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Paul Dunman, Ph.D.

Paul Dunman, Ph.D.

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Office (585) 276-5700

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About Me

Faculty Appointments

Professor - Department of Microbiology and Immunology (SMD)

Professor - Department of Ophthalmology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Wyeth Research; Post-Doctoral Fellow (Infectious Disease) 1999 - 2001

Education

PhD | Univ of Medicine and Dentistry-NJ (UMDNJ). Microbiology. 1999

BS | Delaware Valley College. Arts & Sciences. 1992

Awards

Distinguished Investigator. 2010

Joseph P. Gilmore Outstanding Investigator Award. 2009

Most Promising New Invention Notification. 2009

Young Investigator of the Year. 2003

Research

Dunman Laboratory Research Overview:

Staphylococcus aureus is a Gram-positive bacterial pathogen that is reported to cause more U.S. deaths annually than HIV. Acinetobacter baumannii is a Gram-negative pathogen that is emerging as a predominant cause of infections within military personnel...
Dunman Laboratory Research Overview:

Staphylococcus aureus is a Gram-positive bacterial pathogen that is reported to cause more U.S. deaths annually than HIV. Acinetobacter baumannii is a Gram-negative pathogen that is emerging as a predominant cause of infections within military personnel injured during Operation Iraqi Freedom and has recently caused deadly outbreaks in the U.S., South America, and Europe. In addition to causing high incidences of morbidity and mortality, both organisms have also developed resistance to all currently available antibiotics, further amplifying public health concern and accentuating the need for new antibiotics for the treatment of S. aureus and A. baumannii infections.

Our laboratory uses S. aureus and A. baumannii as model organisms to study bacterial pathogenesis and develop novel strategies for the therapeutic intervention of bacterial infections. That work has revealed that most bacterial virulence factors are post-transcriptionally regulated in a manner that involves the modulation of their mRNA turnover. Current laboratory projects are geared toward characterizing the molecular components that govern 'native' and temporal changes in mRNA degradation. These factors can be broadly categorized as either: small non-coding RNAs, ribonucleases, or RNA binding proteins. We have purified and exploited several of these factors as targets for antimicrobial drug discovery.

Relevant Recent Publications:

1. Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis. Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, and Dunman PM. PLoS Pathogens 2011 (in press).


2. Characterizing the effects of inorganic acid and alkaline shock on the Staphylococcus aureus transcriptome and messenger RNA turnover. Anderson KL, Roux CM, Olson MW, Luong TT, Lee CY, Olson R, and Dunman PM. FEMS Immunol Med Microbiol 2010 60(3):208.

3. Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence. Wyatt MA, Wang W, Roux CM, Beasley FC, Heinrichs DE, Dunman PM and Magarvey NA. Science 2010 329(5989):294.

4. Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis. Jacobs AC, Hood I, Boyd KL, Olson PD, Morrison JM, Carson S, Sayood K, Iwen PC, Skaar EP, and Dunman PM. Infect Immun 2010 78(5):1952.

Patents

Small Molecule RNase Inhibitors and Methods of Use

Issue date: February 23, 2017

Patent #: 2012211253

Country: Australia

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: July 30, 2019

Patent #: 2,825,907

Country: Canada

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use (RNPase2000)

Issue date: September 23, 2016

Patent #: 6010548

Country: Japan

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: February 08, 2017

Patent #: ZL201280015124.6

Country: China, People's Republic of

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: May 31, 2017

Patent #: 2667873

Country: Europe

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: July 28, 2015

Patent #: 9,089,545

Country: United States

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: May 18, 2017

Patent #: 2012211299

Country: Australia

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: June 04, 2019

Patent #: 2,825,905

Country: Canada

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: January 02, 2019

Patent #: 2667872

Country: Europe

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: January 12, 2016

Patent #: 9,233,095

Country: United States

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: December 13, 2016

Patent #: 9,517,230

Country: United States

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: July 04, 2017

Patent #: 9,693,999

Country: United States

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use (RNPase3000)

Issue date: November 24, 2017

Patent #: 6248151

Country: Japan

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Methods and Compositions for Treating Infection

