Home Home Mark Y. Sangster, Ph.D.

Mark Y. Sangster, Ph.D.

Contact

Office (585) 273-3109

About Me
Credentials
Research
Publications

About Me

Faculty Appointments

Research Professor - Department of Medicine, Nephrology (SMD)

Credentials

Education

PhD | Australia-U Western Australia - Perth. Genetics. 1991

BS | Australia-U Western Australia - Perth. Genetics. 1984

Awards

Athelstan and Amy Saw Medical Research Award. 1991

Australian Commonwealth Postgraduate Award for Dissertation Research. 1985

Swan Brewery Prize for Undergraduate Honors Thesis. 1984

Research

Overview

Virus-specific antibodies play a key role in providing a protective barrier to infection and in facilitating viral clearance once an infection is established. Antibody-producing cells or plasma cells are generated from B cells that divide and differentiate following recognition of specific antigen. A critical requirement for optimal antibody responses is the cognate help delivered to activated B cells by CD4 T cells. This help is important for directing antibody isotype switching in B cells, the process by which B cells switch from expressing IgM to expressing alternative isotypes (such as IgG1, IgG2a, and IgA in the mouse) with different functional characteristics. In addition, cognate T cell help is critical if activated B cells are to participate in germinal center reactions, where affinity maturation of the antibody response takes place and the cellular elements of B cell memory are generated. These elements include long-lived plasma cells, which maintain high levels of protective antibodies, and a population of memory B cells that will respond with rapid antibody production on re-exposure to cognate antigen. This brief overview grossly simplifies a remarkable and complex process that is regulated at many levels in ways that modulate the kinetics, magnitude, and quality of the acute B cell response, as well as characteristics of dispersed plasma cell and memory B cell populations. In general terms, our research is aimed at understanding the characteristics of optimally effective B cell responses and applying this knowledge towards the improvement of vaccination regimens.

Specific Research Interests

Our specific research focus is the B cell response to viruses that infect the respiratory tract (with an emphasis on influenza virus) and to vaccination regimens designed to generate B cell-mediated protection against these viruses. Particular research interests include: (i) regulation of the acute B cell response to infection and vaccination and the differentiation pathways that generate B cell memory and virus-neutralizing antibodies, (ii) aspects of B cell memory (plasma cells, memory B cells) in the respiratory tract, including mechanisms of localization, role in protection, and relationship to form of immunization, and (iii) regulation of IgA production and the establishment of antibody-mediated protection at mucosal surfaces.

Publications

Journal Articles

Long-term results of vaccination with adjuvanted recombinant varicella zoster glycoprotein E during initial Bruton tyrosine kinase inhibitors therapy for chronic lymphocytic leukemia or lymphoplasmacytic lymphoma.

Brady MT, Laniewski N, Strawderman M, Chu CC, Kanagaiah P, Sangster MY, Topham DJ, Friedberg JW, Zent CS

American journal of hematology.. 2023 October 98 (10):E288-E290. Epub 07/23/2023.

Association of Human Milk Antibody Induction, Persistence, and Neutralizing Capacity With SARS-CoV-2 Infection vs mRNA Vaccination.

Young BE, Seppo AE, Diaz N, Rosen-Carole C, Nowak-Wegrzyn A, Cruz Vasquez JM, Ferri-Huerta R, Nguyen-Contant P, Fitzgerald T, Sangster MY, Topham DJ, Järvinen KM

JAMA pediatrics.. 2022 February 1176 (2):159-168. Epub 1900 01 01.

Formation and Expansion of Memory B Cells against Coronavirus in Acutely Infected COVID-19 Individuals.

Embong AK, Nguyen-Contant P, Wang J, Kanagaiah P, Chaves FA, Fitzgerald TF, Zhou Q, Kosoy G, Branche AR, Miller BL, Zand MS, Sangster MY, Topham DJ

Pathogens.. 2022 January 2911 (2)Epub 01/29/2022.

