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Maria de la Luz Garcia-Hernandez, Ph.D.

Maria de la Luz Garcia-Hernandez, Ph.D.

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Office (585) 276-5127

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About Me

Faculty Appointments

Research Assistant Professor - Department of Medicine, Allergy/Immunology and Rheumatology (SMD)

Credentials

Education

Ph D | Center of Research and Advanced Studies of the National Polytechnic Institute. Molecular Biomedicine. 2002

Master in Sciences | Center of Research and Advanced Studies of the National Polytechnic Institute. Molecular Biomedicine. 1997

Bachelor Degree | Facultad de Ciencias Quimicas. Benemerita Universidad Autonoma de Puebla. Chemistry, Pharmacology and Biology. 1993

Research

Publications

Journal Articles

Evaluation of Vaccinia Virus Infection in Mice Using Two-Reporter Recombinant Virus.

Nogales A, Chiem K, Lorenzo MM, Rangel-Moreno J, de la Luz Garcia-Hernandez M, Park JG, Blasco R, Martinez-Sobrido L

Methods in molecular biology.. 2025 2860 :157-174. Epub 1900 01 01.

Single-cell RNA sequencing reveals placental response under environmental stress.

Van Buren E, Azzara D, Rangel-Moreno J, Garcia-Hernandez ML, Murphy SP, Cohen ED, Lewis E, Lin X, Park HR

Nature communications.. 2024 August 215 (1):6549. Epub 08/02/2024.

Psoriatic arthritis subtypes are phenocopied in humanized mice.

Ritchlin CT, Rangel-Moreno J, Martino D, Isett B, Paine A, Bhattacharya S, Fox J, Meyer EM, Bao R, Bruno T, Tausk F, de la Luz Garcia-Hernandez M

JCI insight.. 2024 July 29 (15)Epub 07/02/2024.

IL-23 induces CLEC5A IL-17A neutrophils and elicit skin inflammation associated with psoriatic arthritis.

Furuya H, Nguyen CT, Chan T, Marusina AI, Merleev AA, Garcia-Hernandez ML, Hsieh SL, Tsokos GC, Ritchlin CT, Tagkopoulos I, Maverakis E, Adamopoulos IE

Journal of autoimmunity.. 2024 February 143 :103167. Epub 02/01/2024.

Sodium-Glucose Cotransporter-2 Inhibitor, Empagliflozin, Suppresses the Inflammatory Immune Response to Influenza Infection.

Constantinesco NJ, Chinnappan B, DeVito LJ, Moras C, Srikanth S, Garcia-Hernandez ML, Rangel-Moreno J, Gopal R

ImmunoHorizons.. 2023 December 17 (12):861-871. Epub 1900 01 01.

Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems.

Castillo RL, Sidhu I, Dolgalev I, Chu T, Prystupa A, Subudhi I, Yan D, Konieczny P, Hsieh B, Haberman RH, Selvaraj S, Shiomi T, Medina R, Girija PV, Heguy A, Loomis CA, Chiriboga L, Ritchlin C, Garcia-Hernandez ML, Carucci J, Meehan SA, Neimann AL, Gudjonsson JE, Scher JU, Naik S

Science immunology.. 2023 June 88 (84):eabq7991. Epub 06/02/2023.

Cardiac pericytes mediate the remodeling response to myocardial infarction.

Quijada P, Park S, Zhao P, Kolluri KS, Wong D, Shih KD, Fang K, Pezhouman A, Wang L, Daraei A, Tran MD, Rathbun EM, Burgos Villar KN, Garcia-Hernandez ML, Pham TT, Lowenstein CJ, Iruela-Arispe ML, Carmichael ST, Small EM, Ardehali R

The Journal of clinical investigation.. 2023 May 15133 (10)Epub 05/15/2023.

Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control.

Swanson RV, Gupta A, Foreman TW, Lu L, Choreno-Parra JA, Mbandi SK, Rosa BA, Akter S, Das S, Ahmed M, Garcia-Hernandez ML, Singh DK, Esaulova E, Artyomov MN, Gommerman J, Mehra S, Zuniga J, Mitreva M, Scriba TJ, Rangel-Moreno J, Kaushal D, Khader SA

Nature immunology.. 2023 May 24 (5):855-868. Epub 04/03/2023.

