Julie Ryan Wolf, PhD, MPH, is an Associate Professor in the Departments of Dermatology and Radiation Oncology, as well as a member of the University of Rochester NCI Community Oncology Research Program (NCORP) Research Base and the SWOG Cancer Research Network. She received her undergraduate degree ...
Julie Ryan Wolf, PhD, MPH, is an Associate Professor in the Departments of Dermatology and Radiation Oncology, as well as a member of the University of Rochester NCI Community Oncology Research Program (NCORP) Research Base and the SWOG Cancer Research Network. She received her undergraduate degree from University of Chicago, her PhD in Pathology from UNC-Chapel Hill, and her MPH from University of Rochester. Her research and expertise uniquely combines the fields of dermatology, radiation biology, oncology, and health services and outcomes research. Dr. Wolf strives to improve healthcare by facilitating access to evidence-based, integrative, patient-centered care and to optimize metrics for assessing quality of care. Much of her research has been dedicated to understanding and reducing radiation-induced skin reactions and other cancer-treatment-related toxicities. Her interventions have included non-toxic alternative modalities, such as curcumin, ginger, and aromatherapy. She has performed multiple local and national clinical trials and held two FDA INDs.
Faculty Appointments
Associate Professor
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Department of Dermatology (SMD)
Credentials
Education
Masters of Public Health-Clinical Investigation Track | University of Rochester School of Medicine & Dentistry.2007
Ph.D., | University of North Carolina at Chapel Hill.Pathology.2005
B.A. in Biological Sciences | University of Chicago.Biology.1997
Awards
Investigation New Drug (IND) #75,444 Curcumin C3 Complex, Food & Drug Administration.2007
National Institutes of Health Clinical Loan Repayment Program.2006 - 2010
National Cancer Institute Cancer Control Research Training Fellowship Award, Dept of Radiation Oncology.2005 - 2007
Rochester Clinical Research Fellow, Dept of Community and Preventative Medicine.2005 - 2007
Transportation Grant Award, Univ of North Carolina at Chapel Hill Graduate School.2004
Pathobiology of Cancer: The Edward A. Smuckler Memorial Workshop.2004
American Society of Investigative Pathology Travel Award, Experimental Biology Meeting.2002
Environmental Pathology Training Grant (#T32 ES07017).2001 - 2005
Research
Dr. Wolf performs multidisciplinary clinical research that combines dermatology, cancer control, oncology, and health outcomes. She enjoys mentoring and working with medical students, graduate students, and residents. She has conducted multiple local and nationwide clinical trials and has held two F...
Dr. Wolf performs multidisciplinary clinical research that combines dermatology, cancer control, oncology, and health outcomes. She enjoys mentoring and working with medical students, graduate students, and residents. She has conducted multiple local and nationwide clinical trials and has held two FDA INDs (74,555 and 123,414). She received national recognition at ASCO 2009 for the nationwide NCORP trial investigating ginger for chemotherapy-induced nausea. Her NCORP trial investigating oral curcumin for radiation dermatitis in breast cancer patients was the largest botanical product randomized controlled trial to date. A recently completed NCI-supported trial evaluated the effectiveness of prophylactic topical agents for radiation dermatitis and pain. Much of her research has been dedicated to understanding cancer-treatment induced toxicities and evaluating effective interventions to reduce these toxicities. Radiation dermatitis occurs in about 95% of patients and can negatively affect a patient's quality of life due to pain and premature interruption of radiation treatment. Management of radiation dermatitis has a broader significance as well; it has great importance in the morbidity and mortality expected in any potential "dirty bomb" attack. As part of the former University of Rochester Center for Medical Countermeasures Research (CMCR) program grant, Dr. Ryan Wolf investigated the role of altered barrier function and ROS-mediated damage on radiation-induced skin injury and combined radiation skin injury. Dr. Wolf’s research has also focused on elucidating the potential physical and psychosocial factors that influence the frequency and severity of patient-reported outcomes and clinical outcomes, such as skin reactions, pain, anxiety, and itch. Currently, she has a collaborative clinical trial with Roswell Park Cancer Institute, supported by the Wilmot Cancer Institute, investigating the use of aromatherapy as integrative cancer care for chemotherapy-induced symptoms. Another oncology project, in collaboration with Chapman University and SWOG, will evaluate the effectiveness of a novel topical vitamin K1 product for EGFRI-induced rash. Her new dermatology clinical trial, supported by Pfizer, will evaluate the impact of topical tacrolimus and crisaborole treatment on patient-reported outcomes and caregiver burden in children and adolescents with atopic dermatitis. This study will provide valuable insight into how treatment of a chronic disease affects patients, their families, and compliance to therapy. Another project in collaboration with Michigan State University and supported by NSF, involves optimization of a new metric and analysis for quality of care by applying complexity theory to healthcare routines. This novel analysis uses audit trail data from the electronic medical record to evaluate clinic visit process and workflow. Furthermore, Dr. Wolf has established using patient-reported outcome measures (PROMIS domains) as part of routine clinical care in dermatology. Thus far, her work has demonstrated the critical need for patient-reported outcomes in monitoring disease activity and treatment response.
