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Luojing Chen, Ph.D.

Luojing Chen, Ph.D.

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About Me

Dr. Chen's research interests involve B cell signaling pathways. Dr. Chen's laboratory is currently focusing on the role of PKK (a protein kinase) in lymphoma and lupus.
Dr. Chen's research interests involve B cell signaling pathways. Dr. Chen's laboratory is currently focusing on the role of PKK (a protein kinase) in lymphoma and lupus.

Faculty Appointments

Research Assistant Professor - Department of Medicine, Nephrology (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral Fellow
Signaling Transduction Lab
Massachusetts General Hospital
Harvard Medical School
Charlestown, MA 1996 - 2000

Postdoctoral Fellow
Molecular Biology
Massachusetts General Hospital
Harvard Medical School
Boston, MA 1995 - 1996

Postdoctoral Fellow
Genetics Department
Iowa State University
Ames, IA. 1992 - 1995

Education

PhD | Iowa State University. Genetics. 1992

MS | China-Wuhan University. Microbiology. 1985

BS | China-Wuhan University. Biology. 1982

Awards

Award for Experimental Hematopoietic Program pilot project. 2003 - 2004

Massachusetts General Hospital Medical Discovery Award. 1998 - 1999

NIH Training Grant. 1998 - 2000

Fung Endowment Fellowship. 1991

Research

Patents

Methods of Treating B-Cell Cancers

Issue date: February 05, 2013

Patent #: 8,367,633

Country: United States

Inventors: Luojing Chen, Jiyong Zhao

Publications

Journal Articles

Collectrin ( deficiency in proximal tubules causes hypertension in mice and a variant associates with blood pressure in males in a Latino cohort.

Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Wang YT, Chen L, Wassertheil-Smoller S, Cai J, Isakson BE, Franceschini N, Le TH

American journal of physiology. Renal physiology.. 2023 January 1324 (1):F30-F42. Epub 10/20/2022.

TMEM27 expression and clinical characteristics and survival in clear cell renal cell carcinoma.

Grewal R, Choung HYG, Roberts LL, Beane T, Chen L, Gilroy DX, Rappold PM, Le TH

Acta oncologica.. 2022 December 61 (12):1507-1511. Epub 11/11/2022.

Effect of Osteoblast-Specific Deletion of the Proton Receptor OGR1.

Krieger NS, Chen L, Becker J, Chan M, Bushinsky DA

JBMR plus.. 2022 December 6 (12):e10691. Epub 10/31/2022.

Chlorthalidone with potassium citrate decreases calcium oxalate stones and increases bone quality in genetic hypercalciuric stone-forming rats.

Krieger NS, Asplin J, Granja I, Chen L, Spataru D, Wu TT, Grynpas M, Bushinsky DA

Kidney international.. 2021 May 99 (5):1118-1126. Epub 01/05/2021.

Deletion of the proton receptor OGR1 in mouse osteoclasts impairs metabolic acidosis-induced bone resorption.

Krieger NS, Chen L, Becker J, Chan M, Bushinsky DA

Kidney international.. 2021 March 99 (3):609-619. Epub 11/04/2020.

Increased Osteoclast and Decreased Osteoblast Activity Causes Reduced Bone Mineral Density and Quality in Genetic Hypercalciuric Stone-Forming Rats.

Krieger NS, Chen L, Becker J, DeBoyace S, Wang H, Favus MJ, Bushinsky DA

JBMR plus.. 2020 April 4 (4):e10350. Epub 02/25/2020.

Chlorthalidone Is Superior to Potassium Citrate in Reducing Calcium Phosphate Stones and Increasing Bone Quality in Hypercalciuric Stone-Forming Rats.

Krieger NS, Asplin JR, Granja I, Ramos FM, Flotteron C, Chen L, Wu TT, Grynpas MD, Bushinsky DA

Journal of the American Society of Nephrology : JASN.. 2019 July 30 (7):1163-1173. Epub 05/17/2019.

PKK deletion in basal keratinocytes promotes tumorigenesis after chemical carcinogenesis.

Chen L, Hayden MS, Gilmore ES, Alexander-Savino C, Oleksyn D, Gillespie K, Zhao J, Poligone B

Carcinogenesis.. 2018 March 839 (3):418-428. Epub 1900 01 01.

PKK deficiency in B cells prevents lupus development in Sle lupus mice.

Oleksyn D, Zhao J, Vosoughi A, Zhao JC, Misra R, Pentland AP, Ryan D, Anolik J, Ritchlin C, Looney J, Anandarajah AP, Schwartz G, Calvi LM, Georger M, Mohan C, Sanz I, Chen L

Immunology letters.. 2017 May 185 :1-11. Epub 03/06/2017.

A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells.