Issue date: June 26, 2018

Patent #: 10,004,701

Country: United States

Inventors: Paul M Dunman, Dan Flaherty, Damian J Krysan

Small Molecule RNase Inhibitors and Methods of Use

Issue date: December 18, 2017

Patent #: 2016225942

Country: Australia

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule Efflux Pump Inhibitors

Issue date: May 21, 2020

Patent #: 2015274427

Country: Australia

Inventors: Catlyn Blanchard, Paul M Dunman

Small Molecule Efflux Pump Inhibitors

Issue date: March 22, 2022

Patent #: 2,952,111

Country: Canada

Inventors: Catlyn Blanchard, Paul M Dunman

Small Molecule Efflux Pump Inhibitors

Issue date: February 12, 2020

Patent #: 3154534

Country: Europe

Inventors: Catlyn Blanchard, Paul M Dunman

Small Molecule Efflux Pump Inhibitors

Issue date: March 19, 2020

Patent #: 6678599

Country: Japan

Inventors: Catlyn Blanchard, Paul M Dunman

Small Molecule Efflux Pump Inhibitors

Issue date: November 12, 2019

Patent #: 10,471,028

Country: United States

Inventors: Catlyn Blanchard, Paul M Dunman

Synergistic Compositions for Treating Microbial Infections

Issue date: March 12, 2020

Patent #: 2015339039

Country: Australia

Inventors: Wayne Childers, Paul M Dunman

Synergistic Compositions for Treating Microbial Infections

Issue date: November 06, 2020

Patent #: ZL201580057031.3

Country: China, People's Republic of

Inventors: Wayne Childers, Paul M Dunman

Synergistic Compositions for Treating Microbial Infections

Issue date: October 02, 2019

Patent #: 3212183

Country: Europe

Inventors: Wayne Childers, Paul M Dunman

Synergistic Compositions for Treating Microbial Infections

Issue date: September 27, 2019

Patent #: 6590924

Country: Japan

Inventors: Wayne Childers, Paul M Dunman

Synergistic Compositions for Treating Microbial Infections

Issue date: July 24, 2018

Patent #: 10,028,931

Country: United States

Inventors: Wayne Childers, Paul M Dunman

Small Molecule RNase Inhibitors and Methods of Use

Issue date: June 05, 2019

Patent #: 3243513

Country: Europe

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: May 31, 2017

Patent #: FR2667873

Country: France

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: May 31, 2017

Patent #: DE2667873

Country: Germany

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: May 31, 2017

Patent #: GB2667873

Country: United Kingdom

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Prevention and Treatment of Microbial Infections

Issue date: October 07, 2020

Patent #: 2558090

Country: United Kingdom

Inventors: Paul M Dunman

Prevention and Treatment for Microbial Infections

Issue date: July 20, 2021

Patent #: 11,065,274

Country: United States

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: January 27, 2021

Patent #: 3331496

Country: Europe

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: September 03, 2021

Patent #: ZL2016800579666

Country: China, People's Republic of

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: January 07, 2020

Patent #: 10,525,032

Country: United States

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: October 26, 2020

Patent #: 6783476

Country: Japan

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: September 09, 2021

Patent #: 2016301247

Country: Australia

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: September 24, 2021

Patent #: 11201800775V

Country: Singapore

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: January 20, 2022

Patent #: 389498

Country: Mexico

Inventors: Paul M Dunman

Small Molecule RNase Inhibitors and Methods of Use

Issue date: January 02, 2019

Patent #: FR2667872

Country: France

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: January 02, 2019

Patent #: DE2667872

Country: Germany

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: January 02, 2019

Patent #: GB2667872

Country: United Kingdom

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: May 28, 2021

Patent #: HK1254365

Country: Hong Kong

Inventors: Paul M Dunman

Pharmaceutical Composition Containing Polymyxin B/Trimethoprim Based Therapeutics

Issue date: March 23, 2022

Patent #: 3500254

Country: Europe

Inventors: Paul M Dunman, Rachel A Wozniak

Pharmaceutical Composition Containing Polymyxin B/Trimethoprim Based Therapeutics

