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Peter J. Sims, M.D., Ph.D.

Peter J. Sims, M.D., Ph.D.

About Me

Faculty Appointments

Professor Emeritus - Department of Medicine (SMD)

Credentials

Education

MD | Duke University Sch Medicine. Medicine. 1980

PhD | Duke University Sch Medicine. Pharmacology. 1980

BA | Amherst College. Biophysics. 1974

Awards

Adjunct Professor Shanghai Second Medical University Shanghai, China 2004

Chairman, N.I.H. Hematology 1 Study Section 1999 - 2001

N.I.H. (NHLBI) MERIT Award 1995

Walter H. Schroeder Chair in Research,
The Blood Center of Southeastern Wisconsin 1993 - 1999

Chairman, Veterans Administration Merit Review Board - Hematology 1991 - 1992

President, American Heart Association,
Oklahoma Affiliate 1990 - 1991

Man-of-the-Year Award, American Heart Association, Oklahoma Affiliate Chapter 1989

American Society for Clinical Investigation 1988

S. Graham Smith Endowment Distinguished Scientist, Oklahoma Medical Research Foundation, 1988 - 1992

N.I.H. Research Career Development Award (Awarded but not activated in lieu of AHA Established Investigatorship). 1985

Established Investigator of American Heart Association #85-128 1985 - 1990

Clinician-Scientist Award, American Heart Association (Awarded but not activated in lieu of Hartford Fellowship) 1982

John A. and George L. Hartford Fellowship in Biomedical Research 1982 - 1985

Southern Medical Association Research Award 1981

Alpha Omega Alpha, Duke University School of Medicine 1976

B.A., Summa Cum Laude, Amherst College 1974

Medical Scientist Traineeship (PHS), GM-07171 1974 - 1980

Sigma Xi, Amherst College 1972

Phi Beta Kappa, Amherst College 1972

Research

We originally discovered and cloned phospholipid scramblase as a membrane protein with capacity to promote rapid transbilayer movement of phospholipids in response to Ca2+ . This protein turned out to be the first of four that together form the phospholipid scramblase (PLSCR) gene family. Our resear...
We originally discovered and cloned phospholipid scramblase as a membrane protein with capacity to promote rapid transbilayer movement of phospholipids in response to Ca2+ . This protein turned out to be the first of four that together form the phospholipid scramblase (PLSCR) gene family. Our research during the last few years has revealed that PLSCRs may have functions beyond their putative role as membrane phospholipid scramblases. Taking advantage of gene knockout technology, we discovered that mice with a targeted deletion of PLSCR1 display perinatal granulocytopenia due to defective response to hematologic precursors to granulocyte colony-stimulating factor and stem cell factor. Interestingly, PLSCR3-/- mice have a phenotype reminiscent of metabolic syndrome in man: they display aberrant accumulation of abdominal fat, accompanied by the development of insulin resistance, glucose intolerance, and dyslipidemia. These observations and our in vitro data suggest that PLSCRs are involved in signal transduction through growth factor receptors and may be required for normal cell maturation. Furthermore, we have shown that aberrant expression of PLSCR1 may play a role in tumor formation and increased susceptibility to viral infection. Current efforts are focused on unraveling the molecular mechanisms by which PLSCRs mediate these diverse functions.

Publications

Journal Articles

Regulation of the tyrosine phosphorylation of Phospholipid Scramblase 1 in mast cells that are stimulated through the high-affinity IgE receptor.

Kassas A, Moura IC, Yamashita Y, Scheffel J, Guérin-Marchand C, Blank U, Sims PJ, Wiedmer T, Monteiro RC, Rivera J, Charles N, Benhamou M

PloS one.. 2014 9 (10):e109800. Epub 10/07/2014.

Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells.

Kodigepalli KM, Anur P, Spellman P, Sims PJ, Nanjundan M

Molecular cancer.. 2013 April 2612 :32. Epub 04/26/2013.

Phospholipid scramblase-1-induced lipid reorganization regulates compensatory endocytosis in neuroendocrine cells.

Ory S, Ceridono M, Momboisse F, Houy S, Chasserot-Golaz S, Heintz D, Calco V, Haeberlé AM, Espinoza FA, Sims PJ, Bailly Y, Bader MF, Gasman S

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 February 2033 (8):3545-56. Epub 1900 01 01.

Identification of key regulatory pathways of myeloid differentiation using an mESC-based karyotypically normal cell model.

Li D, Yang H, Nan H, Liu P, Pang S, Zhao Q, Karni R, Kamps MP, Xu Y, Zhou J, Wiedmer T, Sims PJ, Wang F

Blood.. 2012 December 6120 (24):4712-9. Epub 10/18/2012.

