BS: PUC-Rio, Brazil; Physics (1989) MS: PUC-Rio, Brazil; Biophysics (1992) PhD: Imperial College, UK; Biophysics (1997) Postdoctoral Fellow - Yale University - Department of Physiology (1997-2000) Postdoctoral Fellow - Mount Sinai School of Medicine - Department of Physi...
EDUCATION
BS: PUC-Rio, Brazil; Physics (1989) MS: PUC-Rio, Brazil; Biophysics (1992) PhD: Imperial College, UK; Biophysics (1997) Postdoctoral Fellow - Yale University - Department of Physiology (1997-2000) Postdoctoral Fellow - Mount Sinai School of Medicine - Department of Physiology and Biophysics (2000-2003)
APPOINTMENTS 2003-2004: Instructor - Mount Sinai School of Medicine - Department of Physiology and Biophysics 2004-2012: Assistant Professor - University of Rochester - Department of medicine - Cardiovascular Research Institute 2013-now: Associate Professor (Research) - University of Rochester - Department of medicine - Cardiovascular Research Institute
Faculty Appointments
Adjunct Associate Professor
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Department of Medicine, Aab Cardiovascular Research Institute (SMD)
Credentials
Education
PhD | Imperial College.Biophysics.1997
MS | Brazil-Pontificia Universidade Catolica.Physics.1992
BS | Brazil-Pontificia Universidade Catolica.Physics.1989
Awards
NIH reviewer ESTA Study Section.2013
AHA reviewer - Cardiac Electrophysiology Study Section.2012
Scientist Development Grant.2004
Postdoctoral Fellowship American Heart Association.2002 - 2004
New York City Board Fellow Award American Heart Association.2002
PhD Scholarship Federal Agency for Post-Graduate Education (CAPES- Brazil).1992 - 1996
Graduate Student Scholarship National Research Council (CNPq Brazil).1990 - 1992
Outstanding Basic Science Student Award PUC-Rio.1987
Full Merit University Scholarship PUC-Rio.1986 - 1989
Outstanding Basic Science Student Award PUC-Rio.1986
Research
We are interested in understanding the regulation of ion channels by diverse G-protein signaling pathways in normal and pathological states.
One major focus of our current work involves the changes in function and regulation of cardiac ion channels that lead to the pathogenesis of the Long Q...
We are interested in understanding the regulation of ion channels by diverse G-protein signaling pathways in normal and pathological states.
One major focus of our current work involves the changes in function and regulation of cardiac ion channels that lead to the pathogenesis of the Long QT syndrome. Our work attempts to translate channel function and dysregulation at the cellular level to patient clinical phenotype and response to treatment.
A second focus of our current research is the study of the pathological remodeling of the slow delayed rectifier-like current (IKs) in heart failure. KCNQ1 is co-assembled with the KCNE1 gene product in the heart to produce IKs, which is one of the main currents responsible for myocyte repolarization. The most commonly inherited cardiac arrhythmia, long-QT1 (LQT1), is due to mutations in the KCNQ1 potassium channel. Heart disease is also known to decrease IKs currents. Our current research focus on stress signals caused by chronic stimulation of kinase signaling pathways, and their consequence for ion channel function and membrane trafficking. We explore possible novel antiarrhythmic treatments to reverse IKs pathological remodeling during heart failure.
Kutyifa V, Daimee U, McNitt S, Polonsky B, Lowenstein C, Cutter K, Lopes C, Zareba W, Moss AJ
Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.. 2018 May 23 (3):e12537. Epub 03/05/2018.