Issue date: August 24, 2021

Patent #: 11,096,923

Country: United States

Inventors: Paul M Dunman, Rachel A Wozniak

Small Molecule RNase Inhibitors and Methods of Use

Issue date: June 05, 2019

Patent #: FR3243513

Country: France

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: June 05, 2019

Patent #: DE3243513

Country: Germany

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Small Molecule RNase Inhibitors and Methods of Use

Issue date: June 05, 2019

Patent #: GB3243513

Country: United Kingdom

Inventors: Wayne Childers, Paul M Dunman, Patrick D Olson

Synergistic Compositions for Treating Microbial Infections

Issue date: October 02, 2019

Patent #: FR3212183

Country: France

Inventors: Wayne Childers, Paul M Dunman

Synergistic Compositions for Treating Microbial Infections

Issue date: October 02, 2019

Patent #: DE3212183

Country: Germany

Inventors: Wayne Childers, Paul M Dunman

Synergistic Compositions for Treating Microbial Infections

Issue date: October 02, 2019

Patent #: GB3212183

Country: United Kingdom

Inventors: Wayne Childers, Paul M Dunman

Small Molecule Efflux Pump Inhibitors

Issue date: February 12, 2020

Patent #: FR3154534

Country: France

Inventors: Catlyn Blanchard, Paul M Dunman

Small Molecule Efflux Pump Inhibitors

Issue date: February 12, 2020

Patent #: DE3154534

Country: Germany

Inventors: Catlyn Blanchard, Paul M Dunman

Small Molecule Efflux Pump Inhibitors

Issue date: February 12, 2020

Patent #: GB3154534

Country: United Kingdom

Inventors: Catlyn Blanchard, Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: January 27, 2021

Patent #: FR3331496

Country: France

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: January 27, 2021

Patent #: DE3331496

Country: Germany

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: January 27, 2021

Patent #: IT3331496

Country: Italy

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: January 27, 2021

Patent #: NL3331496

Country: Netherlands

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: January 27, 2021

Patent #: ES3331496

Country: Spain

Inventors: Paul M Dunman

Antimicrobial Compositions Comprising Mupirocin and Neomycin

Issue date: January 27, 2021

Patent #: GB3331496

Country: United Kingdom

Inventors: Paul M Dunman

Pharmaceutical Composition Containing Polymyxin B/Trimethoprim Based Therapeutics

Issue date: March 23, 2022

Patent #: FR3500254

Country: France

Inventors: Paul M Dunman, Rachel A Wozniak

Pharmaceutical Composition Containing Polymyxin B/Trimethoprim Based Therapeutics

Issue date: March 23, 2022

Patent #: DE3500254

Country: Germany

Inventors: Paul M Dunman, Rachel A Wozniak

Pharmaceutical Composition Containing Polymyxin B/Trimethoprim Based Therapeutics

Issue date: March 23, 2022

Patent #: IT3500254

Country: Italy

Inventors: Paul M Dunman, Rachel A Wozniak

Pharmaceutical Composition Containing Polymyxin B/Trimethoprim Based Therapeutics

Issue date: March 23, 2022

Patent #: NL3500254

Country: Netherlands

Inventors: Paul M Dunman, Rachel A Wozniak

Pharmaceutical Composition Containing Polymyxin B/Trimethoprim Based Therapeutics

Issue date: March 23, 2022

Patent #: ES3500254

Country: Spain

Inventors: Paul M Dunman, Rachel A Wozniak

Pharmaceutical Composition Containing Polymyxin B/Trimethoprim Based Therapeutics

Issue date: March 23, 2022

Patent #: GB3500254

Country: United Kingdom

Inventors: Paul M Dunman, Rachel A Wozniak

Publications

Journal Articles

Efficacy of a Novel Antibiotic Drug Combination Toward Multidrug-Resistant Ocular Pathogens.

Gowtham L, Wozniak RAF, Dunman PM, Sheba E, Garg P, Joseph J

Cornea.. 2024 August 143 (8):1044-1048. Epub 03/26/2024.

Development of phenyl-urea-based small molecules that target penicillin-binding protein 4.

Gondil VS, Butman HS, Young M, Walsh DJ, Narkhede Y, Zeiler MJ, Crow AH, Carpenter ME, Mardikar A, Melander RJ, Wiest O, Dunman PM, Melander C

Chemical biology & drug design.. 2024 June 103 (6):e14569. Epub 1900 01 01.