Phosphatidylserine externalization and membrane blebbing are involved in the nonclassical export of FGF1.

Kirov A, Al-Hashimi H, Solomon P, Mazur C, Thorpe PE, Sims PJ, Tarantini F, Kumar TK, Prudovsky I

Journal of cellular biochemistry.. 2012 March 113 (3):956-66. Epub 1900 01 01.

A minimal nuclear localization signal (NLS) in human phospholipid scramblase 4 that binds only the minor NLS-binding site of importin alpha1.

Lott K, Bhardwaj A, Sims PJ, Cingolani G

The Journal of biological chemistry.. 2011 August 12286 (32):28160-9. Epub 06/20/2011.

Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis.

Chen CW, Sowden M, Zhao Q, Wiedmer T, Sims PJ

Journal of leukocyte biology.. 2011 August 90 (2):221-33. Epub 03/29/2011.

Calcium-dependent phospholipid scrambling by TMEM16F.

Suzuki J, Umeda M, Sims PJ, Nagata S

Nature.. 2010 December 9468 (7325):834-8. Epub 11/24/2010.

Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors.

Bateman A, Finn RD, Sims PJ, Wiedmer T, Biegert A, Söding J

Bioinformatics.. 2009 January 1525 (2):159-62. Epub 11/13/2008.

Expression of the phospholipid scramblase (PLSCR) gene family during the acute phase response.

Lu B, Sims PJ, Wiedmer T, Moser AH, Shigenaga JK, Grunfeld C, Feingold KR

Biochimica et biophysica acta.. 2007 September 1771 (9):1177-85. Epub 05/26/2007.

Mobilization of pro-inflammatory lipids in obese Plscr3-deficient mice.

Mutch DM, O'Maille G, Wikoff WR, Wiedmer T, Sims PJ, Siuzdak G

Genome biology.. 2007 8 (3):R38. Epub 1900 01 01.

Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells.

Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ

Oncogene.. 2006 October 2625 (50):6618-27. Epub 05/15/2006.

The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1.

Li Y, Rogulski K, Zhou Q, Sims PJ, Prochownik EV

Molecular and cellular biology.. 2006 May 26 (9):3401-13. Epub 1900 01 01.

Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK.

Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ

The Journal of biological chemistry.. 2005 December 30280 (52):42707-14. Epub 10/28/2005.

Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression.

Zhou Q, Ben-Efraim I, Bigcas JL, Junqueira D, Wiedmer T, Sims PJ

The Journal of biological chemistry.. 2005 October 14280 (41):35062-8. Epub 08/09/2005.

Phospholipid scramblase 1 contains a nonclassical nuclear localization signal with unique binding site in importin alpha.

Chen MH, Ben-Efraim I, Mitrousis G, Walker-Kopp N, Sims PJ, Cingolani G

The Journal of biological chemistry.. 2005 March 18280 (11):10599-606. Epub 12/17/2004.

Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation.

Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, Shen WZ, Zhao J, Zhou Q, Chen Z, Sims PJ, Wiedmer T, Chen GQ

Blood.. 2004 December 1104 (12):3731-8. Epub 08/12/2004.

Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin.

Giddings KS, Zhao J, Sims PJ, Tweten RK

Nature structural & molecular biology.. 2004 December 11 (12):1173-8. Epub 11/14/2004.

Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3).

Wiedmer T, Zhao J, Li L, Zhou Q, Hevener A, Olefsky JM, Curtiss LK, Sims PJ

Proceedings of the National Academy of Sciences of the United States of America.. 2004 September 7101 (36):13296-301. Epub 08/24/2004.

Phospholipid scramblase 1 potentiates the antiviral activity of interferon.

Dong B, Zhou Q, Zhao J, Zhou A, Harty RN, Bose S, Banerjee A, Slee R, Guenther J, Williams BR, Wiedmer T, Sims PJ, Silverman RH

Journal of virology.. 2004 September 78 (17):8983-93. Epub 1900 01 01.

Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA.

Ben-Efraim I, Zhou Q, Wiedmer T, Gerace L, Sims PJ

Biochemistry.. 2004 March 3043 (12):3518-26. Epub 1900 01 01.

Phospholipid scramblase 1 is imported into the nucleus by a receptor-mediated pathway and interacts with DNA

Ben-Efraim,I.; Zhou,Q.; Wiedmer,T.; Gerace,L.; Sims,P. J.;.

Biochemistry (John Wiley & Sons). 2004; 43(12): 3518-3526.

Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor.

Nanjundan M, Sun J, Zhao J, Zhou Q, Sims PJ, Wiedmer T

The Journal of biological chemistry.. 2003 September 26278 (39):37413-8. Epub 07/18/2003.

