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Minsoo Kim, Ph.D.

Minsoo Kim, Ph.D.

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Program for Advanced Immune Bioimaging

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About Me

Dr. Minsoo Kim is Dean's Professor of Microbiology and Immunology, and a member of the David H. Smith Center for Vaccine Biology and Immunology. He is also Co-Leader of the Cancer Micro...
Dr. Minsoo Kim is Dean's Professor of Microbiology and Immunology, and a member of the David H. Smith Center for Vaccine Biology and Immunology. He is also Co-Leader of the Cancer Microenvironment Research Program and Director of the Tumor Immunotherapy Research Program at the Wilmot Cancer Institute. His research interests are in the area of innate and adaptive immune responses and cancer immunotherapy. He is especially noted for his pioneering contributions to the developments of the most advanced imaging techniques that enable real-time observation and control of dynamic immune responses both in live cells and live animal models.

Faculty Appointments

Professor - Department of Microbiology and Immunology, Center for Vaccine Biology and Immunology (SMD)

Dean's Professorship - Department of Microbiology and Immunology, Center for Vaccine Biology and Immunology (SMD)

Credentials

Post-doctoral Training & Residency

Center for Blood Research, Harvard Medical School, Boston, MA 2001 - 2004

Education

Post-doctoral training | Harvard Medical School. Immunology. 2004

PhD | Ohio State University. Pharmacology. 2001

BS | Korea-Korea University. Genetic Engineering. 1993

Awards

Davey Award. 2020

University of Rochester Dean's Professorship. 2017

Dolph O. Adams Award. 2016

University of Rochester School of Medicine and Dentistry Trainee Academic Mentoring Award. 2015

Brown University Seed Fund Award (Co-investigator). 2007

Rhode Island Foundation, Medical Research Grant. 2005

American Heart Association, Scientist Developmental Grant. 2005

DDW Poster of Distinction. 2001

DDW Poster of Distinction. 2000

American Digestive Health Foundation Student Abstract Award. 2000

Digestive Disease Week (DDW) Poster of Distinction. 1999

Honor student of 1992 by Korea University. 1992

Research

Precise spatial and temporal regulation of cell migration is critical not only for normal immune responses, but also for successful organ development, wound healing, and tumor metastasis. Integrins, a family of membrane receptors, are expressed in all different types of cells in human body and regul...
Precise spatial and temporal regulation of cell migration is critical not only for normal immune responses, but also for successful organ development, wound healing, and tumor metastasis. Integrins, a family of membrane receptors, are expressed in all different types of cells in human body and regulate important cell adhesion and migration. Early in his career, Dr. Kim developed a highly innovative bio-imaging assay using FRET (Fluorescence Resonance Energy Transfer) techniques and show for the first time in live cells that the intracellular domains of integrin LFA-1 moved apart substantially during immune cell migration, and his paper describing this (Kim et al. 2003, Science) has been highly cited and is regarded as a cornerstone of the integrin field. Dr. Kim has continued to develop this area in his lab in Rochester, establishing a role for conformational change in other important integrins like Mac-1 and VLA-4.

Dr. Kim has continued to break new ground, most recently with the identification of important cross-talks between the innate immune and adaptive immune systems during influenza virus infection. This study, published in Science in 2015, developed from the Kim lab's careful observation of innovative fluorescence markers, using their high-resolution live animal imaging technique. In this paper, Dr. Kim showed that, much like birds fly in flocks to conserve energy, dolphins swim in pods to mate and find food, and colonies of ants create complex nests to protect their queens, immune cells engage in coordinated behavior to wipe out viruses like the flu. The findings reveal, for the first time, how immune cells work together to get to their final destination - the site of an injury or infection. The Kim lab discovered that neutrophils - the "first responders" of the immune system - arrive at the site of injury within an hour of infection and leave a chemical "trail" behind them. Killer immune cells called T cells use this trail to find the site of injury and subsequently destroy the virus. This study led to the important paradigm that the adaptive immune system doesn't generate the successful response without instruction from the innate immune system. This novel concept will be highly influential and are of special interest to clinicians. For example, in people with autoimmune disorders like multiple sclerosis and lupus, the immune system mistakenly attacks and destroys healthy body tissue. If scientists understood how to disrupt or stop immune cells' movement to healthy tissue, they may be able to improve the quality of life of people living with these devastating diseases. Similarly, recognizing how to boost the number of immune cells that travel to fight an infection could help scientists design better vaccines for viruses like the flu.