Post-transcriptional control of the essential enzyme MurF by a small regulatory RNA in Brucella abortus.

King KA, Benton AH, Caudill MT, Stoyanof ST, Kang L, Michalak P, Lahmers KK, Dunman PM, DeHart TG, Ahmad SS, Jutras BL, Poncin K, De Bolle X, Caswell CC

Molecular microbiology.. 2024 January 121 (1):129-141. Epub 12/11/2023.

Identifying novel radioprotective drugs via salivary gland tissue chip screening.

Piraino L, Chen CY, Mereness J, Dunman PM, Ovitt C, Benoit D, DeLouise L

bioRxiv : the preprint server for biology.. 2023 July 13 Epub 07/13/2023.

Genetic Determinants of Serum-Associated Adaptive Efflux-Mediated Antibiotic Resistance.

Young M, Chojnacki M, Blanchard C, Cao X, Johnson WL, Flaherty D, Dunman PM

Antibiotics.. 2023 July 1112 (7)Epub 07/11/2023.

Identification of Penicillin Binding Protein 4 (PBP4) Inhibitors.

Young M, Walsh DJ, Masters E, Gondil VS, Laskey E, Klaczko M, Awad H, McGrath J, Schwarz EM, Melander C, Dunman PM

Antibiotics.. 2022 October 411 (10)Epub 10/04/2022.

Antimicrobial Activity of a Triple Antibiotic Combination Toward Ocular Pseudomonas aeruginosa Clinical Isolates.

Mei JA, Johnson W, Kinn B, Laskey E, Nolin L, Bhamare P, Stalker C, Dunman PM, Wozniak RAF

Translational vision science & technology.. 2022 May 211 (5):26. Epub 1900 01 01.

A Modular Synthetic Route Involving -Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents.

Yang H, Kundra S, Chojnacki M, Liu K, Fuse MA, Abouelhassan Y, Kallifidas D, Zhang P, Huang G, Jin S, Ding Y, Luesch H, Rohde KH, Dunman PM, Lemos JA, Huigens RW

Journal of medicinal chemistry.. 2021 June 1064 (11):7275-7295. Epub 04/21/2021.

RnpA Inhibitors: Computational-Guided Design, Synthesis and Initial Biological Evaluation.

Suigo L, Chojnacki M, Zanotto C, Sebastián-Pérez V, Morghen CG, Casiraghi A, Dunman PM, Valoti E, Straniero V

Antibiotics.. 2021 April 1410 (4)Epub 04/14/2021.

Optimization of 2-Acylaminocycloalkylthiophene Derivatives for Activity against RnpA.

Chojnacki M, Cao X, Flaherty DP, Dunman PM

Antibiotics.. 2021 March 3110 (4)Epub 03/31/2021.

Evaluating the Antimicrobial Properties of Commercial Hand Sanitizers.

Chojnacki M, Dobrotka C, Osborn R, Johnson W, Young M, Meyer B, Laskey E, Wozniak RAF, Dewhurst S, Dunman PM

mSphere.. 2021 March 36 (2)Epub 03/03/2021.

Staphylococcus aureus resistance to albocycline can be achieved by mutations that alter cellular NAD/PH pools.

Scherzi T, D'Ambrosio EA, Daher SS, Grimes CL, Dunman PM, Andrade RB

Bioorganic & medicinal chemistry.. 2021 February 1532 :115995. Epub 01/07/2021.

Genomics of Staphylococcus aureus ocular isolates.

Johnson WL, Sohn MB, Taffner S, Chatterjee P, Dunman PM, Pecora N, Wozniak RAF

PloS one.. 2021 16 (5):e0250975. Epub 05/03/2021.

Serum-Associated Antibiotic Tolerance in Pediatric Clinical Isolates of Pseudomonas aeruginosa.

Morrison JM, Chojnacki M, Fadrowski JJ, Bauza C, Dunman PM, Dudas RA, Goldenberg NA, Berman DM

Journal of the Pediatric Infectious Diseases Society.. 2020 December 319 (6):671-679. Epub 1900 01 01.