Spatial resolution of phospholipid scramblase 1 (PLSCR1), caspase-3 activation and DNA-fragmentation in the human hippocampus after cerebral ischemia.

Rami A, Sims J, Botez G, Winckler J

Neurochemistry international.. 2003 July 43 (1):79-87. Epub 1900 01 01.

Caspase-independent exposure of aminophospholipids and tyrosine phosphorylation in bicarbonate responsive human sperm cells.

de Vries KJ, Wiedmer T, Sims PJ, Gadella BM

Biology of reproduction.. 2003 June 68 (6):2122-34. Epub 01/22/2003.

Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE)).

Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y

The Journal of biological chemistry.. 2003 April 25278 (17):15239-45. Epub 02/13/2003.

Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane.

Wiedmer T, Zhao J, Nanjundan M, Sims PJ

Biochemistry.. 2003 February 1142 (5):1227-33. Epub 1900 01 01.

Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane

Wiedmer,T.; Zhao,J.; Nanjundan,M.; Sims,P. J.;.

Biochemistry (John Wiley & Sons). 2003; 42(5): 1227-1233.

Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1.

Zhou Q, Zhao J, Wiedmer T, Sims PJ

Blood.. 2002 June 199 (11):4030-8. Epub 1900 01 01.

Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor.

Sun J, Nanjundan M, Pike LJ, Wiedmer T, Sims PJ

Biochemistry.. 2002 May 2141 (20):6338-45. Epub 1900 01 01.

Suppression of ovarian carcinoma cell growth in vivo by the interferon-inducible plasma membrane protein, phospholipid scramblase 1.

Silverman RH, Halloum A, Zhou A, Dong B, Al-Zoghaibi F, Kushner D, Zhou Q, Zhao J, Wiedmer T, Sims PJ

Cancer research.. 2002 January 1562 (2):397-402. Epub 1900 01 01.

Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor

Sun,J.; Nanjundan,M.; Pike,L. J.; Wiedmer,T.; Sims,P. J.;.

Biochemistry (John Wiley & Sons). 2002; 41(20): 6338-6345.

c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1.

Sun J, Zhao J, Schwartz MA, Wang JY, Wiedmer T, Sims PJ

The Journal of biological chemistry.. 2001 August 3276 (31):28984-90. Epub 06/04/2001.

Unraveling the mysteries of phospholipid scrambling.

Sims PJ, Wiedmer T

Thrombosis and haemostasis.. 2001 July 86 (1):266-75. Epub 1900 01 01.

Identification of three new members of the phospholipid scramblase gene family.

Wiedmer T, Zhou Q, Kwoh DY, Sims PJ

Biochimica et biophysica acta.. 2000 July 311467 (1):244-53. Epub 1900 01 01.

Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipid scrambling and alters cell-surface morphology.

Tepper AD, Ruurs P, Wiedmer T, Sims PJ, Borst J, van Blitterswijk WJ

The Journal of cell biology.. 2000 July 10150 (1):155-64. Epub 1900 01 01.

Transcriptional control of the human plasma membrane phospholipid scramblase 1 gene is mediated by interferon-alpha.

Zhou Q, Zhao J, Al-Zoghaibi F, Zhou A, Wiedmer T, Silverman RH, Sims PJ

Blood.. 2000 April 1595 (8):2593-9. Epub 1900 01 01.

Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression.

Fadeel B, Gleiss B, Högstrand K, Chandra J, Wiedmer T, Sims PJ, Henter JI, Orrenius S, Samali A

Biochemical and biophysical research communications.. 1999 December 20266 (2):504-11. Epub 1900 01 01.

Mechanisms by which elevated intracellular calcium induces S49 cell membranes to become susceptible to the action of secretory phospholipase A2.

Wilson HA, Waldrip JB, Nielson KH, Judd AM, Han SK, Cho W, Sims PJ, Bell JD

The Journal of biological chemistry.. 1999 April 23274 (17):11494-504. Epub 1900 01 01.

Change in conformation of plasma membrane phospholipid scramblase induced by occupancy of its Ca2+ binding site.

Stout JG, Zhou Q, Wiedmer T, Sims PJ

Biochemistry.. 1998 October 2037 (42):14860-6. Epub 1900 01 01.

Expression of proteins controlling transbilayer movement of plasma membrane phospholipids in the B lymphocytes from a patient with Scott syndrome.

Zhou Q, Sims PJ, Wiedmer T

Blood.. 1998 September 192 (5):1707-12. Epub 1900 01 01.

Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids.

Zhao J, Zhou Q, Wiedmer T, Sims PJ

Biochemistry.. 1998 May 537 (18):6361-6. Epub 1900 01 01.

Identity of the residues responsible for the species-restricted complement inhibitory function of human CD59.