Dr. Kim has continued to develop sophisticated new biomedical technologies. Recently, he established a remarkable optogenetic system in which he constructed hybrid receptors that connected the light-sensing properties of rhodopsin to the signaling functions of two chemokine receptors. In this ground-breaking study, his carefully-constructed system allows the migration of T cells to be controlled by light, e.g. attracting more effector T cells into local tumor sites and reducing tumor growth. The achievement of functional hybrid photosensitive receptors represents a real tour de force, and opens up many analytical and therapeutic possibilities. This is particularly important because of the increasing success of adoptive cell therapies for cancer – Dr. Kim's optogenetics approaches will provide further capabilities to such cells.

Patents

Preventing and Treating Sepsis

Issue date: December 23, 2014

Patent #: 8,916,149

Country: United States

Inventors: Minsoo Kim

Publications

Journal Articles

Circadian rhythms of macrophages are altered by the acidic tumor microenvironment.

Knudsen-Clark AM, Mwangi D, Cazarin J, Morris K, Baker C, Hablitz LM, McCall MN, Kim M, Altman BJ

EMBO reports.. 2024 October 16 Epub 10/16/2024.

Process optimization for microfluidic preparation of liposomes using food-grade components.

Hong SC, Hong CR, Kim M, Kang YJ, Jung YH, Park KM, Choi J, Chang PS

Food chemistry.. 2024 September 1451 :139437. Epub 04/24/2024.

Platelet-activating factor (PAF) promotes immunosuppressive neutrophil differentiation within tumors.

Dahal A, Hong Y, Mathew JS, Geber A, Eckl S, Renner S, Sailer CJ, Ryan AT, Mir S, Lim K, Linehan DC, Gerber SA, Kim M

Proceedings of the National Academy of Sciences of the United States of America.. 2024 August 27121 (35):e2406748121. Epub 08/23/2024.

INHIBITION OF INTEGRIN VLA-3 AND TETRASPANIN CD151 PROTECTS AGAINST NEUTROPHIL-MEDIATED ENDOTHELIAL DAMAGE.

Ciambella C, Witt H, Dickinson CM, Smith ML, Coburn N, Messina N, Heffernan DS, Kim M, Reichner JS

Shock.. 2024 August 162 (2):165-172. Epub 05/23/2024.

Circadian rhythms of macrophages are altered by the acidic pH of the tumor microenvironment.

Knudsen-Clark AM, Mwangi D, Cazarin J, Hablitz LM, Kim M, Altman BJ

bioRxiv : the preprint server for biology.. 2024 July 24 Epub 07/24/2024.

Self-regulating CAR-T cells modulate cytokine release syndrome in adoptive T-cell therapy.

Lin MY, Nam E, Shih RM, Shafer A, Bouren A, Ayala Ceja M, Harris C, Khericha M, Vo KH, Kim M, Tseng CH, Chen YY

The Journal of experimental medicine.. 2024 June 3221 (6)Epub 04/12/2024.

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells.

Ryan AT, Dahal A, Mir S, Kim M, Lim K

Journal of visualized experiments : JoVE.. 2024 May 24 (207)Epub 05/24/2024.

Immune Cell Migration to Cancer.

Ryan AT, Kim M, Lim K

Cells.. 2024 May 1613 (10)Epub 05/16/2024.

Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function.

Li C, Ture SK, Nieves-Lopez B, Blick-Nitko SK, Maurya P, Livada AC, Stahl TJ, Kim M, Pietropaoli AP, Morrell CN

Circulation research.. 2024 April 12134 (8):970-986. Epub 03/08/2024.

Longitudinal intravital imaging of the bone marrow for analysis of the race for the surface in a murine osteomyelitis model.

Xie C, Ren Y, Weeks J, Rainbolt J, Mark Kenney H, Xue T, Allen F, Shu Y, Tay AJH, Lekkala S, Yeh SA, Muthukrishnan G, Gill AL, Gill SR, Kim M, Kates SL, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2024 March 42 (3):531-538. Epub 10/17/2023.

Immunoengineering can overcome the glycocalyx armour of cancer cells.

Park S, Colville MJ, Paek JH, Shurer CR, Singh A, Secor EJ, Sailer CJ, Huang LT, Kuo JC, Goudge MC, Su J, Kim M, DeLisa MP, Neelamegham S, Lammerding J, Zipfel WR, Fischbach C, Reesink HL, Paszek MJ

Nature materials.. 2024 March 23 (3):429-438. Epub 02/15/2024.

Author Correction: Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity.

