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Fabeha Fazal, Ph.D.

Fabeha Fazal, Ph.D.

Contact

Office (585) 275-9917
Fax (585) 756-7780
Administrative (585) 275-5948

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About Me

Faculty Appointments

Associate Professor - Department of Pediatrics, Neonatology (SMD)

Credentials

Post-doctoral Training & Residency

Research Assistant Professor, Department of Pediatrics, University of Rochester, Rochester, NY 2003 - 2011

Research Assistant Professor, Department of Physiology and Biophysics, University of Illinois, Chicago, IL 1999 - 2003

Research Associate, Loyola University Medical Center, Maywood, IL 1995 - 1998

Research Associate, Loyola University Medical Center, Maywood, IL; Advisor: Susan Baker, PhD 1992 - 1995

Education

PhD | A.M. University. Biochemistry. 1992

MSc | A.M. University. Biochemistry. 1987

BSc | A.M. University. Chemistry. 1985

Awards

University Gold Medal for standing first in M.S. Examination. 1987

University Gold Medal for standing first in B.S. Examination. 1985

Research

My lab focuses on understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition, which affects over a quarter of million patients in the U.S. with a mortality rate of approximately 40 percent. It is associated with pneumonia, sepsis, and trauma, leadi...
My lab focuses on understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition, which affects over a quarter of million patients in the U.S. with a mortality rate of approximately 40 percent. It is associated with pneumonia, sepsis, and trauma, leading to pulmonary insufficiency and eventually multisystem organ failure. So far, there are no effective therapy targeting the underlying molecular and cellular mechanisms. The two major pathogenic features of ALI involves disruption of pulmonary vascular endothelial barrier and acquisition of a proinflammatory phenotype. The long term goal of my research is to identify novel mechanistic targets and assess the preventive and therapeutic benefit of targeting them against evolving ALI. In our lab we use integration of in vitro and in vivo techniques to dissect the pathways that are critical to endothelial cell (EC) inflammation and permeability. We use multidisciplinary approaches ranging from biochemical, cellular, and molecular biology to in vivo gene delivery and lung physiology.

Publications

Journal Articles

Critical Role of Mortalin/GRP75 in Endothelial Cell Dysfunction Associated with Acute Lung Injury.

Leonard A, Su PY, Yule DI, Rahman A, Fazal F

Shock.. 2020 August 54 (2):245-255. Epub 1900 01 01.

Critical role of autophagy regulator Beclin1 in endothelial cell inflammation and barrier disruption.

Leonard A, Millar MW, Slavin SA, Bijli KM, Dionisio Santos, Dean DA, Fazal F, Rahman A

Cellular signalling.. 2019 September 61 :120-129. Epub 05/01/2019.

Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury.

Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F

Scientific reports.. 2019 February 149 (1):2096. Epub 02/14/2019.

Importins ? and ? signaling mediates endothelial cell inflammation and barrier disruption.

Leonard A, Rahman A, Fazal F

Cellular signalling.. 2018 April 44 :103-117. Epub 01/11/2018.

Autophagy inhibitor 3-methyladenine protects against endothelial cell barrier dysfunction in acute lung injury.

Slavin SA, Leonard A, Grose V, Fazal F, Rahman A

American journal of physiology. Lung cellular and molecular physiology.. 2018 March 1314 (3):L388-L396. Epub 10/26/2017.

The role of high airway pressure and dynamic strain on ventilator-induced lung injury in a heterogeneous acute lung injury model.

Jain SV, Kollisch-Singule M, Satalin J, Searles Q, Dombert L, Abdel-Razek O, Yepuri N, Leonard A, Gruessner A, Andrews P, Fazal F, Meng Q, Wang G, Gatto LA, Habashi NM, Nieman GF

Intensive care medicine experimental.. 2017 December 5 (1):25. Epub 05/12/2017.

Featured Article: Electroporation-mediated gene delivery of surfactant protein B (SP-B) restores expression and improves survival in mouse model of SP-B deficiency.

Barnett RC, Lin X, Barravecchia M, Norman RA, de Mesy Bentley KL, Fazal F, Young JL, Dean DA

Experimental biology and medicine. 2017 July 242 (13):1345-1354. Epub 06/05/2017.

Phospholipase C-? signaling mediates endothelial cell inflammation and barrier disruption in acute lung injury.

Bijli KM, Fazal F, Slavin SA, Leonard A, Grose V, Alexander WB, Smrcka AV, Rahman A

American journal of physiology. Lung cellular and molecular physiology.. 2016 August 1311 (2):L517-24. Epub 07/01/2016.

Regulation of endothelial cell inflammation and lung polymorphonuclear lymphocyte infiltration by transglutaminase 2.

Bijli KM, Kanter BG, Minhajuddin M, Leonard A, Xu L, Fazal F, Rahman A

Shock.. 2014 December 42 (6):562-9. Epub 1900 01 01.

