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Anne E. Luebke, Ph.D.

Anne E. Luebke, Ph.D.

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Office (585) 273-1635

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About Me

Faculty Appointments

Associate Professor - Department of Biomedical Engineering (SMD)

Associate Professor - Department of Neuroscience (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Molecular Neuroscience,
University of Miami School of Medicine,
Miami, Florida
Mentor: Dr KJ Muller, Prof. of Physiology and Biophysics 1991 - 1994

Education

PhD | Johns Hopkins U Sch Medicine. Bioengineering. 1991

BS | Oklahoma State Univ. Chemical Engineering. 1984

Awards

Dean's Award -Young Laboratory Research Scientist 2001

Teaching Appreciation Award.
Certificate for dedication and excellence in teaching the Univ. of Miami medical-student class of 2000. 2000

Stanley Glaser Research Award 1999 - 2000

Miami Commitment Program's Employer of the Year 1997 - 1998

National Institutes of Health USPHS Individual Postdoctoral Fellowship Award 1991 - 1993

Research

Publications

Journal Articles

Loss of Calcitonin Gene Related Receptor component protein (RCP) in nervous system can bias "gepant" antagonism.

Rahman SM, Dickerson I, Luebke AE

bioRxiv : the preprint server for biology.. 2024 October 26 Epub 10/26/2024.

Musical training does not enhance neural sound encoding at early stages of the auditory system: A large-scale multisite investigation.

Whiteford KL, Baltzell LS, Chiu M, Cooper JK, Faucher S, Goh PY, Hagedorn A, Irsik VC, Irvine A, Lim SJ, Mesik J, Mesquita B, Oakes B, Rajappa N, Roverud E, Schrlau AE, Van Hedger SC, Bharadwaj HM, Johnsrude IS, Kidd G, Luebke AE, Maddox RK, Marvin EW, Perrachione TK, Shinn-Cunningham BG, Oxenham AJ

bioRxiv : the preprint server for biology.. 2024 September 4 Epub 09/04/2024.

Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2-infected older mice with neurological signs.

Rahman SM, Buchholz DW, Imbiakha B, Jager MC, Leach J, Osborn RM, Birmingham AO, Dewhurst S, Aguilar HC, Luebke AE

Journal of virology.. 2024 July 2398 (7):e0006624. Epub 05/30/2024.

A Vestibular Challenge Combined with Calcitonin Gene-Related Peptide (CGRP) Promotes Anxiety-Like Behaviors.

Rahman SM, Hauser C, Faucher S, Fine E, Luebke AE

eNeuro.. 2024 July 11 (7)Epub 07/26/2024.

Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2 infected older mice with neurological signs.

Rahman SM, Buchholz DW, Imbiakha B, Jager MC, Leach J, Osborn RM, Birmingham AO, Dewhurst S, Aguilar HC, Luebke AE

bioRxiv : the preprint server for biology.. 2024 January 23 Epub 01/23/2024.

Calcitonin gene-related peptide receptor antagonism reduces motion sickness indicators in mouse migraine models.

Rahman SM, Luebke AE

Cephalalgia : an international journal of headache.. 2024 January 44 (1):3331024231223971. Epub 1900 01 01.

Loss of calcitonin gene-related peptide (?CGRP) and use of a vestibular challenge highlight balance deficiencies in aging mice.

Rahman SM, Hauser C, Luebke AE

PloS one.. 2024 19 (6):e0303801. Epub 06/12/2024.

Human RAMP1 overexpressing mice are resistant to migraine therapies for motion sensitivity: a mouse model of vestibular migraine.

Rahman SM, Guo L, Minarovich C, Moon L, Guo A, Luebke AE

bioRxiv : the preprint server for biology.. 2023 November 28 Epub 11/28/2023.

Both systemic Calcitonin Gene Related Peptide (CGRP) and a vestibular challenge promote anxiety-related behaviors and dynamic imbalance in mice.

Rahman SM, Hauser C, Faucher S, Fine E, Luebke AE

bioRxiv : the preprint server for biology.. 2023 August 2 Epub 08/02/2023.

Age-Related Balance Problems in Mice Are Sharpened by the Loss of Calcitonin Gene-Related Peptide (CGRP) and a Vestibular Challenge.