Synthesis and biological evaluation of semi-synthetic albocycline analogs.

Daher SS, Franklin KP, Scherzi T, Dunman PM, Andrade RB

Bioorganic & medicinal chemistry letters.. 2020 November 130 (21):127509. Epub 08/19/2020.

Optimization of 4-Substituted Benzenesulfonamide Scaffold To Reverse Acinetobacter baumannii Serum-Adaptive Efflux Associated Antibiotic Tolerance.

Chojnacki M, Cao X, Young M, Fritz RN, Dunman PM, Flaherty DP

ChemMedChem.. 2020 September 1615 (18):1731-1740. Epub 08/13/2020.

Characterizing the Antimicrobial Properties of 405?nm Light and the Corning® Light-Diffusing Fiber Delivery System.

Shehatou C, Logunov SL, Dunman PM, Haidaris CG, Klubben WS

Lasers in surgery and medicine.. 2019 December 51 (10):887-896. Epub 07/14/2019.

A Novel, Broad-Spectrum Antimicrobial Combination for the Treatment of Pseudomonas aeruginosa Corneal Infections.

Chojnacki M, Philbrick A, Scherzi T, Pecora N, Dunman PM, Wozniak RAF

Antimicrobial agents and chemotherapy.. 2019 October 63 (10)Epub 09/23/2019.

Identification of Small Molecule Inhibitors of RnpA.

Colquhoun JM, Ha L, Beckley A, Meyers B, Flaherty DP, Dunman PM

Antibiotics.. 2019 April 288 (2)Epub 04/28/2019.

Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis.

Trombetta RP, Ninomiya MJ, El-Atawneh IM, Knapp EK, de Mesy Bentley KL, Dunman PM, Schwarz EM, Kates SL, Awad HA

Pharmaceutics.. 2019 February 2211 (2)Epub 02/22/2019.

Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal Infections.

Chojnacki M, Philbrick A, Wucher B, Reed JN, Tomaras A, Dunman PM, Wozniak RAF

Antimicrobial agents and chemotherapy.. 2019 January 63 (1)Epub 12/21/2018.

A High-Throughput Screening Approach To Repurpose FDA-Approved Drugs for Bactericidal Applications against Staphylococcus aureus Small-Colony Variants.

Trombetta RP, Dunman PM, Schwarz EM, Kates SL, Awad HA

mSphere.. 2018 October 313 (5)Epub 10/31/2018.

Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus.

Ha L, Colquhoun J, Noinaj N, Das C, Dunman PM, Flaherty DP

Acta crystallographica. Section F, Structural biology communications.. 2018 October 174 (Pt 10):632-637. Epub 09/19/2018.

Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus.

Liang H, Zhou G, Ge Y, D'Ambrosio EA, Eidem TM, Blanchard C, Shehatou C, Chatare VK, Dunman PM, Valentine AM, Voelz VA, Grimes CL, Andrade RB

Bioorganic & medicinal chemistry.. 2018 July 2326 (12):3453-3460. Epub 05/24/2018.

Endoribonuclease YbeY Is Linked to Proper Cellular Morphology and Virulence in Brucella abortus.

Budnick JA, Sheehan LM, Colquhoun JM, Dunman PM, Walker GC, Roop RM, Caswell CC

Journal of bacteriology.. 2018 June 15200 (12)Epub 05/24/2018.

Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin.

Lounsbury N, Eidem T, Colquhoun J, Mateo G, Abou-Gharbia M, Dunman PM, Childers WE

Bioorganic & medicinal chemistry letters.. 2018 April 128 (6):1127-1131. Epub 01/31/2018.

Identification of Staphylococcus aureus Cellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray.

Schwan WR, Polanowski R, Dunman PM, Medina-Bielski S, Lane M, Rott M, Lipker L, Wescott A, Monte A, Cook JM, Baumann DD, Tiruveedhula VVNPB, Witzigmann CM, Mikel C, Rahman MT

Antibiotics.. 2017 September 116 (3)Epub 09/11/2017.

A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus.