Zhao XJ, Zhao J, Zhou Q, Sims PJ

The Journal of biological chemistry.. 1998 April 24273 (17):10665-71. Epub 1900 01 01.

Level of expression of phospholipid scramblase regulates induced movement of phosphatidylserine to the cell surface.

Zhao J, Zhou Q, Wiedmer T, Sims PJ

The Journal of biological chemistry.. 1998 March 20273 (12):6603-6. Epub 1900 01 01.

Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids.

Zhou Q, Sims PJ, Wiedmer T

Biochemistry.. 1998 February 2437 (8):2356-60. Epub 1900 01 01.

Change in conformation of plasma membrane phospholipid scramblase induced by occupancy of its Ca2+ binding site

Stout,J. G.; Zhou,Q.; Wiedmer,T.; Sims,P. J.;.

Biochemistry (John Wiley & Sons). 1998; 37(42): 14860-14866.

Palmitoylation of phospholipid scramblase is required for normal function in promoting Ca2+-activated transbilayer movement of membrane phospholipids

Zhao,J.; Zhou,Q.; Wiedmer,T.; Sims,P. J.;.

Biochemistry (John Wiley & Sons). 1998; 37(18): 6361-6366.

Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids

Zhou,Q.; Sims,P. J.; Wiedmer,T.;.

Biochemistry (John Wiley & Sons). 1998; 37(8): 2356-2360.

Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids.

Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ

The Journal of biological chemistry.. 1997 July 18272 (29):18240-4. Epub 1900 01 01.

Production and characterization of a mutant cell line defective in aminophospholipid translocase.

Zhao J, Sims PJ, Wiedmer T

Biochimica et biophysica acta.. 1997 June 51357 (1):57-64. Epub 1900 01 01.

Scott syndrome erythrocytes contain a membrane protein capable of mediating Ca2+-dependent transbilayer migration of membrane phospholipids.

Stout JG, Bassé F, Luhm RA, Weiss HJ, Wiedmer T, Sims PJ

The Journal of clinical investigation.. 1997 May 199 (9):2232-8. Epub 1900 01 01.

Complement C5b-9 increases plasminogen binding and activation on human endothelial cells.

Christiansen VJ, Sims PJ, Hamilton KK

Arteriosclerosis, thrombosis, and vascular biology.. 1997 January 17 (1):164-71. Epub 1900 01 01.

Expression of recombinant CD59 with an N-terminal peptide epitope facilitates analysis of residues contributing to its complement-inhibitory function.

Zhou Q, Zhao J, Hüsler T, Sims PJ

Molecular immunology.. 1996 October 33 (14):1127-34. Epub 1900 01 01.

Elimination of potential sites of glycosylation fails to abrogate complement regulatory function of cell surface CD59.

Rother RP, Zhao J, Zhou Q, Sims PJ

The Journal of biological chemistry.. 1996 September 27271 (39):23842-5. Epub 1900 01 01.

Isolation of an erythrocyte membrane protein that mediates Ca2+-dependent transbilayer movement of phospholipid.

Bassé F, Stout JG, Sims PJ, Wiedmer T

The Journal of biological chemistry.. 1996 July 19271 (29):17205-10. Epub 1900 01 01.

Role of a disulfide-bonded peptide loop within human complement C9 in the species-selectivity of complement inhibitor CD59.

Husler T, Lockert DH, Sims PJ

Biochemistry.. 1996 March 1235 (10):3263-9. Epub 1900 01 01.

Role of a disulfide-bonded peptide loop within human complement C9 in the species-selectivity of complement inhibitor CD59

Husler,T.; Lockert,D. H.; Sims,P. J.;.

Biochemistry (John Wiley & Sons). 1996; 35(10): 3263-3269.

Structure-function relationships of the complement regulatory protein, CD59.

Petranka J, Zhao J, Norris J, Tweedy NB, Ware RE, Sims PJ, Rosse WF

Blood cells, molecules & diseases.. 1996 22 (3):281-96. Epub 1900 01 01.

Induction of cellular procoagulant activity by the membrane attack complex of complement.

Sims PJ, Wiedmer T

Seminars in cell biology. 1995 October 6 (5):275-82. Epub 1900 01 01.

The complex of phosphatidylinositol 4,5-bisphosphate and calcium ions is not responsible for Ca2+-induced loss of phospholipid asymmetry in the human erythrocyte: a study in Scott syndrome, a disorder of calcium-induced phospholipid scrambling.

Bevers EM, Wiedmer T, Comfurius P, Zhao J, Smeets EF, Schlegel RA, Schroit AJ, Weiss HJ, Williamson P, Zwaal RF, Sims PJ

Blood.. 1995 September 186 (5):1983-91. Epub 1900 01 01.