Wang Y, Allsop MJ, Epstein JB, Howell D, Rapoport BL, Schofield P, Van Sebille Y, Thong MSY, Walraven I, Ryan Wolf J, van den Hurk CJG
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2024 February 2232 (3):182. Epub 02/22/2024.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2023 September 1131 (10):568. Epub 09/11/2023.
Lee SF, Wong HCY, Chan AW, Caini S, Shariati S, Rades D, Chan RJ, Kennedy SKF, Wolf JR, van den Hurk C, Behroozian T, Bonomo P, Ho FCH, Chow E, Herst P
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2023 August 1831 (9):527. Epub 08/18/2023.
Lee SF, Shariati S, Caini S, Wong H, Chan AW, Gojsevic M, Ogita M, Ye JC, Chia D, Chao M, Sung K, Kennedy SKF, Rajeswaran T, van den Hurk C, Wolf JR, Chan RJ, Behroozian T, Bonomo P, Chow E
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2023 August 931 (9):515. Epub 08/09/2023.
Behroozian T, Goldshtein D, Ryan Wolf J, van den Hurk C, Finkelstein S, Lam H, Patel P, Kanee L, Lee SF, Chan AW, Wong HCY, Caini S, Mahal S, Kennedy S, Chow E, Bonomo P,
EClinicalMedicine.. 2023 April 58 :101886. Epub 03/27/2023.
Behroozian T, Fatima S, Finkelstein S, Kanee L, Bonomo P, Wolf JR, Vassiliou V, van den Hurk C, Chow E, Beveridge M
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2022 December 30 (12):9681-9685. Epub 10/24/2022.
Ryan Wolf J, Gewandter JS, Bautista J, Heckler CE, Strasser J, Dyk P, Anderson T, Gross H, Speer T, Dolohanty L, Bylund K, Pentland AP, Morrow GR
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2020 July 28 (7):3303-3311. Epub 11/22/2019.
Peoples AR, Garland SN, Pigeon WR, Perlis ML, Wolf JR, Heffner KL, Mustian KM, Heckler CE, Peppone LJ, Kamen CS, Morrow GR, Roscoe JA
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.. 2019 January 1515 (1):129-137. Epub 01/15/2019.
Ryan Wolf J, Heckler CE, Guido JJ, Peoples AR, Gewandter JS, Ling M, Vinciguerra VP, Anderson T, Evans L, Wade J, Pentland AP, Morrow GR
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2018 May 26 (5):1543-1552. Epub 12/01/2017.
Peoples AR, Roscoe JA, Block RC, Heckler CE, Ryan JL, Mustian KM, Janelsins MC, Peppone LJ, Moore DF, Coles C, Hoelzer KL, Morrow GR, Dozier AM
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2017 April 25 (4):1271-1278. Epub 12/20/2016.