Preconditioning with endoplasmic reticulum stress ameliorates endothelial cell inflammation.

Leonard A, Paton AW, El-Quadi M, Paton JC, Fazal F

PloS one.. 2014 9 (10):e110949. Epub 10/30/2014.

Thrombin selectively engages LIM kinase 1 and slingshot-1L phosphatase to regulate NF-?B activation and endothelial cell inflammation.

Leonard A, Marando C, Rahman A, Fazal F

American journal of physiology. Lung cellular and molecular physiology.. 2013 November 1305 (9):L651-64. Epub 09/13/2013.

Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration.

Fazal F, Bijli KM, Murrill M, Leonard A, Minhajuddin M, Anwar KN, Finkelstein JN, Watterson DM, Rahman A

PloS one.. 2013 8 (3):e59965. Epub 03/21/2013.

Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2.

Bijli KM, Fazal F, Rahman A

American journal of respiratory cell and molecular biology.. 2012 November 47 (5):660-8. Epub 07/27/2012.

Blocking NF-?B: an inflammatory issue.

Rahman A, Fazal F

Proceedings of the American Thoracic Society.. 2011 November 8 (6):497-503. Epub 1900 01 01.

GPR56 Regulates VEGF production and angiogenesis during melanoma progression.

Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes R, Xu L

Cancer research.. 2011 August 1571 (16):5558-68. Epub 07/01/2011.

Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells.

Fazal F, Bijli KM, Minhajuddin M, Rein T, Finkelstein JN, Rahman A

The Journal of biological chemistry.. 2009 July 31284 (31):21047-56. Epub 05/29/2009.

Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration.

Rahman A, Fazal F

Antioxidants & redox signaling.. 2009 April 11 (4):823-39. Epub 1900 01 01.

Protein kinase C-delta and phosphatidylinositol 3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappaB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells.

Minhajuddin M, Bijli KM, Fazal F, Sassano A, Nakayama KI, Hay N, Platanias LC, Rahman A

The Journal of biological chemistry.. 2009 February 13284 (7):4052-61. Epub 12/13/2008.

Activation of Syk by protein kinase C-delta regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via tyrosine phosphorylation of RelA/p65.

Bijli KM, Fazal F, Minhajuddin M, Rahman A

The Journal of biological chemistry.. 2008 May 23283 (21):14674-84. Epub 03/24/2008.

Evidence for actin cytoskeleton-dependent and -independent pathways for RelA/p65 nuclear translocation in endothelial cells.

Fazal F, Minhajuddin M, Bijli KM, McGrath JL, Rahman A

The Journal of biological chemistry.. 2007 February 9282 (6):3940-50. Epub 12/08/2006.

c-Src interacts with and phosphorylates RelA/p65 to promote thrombin-induced ICAM-1 expression in endothelial cells.

Bijli KM, Minhajuddin M, Fazal F, O'Reilly MA, Platanias LC, Rahman A

American journal of physiology. Lung cellular and molecular physiology.. 2007 February 292 (2):L396-404. Epub 09/29/2006.

Inhibiting myosin light chain kinase induces apoptosis in vitro and in vivo.

Fazal F, Gu L, Ihnatovych I, Han Y, Hu W, Antic N, Carreira F, Blomquist JF, Hope TJ, Ucker DS, de Lanerolle P

Molecular and cellular biology.. 2005 July 25 (14):6259-66. Epub 1900 01 01.

Inhibition of mammalian target of rapamycin potentiates thrombin-induced intercellular adhesion molecule-1 expression by accelerating and stabilizing NF-kappa B activation in endothelial cells.

Minhajuddin M, Fazal F, Bijli KM, Amin MR, Rahman A

The Journal of immunology : official journal of the American Association of Immunologists.. 2005 May 1174 (9):5823-9. Epub 1900 01 01.

RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65.

Anwar KN, Fazal F, Malik AB, Rahman A

The Journal of immunology : official journal of the American Association of Immunologists.. 2004 December 1173 (11):6965-72. Epub 1900 01 01.

Rho kinase mediates serum-induced contraction in fibroblast fibers independent of myosin LC20 phosphorylation.

Nobe H, Nobe K, Fazal F, De Lanerolle P, Paul RJ

American journal of physiology. Cell physiology.. 2003 March 284 (3):C599-606. Epub 10/03/2002.

Evolution of mouse hepatitis virus (MHV) during chronic infection: quasispecies nature of the persisting MHV RNA.

Adami C, Pooley J, Glomb J, Stecker E, Fazal F, Fleming JO, Baker SC

Virology.. 1995 June 1209 (2):337-46. Epub 1900 01 01.

Books

Glimpses in Plant Research XI: Medicinal Plants; New Vistas of Research [Part 2] (1993)

Chapter: Strand scission in DNA induced by dietary flavonoids: Role of Cu (II) and oxygen free radicals.