Identity of the segment of human complement C8 recognized by complement regulatory protein CD59.

Lockert DH, Kaufman KM, Chang CP, Hüsler T, Sodetz JM, Sims PJ

The Journal of biological chemistry.. 1995 August 25270 (34):19723-8. Epub 1900 01 01.

Chimeras of human complement C9 reveal the site recognized by complement regulatory protein CD59.

Hüsler T, Lockert DH, Kaufman KM, Sodetz JM, Sims PJ

The Journal of biological chemistry.. 1995 February 24270 (8):3483-6. Epub 1900 01 01.

Production and characterization of transformed B-lymphocytes expressing the membrane defect of Scott syndrome.

Kojima H, Newton-Nash D, Weiss HJ, Zhao J, Sims PJ, Wiedmer T

The Journal of clinical investigation.. 1994 December 94 (6):2237-44. Epub 1900 01 01.

Identity of a peptide domain of human C9 that is bound by the cell-surface complement inhibitor, CD59.

Chang CP, Hüsler T, Zhao J, Wiedmer T, Sims PJ

The Journal of biological chemistry.. 1994 October 21269 (42):26424-30. Epub 1900 01 01.

CD59 costimulation of T cell activation. CD58 dependence and requirement for glycosylation.

Menu E, Tsai BC, Bothwell AL, Sims PJ, Bierer BE

The Journal of immunology : official journal of the American Association of Immunologists.. 1994 September 15153 (6):2444-56. Epub 1900 01 01.

Protection of porcine aortic endothelial cells from complement-mediated cell lysis and activation by recombinant human CD59.

Kennedy SP, Rollins SA, Burton WV, Sims PJ, Bothwell AL, Squinto SP, Zavoico GB

Transplantation.. 1994 May 2757 (10):1494-501. Epub 1900 01 01.

Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria.

Wiedmer T, Hall SE, Ortel TL, Kane WH, Rosse WF, Sims PJ

Blood.. 1993 August 1582 (4):1192-6. Epub 1900 01 01.

Contribution of platelet microparticle formation and granule secretion to the transmembrane migration of phosphatidylserine.

Chang CP, Zhao J, Wiedmer T, Sims PJ

The Journal of biological chemistry.. 1993 April 5268 (10):7171-8. Epub 1900 01 01.

Interaction between apolipoproteins A-I and A-II and the membrane attack complex of complement. Affinity of the apoproteins for polymeric C9.

Hamilton KK, Zhao J, Sims PJ

The Journal of biological chemistry.. 1993 February 15268 (5):3632-8. Epub 1900 01 01.

Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles.

Dahlbäck B, Wiedmer T, Sims PJ

Biochemistry.. 1992 December 2931 (51):12769-77. Epub 1900 01 01.

Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9.

Shattil SJ, Cunningham M, Wiedmer T, Zhao J, Sims PJ, Brass LF

The Journal of biological chemistry.. 1992 September 15267 (26):18424-31. Epub 1900 01 01.

Inhibition of the complement membrane attack complex by the galactose-specific adhesion of Entamoeba histolytica.

Braga LL, Ninomiya H, McCoy JJ, Eacker S, Wiedmer T, Pham C, Wood S, Sims PJ, Petri WA

The Journal of clinical investigation.. 1992 September 90 (3):1131-7. Epub 1900 01 01.

The human complement regulatory protein CD59 binds to the alpha-chain of C8 and to the "b"domain of C9.

Ninomiya H, Sims PJ

The Journal of biological chemistry.. 1992 July 5267 (19):13675-80. Epub 1900 01 01.

Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59.

Hahn WC, Menu E, Bothwell AL, Sims PJ, Bierer BE

Science.. 1992 June 26256 (5065):1805-7. Epub 1900 01 01.

Contribution of the N-linked carbohydrate of erythrocyte antigen CD59 to its complement-inhibitory activity.

Ninomiya H, Stewart BH, Rollins SA, Zhao J, Bothwell AL, Sims PJ

The Journal of biological chemistry.. 1992 April 25267 (12):8404-10. Epub 1900 01 01.

Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome.

Bevers EM, Wiedmer T, Comfurius P, Shattil SJ, Weiss HJ, Zwaal RF, Sims PJ

Blood.. 1992 January 1579 (2):380-8. Epub 1900 01 01.

Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles

Dahlback,B.; Wiedmer,T.; Sims,P. J.;.

Biochemistry (John Wiley & Sons). 1992; 31(51): 12769-12777.

Inhibition of the complement membrane attack complex by the galactose-specific adhesin of Entamoeba histolytica.

Braga LL, Ninomiya H, McCoy JJ, Adal K, Wiedmer T, Pham C, Sims PJ, Petri WA

Archives of medical research.. 1992 23 (2):133. Epub 1900 01 01.

