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Jinjiang Pang, B.Med., Ph.D.

Jinjiang Pang, B.Med., Ph.D.

Contact

Office (585) 276-7707
Fax (585) 276-9829
Administrative (585) 276-7698

About Me

Faculty Appointments

Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral Research Associate , Center for Cardiovascular Research, University of Rochester,Rochester, NY 2006 - 2008

Postdoctoral Fellow , Louisiana State University Health Science Center, New Orleans, LA 2004 - 2006

Education

PhD | Physiology, Peking Union Medical College & Chinese Academy of Medical sciences (PUMC &CAMC). Cardiovascular Physiology. 2004

MS | Lanzhou University. Muscle Physiology. 2001

Awards

AHA Innovative Project Award. 2019

American Heart Association Scientist Development Grant Award. 2008

American Heart Association Cournand and Comroe Young Investigator Award. 2007 - 2007

Excellent Graduate Award, PUMC & CAMS, Beijing, China. 2003 - 2003

Excellent Graduate Award, Medical College of Lanzhou University, Lanzhou,China. 1999 - 1999

Research

Blood vessels are responsible for the transportation of nutrients and oxygen throughout the whole body. Changes in oxygen level or metabolites lead to neovascularization, angiogenesis, or vascular network trimming (also called vessel pruning) or regression, which are essential steps for establishing...
Blood vessels are responsible for the transportation of nutrients and oxygen throughout the whole body. Changes in oxygen level or metabolites lead to neovascularization, angiogenesis, or vascular network trimming (also called vessel pruning) or regression, which are essential steps for establishing a functional and hierarchical mature vascular network to meet the needs of various organs. These processes are critical for tissue development and repair, as well as being associated with many diseases (e.g. bronchopulmonary dysplasia, pulmonary artery hypertension, ischemic cardiomyopathy, retinopathy, and tumor growth). The long-term goal of Pang's lab is to delineate the molecular mechanisms of these events under physiological and pathological conditions.

Patents

Method of Inhibiting Angiogenesis Using Inhibitors of G-Protein -Coupled Receptor Kinase Interacting Protein-1 (GIT1)

Issue date: June 06, 2017

Publications

Journal Articles

Vessel tech: a high-accuracy pipeline for comprehensive mouse retinal vasculature characterization.

Wang X, Zhu G, Wang S, Rhen J, Pang J, Zhang Z

Angiogenesis.. 2021 February 24 (1):7-11. Epub 10/09/2020.

Endothelial-to-Mesenchymal Transition and Inflammation Play Key Roles in Cyclophilin A-Induced Pulmonary Arterial Hypertension.

Xue C, Senchanthisai S, Sowden M, Pang J, White J, Berk BC

Hypertension.. 2020 October 76 (4):1113-1123. Epub 08/24/2020.

Rare Pulmonary Connective Tissue Type Mast Cells Regulate Lung Endothelial Cell Angiogenesis.

Ren Y, Lyu Y, Mereness JA, Wang S, Pang J, Mariani TJ

The American journal of pathology.. 2020 August 190 (8):1763-1773. Epub 05/22/2020.

Dll4-Notch1 signaling but not VEGF-A is essential for hyperoxia induced vessel regression in retina.

Zhu G, Lin Y, Liu H, Jiang D, Singh S, Li X, Yu Z, Fan L, Wang S, Rhen J, Li W, Xu Y, Ge J, Pang J

Biochemical and biophysical research communications.. 2018 December 9507 (1-4):400-406. Epub 11/15/2018.

Phospholipase C?1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity.

Jiang D, Zhuang J, Peng W, Lu Y, Liu H, Zhao Q, Chi C, Li X, Zhu G, Xu X, Yan C, Xu Y, Ge J, Pang J

Journal of the American Heart Association.. 2017 July 116 (7)Epub 07/11/2017.

Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis.

Liao P, Wang W, Li Y, Wang R, Jin J, Pang W, Chen Y, Shen M, Wang X, Jiang D, Pang J, Liu M, Lin X, Feng XH, Wang P, Ge X

eLife.. 2017 March 316 Epub 03/31/2017.

G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.

Majumder S, Zhu G, Xu X, Senchanthisai S, Jiang D, Liu H, Xue C, Wang X, Coia H, Cui Z, Smolock EM, Libby RT, Berk BC, Pang J

Cell reports.. 2016 December 617 (10):2532-2541. Epub 1900 01 01.