Wang MS, Hu Y, Sanchez EE, Xie X, Roy NH, de Jesus M, Winer BY, Zale EA, Jin W, Sachar C, Lee JH, Hong Y, Kim M, Kam LC, Salaita K, Huse M

Nature communications.. 2023 December 1814 (1):8401. Epub 12/18/2023.

ST3GAL1 and ?II-spectrin pathways control CAR T cell migration to target tumors.

Hong Y, Walling BL, Kim HR, Serratelli WS, Lozada JR, Sailer CJ, Amitrano AM, Lim K, Mongre RK, Kim KD, Capece T, Lomakina EB, Reilly NS, Vo K, Gerber SA, Fan TC, Yu AL, Oakes PW, Waugh RE, Jun CD, Reagan PM, Kim M

Nature immunology.. 2023 June 24 (6):1007-1019. Epub 04/17/2023.

Thrombocytopenia Independently Leads to Monocyte Immune Dysfunction.

Li C, Ture SK, Nieves-Lopez B, Blick-Nitko SK, Maurya P, Livada AC, Stahl TJ, Kim M, Pietropaoli AP, Morrell CN

bioRxiv : the preprint server for biology.. 2023 May 12 Epub 05/12/2023.

Protein kinase D3 promotes neutrophil migration during viral infection.

Veazey JM, Wong GS, Eliseeva SI, Smyth TR, Chapman TJ, Lim K, Kim M, Georas SN

Immunology and cell biology.. 2023 February 101 (2):130-141. Epub 11/24/2022.

Polydopamine/polypyrrole-modified graphite felt enhances biocompatibility for electroactive bacteria and power density of microbial fuel cell.

Kim M, Li S, Kong DS, Song YE, Park SY, Kim HI, Jae J, Chung I, Kim JR

Chemosphere.. 2023 February 313 :137388. Epub 11/28/2022.

Metabolic Challenges in Anticancer CD8 T Cell Functions.

Amitrano AM, Kim M

Immune network.. 2023 February 23 (1):e9. Epub 01/27/2023.

Activation effects on the physical characteristics of T lymphocytes.

Waugh RE, Lomakina E, Amitrano A, Kim M

Frontiers in bioengineering and biotechnology.. 2023 11 :1175570. Epub 05/15/2023.

PD-1 CAR-T cells provide superior protection against solid tumors.

Sailer CJ, Hong Y, Dahal A, Ryan AT, Mir S, Gerber SA, Reagan PM, Kim M

Frontiers in immunology.. 2023 14 :1187850. Epub 06/14/2023.

Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity.

Wang MS, Hu Y, Sanchez EE, Xie X, Roy NH, de Jesus M, Winer BY, Zale EA, Jin W, Sachar C, Lee JH, Hong Y, Kim M, Kam LC, Salaita K, Huse M

Nature communications.. 2022 June 913 (1):3222. Epub 06/09/2022.

Neutrophil heterogeneity in complement C1q expression associated with sepsis mortality.

Trzeciak A, Mongre RK, Kim MR, Lim K, Madero RA, Parkhurst CN, Pietropaoli AP, Kim M

Frontiers in immunology.. 2022 13 :965305. Epub 08/02/2022.

The spatio-temporal control of effector T cell migration.

Fowell DJ, Kim M

Nature reviews. Immunology.. 2021 September 21 (9):582-596. Epub 02/24/2021.

A Fully Biodegradable Ferroelectric Skin Sensor from Edible Porcine Skin Gelatine.

Ghosh SK, Park J, Na S, Kim MP, Ko H

Advanced science.. 2021 July 8 (13):2005010. Epub 05/07/2021.

Intertumoral Genetic Heterogeneity Generates Distinct Tumor Microenvironments in a Novel Murine Synchronous Melanoma Model.

Qin SS, Han BJ, Williams A, Jackson KM, Jewell R, Chacon AC, Lord EM, Linehan DC, Kim M, Reuben A, Gerber SA, Prieto PA

Cancers.. 2021 May 1113 (10)Epub 05/11/2021.

Optical Control of CD8 T Cell Metabolism and Effector Functions.

Amitrano AM, Berry BJ, Lim K, Kim KD, Waugh RE, Wojtovich AP, Kim M

Frontiers in immunology.. 2021 12 :666231. Epub 06/03/2021.

CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection.

Reilly EC, Sportiello M, Emo KL, Amitrano AM, Jha R, Kumar ABR, Laniewski NG, Yang H, Kim M, Topham DJ

Frontiers in immunology.. 2021 12 :728669. Epub 09/09/2021.

Hyperspectral multiphoton microscopy for visualization of multiple, spectrally overlapped fluorescent labels.