Rahman SM, Hauser C, Luebke AE

bioRxiv : the preprint server for biology.. 2023 August 1 Epub 08/01/2023.

Preface.

Anastasio TJ, Demer JL, Leigh RJ, Luebke AE, von Opstal AJ, Optican LM, Ramat S, Zee DS

Progress in brain research.. 2022 267 (1):xvii-xviii. Epub 1900 01 01.

Rescuing Auditory Temporal Processing with a Novel Augmented Acoustic Environment in an Animal Model of Congenital Hearing Loss.

Dziorny AC, Luebke AE, Scott LL, Walton JP

eNeuro.. 2021 8 (4)Epub 07/14/2021.

Care Gaps and Recommendations in Vestibular Migraine: An Expert Panel Summit.

Mallampalli MP, Rizk HG, Kheradmand A, Beh SC, Abouzari M, Bassett AM, Buskirk J, Ceriani CEJ, Crowson MG, Djalilian H, Goebel JA, Kuhn JJ, Luebke AE, Mandalà M, Nowaczewska M, Spare N, Teggi R, Versino M, Yuan H, Zaleski-King A, Teixido M, Godley F

Frontiers in neurology. 2021 12 :812678. Epub 01/03/2022.

Loss of ?-Calcitonin Gene-Related Peptide (?CGRP) Reduces Otolith Activation Timing Dynamics and Impairs Balance.

Jones SM, Vijayakumar S, Dow SA, Holt JC, Jordan PM, Luebke AE

Frontiers in molecular neuroscience.. 2018 11 :289. Epub 08/24/2018.

Loss of the Cochlear Amplifier Prestin Reduces Temporal Processing Efficacy in the Central Auditory System.

Walton JP, Dziorny AC, Vasilyeva ON, Luebke AE

Frontiers in cellular neuroscience.. 2018 12 :291. Epub 09/21/2018.

Children with autism spectrum disorder have reduced otoacoustic emissions at the 1 kHz mid-frequency region.

Bennetto L, Keith JM, Allen PD, Luebke AE

Autism research : official journal of the International Society for Autism Research.. 2017 February 10 (2):337-345. Epub 07/12/2016.

Reflex Modification Audiometry Reveals Dual Roles for Olivocochlear Neurotransmission.

Allen PD, Luebke AE

Frontiers in cellular neuroscience.. 2017 11 :361. Epub 11/22/2017.

Maturation of suprathreshold auditory nerve activity involves cochlear CGRP-receptor complex formation.

Dickerson IM, Bussey-Gaborski R, Holt JC, Jordan PM, Luebke AE

Physiological reports.. 2016 July 4 (14)Epub 1900 01 01.

Prenatal low dosage dioxin (TCDD) exposure impairs cochlear function resulting in auditory neuropathy.

Safe TM, Luebke AE

Hearing research.. 2016 January 331 :7-12. Epub 10/14/2015.

Influence of sound-conditioning on noise-induced susceptibility of distortion-product otoacoustic emissions.

Luebke AE, Stagner BB, Martin GK, Lonsbury-Martin BL

The Journal of the Acoustical Society of America.. 2015 July 138 (1):58-64. Epub 1900 01 01.

Loss of ?-calcitonin gene-related peptide (?CGRP) reduces the efficacy of the Vestibulo-ocular Reflex (VOR).

Luebke AE, Holt JC, Jordan PM, Wong YS, Caldwell JS, Cullen KE

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 July 3034 (31):10453-8. Epub 1900 01 01.

Adaptation of distortion product otoacoustic emissions predicts susceptibility to acoustic over-exposure in alert rabbits.

Luebke AE, Stagner BB, Martin GK, Lonsbury-Martin BL

The Journal of the Acoustical Society of America.. 2014 April 135 (4):1941-9. Epub 1900 01 01.

Identifying a window of vulnerability during fetal development in a maternal iron restriction model.

Mihaila C, Schramm J, Strathmann FG, Lee DL, Gelein RM, Luebke AE, Mayer-Pröschel M

PloS one.. 2011 March 156 (3):e17483. Epub 03/15/2011.