Broadly Reactive IgG Responses to Heterologous H5 Prime-Boost Influenza Vaccination Are Shaped by Antigenic Relatedness to Priming Strains.

Wang J, Li D, Perry S, Hilchey SP, Wiltse A, Treanor JJ, Sangster MY, Zand MS

mBio.. 2021 August 3112 (4):e0044921. Epub 07/06/2021.

Short term results of vaccination with adjuvanted recombinant varicella zoster glycoprotein E during initial BTK inhibitor therapy for CLL or lymphoplasmacytic lymphoma.

Zent CS, Brady MT, Delage C, Strawderman M, Laniewski N, Contant PN, Kanagaiah P, Sangster MY, Barr PM, Chu CC, Topham DJ, Friedberg JW

Leukemia.. 2021 June 35 (6):1788-1791. Epub 10/30/2020.

Squalene-Based Influenza Vaccine Adjuvants and Their Impact on the Hemagglutinin-Specific B Cell Response.

Nguyen-Contant P, Sangster MY, Topham DJ

Pathogens.. 2021 March 1710 (3)Epub 03/17/2021.

Immunity to Influenza Infection in Humans.

Topham DJ, DeDiego ML, Nogales A, Sangster MY, Sant A

Cold Spring Harbor perspectives in medicine.. 2021 March 111 (3)Epub 03/01/2021.

Characterization of SARS-CoV-2 RNA, Antibodies, and Neutralizing Capacity in Milk Produced by Women with COVID-19.

Pace RM, Williams JE, Järvinen KM, Belfort MB, Pace CDW, Lackey KA, Gogel AC, Nguyen-Contant P, Kanagaiah P, Fitzgerald T, Ferri R, Young B, Rosen-Carole C, Diaz N, Meehan CL, Caffé B, Sangster MY, Topham D, McGuire MA, Seppo A, McGuire MK

mBio.. 2021 February 912 (1)Epub 02/09/2021.

Array-based analysis of SARS-CoV-2, other coronaviruses, and influenza antibodies in convalescent COVID-19 patients.

Steiner DJ, Cognetti JS, Luta EP, Klose AM, Bucukovski J, Bryan MR, Schmuke JJ, Nguyen-Contant P, Sangster MY, Topham DJ, Miller BL

Biosensors & bioelectronics.. 2020 December 1169 :112643. Epub 09/21/2020.

Analysis of Antigen-Specific Human Memory B Cell Populations Based on In Vitro Polyclonal Stimulation.

Nguyen-Contant P, Embong AK, Topham DJ, Sangster MY

Current protocols in immunology / edited by John E. Coligan ... [et

S Protein-Reactive IgG and Memory B Cell Production after Human SARS-CoV-2 Infection Includes Broad Reactivity to the S2 Subunit.

Nguyen-Contant P, Embong AK, Kanagaiah P, Chaves FA, Yang H, Branche AR, Topham DJ, Sangster MY

mBio.. 2020 September 2511 (5)Epub 09/25/2020.

COVID-19 and human milk: SARS-CoV-2, antibodies, and neutralizing capacity.

Pace RM, Williams JE, Järvinen KM, Belfort MB, Pace CD, Lackey KA, Gogel AC, Nguyen-Contant P, Kanagaiah P, Fitzgerald T, Ferri R, Young B, Rosen-Carole C, Diaz N, Meehan C, Caffe B, Sangster MY, Topham DJ, McGuire MA, Seppo A, McGuire MK

medRxiv : the preprint server for health sciences.. 2020 September 18 Epub 09/18/2020.

Implementing sequence-based antigenic distance calculation into immunological shape space model.

Anderson CS, Sangster MY, Yang H, Mariani TJ, Chaudhury S, Topham DJ

BMC bioinformatics.. 2020 June 1921 (1):256. Epub 06/19/2020.

Characterizing Emerging Canine H3 Influenza Viruses.