Bares AJ, Mejooli MA, Pender MA, Leddon SA, Tilley S, Lin K, Dong J, Kim M, Fowell DJ, Nishimura N, Schaffer CB

Optica.. 2020 November 207 (11):1587-1601. Epub 1900 01 01.

In situ neutrophil efferocytosis shapes T cell immunity to influenza infection.

Lim K, Kim TH, Trzeciak A, Amitrano AM, Reilly EC, Prizant H, Fowell DJ, Topham DJ, Kim M

Nature immunology.. 2020 September 21 (9):1046-1057. Epub 08/03/2020.

Lung SOD3 limits neurovascular reperfusion injury and systemic immune activation following transient global cerebral ischemia.

Mai N, Prifti V, Lim K, O'Reilly MA, Kim M, Halterman MW

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.. 2020 September 29 (9):104942. Epub 05/14/2020.

Characterization of neutrophil-neuronal co-cultures to investigate mechanisms of post-ischemic immune-mediated neurotoxicity.

Mai N, Prifti V, Kim M, Halterman MW

Journal of neuroscience methods.. 2020 July 15341 :108782. Epub 05/20/2020.

Biomarkers and Associated Immune Mechanisms for Early Detection and Therapeutic Management of Sepsis.

Trzeciak A, Pietropaoli AP, Kim M

Immune network.. 2020 June 20 (3):e23. Epub 06/22/2020.

Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance.

Berry BJ, Trewin AJ, Milliken AS, Baldzizhar A, Amitrano AM, Lim Y, Kim M, Wojtovich AP

EMBO reports.. 2020 April 321 (4):e49113. Epub 02/11/2020.

Long-Term Microgliosis Driven by Acute Systemic Inflammation.

Trzeciak A, Lerman YV, Kim TH, Kim MR, Mai N, Halterman MW, Kim M

The Journal of immunology : official journal of the American Association of Immunologists.. 2019 December 1203 (11):2979-2989. Epub 10/16/2019.

Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites.

Gaylo-Moynihan A, Prizant H, Popovic M, Fernandes NRJ, Anderson CS, Chiou KK, Bell H, Schrock DC, Schumacher J, Capece T, Walling BL, Topham DJ, Miller J, Smrcka AV, Kim M, Hughson A, Fowell DJ

Immunity.. 2019 August 2051 (2):298-309.e6. Epub 08/06/2019.

Lung-Derived SOD3 Attenuates Neurovascular Injury After Transient Global Cerebral Ischemia.

Mai N, Miller-Rhodes K, Prifti V, Kim M, O'Reilly MA, Halterman MW

Journal of the American Heart Association.. 2019 May 78 (9):e011801. Epub 1900 01 01.

LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and II.

Hyun YM, Choe YH, Park SA, Kim M

Experimental & molecular medicine.. 2019 April 951 (4):1-13. Epub 04/09/2019.

Accessible quantitative phase imaging in confocal microscopy with sinusoidal-phase synthetic optical holography.

Canales-Benavides A, Zhuo Y, Amitrano AM, Kim M, Hernandez-Aranda RI, Carney PS, Schnell M

Applied optics.. 2019 February 1058 (5):A55-A64. Epub 1900 01 01.

A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis.

Arandjelovic S, Perry JSA, Lucas CD, Penberthy KK, Kim TH, Zhou M, Rosen DA, Chuang TY, Bettina AM, Shankman LS, Cohen AH, Gaultier A, Conrads TP, Kim M, Elliott MR, Ravichandran KS

Nature immunology.. 2019 February 20 (2):141-151. Epub 01/14/2019.

Use the Protonmotive Force: Mitochondrial Uncoupling and Reactive Oxygen Species.

Berry BJ, Trewin AJ, Amitrano AM, Kim M, Wojtovich AP

Journal of molecular biology.. 2018 October 19430 (21):3873-3891. Epub 04/04/2018.

T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells.

Kim HR, Mun Y, Lee KS, Park YJ, Park JS, Park JH, Jeon BN, Kim CH, Jun Y, Hyun YM, Kim M, Lee SM, Park CS, Im SH, Jun CD

Nature communications.. 2018 September 79 (1):3630. Epub 09/07/2018.

LFA-1 in T Cell Migration and Differentiation.

Walling BL, Kim M

Frontiers in immunology.. 2018 9 :952. Epub 05/03/2018.

A novel intracellular pool of LFA-1 is critical for asymmetric CD8 T cell activation and differentiation.