XAV939 Inhibits Intima Formation by Decreasing Vascular Smooth Muscle Cell Proliferation and Migration Through Blocking Wnt Signaling.

Chen L, Zhuang J, Singh S, Wang K, Xiong M, Xu D, Chen W, Pang J, Xu Y, Li X

Journal of cardiovascular pharmacology.. 2016 December 68 (6):414-424. Epub 1900 01 01.

G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation.

Majumder S, Sowden MP, Gerber SA, Thomas T, Christie CK, Mohan A, Yin G, Lord EM, Berk BC, Pang J

Arteriosclerosis, thrombosis, and vascular biology.. 2014 February 34 (2):419-26. Epub 11/21/2013.

Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice.

Yin G, Sheu TJ, Menon P, Pang J, Ho HC, Shi S, Xie C, Smolock E, Yan C, Zuscik MJ, Berk BC

PloS one.. 2014 9 (2):e89127. Epub 02/19/2014.

G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migration.

Pang J, Xu X, Wang X, Majumder S, Wang J, Korshunov VA, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2013 May 33 (5):999-1005. Epub 02/21/2013.

Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis.

Park Y, Park SY, Shi X, Pang J, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2013 April 33 (4):737-43. Epub 02/07/2013.

Phospholipase C? hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV

Cell.. 2013 March 28153 (1):216-27. Epub 1900 01 01.

Chronic administration of hexarelin attenuates cardiac fibrosis in the spontaneously hypertensive rat.

Xu X, Ding F, Pang J, Gao X, Xu RK, Hao W, Cao JM, Chen C

American journal of physiology. Heart and circulatory physiology.. 2012 September 15303 (6):H703-11. Epub 07/27/2012.

EVI1 acts as an inducible negative-feedback regulator of NF-?B by inhibiting p65 acetylation.

Xu X, Woo CH, Steere RR, Lee BC, Huang Y, Wu J, Pang J, Lim JH, Xu H, Zhang W, Konduru AS, Yan C, Cheeseman MT, Brown SD, Li JD

The Journal of immunology : official journal of the American Association of Immunologists.. 2012 June 15188 (12):6371-80. Epub 05/11/2012.

G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is required for mitochondrial biogenesis in heart

Pang J (Corresponding Author), Xu X, Shi X, Mohan A, Burns B and Berk BC.

J Mol Cell Cardiol. 2011; Nov;51(5):769-76.

Activation of epidermal growth factor receptor is required for NTHi-induced NF-?B-dependent inflammation.

Xu X, Rachel RR, Feorchuk CA, Pang J, Lee JY, Lim JH, Xu H, Pan ZK, Maggirwar SB and Li JD.

PLoS One, In Press. 2011; .

Activation of epidermal growth factor receptor is required for NTHi-induced NF-?B-dependent inflammation.

Xu X, Steere RR, Fedorchuk CA, Pang J, Lee JY, Lim JH, Xu H, Pan ZK, Maggirwar SB, Li JD

PloS one.. 2011 6 (11):e28216. Epub 11/23/2011.

Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells.

Wang J, Yin G, Menon P, Pang J, Smolock EM, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2010 October 30 (10):1976-82. Epub 08/05/2010.

Hexarelin suppresses high lipid diet and vitamin D3-induced atherosclerosis in the rat.

Pang J, Xu Q, Xu X, Yin H, Xu R, Guo S, Hao W, Wang L, Chen C, Cao JM

Peptides.. 2010 April 31 (4):630-8. Epub 11/30/2009.

G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development.

Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, White RJ, Xu X, O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC

Circulation.. 2009 March 24119 (11):1524-32. Epub 03/09/2009.

GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma.

Wang J, Taba Y, Pang J, Yin G, Yan C, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2009 February 29 (2):202-8. Epub 11/20/2008.

An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.

Cavet ME, Pang J, Yin G, Berk BC

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2008 October 22 (10):3607-16. Epub 06/03/2008.

Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells.

Cavet ME, Smolock EM, Ozturk OH, World C, Pang J, Konishi A, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2008 May 28 (5):886-91. Epub 02/21/2008.

GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells.

Pang J, Yan C, Natarajan K, Cavet ME, Massett MP, Yin G, Berk BC

Arteriosclerosis, thrombosis, and vascular biology.. 2008 May 28 (5):892-8. Epub 02/21/2008.