Dysregulation of Bile Acids, Lipids, and Nucleotides in Psoriatic Arthritis Revealed by Unbiased Profiling of Serum Metabolites.

Paine A, Brookes PS, Bhattacharya S, Li D, Garcia-Hernandez ML, Tausk F, Ritchlin C

Arthritis & rheumatology.. 2023 January 75 (1):53-63. Epub 11/25/2022.

Small Molecule Inhibitors of Nuclear Export and the Amelioration of Lupus by Modulation of Plasma Cell Generation and Survival.

Rangel-Moreno J, Garcia-Hernandez ML, Owen T, Barnard J, Becerril-Villanueva E, Kashyap T, Argueta C, Gamboa-Dominguez A, Tamir S, Landesman Y, Goldman BI, Ritchlin CT, Anolik JH

Arthritis & rheumatology.. 2022 August 74 (8):1363-1375. Epub 06/28/2022.

New Tech Provides Insights into the Pathogenesis of Psoriatic Arthritis

Garcia-Hernandez ML and Ritchlin CT.

The Rheumatologist. 2022; .

Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis.

Garcia-Hernandez ML, Rangel-Moreno J, Garcia-Castaneda M, Kenney HM, Paine A, Thullen M, Anandarajah AP, Schwarz EM, Dirksen RT, Ritchlin CT

Frontiers in immunology.. 2022 13 :1026574. Epub 11/07/2022.

Bi-Reporter Vaccinia Virus for Tracking Viral Infections and .

Chiem K, Lorenzo MM, Rangel-Moreno J, Garcia-Hernandez ML, Park JG, Nogales A, Blasco R, Martínez-Sobrido L

Microbiology spectrum.. 2021 December 229 (3):e0160121. Epub 11/24/2021.

The immune landscape in tuberculosis reveals populations linked to disease and latency.

Esaulova E, Das S, Singh DK, Choreño-Parra JA, Swain A, Arthur L, Rangel-Moreno J, Ahmed M, Singh B, Gupta A, Fernández-López LA, de la Luz Garcia-Hernandez M, Bucsan A, Moodley C, Mehra S, García-Latorre E, Zuniga J, Atkinson J, Kaushal D, Artyomov MN, Khader SA

Cell host & microbe.. 2021 February 1029 (2):165-178.e8. Epub 12/18/2020.

Tumor Necrosis Factor Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease-Associated Pulmonary Arterial Hypertension.

Bell RD, White RJ, Garcia-Hernandez ML, Wu E, Rahimi H, Marangoni RG, Slattery P, Duemmel S, Nuzzo M, Huertas N, Yee M, O'Reilly MA, Morrell C, Ritchlin CT, Schwarz EM, Korman BD

Arthritis & rheumatology.. 2020 October 72 (10):1759-1770. Epub 08/20/2020.

Neutrophil elastase from myeloid cells promotes TSC2-null tumor growth.

Hammes SR, Gibbons E, Minor B, Rangel-Moreno J, Garcia-Hernandez M, Taya M

Endocrine-related cancer.. 2020 April 27 (4):261-274. Epub 1900 01 01.

Inducible Bronchus-Associated Lymphoid Tissue (iBALT) Attenuates Pulmonary Pathology in a Mouse Model of Allergic Airway Disease.

Hwang JY, Silva-Sanchez A, Carragher DM, Garcia-Hernandez ML, Rangel-Moreno J, Randall TD

Frontiers in immunology.. 2020 11 :570661. Epub 09/25/2020.

Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor-Transgenic Mouse Model of Rheumatoid Arthritis.

Bell DR, Wu E, Rudmann C, Forney M, Kaiser C, Wood R, Chakkalakal J, Paris N, Klose A, Xiao GQ, Rangel-Moreno J, Garcia-Hernandez M, Ritchlin C, Schwarz E, Rahimi H

Arthritis & rheumatology.. 2019 September 71 (9):1512-1523. Epub 07/22/2019.

Publisher Correction: Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.

Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la, Ulland TK, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung'u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Zúñiga J, Horsnell W, Yokoyama WM, Shalek AK, Kløverpris HN, Colonna M, Leslie A, Khader SA

Nature.. 2019 August 572 (7768):E10. Epub 1900 01 01.

Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis.