Chen L, Oleksyn D, Pulvino M, Sanz I, Ryan D, Ryan C, Lin CS, Poligone B, Pentland AP, Ritchlin C, Zhao J

Immunology letters.. 2016 April 172 :67-78. Epub 02/26/2016.

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline.

Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, Deshaies RJ, Land H, Zhao J

Oncotarget.. 2015 June 206 (17):14796-813. Epub 1900 01 01.

PKK suppresses tumor growth and is decreased in squamous cell carcinoma of the skin.

Poligone B, Gilmore ES, Alexander C, Oleksyn D, Gillespie K, Zhao J, Ibrahim S, Pentland AP, Brown M, Chen L

The Journal of investigative dermatology.. 2015 March 135 (3):869-876. Epub 10/06/2014.

Protein kinase C-associated kinase regulates NF-?B activation through inducing IKK activation.

Kim SW, Schifano M, Oleksyn D, Jordan CT, Ryan D, Insel R, Zhao J, Chen L.

Int J Oncol. 2014; 45(4):1707-14.

Protein kinase C? is required for lupus development in Sle mice.

Oleksyn D, Pulvino M, Zhao J, Misra R, Vosoughi A, Jenks S, Tipton C, Lund F, Schwartz G, Goldman B, Mohan C, Mehta K, Mehta M, Leitgets M, Sanz I, Chen L.

Arthritis Rheum. 2013; 65(4): 1022.

A role for NF-?B activity in skin hyperplasia and the development of keratoacanthomata in mice

Poligone B, Hayden MS, Chen L, Pentland AP, Jimi E, Ghosh S.

PLoS One. 2013; 9;8(8):e71887.

Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A.

Pulvino M, Liang Y, Oleksyn D, Deran M, Van Pelt E, Shapiro J, Sanz I, Chen L, Zhao J

Blood.. 2012 August 23120 (8):1668-77. Epub 07/12/2012.

Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells.

Kim SW, Oleksyn DW, Rossi RM, Jordan CT, Sanz I, Chen L, Zhao J

Blood.. 2008 February 1111 (3):1644-53. Epub 11/19/2007.

Mad1 is a transcriptional repressor of Bcl-6.

Lee SC, Bottaro A, Chen L, Insel RA

Molecular immunology.. 2006 May 43 (12):1965-71. Epub 01/19/2006.

A catalytically inactive form of protein kinase C-associated kinase/receptor interacting protein 4, a protein kinase C beta-associated kinase that mediates NF-kappa B activation, interferes with early B cell development.

Cariappa A, Chen L, Haider K, Tang M, Nebelitskiy E, Moran ST, Pillai S

The Journal of immunology : official journal of the American Association of Immunologists.. 2003 August 15171 (4):1875-80. Epub 1900 01 01.

Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner.

Moran ST, Haider K, Ow Y, Milton P, Chen L, Pillai S

The Journal of biological chemistry.. 2003 June 13278 (24):21526-33. Epub 04/03/2003.

PKC associated kinase (PKK), a novel membrane-associated, ankyrin repeat containing protein kinase

Chen, L.; Haider, K.; Cariappa, A.; Rowitch, D.; Pillai, S.

Journal of Biological and Chemistry. 2001; 276(24): 21737-21744.

Inhibition of caspase activity prevents anti-IgM induced apoptosis but not ceramide generation in WEHI 231 B cells.

Chen L, Kim TJ, Pillai S

Molecular immunology.. 1998 March 35 (4):195-205. Epub 1900 01 01.

Deletion analysis of the starch-binding domain of Aspergillus glucoamylase.

Chen L, Coutinho PM, Nikolov Z, Ford C

Protein engineering. 1995 October 8 (10):1049-55. Epub 1900 01 01.

Cloning and sequencing of stearyol-ACP desaturase gene from soybean

Chen, L.; Moon, Y.; Atherly, A.

Plant Physiology. 1995; 109: 1498-1501.

Mechanical shear of high molecular weight DNA in agarose plugs

Chen, L.; Kosslak, R.; Atherly, A.

Bio Techniques. 1994; 16: 228-229.

Adsorption to starch of a beta-galactosidase fusion protein containing the starch-binding region of Aspergillus glucoamylase.

Chen LJ, Ford C, Nikolov Z

Gene.. 1991 March 199 (1):121-6. Epub 1900 01 01.

Improved adsorption to starch of a b-galactosidase fusion protein containing the starch-binding domain from Aspergillus glucoamylase

Chen, L.; Ford, C.; Kusanadi, A.; Nikolov, Z.

Biotechical Progress. 1991; 77: 225-229.

Transposon Tn5 mutagenesis in Bradyhizobium Japonicum

Chen, L.; Zhou, L.; Cen, Y.

Acta Microbiologica Sinica. 1986; 26: 321-325.