Capece T, Walling BL, Lim K, Kim KD, Bae S, Chung HL, Topham DJ, Kim M

The Journal of cell biology.. 2017 November 6216 (11):3817-3829. Epub 09/27/2017.

Activated Protein C Attenuates Severe Inflammation by Targeting VLA-3 Neutrophil Subpopulation in Mice.

Sarangi PP, Lee HW, Lerman YV, Trzeciak A, Harrower EJ, Rezaie AR, Kim M

The Journal of immunology : official journal of the American Association of Immunologists.. 2017 October 15199 (8):2930-2936. Epub 09/06/2017.

Dendritic Cell-Specific Transmembrane Protein (DC-STAMP) Regulates Osteoclast Differentiation via the Ca /NFATc1 Axis.

Chiu YH, Schwarz E, Li D, Xu Y, Sheu TR, Li J, Bentley KL, Feng C, Wang B, Wang JC, Albertorio-Saez L, Wood R, Kim M, Wang W, Ritchlin CT

Journal of cellular physiology.. 2017 September 232 (9):2538-2549. Epub 04/12/2017.

Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.

Kim KD, Bae S, Capece T, Nedelkovska H, de Rubio RG, Smrcka AV, Jun CD, Jung W, Park B, Kim TI, Kim M

Nature communications.. 2017 May 158 :15365. Epub 05/15/2017.

Integrin Cross-Talk Regulates the Human Neutrophil Response to Fungal ?-Glucan in the Context of the Extracellular Matrix: A Prominent Role for VLA3 in the Antifungal Response.

Johnson CM, O'Brien XM, Byrd AS, Parisi VE, Loosely AJ, Li W, Witt H, Faridi HM, Lefort CT, Gupta V, Kim M, Reichner JS

The Journal of immunology : official journal of the American Association of Immunologists.. 2017 January 1198 (1):318-334. Epub 11/16/2016.

Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes.

Connolly KA, Belt BA, Figueroa NM, Murthy A, Patel A, Kim M, Lord EM, Linehan DC, Gerber SA

Oncotarget.. 2016 December 277 (52):86522-86535. Epub 1900 01 01.

Live Imaging of Influenza Infection of the Trachea Reveals Dynamic Regulation of CD8+ T Cell Motility by Antigen.

Lambert Emo K, Hyun YM, Reilly E, Barilla C, Gerber S, Fowell D, Kim M, Topham DJ

PLoS pathogens.. 2016 September 12 (9):e1005881. Epub 09/19/2016.

The Role of Lymphatic Niches in T Cell Differentiation.

Capece T, Kim M

Molecules and cells.. 2016 July 39 (7):515-23. Epub 06/16/2016.

Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits G?i-GTP and G??.

Surve CR, To JY, Malik S, Kim M, Smrcka AV

Science signaling.. 2016 February 239 (416):ra22. Epub 02/23/2016.

Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node.

Nedelkovska H, Rosenberg AF, Hilchey SP, Hyrien O, Burack WR, Quataert SA, Baker CM, Azadniv M, Welle SL, Ansell SM, Kim M, Bernstein SH

PloS one.. 2016 11 (5):e0155347. Epub 05/26/2016.

Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration.

Haynes-Gimore N, Banach M, Brown E, Dawes R, Edholm ES, Kim M, Robert J

Developmental biology.. 2015 December 15408 (2):205-12. Epub 01/17/2015.

Visualization of integrin Mac-1 in vivo.

Lim K, Hyun YM, Lambert-Emo K, Topham DJ, Kim M

Journal of immunological methods.. 2015 November 426 :120-7. Epub 09/02/2015.

Neutrophil trails guide influenza-specific CD8? T cells in the airways.

Lim K, Hyun YM, Lambert-Emo K, Capece T, Bae S, Miller R, Topham DJ, Kim M

Science.. 2015 September 4349 (6252):aaa4352. Epub 1900 01 01.

TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.

Na BR, Kim HR, Piragyte I, Oh HM, Kwon MS, Akber U, Lee HS, Park DS, Song WK, Park ZY, Im SH, Rho MC, Hyun YM, Kim M, Jun CD

The Journal of cell biology.. 2015 April 13209 (1):143-62. Epub 1900 01 01.

Neutrophil migration under normal and sepsis conditions.

Lerman YV, Kim M

Cardiovascular & hematological disorders drug targets.. 2015 15 (1):19-28. Epub 1900 01 01.

Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin ?3?1-dependent.

Lerman YV, Lim K, Hyun YM, Falkner KL, Yang H, Pietropaoli AP, Sonnenberg A, Sarangi PP, Kim M

Blood.. 2014 December 4124 (24):3515-23. Epub 10/02/2014.