Ardain A, Domingo-Gonzalez R, Das S, Kazer SW, Howard NC, Singh A, Ahmed M, Nhamoyebonde S, Rangel-Moreno J, Ogongo P, Lu L, Ramsuran D, de la, K Ulland, Darby M, Park E, Karim F, Melocchi L, Madansein R, Dullabh KJ, Dunlap M, Marin-Agudelo N, Ebihara T, Ndung'u T, Kaushal D, Pym AS, Kolls JK, Steyn A, Zúñiga J, Horsnell W, Yokoyama WM, Shalek AK, Kløverpris HN, Colonna M, Leslie A, Khader SA

Nature.. 2019 June 570 (7762):528-532. Epub 06/05/2019.

Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression.

Lerman I, Ma X, Seger C, Maolake A, Garcia-Hernandez ML, Rangel-Moreno J, Ackerman J, Nastiuk KL, Susiarjo M, Hammes SR

Molecular cancer research : MCR.. 2019 April 17 (4):845-859. Epub 01/04/2019.

Thy1 is a positive regulator of osteoblast differentiation and modulates bone homeostasis in obese mice.

Paine A, Woeller CF, Zhang H, de la Luz Garcia-Hernandez M, Huertas N, Xing L, Phipps RP, Ritchlin CT

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 June 32 (6):3174-3183. Epub 01/17/2018.

Interleukin-17 limits hypoxia-inducible factor 1? and development of hypoxic granulomas during tuberculosis.

Domingo-Gonzalez R, Das S, Griffiths KL, Ahmed M, Bambouskova M, Gopal R, Gondi S, Muñoz-Torrico M, Salazar-Lezama MA, Cruz-Lagunas A, Jiménez-Álvarez L, Ramirez-Martinez G, Espinosa-Soto R, Sultana T, Lyons-Weiler J, Reinhart TA, Arcos J, de la Luz Garcia-Hernandez M, Mastrangelo MA, Al-Hammadi N, Townsend R, Balada-Llasat JM, Torrelles JB, Kaplan G, Horne W, Kolls JK, Artyomov MN, Rangel-Moreno J, Zúñiga J, Khader SA

JCI insight.. 2017 October 52 (19)Epub 10/05/2017.

Infiltrating Myeloid Cells Exert Protumorigenic Actions via Neutrophil Elastase.

Lerman I, Garcia-Hernandez ML, Rangel-Moreno J, Chiriboga L, Pan C, Nastiuk KL, Krolewski JJ, Sen A, Hammes SR

Molecular cancer research : MCR.. 2017 September 15 (9):1138-1152. Epub 05/16/2017.

Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.

Eddens T, Elsegeiny W, Garcia-Hernadez ML, Castillo P, Trevejo-Nunez G, Serody K, Campfield BT, Khader SA, Chen K, Rangel-Moreno J, Kolls JK

Cell reports.. 2017 March 2818 (13):3078-3090. Epub 1900 01 01.

A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression.

García-Hernández ML, Uribe-Uribe NO, Espinosa-González R, Kast WM, Khader SA, Rangel-Moreno J

Frontiers in immunology.. 2017 8 :563. Epub 05/17/2017.

Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function.

Rangel-Moreno J, de la Luz Garcia-Hernandez M, Ramos-Payan R, Biear J, Hernady E, Sangster MY, Randall TD, Johnston CJ, Finkelstein JN, Williams JP

Radiation research.. 2015 October 184 (4):352-66. Epub 09/23/2015.

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs.

Barone F, Nayar S, Campos J, Cloake T, Withers DR, Toellner KM, Zhang Y, Fouser L, Fisher B, Bowman S, Rangel-Moreno J, Garcia-Hernandez ML, Randall TD, Lucchesi D, Bombardieri M, Pitzalis C, Luther SA, Buckley CD

Proceedings of the National Academy of Sciences of the United States of America.. 2015 September 1112 (35):11024-9. Epub 08/18/2015.

Syntaxin-binding protein STXBP5 inhibits endothelial exocytosis and promotes platelet secretion.

Zhu Q, Yamakuchi M, Ture S, de la Luz Garcia-Hernandez M, Ko KA, Modjeski KL, LoMonaco MB, Johnson AD, O'Donnell CJ, Takai Y, Morrell CN, Lowenstein CJ

The Journal of clinical investigation.. 2014 October 124 (10):4503-16. Epub 09/17/2014.