Martinez-Sobrido L, Blanco-Lobo P, Rodriguez L, Fitzgerald T, Zhang H, Nguyen P, Anderson CS, Holden-Wiltse J, Bandyopadhyay S, Nogales A, DeDiego ML, Wasik BR, Miller BL, Henry C, Wilson PC, Sangster MY, Treanor JJ, Topham DJ, Byrd-Leotis L, Steinhauer DA, Cummings RD, Luczo JM, Tompkins SM, Sakamoto K, Jones CA, Steel J, Lowen AC, Danzy S, Tao H, Fink AL, Klein SL, Wohlgemuth N, Fenstermacher KJ, El Najjar F, Pekosz A, Sauer L, Lewis MK, Shaw-Saliba K, Rothman RE, Liu ZY, Chen KF, Parrish CR, Voorhees IEH, Kawaoka Y, Neumann G, Chiba S, Fan S, Hatta M, Kong H, Zhong G, Wang G, Uccellini MB, García-Sastre A, Perez DR, Ferreri LM, Herfst S, Richard M, Fouchier R, Burke D, Pattinson D, Smith DJ, Meliopoulos V, Freiden P, Livingston B, Sharp B, Cherry S, Dib JC, Yang G, Russell CJ, Barman S, Webby RJ, Krauss S, Danner A, Woodard K, Peiris M, Perera RAPM, Chan MCW, Govorkova EA, Marathe BM, Pascua PNQ, Smith G, Li YT, Thomas PG, Schultz-Cherry S

PLoS pathogens.. 2020 April 16 (4):e1008409. Epub 04/14/2020.

Role of Memory B Cells in Hemagglutinin-Specific Antibody Production Following Human Influenza A Virus Infection.

Sangster MY, Nguyen PQT, Topham DJ

Pathogens.. 2019 September 288 (4)Epub 09/28/2019.

Broad Hemagglutinin-Specific Memory B Cell Expansion by Seasonal Influenza Virus Infection Reflects Early-Life Imprinting and Adaptation to the Infecting Virus.

Tesini BL, Kanagaiah P, Wang J, Hahn M, Halliley JL, Chaves FA, Nguyen PQT, Nogales A, DeDiego ML, Anderson CS, Ellebedy AH, Strohmeier S, Krammer F, Yang H, Bandyopadhyay S, Ahmed R, Treanor JJ, Martinez-Sobrido L, Golding H, Khurana S, Zand MS, Topham DJ, Sangster MY

Journal of virology.. 2019 April 1593 (8)Epub 04/03/2019.

Pandemic influenza vaccines: what they have taught us about B cell immunology.

Topham DJ, Nguyen P, Sangster MY

Current opinion in immunology.. 2018 August 53 :203-208. Epub 06/26/2018.

Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice.

Wang J, Hilchey SP, DeDiego M, Perry S, Hyrien O, Nogales A, Garigen J, Amanat F, Huertas N, Krammer F, Martinez-Sobrido L, Topham DJ, Treanor JJ, Sangster MY, Zand MS

PloS one.. 2018 13 (4):e0193680. Epub 04/11/2018.

Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins.

Clark AM, DeDiego ML, Anderson CS, Wang J, Yang H, Nogales A, Martinez-Sobrido L, Zand MS, Sangster MY, Topham DJ

PloS one.. 2017 12 (11):e0188267. Epub 11/16/2017.

Generation and Protective Ability of Influenza Virus-Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge.

Jegaskanda S, Luke C, Hickman HD, Sangster MY, Wieland-Alter WF, McBride JM, Yewdell JW, Wright PF, Treanor J, Rosenberger CM, Subbarao K

The Journal of infectious diseases.. 2016 September 15214 (6):945-52. Epub 06/28/2016.

High-Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine After Priming With Live Attenuated Influenza Vaccine.

Halliley JL, Khurana S, Krammer F, Fitzgerald T, Coyle EM, Chung KY, Baker SF, Yang H, Martínez-Sobrido L, Treanor JJ, Subbarao K, Golding H, Topham DJ, Sangster MY

The Journal of infectious diseases.. 2015 October 15212 (8):1270-8. Epub 04/02/2015.

Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function.

Rangel-Moreno J, de la Luz Garcia-Hernandez M, Ramos-Payan R, Biear J, Hernady E, Sangster MY, Randall TD, Johnston CJ, Finkelstein JN, Williams JP

Radiation research.. 2015 October 184 (4):352-66. Epub 09/23/2015.

Robust mucosal-homing antibody-secreting B cell responses induced by intramuscular administration of adjuvanted bivalent human norovirus-like particle vaccine.

Sundararajan A, Sangster MY, Frey S, Atmar RL, Chen WH, Ferreira J, Bargatze R, Mendelman PM, Treanor JJ, Topham DJ

Vaccine.. 2015 January 1533 (4):568-76. Epub 11/22/2014.

Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine.

Babu TM, Levine M, Fitzgerald T, Luke C, Sangster MY, Jin H, Topham D, Katz J, Treanor J, Subbarao K

Vaccine.. 2014 November 2832 (50):6798-804. Epub 10/16/2014.

CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection.

Alam S, Knowlden ZA, Sangster MY, Sant AJ

Journal of virology.. 2014 January 88 (1):314-24. Epub 10/23/2013.

Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection.

Miao H, Sangster MY, Livingstone AM, Hilchey SP, Zhang L, Topham DJ, Mosmann TR, Holden-Wiltse J, Perelson AS, Wu H, Zand MS

PloS one.. 2014 9 (8):e104781. Epub 08/29/2014.

Passive broad-spectrum influenza immunoprophylaxis.

Berry CM, Penhale WJ, Sangster MY

Influenza research and treatment.. 2014 2014 :267594. Epub 09/22/2014.

B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination.

Sangster MY, Baer J, Santiago FW, Fitzgerald T, Ilyushina NA, Sundararajan A, Henn AD, Krammer F, Yang H, Luke CJ, Zand MS, Wright PF, Treanor JJ, Topham DJ, Subbarao K

Clinical and vaccine immunology : CVI.. 2013 June 20 (6):867-76. Epub 04/10/2013.

Heterovariant cross-reactive B-cell responses induced by the 2009 pandemic influenza virus A subtype H1N1 vaccine.

He XS, Sasaki S, Baer J, Khurana S, Golding H, Treanor JJ, Topham DJ, Sangster MY, Jin H, Dekker CL, Subbarao K, Greenberg HB

The Journal of infectious diseases.. 2013 January 15207 (2):288-96. Epub 10/29/2012.

Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization.

Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ, Sangster MY

PloS one.. 2012 7 (3):e34377. Epub 03/23/2012.

T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses.

Sharma S, Sundararajan A, Suryawanshi A, Kumar N, Veiga-Parga T, Kuchroo VK, Thomas PG, Sangster MY, Rouse BT

Proceedings of the National Academy of Sciences of the United States of America.. 2011 November 22108 (47):19001-6. Epub 11/03/2011.

Time-dependent effects of pomegranate juice and pomegranate polyphenols on foodborne viral reduction.

Su X, Sangster MY, D'Souza DH

Foodborne pathogens and disease.. 2011 November 8 (11):1177-83. Epub 07/21/2011.

In vitro effects of pomegranate juice and pomegranate polyphenols on foodborne viral surrogates.

Su X, Sangster MY, D'Souza DH

Foodborne pathogens and disease.. 2010 December 7 (12):1473-9. Epub 08/31/2010.

Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins.

Sundararajan A, Ganapathy R, Huan L, Dunlap JR, Webby RJ, Kotwal GJ, Sangster MY

Antiviral research.. 2010 October 88 (1):1-9. Epub 07/14/2010.

Quantitative analysis of influenza virus-specific B cell memory generated by different routes of inactivated virus vaccination.

Joo HM, He Y, Sundararajan A, Huan L, Sangster MY

Vaccine.. 2010 March 228 (10):2186-2194. Epub 01/05/2010.

Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma.