Essential role of Elmo1 in Dock2-dependent lymphocyte migration.

Stevenson C, de la Rosa G, Anderson CS, Murphy PS, Capece T, Kim M, Elliott MR

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 June 15192 (12):6062-70. Epub 05/12/2014.

Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model.

Baik SH, Cha MY, Hyun YM, Cho H, Hamza B, Kim DK, Han SH, Choi H, Kim KH, Moon M, Lee J, Kim M, Irimia D, Mook-Jung I

Neurobiology of aging.. 2014 June 35 (6):1286-92. Epub 01/08/2014.

Optogenetic control of chemokine receptor signal and T-cell migration.

Xu Y, Hyun YM, Lim K, Lee H, Cummings RJ, Gerber SA, Bae S, Cho TY, Lord EM, Kim M

Proceedings of the National Academy of Sciences of the United States of America.. 2014 April 29111 (17):6371-6. Epub 04/14/2014.

MLK3 regulates fMLP-stimulated neutrophil motility.

Polesskaya O, Wong C, Lebron L, Chamberlain JM, Gelbard HA, Goodfellow V, Kim M, Daiss JL, Dewhurst S

Molecular immunology.. 2014 April 58 (2):214-22. Epub 01/03/2014.

Regulation of T cell motility in vitro and in vivo by LPA and LPA2.

Knowlden SA, Capece T, Popovic M, Chapman TJ, Rezaee F, Kim M, Georas SN

PloS one.. 2014 9 (7):e101655. Epub 07/08/2014.

Inflammation-induced interstitial migration of effector CD4? T cells is dependent on integrin ?V.

Overstreet MG, Gaylo A, Angermann BR, Hughson A, Hyun YM, Lambert K, Acharya M, Billroth-Maclurg AC, Rosenberg AF, Topham DJ, Yagita H, Kim M, Lacy-Hulbert A, Meier-Schellersheim M, Fowell DJ

Nature immunology.. 2013 September 14 (9):949-58. Epub 08/11/2013.

Hydrogen sulfide reduces neutrophil recruitment in hind-limb ischemia-reperfusion injury in an L-selectin and ADAM-17-dependent manner.

Ball CJ, Reiffel AJ, Chintalapani S, Kim M, Spector JA, King MR

Plastic and reconstructive surgery.. 2013 March 131 (3):487-497. Epub 1900 01 01.

PRBC-derived plasma induces non-muscle myosin type IIA-mediated neutrophil migration and morphologic change.

Yu C, Xu L, Chen LF, Guan YJ, Kim M, Biffl WL, Eugene Chin Y

Immunopharmacology and immunotoxicology.. 2013 February 35 (1):71-9. Epub 10/19/2012.

Role of ?1 integrin in tissue homing of neutrophils during sepsis.

Sarangi PP, Hyun YM, Lerman YV, Pietropaoli AP, Kim M

Shock.. 2012 August 38 (3):281-7. Epub 1900 01 01.

Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.

Hyun YM, Sumagin R, Sarangi PP, Lomakina E, Overstreet MG, Baker CM, Fowell DJ, Waugh RE, Sarelius IH, Kim M

The Journal of experimental medicine.. 2012 July 2209 (7):1349-62. Epub 06/18/2012.

Opposing roles for RhoH GTPase during T-cell migration and activation.

Baker CM, Comrie WA, Hyun YM, Chung HL, Fedorchuk CA, Lim K, Brakebusch C, McGrath JL, Waugh RE, Meier-Schellersheim M, Kim M

Proceedings of the National Academy of Sciences of the United States of America.. 2012 June 26109 (26):10474-9. Epub 06/11/2012.

Lectin site ligation of CR3 induces conformational changes and signaling.

O'Brien XM, Heflin KE, Lavigne LM, Yu K, Kim M, Salomon AR, Reichner JS

The Journal of biological chemistry.. 2012 January 27287 (5):3337-48. Epub 12/09/2011.

Monitoring integrin activation by fluorescence resonance energy transfer.

Lefort CT, Hyun YM, Kim M

Methods in molecular biology.. 2012 757 :205-14. Epub 1900 01 01.

Cutting edge: A role for inside-out signaling in TCR regulation of CD28 ligand binding.

Sanchez-Lockhart M, Kim M, Miller J

The Journal of immunology : official journal of the American Association of Immunologists.. 2011 December 1187 (11):5515-9. Epub 11/07/2011.