Gewandter JS, Mohile SG, Heckler CE, Ryan JL, Kirshner JJ, Flynn PJ, Hopkins JO, Morrow GR
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2014 July 22 (7):1807-14. Epub 02/16/2014.
Ryan JL, Heckler CE, Roscoe JA, Dakhil SR, Kirshner J, Flynn PJ, Hickok JT, Morrow GR
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer.. 2012 July 20 (7):1479-89. Epub 08/05/2011.
Figueroa-Moseley C, Jean-Pierre P, Roscoe JA, Ryan JL, Kohli S, Palesh OG, Ryan EP, Carroll J, Morrow GR
Journal of the National Comprehensive Cancer Network : JNCCN.. 2007 January 5 (1):44-50. Epub 1900 01 01.
A Phase II/III Randomized, Placebo-Controlled Double-Blind Clinical Trial of Ginger (Zingiber officinale) for Nausea Caused by Chemotherapy for Cancer: A Currently Accruing URCC CCOP Cancer Control Study.
Hickok JT, Roscoe JA, Morrow GR, Ryan JL.
Supportive Cancer Therapy. 2007; 4: 247-50.
Post-treatment skin reactions reported by cancer patients differ by race, not by treatment or expectations.
Ryan JL, Bole C, Hickok JT, Figueroa-Moseley C, Pentland AP, Morrow GR.
British Journal Cancer. 2007; 97(1): 14-21.
Cancer-related fatigue: The scale of the problem.
Hofman M, Ryan JL, Figueroa-Moseley C, Jean-Pierre P, Morrow GR.
The Oncologist. 2007; 12(Sup 1): 4-10.
Mechanisms of cancer-related fatigue.
Ryan JL, Carroll J, Ryan E, Fiscella K, Morrow GR.
The Oncologist. 2007; 12(Sup 1): 22-34.
Cancer-related fatigue and sleep disorders.
Roscoe JA, Matteson S, Palesh O, Ryan JL, Kohli S, Perlis M.
The Oncologist. 2007; 12(Sup 1): 35-42.
Behavioral interventions in treating anticipatory nausea and vomiting; theoretical models,basic mechanisms, and clinical management.
Figueroa-Moseley C, Jean-Pierre P, Roscoe JA, Ryan JL, Kohli S, Palesh OG, Ryan EP, Carroll J, Morrow GR.
J National Comprehensive Cancer Network. 2007; 5(1): 44-50.
Deletion of prostaglandin E2 EP2 receptor protects against ultraviolet (UV) induced carcinogenesis, but increases tumor aggressiveness.
Brouxhon S, Konger RL, VanBuskirk J, Sheu T, Ryan JL, Erdle B, Almundevar A, Breyer RM, Scott G, Pentland AP.
Okunieff P, Xu J, Hu D, Liu W, Zhang L, Morrow G, Pentland A, Ryan JL, Ding I
International journal of radiation oncology, biology, physics.. 2006 July 165 (3):890-8. Epub 1900 01 01.
Clonal evolution of lymphoblastoid cell lines.
Ryan JL, Kaufmann WK, Oglesbee SE, Raab-Traub N, Carey LA, Gulley ML.
Laboratory Investigation. 2006; : 1193-2000.
Decreased mRNA expression of inflammatory and fibrogenic cytokines by curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice.
Okunieff P, Xu J, Hu D, Liu W, Williams JP, Zhang L, Ryan JL, Pentland AP, Ding I.
International Journal of Radiation Oncology, Biology, and Physics 65(3): 890-898, 2006. 2006; 65(3): 890-898.
Real-time PCR of Epstein-Barr virus in invasive breast carcinoma.
Thorne LB, Ryan JL, Elmore SH, Glaser SL, Gulley ML.
Diagnostic Molecular Pathology. 2005; 14: 29-33.
Epstein-Barr virus quantitation by real-time PCR targeting multiple gene segments: A novel approach to screen for the virus in paraffin-embedded tissues and plasma.
Ryan JL, Fan H, Glaser S, Schichman SA, Raab-Traub N, Gulley ML.
