulation of ALI pathogenesis. The Syk project seeks to clarify the mechanism by which Syk regulates EC dysfunction (permeability and inflammation) in ALI and evaluate the therapeutic efficacy of Syk inhibition against evolving ALI in mice with sepsis. The MTOR project builds logically on our prior work and seeks to clarify the role of MTOR in ALI and evaluate the preventive and therapeutic efficacy of modulation of MTOR signaling against ALI. In a nutshell, the research in my lab uses genetically modified mice, primary cell cultures, and multidisciplinary approaches ranging from biochemical, cellular, and molecular biology to in vivo gene delivery (cell-specific transfer of genes and shRNA to endothelial cells in the lung) and multiple mouse models of ALI to identify viable therapeutic targets and mechanisms to limit ALI.
Vandewouw MM, Norris-Brilliant A, Rahman A, Assimopoulos S, Morton SU, Kushki A, Cunningham S, King E, Goldmuntz E, Miller TA, Thomas NH, Adams HR, Cleveland J, Cnota JF, Ellen Grant P, Goldberg CS, Huang H, Li JS, McQuillen P, Porter GA, Roberts AE, Russell MW, Seidman CE, Tivarus ME, Chung WK, Hagler DJ, Newburger JW, Panigrahy A, Lerch JP, Gelb BD, Anagnostou E
NeuroImage.. 2024 August 15297 :120721. Epub 07/04/2024.
Schartz DA, Ismail RF, Rahman AA, Bender MT, Westesson PL, Mesfin A, Kessler A
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences.. 2024 February 30 (1):137-142. Epub 07/11/2022.
Kambhampati S, Li Y, Verma A, Sassano A, Majchrzak B, Deb DK, Parmar S, Giafis N, Kalvakolanu DV, Rahman A, Uddin S, Minucci S, Tallman MS, Fish EN, Platanias LC
The Journal of biological chemistry.. 2003 August 29278 (35):32544-51. Epub 06/12/2003.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.. 1991 October 29 (10):719-21. Epub 1900 01 01.