Multiple redundant effector mechanisms of CD8+ T cells protect against influenza infection.

Hamada H, Bassity E, Flies A, Strutt TM, Garcia-Hernandez Mde L, McKinstry KK, Zou T, Swain SL, Dutton RW

The Journal of immunology : official journal of the American Association of Immunologists.. 2013 January 1190 (1):296-306. Epub 11/28/2012.

Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection.

Brown DM, Lee S, Garcia-Hernandez Mde L, Swain SL

Journal of virology.. 2012 June 86 (12):6792-803. Epub 04/04/2012.

The development of inducible bronchus-associated lymphoid tissue depends on IL-17.

Rangel-Moreno J, Carragher DM, de la Luz Garcia-Hernandez M, Hwang JY, Kusser K, Hartson L, Kolls JK, Khader SA, Randall TD

Nature immunology.. 2011 June 1212 (7):639-46. Epub 06/12/2011.

Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice.

Garcia-Hernandez Mde L, Hamada H, Reome JB, Misra SK, Tighe MP, Dutton RW

The Journal of immunology : official journal of the American Association of Immunologists.. 2010 April 15184 (8):4215-27. Epub 03/17/2010.

Prostate cancer immunotherapy yields superior long-term survival in TRAMP mice when administered at an early stage of carcinogenesis prior to the establishment of tumor-associated immunosuppression at later stages.

Gray A, de la Luz Garcia-Hernandez M, van West M, Kanodia S, Hubby B, Kast WM

Vaccine.. 2009 December 3027 Suppl 6 (Suppl 6):G52-9. Epub 1900 01 01.

Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.

Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton RW

The Journal of immunology : official journal of the American Association of Immunologists.. 2009 March 15182 (6):3469-81. Epub 1900 01 01.

Entamoeba histolytica EhDEAD1 is a conserved DEAD-box RNA helicase with ATPase and ATP-dependent RNA unwinding activities.

López-Camarillo C, de la Luz García-Hernández M, Marchat LA, Luna-Arias JP, Hernández de la Cruz O, Mendoza L, Orozco E

Gene.. 2008 May 15414 (1-2):19-31. Epub 02/16/2008.

Prostate stem cell antigen vaccination induces a long-term protective immune response against prostate cancer in the absence of autoimmunity.

Garcia-Hernandez Mde L, Gray A, Hubby B, Klinger OJ, Kast WM

Cancer research.. 2008 February 168 (3):861-9. Epub 1900 01 01.

In vivo effects of vaccination with six-transmembrane epithelial antigen of the prostate: a candidate antigen for treating prostate cancer.

Garcia-Hernandez Mde L, Gray A, Hubby B, Kast WM

Cancer research.. 2007 February 167 (3):1344-51. Epub 1900 01 01.

Pulmonary tuberculosis in BALB/c mice with non-functional IL-4 genes: changes in the inflammatory effects of TNF-alpha and in the regulation of fibrosis.

Hernandez-Pando R, Aguilar D, Hernandez ML, Orozco H, Rook G

European journal of immunology.. 2004 January 34 (1):174-83. Epub 1900 01 01.

Tumor Escape Immune Mechanisms (PDF)

Koh YT; Garcia-Hernandez ML and Kast WM.

Cancer Drug Discovery and Development: Cancer Drug Resistance. 2004; : 577-602.

Telomerase activity in well-differentiated papillary thyroid carcinoma correlates with advanced clinical stage of the disease.

Bornstein-Quevedo L, García-Hernández ML, Camacho-Arroyo I, Herrera MF, Angeles AA, Treviño OG, Gamboa-Domínguez A

Endocrine pathology.. 2003 14 (3):213-19. Epub 1900 01 01.

The role of prostaglandin E2 in the immunopathogenesis of experimental pulmonary tuberculosis.

Rangel Moreno J, Estrada García I, De La Luz García Hernández M, Aguilar Leon D, Marquez R, Hernández Pando R

Immunology.. 2002 June 106 (2):257-66. Epub 1900 01 01.

Interleukin-10 promotes B16-melanoma growth by inhibition of macrophage functions and induction of tumour and vascular cell proliferation.

García-Hernández ML, Hernández-Pando R, Gariglio P, Berumen J

Immunology.. 2002 February 105 (2):231-43. Epub 1900 01 01.