Participation of protein kinases in complement C5b-9-induced shedding of platelet plasma membrane vesicles.

Wiedmer T, Sims PJ

Blood.. 1991 December 178 (11):2880-6. Epub 1900 01 01.

The terminal complement proteins C5b-9 augment binding of high density lipoprotein and its apolipoproteins A-I and A-II to human endothelial cells.

Hamilton KK, Sims PJ

The Journal of clinical investigation.. 1991 December 88 (6):1833-40. Epub 1900 01 01.

Platelet-derived microparticles express high affinity receptors for factor VIII.

Gilbert GE, Sims PJ, Wiedmer T, Furie B, Furie BC, Shattil SJ

The Journal of biological chemistry.. 1991 September 15266 (26):17261-8. Epub 1900 01 01.

The response of human platelets to activated components of the complement system.

Sims PJ, Wiedmer T

Immunology today.. 1991 September 12 (9):338-42. Epub 1900 01 01.

Amplified gene expression in CD59-transfected Chinese hamster ovary cells confers protection against the membrane attack complex of human complement.

Zhao J, Rollins SA, Maher SE, Bothwell AL, Sims PJ

The Journal of biological chemistry.. 1991 July 15266 (20):13418-22. Epub 1900 01 01.

Isolation of a tryptic fragment from Clostridium perfringens theta-toxin that contains sites for membrane binding and self-aggregation.

Tweten RK, Harris RW, Sims PJ

The Journal of biological chemistry.. 1991 July 5266 (19):12449-54. Epub 1900 01 01.

Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes.

Harris RW, Sims PJ, Tweten RK

Infection and immunity.. 1991 July 59 (7):2499-501. Epub 1900 01 01.

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex.

Sims PJ, Ginsberg MH, Plow EF, Shattil SJ

The Journal of biological chemistry.. 1991 April 25266 (12):7345-52. Epub 1900 01 01.

Kinetic aspects of the aggregation of Clostridium perfringens theta-toxin on erythrocyte membranes. A fluorescence energy transfer study.

Harris RW, Sims PJ, Tweten RK

The Journal of biological chemistry.. 1991 April 15266 (11):6936-41. Epub 1900 01 01.

Inhibition of homologous complement by CD59 is mediated by a species-selective recognition conferred through binding to C8 within C5b-8 or C9 within C5b-9.

Rollins SA, Zhao J, Ninomiya H, Sims PJ

The Journal of immunology : official journal of the American Association of Immunologists.. 1991 April 1146 (7):2345-51. Epub 1900 01 01.

Identification of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome.

Gerrard JM, Lint D, Sims PJ, Wiedmer T, Fugate RD, McMillan E, Robertson C, Israels SJ

Blood.. 1991 January 177 (1):101-12. Epub 1900 01 01.

Inhibition of homologous complement by CD59 is mediated by a species-selective recognition conferred through binding to C8 within C5b-8 or C9 within C5b-9

Rollins,S. A.; Zhao,J.; Ninomiya,H.; Sims,P. J.;.

Journal of immunology (Baltimore, Md.). 1991; 146(7): 2345-2351.

Regulatory control of the terminal complement proteins at the surface of human endothelial cells: neutralization of a C5b-9 inhibitor by antibody to CD59.

Hamilton KK, Ji Z, Rollins S, Stewart BH, Sims PJ

Blood.. 1990 December 1576 (12):2572-7. Epub 1900 01 01.

The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9.

Rollins SA, Sims PJ

The Journal of immunology : official journal of the American Association of Immunologists.. 1990 May 1144 (9):3478-83. Epub 1900 01 01.

Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex.

Hamilton KK, Hattori R, Esmon CT, Sims PJ

The Journal of biological chemistry.. 1990 March 5265 (7):3809-14. Epub 1900 01 01.

Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor.

Wiedmer T, Shattil SJ, Cunningham M, Sims PJ

Biochemistry.. 1990 January 2329 (3):623-32. Epub 1900 01 01.

The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of C9 into membrane C5b-9

Rollins,S. A.; Sims,P. J.;.

Journal of immunology (Baltimore, Md.). 1990; 144(9): 3478-3483.

Role of calcium and calpain in complement-induced vesiculation of the platelet plasma membrane and in the exposure of the platelet factor Va receptor

Wiedmer,T.; Shattil,S. J.; Cunningham,M.; Sims,P. J.;.

Biochemistry (John Wiley & Sons). 1990; 29(3): 623-632.

Regulatory control of complement on blood platelets. Modulation of platelet procoagulant responses by a membrane inhibitor of the C5b-9 complex.

