Dr. Morrell earned his undergraduate degree from Brown University in 1995. He then graduated from Tufts University School of Veterinary Medicine in 2000 before beginning a comparative pathology fellowship at The Johns Hopkins University School of Medicine. While at Hopkins Dr. Morrell concurrently c...
Dr. Morrell earned his undergraduate degree from Brown University in 1995. He then graduated from Tufts University School of Veterinary Medicine in 2000 before beginning a comparative pathology fellowship at The Johns Hopkins University School of Medicine. While at Hopkins Dr. Morrell concurrently completed a PhD in the laboratory of Dr. Charles Lowenstein in 2005 where he investigated molecular mechanisms of nitric oxide inhibition of platelet degranulation and received a K08 award. Dr. Morrell then established an \ independent laboratory in the Department of Molecular and Comparative Pathobiology at Hopkins from 2005-2009, before moving to the University of Rochester's Aab Cardiovascular Research Institute. His current research interests include platelets and vascular inflammation.
Faculty Appointments
Professor
-
Department of Medicine, Aab Cardiovascular Research Institute (SMD)
Dean's Professorship
-
Department of Medicine (SMD)
Associate Director
-
Aab Cardiovascular Research Institute
Professor
-
Department of Microbiology and Immunology (SMD) - Joint
Professor
-
Department of Pathology and Laboratory Medicine (SMD) - Joint
Credentials
Post-doctoral Training & Residency
Department of Comparative Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 2000 - 2005
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 2000 - 2005
Education
PhD | The Johns Hopkins U Sch Medicine.Pathobiology.2005
DVM | Tufts University School of Veterinary Medicine.Veterinary Medicine.2000
Sc.B | Brown University.Biology.1995
Awards
Kenneth M. Brinkous Young Investigators Prize in Thrombosis Research.2008
Deans Gift, A monetary research award given to new investigators of outstanding potential.2006
Travel Scholarship.2005
Travel Scholarship.2005
Young Investigator Award, Basic Science.2004
Cheif Fellow, Comparative Pathology.2003 - 2004
Young Investigators Award, First Place, Experimental Disease.2003
Pathology Award-Excellence in Pathology.2000
Research
Research in our lab is focused on the complex interface between platelets, the vasculature, and immune cells. Platelets are not only the cellular mediators of thrombosis, but also have important roles in inflammatory and immune cell responses. Ongoing and past studies by our group have examined plat...
Research in our lab is focused on the complex interface between platelets, the vasculature, and immune cells. Platelets are not only the cellular mediators of thrombosis, but also have important roles in inflammatory and immune cell responses. Ongoing and past studies by our group have examined platelet, and platelet derived inflammatory mediator interactions with both vascular and immune cells, and the impact of these interactions on tissue injury responses in disease relevant contexts. These studies demonstrated that platelets are regulators of all aspects of inflammatory responses, including the induction of acute phase responses, innate immune cell activation and trafficking, T helper cell differentiation, and B cell development. Our lab regularly uses advanced mouse models to dissect molecular interactions and vascular inflammatory signaling pathways both in vitro and in vivo, establishing our lab as leaders in understanding how platelets regulate vascular and immune cell homeostatic and inflammatory responses. Our work continues to define many novel implications for platelet immune regulation in vascular and inflammatory disease processes.
Patents
Antigen Presenting Platelets and Methods of Eliciting an Immune Response
Modjeski KL, Levy SC, Ture SK, Field DJ, Shi G, Ko K, Zhu Q, Morrell CN
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.. 2016 May 16 (5):1383-93. Epub 02/25/2016.
Sun H, Swaim A, Herrera JE, Becker D, Becker L, Srivastava K, Thompson LE, Shero MR, Perez-Tamayo A, Suktitpat B, Mathias R, Contractor A, Faraday N, Morrell CN
Circulation research.. 2009 September 11105 (6):595-603. Epub 08/13/2009.
Morrell CN, Sun H, Ikeda M, Beique JC, Swaim AM, Mason E, Martin TV, Thompson LE, Gozen O, Ampagoomian D, Sprengel R, Rothstein J, Faraday N, Huganir R, Lowenstein CJ
The Journal of experimental medicine.. 2008 March 17205 (3):575-84. Epub 02/18/2008.
Mathiowitz E, Jacob JS, Jong YS, Carino GP, Chickering DE, Chaturvedi P, Santos CA, Vijayaraghavan K, Montgomery S, Bassett M, Morrell C
Nature.. 1997 March 27386 (6623):410-4. Epub 1900 01 01.
Bioadhesive Microspheres: III. An In Vivo Transit and Bioavailability Study of Drug-Loaded Alginate and Poly(Fumaric-co-Sebacic Anhydride) Microspheres
Chickering, D.E.; Jacob, J.S.; Desai, M.; Harrison, W.P.; Morrell, C.N.; Chatuverdi, P.; Mathiowitz, E.