Choby JE, Mike LA, Mashruwala AA, Dutter BF, Dunman PM, Sulikowski GA, Boyd JM, Skaar EP

Cell chemical biology.. 2016 November 1723 (11):1351-1361. Epub 10/20/2016.

Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments.

Blanchard C, Brooks L, Beckley A, Colquhoun J, Dewhurst S, Dunman PM

Antimicrobial agents and chemotherapy.. 2016 February 60 (2):862-72. Epub 11/23/2015.

Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment.

Blanchard C, Brooks L, Ebsworth-Mojica K, Didione L, Wucher B, Dewhurst S, Krysan D, Dunman PM, Wozniak RA

mSphere.. 2016 1 (5)Epub 09/14/2016.

Bacterial Hypoxic Responses Revealed as Critical Determinants of the Host-Pathogen Outcome by TnSeq Analysis of Staphylococcus aureus Invasive Infection.

Wilde AD, Snyder DJ, Putnam NE, Valentino MD, Hammer ND, Lonergan ZR, Hinger SA, Aysanoa EE, Blanchard C, Dunman PM, Wasserman GA, Chen J, Shopsin B, Gilmore MS, Skaar EP, Cassat JE

PLoS pathogens.. 2015 December 11 (12):e1005341. Epub 12/18/2015.

A LysR-family transcriptional regulator required for virulence in Brucella abortus is highly conserved among the ?-proteobacteria.

Sheehan LM, Budnick JA, Blanchard C, Dunman PM, Caswell CC

Molecular microbiology.. 2015 October 98 (2):318-28. Epub 08/14/2015.

In the midst of the antimicrobial discovery conundrum: an overview.

Tomaras AP, Dunman PM

Current opinion in microbiology.. 2015 October 27 :103-7. Epub 09/08/2015.

Translational deficiencies in antibacterial discovery and new screening paradigms.

Dunman PM, Tomaras AP

Current opinion in microbiology.. 2015 October 27 :108-13. Epub 09/08/2015.

Editorial overview: Antimicrobials.

Dunman PM, Tomaras AP

Current opinion in microbiology.. 2015 October 27 :v-vii. Epub 09/15/2015.

Small-molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing.

Eidem TM, Lounsbury N, Emery JF, Bulger J, Smith A, Abou-Gharbia M, Childers W, Dunman PM

Antimicrobial agents and chemotherapy.. 2015 April 59 (4):2016-28. Epub 01/20/2015.

Rot is a key regulator of Staphylococcus aureus biofilm formation.

Mootz JM, Benson MA, Heim CE, Crosby HA, Kavanaugh JS, Dunman PM, Kielian T, Torres VJ, Horswill AR

Molecular microbiology.. 2015 April 96 (2):388-404. Epub 02/26/2015.

A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis.

Forbes L, Ebsworth-Mojica K, DiDone L, Li SG, Freundlich JS, Connell N, Dunman PM, Krysan DJ

PloS one.. 2015 10 (6):e0129234. Epub 06/22/2015.

Clinically Relevant Growth Conditions Alter Acinetobacter baumannii Antibiotic Susceptibility and Promote Identification of Novel Antibacterial Agents.

Colquhoun JM, Wozniak RA, Dunman PM

PloS one.. 2015 10 (11):e0143033. Epub 11/11/2015.

Identification of Acinetobacter baumannii serum-associated antibiotic efflux pump inhibitors.

Blanchard C, Barnett P, Perlmutter J, Dunman PM

Antimicrobial agents and chemotherapy.. 2014 November 58 (11):6360-70. Epub 08/11/2014.

Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus.

Perlmutter JI, Forbes LT, Krysan DJ, Ebsworth-Mojica K, Colquhoun JM, Wang JL, Dunman PM, Flaherty DP

Journal of medicinal chemistry.. 2014 October 2357 (20):8540-62. Epub 10/06/2014.

Staphylococcus epidermidis agr quorum-sensing system: signal identification, cross talk, and importance in colonization.

Olson ME, Todd DA, Schaeffer CR, Paharik AE, Van Dyke MJ, Büttner H, Dunman PM, Rohde H, Cech NB, Fey PD, Horswill AR

Journal of bacteriology.. 2014 October 196 (19):3482-93. Epub 07/28/2014.