Sims PJ, Rollins SA, Wiedmer T

The Journal of biological chemistry.. 1989 November 15264 (32):19228-35. Epub 1900 01 01.

Complement proteins C5b-9 induce transbilayer migration of membrane phospholipids.

Van der Meer BW, Fugate RD, Sims PJ

Biophysical journal.. 1989 November 56 (5):935-46. Epub 1900 01 01.

Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity.

Sims PJ, Wiedmer T, Esmon CT, Weiss HJ, Shattil SJ

The Journal of biological chemistry.. 1989 October 15264 (29):17049-57. Epub 1900 01 01.

Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface.

Hattori R, Hamilton KK, McEver RP, Sims PJ

The Journal of biological chemistry.. 1989 May 25264 (15):9053-60. Epub 1900 01 01.

Stimulated secretion of endothelial von Willebrand factor is accompanied by rapid redistribution to the cell surface of the intracellular granule membrane protein GMP-140.

Hattori R, Hamilton KK, Fugate RD, McEver RP, Sims PJ

The Journal of biological chemistry.. 1989 May 15264 (14):7768-71. Epub 1900 01 01.

The secretory release reaction initiated by complement proteins C5b-9 occurs without platelet aggregation through glycoprotein IIb-IIIa.

Ando B, Wiedmer T, Sims PJ

Blood.. 1989 February 73 (2):462-7. Epub 1900 01 01.

Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity.

Sims PJ, Faioni EM, Wiedmer T, Shattil SJ

The Journal of biological chemistry.. 1988 December 5263 (34):18205-12. Epub 1900 01 01.

Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-IIIa.

Ando B, Wiedmer T, Hamilton KK, Sims PJ

The Journal of biological chemistry.. 1988 August 25263 (24):11907-14. Epub 1900 01 01.

The interaction of a Ca2+-dependent monoclonal antibody with the protein C activation peptide region. Evidence for obligatory Ca2+ binding to both antigen and antibody.

Stearns DJ, Kurosawa S, Sims PJ, Esmon NL, Esmon CT

The Journal of biological chemistry.. 1988 January 15263 (2):826-32. Epub 1900 01 01.

Complement C5b-9-stimulated platelet secretion is associated with a Ca2+-initiated activation of cellular protein kinases.

Wiedmer T, Ando B, Sims PJ

The Journal of biological chemistry.. 1987 October 5262 (28):13674-81. Epub 1900 01 01.

Changes in cytosolic Ca2+ associated with von Willebrand factor release in human endothelial cells exposed to histamine. Study of microcarrier cell monolayers using the fluorescent probe indo-1.

Hamilton KK, Sims PJ

The Journal of clinical investigation.. 1987 February 79 (2):600-8. Epub 1900 01 01.

On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity.

Wiedmer T, Esmon CT, Sims PJ

The Journal of biological chemistry.. 1986 November 5261 (31):14587-92. Epub 1900 01 01.

Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase.

Wiedmer T, Esmon CT, Sims PJ

Blood.. 1986 October 68 (4):875-80. Epub 1900 01 01.

Repolarization of the membrane potential of blood platelets after complement damage: evidence for a Ca++ -dependent exocytotic elimination of C5b-9 pores.

Sims PJ, Wiedmer T

Blood.. 1986 August 68 (2):556-61. Epub 1900 01 01.

Single-channel analysis of the conductance fluctuations induced in lipid bilayer membranes by complement proteins C5b-9.

Benz R, Schmid A, Wiedmer T, Sims PJ

The Journal of membrane biology.. 1986 94 (1):37-45. Epub 1900 01 01.

Effect of complement proteins C5b-9 on blood platelets. Evidence for reversible depolarization of membrane potential.

Wiedmer T, Sims PJ

The Journal of biological chemistry.. 1985 July 5260 (13):8014-9. Epub 1900 01 01.

Fluorescence resonance energy transfer study of the associative state of membrane-bound complexes of complement proteins C5b-8.

Cheng KH, Wiedmer T, Sims PJ

The Journal of immunology : official journal of the American Association of Immunologists.. 1985 July 135 (1):459-64. Epub 1900 01 01.

Characterization of the complement sensitivity of paroxysmal nocturnal hemoglobinuria erythrocytes.

Parker CJ, Wiedmer T, Sims PJ, Rosse WF

The Journal of clinical investigation.. 1985 June 75 (6):2074-84. Epub 1900 01 01.

Cyanine dye fluorescence used to measure membrane potential changes due to the assembly of complement proteins C5b-9.

Wiedmer T, Sims PJ

The Journal of membrane biology.. 1985 84 (3):249-58. Epub 1900 01 01.

Complement protein C9 labeled with fluorescein isothiocyanate can be used to monitor C9 polymerization and formation of the cytolytic membrane lesion.