Phospho-SXXE/D motif mediated TNF receptor 1-TRADD death domain complex formation for T cell activation and migration.

Guan YJ, Zhang Z, Yu C, Ma L, Hu W, Xu L, Gao JS, Chung CS, Wang L, Yang ZF, Fast LD, Chung AS, Kim M, Ayala A, Zhuang S, Zheng S, Chin YE

The Journal of immunology : official journal of the American Association of Immunologists.. 2011 August 1187 (3):1289-97. Epub 07/01/2011.

Acetylation modulates prolactin receptor dimerization.

Ma L, Gao JS, Guan Y, Shi X, Zhang H, Ayrapetov MK, Zhang Z, Xu L, Hyun YM, Kim M, Zhuang S, Chin YE

Proceedings of the National Academy of Sciences of the United States of America.. 2010 November 9107 (45):19314-9. Epub 10/20/2010.

Human T lymphocyte isolation, culture and analysis of migration in vitro.

Lefort CT, Kim M

Journal of visualized experiments : JoVE.. 2010 June 1 (40)Epub 06/01/2010.

Combinatorial libraries against libraries for selecting neoepitope activation-specific antibodies.

Hu X, Kang S, Lefort C, Kim M, Jin MM

Proceedings of the National Academy of Sciences of the United States of America.. 2010 April 6107 (14):6252-7. Epub 03/22/2010.

Activated protein C action in inflammation.

Sarangi PP, Lee HW, Kim M

British journal of haematology.. 2010 March 148 (6):817-33. Epub 12/08/2009.

Leukocyte integrins and their ligand interactions.

Hyun YM, Lefort CT, Kim M

Immunologic research.. 2009 December 45 (2-3):195-208. Epub 01/29/2009.

Outside-in signal transmission by conformational changes in integrin Mac-1.

Lefort CT, Hyun YM, Schultz JB, Law FY, Waugh RE, Knauf PA, Kim M

The Journal of immunology : official journal of the American Association of Immunologists.. 2009 November 15183 (10):6460-8. Epub 10/28/2009.

Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1.

Hyun YM, Chung HL, McGrath JL, Waugh RE, Kim M

The Journal of immunology : official journal of the American Association of Immunologists.. 2009 July 1183 (1):359-69. Epub 1900 01 01.

Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30.

Quinn JA, Graeber CT, Frackelton AR, Kim M, Schwarzbauer JE, Filardo EJ

Molecular endocrinology.. 2009 July 23 (7):1052-64. Epub 04/02/2009.

Recombinant human activated protein C inhibits integrin-mediated neutrophil migration.

Elphick GF, Sarangi PP, Hyun YM, Hollenbaugh JA, Ayala A, Biffl WL, Chung HL, Rezaie AR, McGrath JL, Topham DJ, Reichner JS, Kim M

Blood.. 2009 April 23113 (17):4078-85. Epub 02/24/2009.

Selective sensing of anions with calix[4]pyrroles strapped with chromogenic dipyrrolylquinoxalines.

Yoo J, Kim MS, Hong SJ, Sessler JL, Lee CH

The Journal of organic chemistry.. 2009 February 674 (3):1065-9. Epub 1900 01 01.

Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils.

Kaba NK, Schultz J, Law FY, Lefort CT, Martel-Gallegos G, Kim M, Waugh RE, Arreola J, Knauf PA

American journal of physiology. Cell physiology.. 2008 November 295 (5):C1454-63. Epub 10/01/2008.

Luteimonas aestuarii sp. nov., isolated from tidal flat sediment.

Roh SW, Kim KH, Nam YD, Chang HW, Kim MS, Yoon JH, Oh HM, Bae JW

The journal of microbiology.. 2008 October 46 (5):525-9. Epub 10/31/2008.

Aliihoeflea aestuarii gen. nov., sp. nov., a novel bacterium isolated from tidal flat sediment.

Roh SW, Kim KH, Nam YD, Chang HW, Kim MS, Shin KS, Yoon JH, Oh HM, Bae JW

The journal of microbiology.. 2008 October 46 (5):594-8. Epub 10/31/2008.

Activated polymorphonuclear cells promote injury and excitability of dorsal root ganglia neurons.

Shaw SK, Owolabi SA, Bagley J, Morin N, Cheng E, LeBlanc BW, Kim M, Harty P, Waxman SG, Saab CY

Experimental neurology.. 2008 April 210 (2):286-94. Epub 12/04/2007.

Cubital tunnel syndrome, associated with synovial chondromatosis.

Kim CH, Kim SH, Kim MS, Chang CH

Journal of Korean Neurosurgical Society.. 2008 February 43 (2):109-10. Epub 02/20/2008.

Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration.

Morin NA, Oakes PW, Hyun YM, Lee D, Chin YE, Chin EY, King MR, Springer TA, Shimaoka M, Tang JX, Reichner JS, Kim M

The Journal of experimental medicine.. 2008 January 21205 (1):195-205. Epub 01/14/2008.

Arachnoid cyst with spontaneous intracystic hemorrhage and chronic subdural hematoma.

Hong JC, Kim MS, Chang CH, Kim SH

Journal of Korean Neurosurgical Society.. 2008 January 43 (1):54-6. Epub 01/20/2008.

Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.

Zhu J, Carman CV, Kim M, Shimaoka M, Springer TA, Luo BH

Blood.. 2007 October 1110 (7):2475-83. Epub 07/05/2007.

Integrin engagement mediates the human polymorphonuclear leukocyte response to a fungal pathogen-associated molecular pattern.

Lavigne LM, O'Brien XM, Kim M, Janowski JW, Albina JE, Reichner JS

The Journal of immunology : official journal of the American Association of Immunologists.. 2007 June 1178 (11):7276-82. Epub 1900 01 01.

Mechanically evoked 5-hydroxytryptamine release is mediated by caveolin-associated cholesterol rich membrane domains.

Kim M, Christofi FL, Xue J, Robinson JM, Cooke HJ

Neurogastroenterology and motility.. 2007 April 19 (4):309-17. Epub 1900 01 01.

Neutrophils invade lumbar dorsal root ganglia after chronic constriction injury of the sciatic nerve.

Morin N, Owolabi SA, Harty MW, Papa EF, Tracy TF, Shaw SK, Kim M, Saab CY

Journal of neuroimmunology.. 2007 March 184 (1-2):164-71. Epub 02/01/2007.

A small molecule agonist of an integrin, alphaLbeta2.

Yang W, Carman CV, Kim M, Salas A, Shimaoka M, Springer TA

The Journal of biological chemistry.. 2006 December 8281 (49):37904-12. Epub 10/05/2006.

AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.

Shimaoka M, Kim M, Cohen EH, Yang W, Astrof N, Peer D, Salas A, Ferrand A, Springer TA

Proceedings of the National Academy of Sciences of the United States of America.. 2006 September 19103 (38):13991-6. Epub 09/08/2006.

Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2.

Chen J, Yang W, Kim M, Carman CV, Springer TA

Proceedings of the National Academy of Sciences of the United States of America.. 2006 August 29103 (35):13062-7. Epub 08/18/2006.

Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state.

Salas A, Shimaoka M, Phan U, Kim M, Springer TA

The Journal of biological chemistry.. 2006 April 21281 (16):10876-82. Epub 02/27/2006.

The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2.

Kim M, Carman CV, Yang W, Salas A, Springer TA

The Journal of cell biology.. 2004 December 20167 (6):1241-53. Epub 1900 01 01.

Endogenous adenosine differentially modulates 5-hydroxytryptamine release from a human enterochromaffin cell model.

Christofi FL, Kim M, Wunderlich JE, Xue J, Suntres Z, Cardounel A, Javed NH, Yu JG, Grants I, Cooke HJ

Gastroenterology.. 2004 July 127 (1):188-202. Epub 1900 01 01.

Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins.

Kim M, Carman CV, Springer TA

Science.. 2003 September 19301 (5640):1720-5. Epub 1900 01 01.

D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells.

Kim M, Cooke HJ, Javed NH, Carey HV, Christofi F, Raybould HE

Gastroenterology.. 2001 December 121 (6):1400-6. Epub 1900 01 01.

Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system.

Christofi FL, Zhang H, Yu JG, Guzman J, Xue J, Kim M, Wang YZ, Cooke HJ

The Journal of comparative neurology.. 2001 October 8439 (1):46-64. Epub 1900 01 01.

Mechanical stimulation activates Galphaq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells.

Kim M, Javed NH, Yu JG, Christofi F, Cooke HJ

The Journal of clinical investigation.. 2001 October 108 (7):1051-9. Epub 1900 01 01.

Books

Current Topics in Membrane (2011)

Chapter: Fluorescence resonance energy transfer in the studies of integrin activation.

Authors: CT Lefort and M. Kim

Publisher: Academic Press 2011

Progress in Inflammation Research, (2006)

Chapter: Adhesion Molecules: Function and Inhibition.

Authors: A. Schenkel and M. Kim

Publisher: Birkhauser Publishing, Basel, Switzerland 2006