Li Z, Wang H, Xue L, Shin DM, Roopenian D, Xu W, Qi CF, Sangster MY, Orihuela CJ, Tuomanen E, Rehg JE, Cui X, Zhang Q, Morse HC, Morris SW

Blood.. 2009 November 5114 (19):4158-68. Epub 08/20/2009.

The generation of influenza-specific humoral responses is impaired in ST6Gal I-deficient mice.

Zeng J, Joo HM, Rajini B, Wrammert JP, Sangster MY, Onami TM

The Journal of immunology : official journal of the American Association of Immunologists.. 2009 April 15182 (8):4721-7. Epub 1900 01 01.

Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia.

Joo HM, He Y, Sangster MY

Proceedings of the National Academy of Sciences of the United States of America.. 2008 March 4105 (9):3485-90. Epub 02/25/2008.

Quantitative analysis of herpes simplex virus type 1-specific memory B cells generated by different routes of infection.

Vanitha DJ, Joo HM, Rouse BT, Sangster MY

Virology.. 2007 March 30360 (1):136-42. Epub 11/17/2006.

A strategy for selective, CD4+ T cell-independent activation of virus-specific memory B cells for limiting dilution analysis.

Li X, Vanitha DJ, Joo HM, He Y, Rouse BT, Sangster MY

Journal of immunological methods.. 2006 June 30313 (1-2):110-8. Epub 05/15/2006.

Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses.

Lipatov AS, Andreansky S, Webby RJ, Hulse DJ, Rehg JE, Krauss S, Perez DR, Doherty PC, Webster RG, Sangster MY

The Journal of general virology.. 2005 April 86 (Pt 4):1121-1130. Epub 1900 01 01.

An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions.

Sangster MY, Riberdy JM, Gonzalez M, Topham DJ, Baumgarth N, Doherty PC

The Journal of experimental medicine.. 2003 October 6198 (7):1011-21. Epub 09/29/2003.

Measuring the diaspora for virus-specific CD8+ T cells.

Marshall DR, Turner SJ, Belz GT, Wingo S, Andreansky S, Sangster MY, Riberdy JM, Liu T, Tan M, Doherty PC

Proceedings of the National Academy of Sciences of the United States of America.. 2001 May 2298 (11):6313-8. Epub 05/08/2001.

Dissecting the host response to a gamma-herpesvirus.

Doherty PC, Christensen JP, Belz GT, Stevenson PG, Sangster MY

Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 2001 April 29356 (1408):581-93. Epub 1900 01 01.

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors.

Wang D, Feng J, Wen R, Marine JC, Sangster MY, Parganas E, Hoffmeyer A, Jackson CW, Cleveland JL, Murray PJ, Ihle JN

Immunity.. 2000 July 13 (1):25-35. Epub 1900 01 01.

Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirus.

Sangster MY, Topham DJ, D'Costa S, Cardin RD, Marion TN, Myers LK, Doherty PC

The Journal of immunology : official journal of the American Association of Immunologists.. 2000 February 15164 (4):1820-8. Epub 1900 01 01.

TH cells primed during influenza virus infection provide help for qualitatively distinct antibody responses to subsequent immunization.

Marshall D, Sealy R, Sangster M, Coleclough C

The Journal of immunology : official journal of the American Association of Immunologists.. 1999 November 1163 (9):4673-82. Epub 1900 01 01.

Development and characterization of new flavivirus-resistant mouse strains bearing Flv(r)-like and Flv(mr) alleles from wild or wild-derived mice.

Urosevic N, Silvia OJ, Sangster MY, Mansfield JP, Hodgetts SI, Shellam GR

The Journal of general virology.. 1999 April 80 ( Pt 4) :897-906. Epub 1900 01 01.

Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.

Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN

Immunity.. 1999 February 10 (2):249-59. Epub 1900 01 01.

Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice.

Brown MP, Topham DJ, Sangster MY, Zhao J, Flynn KJ, Surman SL, Woodland DL, Doherty PC, Farr AG, Pattengale PK, Brenner MK

Nature medicine.. 1998 November 4 (11):1253-60. Epub 1900 01 01.