Loss of prestin does not alter the development of auditory cortical dendritic spines.

Bogart LJ, Levy AD, Gladstone M, Allen PD, Zettel M, Ison JR, Luebke AE, Majewska AK

Neural plasticity.. 2011 2011 :305621. Epub 05/15/2011.

Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure.

Polesskaya O, Cunningham LL, Francis SP, Luebke AE, Zhu X, Collins D, Vasilyeva ON, Sahler J, Desmet EA, Gelbard HA, Maggirwar SB, Walton JP, Frisina RD, Dewhurst S

Hearing research.. 2010 December 1270 (1-2):21-7. Epub 10/27/2010.

Adenoviral and AAV-mediated gene transfer to the inner ear: role of serotype, promoter, and viral load on in vivo and in vitro infection efficiencies.

Luebke AE, Rova C, Von Doersten PG, Poulsen DJ

Advances in oto-rhino-laryngology. 2009 66 :87-98. Epub 06/02/2009.

Lead exposure during development results in increased neurofilament phosphorylation, neuritic beading, and temporal processing deficits within the murine auditory brainstem.

Jones LG, Prins J, Park S, Walton JP, Luebke AE, Lurie DI

The Journal of comparative neurology.. 2008 February 20506 (6):1003-17. Epub 1900 01 01.

Alpha-9 nicotinic acetylcholine receptor immunoreactivity in the rodent vestibular labyrinth.

Luebke AE, Maroni PD, Guth SM, Lysakowski A

The Journal of comparative neurology.. 2005 November 21492 (3):323-33. Epub 1900 01 01.

Evaluating cochlear function and the effects of noise exposure in the B6.CAST+Ahl mouse with distortion product otoacoustic emissions.

Vázquez AE, Jimenez AM, Martin GK, Luebke AE, Lonsbury-Martin BL

Hearing research.. 2004 August 194 (1-2):87-96. Epub 1900 01 01.

Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerve.

Maison SF, Emeson RB, Adams JC, Luebke AE, Liberman MC

Journal of neurophysiology.. 2003 November 90 (5):2941-9. Epub 08/06/2003.

Expression of endothelin 1 in rat random-pattern skin flaps treated with topical nifedipine.

Mobley SR, Glassberg MK, Luebke A, Perlyn CA, Davis RE

Archives of facial plastic surgery : official publication for the

Efferent protection from acoustic injury is mediated via alpha9 nicotinic acetylcholine receptors on outer hair cells.

Maison SF, Luebke AE, Liberman MC, Zuo J

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2002 December 1522 (24):10838-46. Epub 1900 01 01.

CGRP- and cholinergic-containing fibers project to guinea pig outer hair cells.

Cabanillas LA, Luebke AE

Hearing research.. 2002 October 172 (1-2):14-7. Epub 1900 01 01.

Variation in inter-animal susceptibility to noise damage is associated with alpha 9 acetylcholine receptor subunit expression level.

Luebke AE, Foster PK

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2002 May 1522 (10):4241-7. Epub 1900 01 01.

A model for perilymphatic fistula induced hearing loss in the guinea pig cochlea.

Foster PK, Luebke AE

Hearing research.. 2002 May 167 (1-2):175-9. Epub 1900 01 01.

A multifrequency method for determining cochlear efferent activity.

Luebke AE, Foster PK, Stagner BB

Journal of the Association for Research in Otolaryngology : JARO.. 2002 March 3 (1):16-25. Epub 1900 01 01.

A multi-frequency method for determining cochlear efferent activity.

Luebke A.E.; Foster P.K.; Stagner B.B.

Journal of the Association for Research in Otolaryngolgy. 2002; : 16-25.

Temporary and permanent noise-induced changes in distortion product otoacoustic emissions in CBA/CaJ mice.

Vázquez AE, Luebke AE, Martin GK, Lonsbury-Martin BL

Hearing research.. 2001 June 156 (1-2):31-43. Epub 1900 01 01.

Cochlear function and transgene expression in the guinea pig cochlea, using adenovirus- and adeno-associated virus-directed gene transfer.

Luebke AE, Foster PK, Muller CD, Peel AL

Human gene therapy.. 2001 May 112 (7):773-81. Epub 1900 01 01.