Sims PJ

Biochemistry.. 1984 July 323 (14):3248-60. Epub 1900 01 01.

Kinetics of polymerization of a fluoresceinated derivative of complement protein C9 by the membrane-bound complex of complement proteins C5b-8.

Sims PJ, Wiedmer T

Biochemistry.. 1984 July 323 (14):3260-7. Epub 1900 01 01.

Complement protein C9 labeled with fluorescein isothiocyanate can be used to monitor C9 polymerization and formation of the cytolytic membrane lesion

Sims,P. J.;.

Biochemistry (John Wiley & Sons). 1984; 23(14): 3248-3260.

Kinetics of polymerization of a fluoresceinated derivative of complement protein C9 by the membrane-bound complex of complement proteins C5b-8

Sims,P. J.; Wiedmer,T.;.

Biochemistry (John Wiley & Sons). 1984; 23(14): 3260-3267.

The influence of electrochemical gradients of Na+ and K+ upon the membrane binding and pore forming activity of the terminal complement proteins.

Sims PJ, Wiedmer T

The Journal of membrane biology.. 1984 78 (2):169-76. Epub 1900 01 01.

The measurement of platelet-associated IgG by a microplate quantitative antiglobulin consumption assay using automated through-the-well spectrophotometry.

Sims PJ, Boswell EB

The Journal of laboratory and clinical medicine.. 1983 September 102 (3):352-60. Epub 1900 01 01.

Complement pores in erythrocyte membranes. Analysis of C8/C9 binding required for functional membrane damage.

Sims PJ

Biochimica et biophysica acta.. 1983 August 10732 (3):541-52. Epub 1900 01 01.

Elevated platelet-bound IgG associated with an episode of thrombotic thrombocytopenic purpura.

Sims PJ, Boswell EB

Blood.. 1981 October 58 (4):682-4. Epub 1900 01 01.

Permeability characteristics of complement-damaged membranes: evaluation of the membrane leak generated by the complement proteins C5b-9.

Sims PJ

Proceedings of the National Academy of Sciences of the United States of America.. 1981 March 78 (3):1838-42. Epub 1900 01 01.

Analysis of solute diffusion across the C5b-9 membrane lesion of complement: evidence that individual C5b-9 complexes do not function as discrete, uniform pores.

Sims PJ, Lauf PK

The Journal of immunology : official journal of the American Association of Immunologists.. 1980 December 125 (6):2617-25. Epub 1900 01 01.

Steady-state analysis of tracer exchange across the C5b-9 complement lesion in a biological membrane.

Sims PJ, Lauf PK

Proceedings of the National Academy of Sciences of the United States of America.. 1978 November 75 (11):5669-73. Epub 1900 01 01.

Studies on the mechanism by which cyanine dyes measure membrane potential in red blood cells and phosphatidylcholine vesicles.

Sims PJ, Waggoner AS, Wang CH, Hoffman JF

Biochemistry.. 1974 July 3013 (16):3315-30. Epub 1900 01 01.

Studies on the mechanism by which cyanine dyes measure membrane potential in red blood cells and phosphatidylcholine vesicles

Sims,P. J.; Waggoner,A. S.; Wang,C. H.; Hoffman,J. F.;.

Biochemistry (John Wiley & Sons). 1974; 13(16): 3315-3330.

Books

Constitutional Resistance to Infection (1994)

Chapter: Entamoeba Histolytica Resistance to Lysis by the Complement Membrane Attack Complex

Authors: Petri, W. Jrs, Sims, P.J.

Publisher: RG Landes, Austin 1994

Hematology: Basic Principles and Practice (1993)

Chapter: Complement Biology

Authors: Sims,P.J., Wiedmer,T.

Publisher: Churchill Livingstone, N.Y. 1993

Human Protein Data (1993)

Chapter: CD59

Authors: Sims,P.J.

Publisher: VCH Verlagsgesellschaft, Weinheim 1993

Biology of Vitronectins and Their Receptors (1993)

Chapter: Structure and Function of CD59

Authors: Sims,P.J.

Publisher: Elsevier, Amsterdam 1993

Hematology: Basic Principles and Practice (1990)

Chapter: Plasma Proteins: Complement

Authors: Sims,P.J.

Publisher: Churchill Livingstone, N.Y. 1990

Platelet Immunobiology, Molecular and Clinical Aspects (1989)

Chapter: Interaction of Human Platelets with the Completment System

Authors: Sims, P.J.

Publisher: JB Lippincott, Philidelphia 1989

Hematology (1989)

Chapter: The Anemias

Authors: Spivak, J.L., Sims,P.J., Selby, G.B.

Publisher: Grune & Stratton, Philidelphia 1989