Genetic control of host resistance to flavivirus infection in animals.

Shellam GR, Sangster MY, Urosevic N

Revue scientifique et technique. 1998 April 17 (1):231-48. Epub 1900 01 01.

Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer.

Bunting KD, Sangster MY, Ihle JN, Sorrentino BP

Nature medicine.. 1998 January 4 (1):58-64. Epub 1900 01 01.

Genetically determined resistance to flavivirus infection in wild Mus musculus domesticus and other taxonomic groups in the genus Mus.

Sangster MY, Mackenzie JS, Shellam GR

Archives of virology.. 1998 143 (4):697-715. Epub 1900 01 01.

HEL-Flu: an influenza virus containing the hen egg lysozyme epitope recognized by CD4+ T cells from mice transgenic for an alphabeta TCR.

Walker WS, Castrucci MR, Sangster MY, Carson RT, Kawaoka Y

The Journal of immunology : official journal of the American Association of Immunologists.. 1997 September 15159 (6):2563-6. Epub 1900 01 01.

Matching antibody class with pathogen type and portal of entry: cognate mechanisms regulate local isotype expression patterns in lymph nodes draining the respiratory tract of mice inoculated with respiratory viruses, according to virus replication competence and site of inoculation.

Sangster MY, Mo XY, Sealy R, Coleclough C

The Journal of immunology : official journal of the American Association of Immunologists.. 1997 August 15159 (4):1893-902. Epub 1900 01 01.

Intranasal Sendai virus vaccine protects African green monkeys from infection with human parainfluenza virus-type one.

Hurwitz JL, Soike KF, Sangster MY, Portner A, Sealy RE, Dawson DH, Coleclough C

Vaccine.. 1997 April 15 (5):533-40. Epub 1900 01 01.

The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon.

Mo XY, Tripp RA, Sangster MY, Doherty PC

Journal of virology.. 1997 March 71 (3):1906-10. Epub 1900 01 01.

Modification of the Sendai virus-specific antibody and CD8+ T-cell responses in mice homozygous for disruption of the interleukin-4 gene.

Mo XY, Sangster MY, Tripp RA, Doherty PC

Journal of virology.. 1997 March 71 (3):2518-21. Epub 1900 01 01.

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells.

Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC, Ihle JN

Nature.. 1996 July 11382 (6587):171-4. Epub 1900 01 01.

Protective immune responses to the E and NS1 proteins of Murray Valley encephalitis virus in hybrids of flavivirus-resistant mice.

Hall RA, Brand TN, Lobigs M, Sangster MY, Howard MJ, Mackenzie JS

The Journal of general virology.. 1996 June 77 ( Pt 6) :1287-94. Epub 1900 01 01.

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.

Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DA, Doherty PC, Grosveld G, Paul WE, Ihle JN

Nature.. 1996 April 18380 (6575):630-3. Epub 1900 01 01.

Immune CD4+ T cells promote the clearance of influenza virus from major histocompatibility complex class II -/- respiratory epithelium.

Topham DJ, Tripp RA, Sarawar SR, Sangster MY, Doherty PC

Journal of virology.. 1996 February 70 (2):1288-91. Epub 1900 01 01.

Human parainfluenza virus type 1 immunization of infant mice protects from subsequent Sendai virus infection.

Sangster M, Smith FS, Coleclough C, Hurwitz JL

Virology.. 1995 September 10212 (1):13-9. Epub 1900 01 01.

Differential antigen burden modulates the gamma interferon but not the immunoglobulin response in mice that vary in susceptibility to Sendai virus pneumonia.

Mo XY, Sangster M, Sarawar S, Coleclough C, Doherty PC

Journal of virology.. 1995 September 69 (9):5592-8. Epub 1900 01 01.

Distinctive kinetics of the antibody-forming cell response to Sendai virus infection of mice in different anatomical compartments.

Sangster M, Hyland L, Sealy R, Coleclough C