A modified adenovirus can transfect cochlear hair cells in vivo without compromising cochlear function.

Luebke AE, Steiger JD, Hodges BL, Amalfitano A

Gene therapy.. 2001 May 8 (10):789-94. Epub 1900 01 01.

Cloning and expression of the alpha9 nicotinic acetylcholine receptor subunit in cochlear hair cells of the chick.

Hiel H, Luebke AE, Fuchs PA

Brain research.. 2000 March 6858 (1):215-25. Epub 1900 01 01.

Cloning and expression of the alpha 9 acetylcholine receptor subunit in cochlear hair cells of the chick.

Hiel H.; Luebke A.E.; Fuchs P.A.

Brain Research. 1999; : 215-225.

Isolation of a cDNA encoding a Kex2-like endoprotease with homology to furin from the nematode Caenorhabditis elegans.

Gómez-Saladín E, Luebke AE, Wilson DL, Dickerson IM

DNA and cell biology.. 1997 May 16 (5):663-9. Epub 1900 01 01.

Identification of a pore lining segment in gap junction hemichannels.

Zhou, X.W.; Pfahnl, A.; Werner, R.; Hudder, A.; Llanes, A.; Luebke, A.; Dahl, G.

Biophysics Journal. 1997; : 1946-1953.

Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay.

Luebke AE, Dahl GP, Roos BA, Dickerson IM

Proceedings of the National Academy of Sciences of the United States of America.. 1996 April 1693 (8):3455-60. Epub 1900 01 01.

In situ hybridization reveals transient laminin B-chain expression by individual glial and muscle cells in embryonic leech central nervous system.

Luebke AE, Dickerson IM, Muller KJ

Journal of neurobiology.. 1995 May 27 (1):1-14. Epub 1900 01 01.

Modification of the cat's vestibulo-ocular reflex survives flocculus deactivation.

Luebke, A.E.; Robinson, D.A.

Experimental. Brain Research. 1994; : 379-390.

Gain changes of the cat's vestibulo-ocular reflex after flocculus deactivation.

Luebke AE, Robinson DA

Experimental brain research.. 1994 98 (3):379-90. Epub 1900 01 01.

Climbing fiber intervention blocks plasticity of the vestibuloocular reflex.

Luebke AE, Robinson DA

Annals of the New York Academy of Sciences.. 1992 May 22656 :428-30. Epub 1900 01 01.

Phoria adaptation in patients with cerebellar dysfunction.

Hain TC, Luebke AE

Investigative ophthalmology & visual science.. 1990 July 31 (7):1394-7. Epub 1900 01 01.

Phoria adaptation in patients with cerebellar dysfunction.

Hain, T.C.; Luebke, A.E.

Invest. Ophthalmoogyl. and Vision. Science. 1990; : 1394-1397.

Smooth pursuit eye movements in schizophrenics: Quantitative measurements with the search-coil technique.

Levin, S.; Luebke, A.E.; Zee, D.S.; Hain, T.C.; Robinson, D.A.; Holzman, P.S.

J. Psychiatric. Research. 1988; : 195-206.

Transition dynamics between pursuit and fixation suggest different systems.

Luebke AE, Robinson DA

Vision research.. 1988 28 (8):941-6. Epub 1900 01 01.

Alpha 9 nicotinic acetylcholine receptor (a9 nAChR) immunoreactivity in the rodent vestibular system.

Luebke A.E.; Maroni P.; Guth S.M.; Price S.D.; Lysakowski A.

J Comp Neuro. .

Books

Otorhinolaryngology: Head and Neck Surgery (1996)

Chapter: Physiology of the auditory and vestibular systems.

Authors: Lonsbury-Martin BL; Martin GK; Luebke AE.

Publisher: Williams & Wilkins, Baltimore MD 1996

Contemporary Ocular Motor and Vestibular Research: A Tribute to David A Robinson (1994)

Chapter: Contemporary Ocular Motor and Vestibular Research: A Tribute to David A Robinson.

Authors: Luebke AE, Robinson DA. Gain changes of the cat's vestibulo-ocular reflex survive floccular shutdown.

Publisher: Georg Thieme Verlag, Stuttgart Germany 1994