Hexarelin suppresses cardiac fibroblast proliferation and collagen synthesis in rat.

Xu X, Pang J, Yin H, Li M, Hao W, Chen C, Cao JM

American journal of physiology. Heart and circulatory physiology.. 2007 November 293 (5):H2952-8. Epub 08/31/2007.

NMDA receptor activation induces mitochondrial dysfunction, oxidative stress and apoptosis in cultured neonatal rat cardiomyocytes.

Gao X, Xu X, Pang J, Zhang C, Ding JM, Peng X, Liu Y, Cao JM

Physiological research. 2007 56 (5):559-569. Epub 08/22/2006.

Cardiomycyte Apoptosis and Heart Failure (Review In Chinese)

Li CR; Pang J; Hao W; Cao JM.

Chinese Medical Research & Clinical. 2006; 4(4): 31-5.

GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure.

Xu XB, Pang JJ, Cao JM, Ni C, Xu RK, Peng XZ, Yu XX, Guo S, Chen MC, Chen C

American journal of physiology. Heart and circulatory physiology.. 2005 October 289 (4):H1643-51. Epub 06/10/2005.

Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro.

Pang JJ, Xu RK, Xu XB, Cao JM, Ni C, Zhu WL, Asotra K, Chen MC, Chen C

American journal of physiology. Heart and circulatory physiology.. 2004 March 286 (3):H1063-9. Epub 11/13/2003.

Enhance Immunity Function of Mouse (In Chinese)

Pang J; Lu CH; Xu JN; Zhao SM; Peng SX.

World Clinical Drugs. 2004; 25(7): 444-8.

The positive inotropic and calcium-mobilizing effects of growth hormone-releasing peptides on rat heart.

Xu XB, Cao JM, Pang JJ, Xu RK, Ni C, Zhu WL, Asotra K, Chen MC, Chen C

Endocrinology.. 2003 November 144 (11):5050-7. Epub 08/07/2003.

Effect of progesterone on contraction of isolated trachea smooth muscle in rabbits (In Chinese)

Zhang XY; Pang J; Zheng TZ.

Chin J Appl Physiol. 2003; 19(4): 388-401.

Vasodilatory effect of water decoction of dried flower of Carthamus tinctorius on rabbit aorta in vitro (In Chinese)

Li HF; Wang LD; Pang J.

Chinese Traditional and Herbal Drugs. 2003; 34: 430-33.

Inhibition of beta-estradiol on trachea smooth muscle contraction in vitro and in vivo.

Pang JJ, Xu XB, Li HF, Zhang XY, Zheng TZ, Qu SY

Acta pharmacologica Sinica.. 2002 March 23 (3):273-7. Epub 1900 01 01.

Muscarinic Receptors and Airway Smooth Muscle (Review in Chinese)

Pang J; Zheng TZ; Xu XB.

Journal of Lanzhou University. 2002; 38((Supp)): 22-6.

Tensive Effect of Water Decoction of Flos Rosae Rugosae on the Rabbit Aorta in Vitro (In Chinese)

Li, H.F.; Pang, J.; Ding, Y.H.; Wei, Y.L.

Pharmacology and Clinics of Chinese Materia Medica. 2002; 18(2): 20-21.

[Effect of Curcuma zedoaria (Berg.) Bosc on the myoelectric activity of uterus in rats and study of its mechanisms].

Xu XB, Qin XM, Xu JD, Pang JJ

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.. 2001 May 26 (5):334-7. Epub 1900 01 01.

[Effect of unprepared and prepared "he zi" on contraction of isolated trachea smooth muscle in rabbits].

Pang J, Zheng T, Zhang X, Li H, Ding Y, Wei Y

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.. 2001 February 24 (2):120-2. Epub 1900 01 01.

The Effect of Potassium Channel Openers on Airway Smooth Muscle (Review in Chinese).

Pang J; Zheng TZ; Zhang XY; Xu XB.

Journal of Lanzhou University. 2000; 36: 229-33.

Contractile Mechanism and Influencing Factors of Uterine Smooth Muscle (Review in Chinese).

Xu XB; Qin XM; Xu JD; Pang J.

Journal of Lanzhou University. 2000; : 211-15.

Books

Clinical Endocrinology (In Chinese) (2004)