Arginine deiminase in Staphylococcus epidermidis functions to augment biofilm maturation through pH homeostasis.

Lindgren JK, Thomas VC, Olson ME, Chaudhari SS, Nuxoll AS, Schaeffer CR, Lindgren KE, Jones J, Zimmerman MC, Dunman PM, Bayles KW, Fey PD

Journal of bacteriology.. 2014 June 196 (12):2277-89. Epub 04/11/2014.

Drug-eluting cements for hard tissue repair: a comparative study using vancomycin and RNPA1000 to inhibit growth of Staphylococcus aureus.

Eidem TM, Coughlan A, Towler MR, Dunman PM, Wren AW

Journal of biomaterials applications.. 2014 April 28 (8):1235-46. Epub 09/12/2013.

An ribonuclease T2 family protein modulates Acinetobacter baumannii abiotic surface colonization.

Jacobs AC, Blanchard CE, Catherman SC, Dunman PM, Murata Y

PloS one.. 2014 9 (1):e85729. Epub 01/28/2014.

Staphylococcus aureus gene expression in a rat model of infective endocarditis.

Hanses F, Roux C, Dunman PM, Salzberger B, Lee JC

Genome medicine.. 2014 6 (10):93. Epub 11/03/2014.

Global transcriptome analysis of Staphylococcus aureus biofilms in response to innate immune cells.

Scherr TD, Roux CM, Hanke ML, Angle A, Dunman PM, Kielian T

Infection and immunity.. 2013 December 81 (12):4363-76. Epub 09/16/2013.

The Staphylococcus aureus SrrAB two-component system promotes resistance to nitrosative stress and hypoxia.

Kinkel TL, Roux CM, Dunman PM, Fang FC

mBio.. 2013 November 124 (6):e00696-13. Epub 11/12/2013.

Transcriptional profiling of Staphylococcus aureus during growth in 2 M NaCl leads to clarification of physiological roles for Kdp and Ktr K+ uptake systems.

Price-Whelan A, Poon CK, Benson MA, Eidem TT, Roux CM, Boyd JM, Dunman PM, Torres VJ, Krulwich TA

mBio.. 2013 August 204 (4)Epub 08/20/2013.

Semen-derived enhancer of viral infection (SEVI) binds bacteria, enhances bacterial phagocytosis by macrophages, and can protect against vaginal infection by a sexually transmitted bacterial pathogen.

Easterhoff D, Ontiveros F, Brooks LR, Kim Y, Ross B, Silva JN, Olsen JS, Feng C, Hardy DJ, Dunman PM, Dewhurst S

Antimicrobial agents and chemotherapy.. 2013 June 57 (6):2443-50. Epub 03/18/2013.

Diverse genetic regulon of the virulence-associated transcriptional regulator MucR in Brucella abortus 2308.

Caswell CC, Elhassanny AE, Planchin EE, Roux CM, Weeks-Gorospe JN, Ficht TA, Dunman PM, Roop RM

Infection and immunity.. 2013 April 81 (4):1040-51. Epub 01/14/2013.

genetic determinants of intrinsic colistin tolerance in Acinetobacter baumannii.

Hood MI, Becker K, Roux CM, Dunman PM, Skaar EP

Infection and immunity.. 2013 February 81 (2):542-51. Epub 12/10/2012.

Adenylate kinase release as a high-throughput-screening-compatible reporter of bacterial lysis for identification of antibacterial agents.

Jacobs AC, Didone L, Jobson J, Sofia MK, Krysan D, Dunman PM

Antimicrobial agents and chemotherapy.. 2013 January 57 (1):26-36. Epub 10/01/2012.

Characterization of the effects of an rpoC mutation that confers resistance to the Fst peptide toxin-antitoxin system toxin.

Brinkman CL, Bumgarner R, Kittichotirat W, Dunman PM, Kuechenmeister LJ, Weaver KE

Journal of bacteriology.. 2013 January 195 (1):156-66. Epub 10/26/2012.

Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA.

Annadurai S, Martinez R, Canney DJ, Eidem T, Dunman PM, Abou-Gharbia M

Bioorganic & medicinal chemistry letters.. 2012 December 1522 (24):7719-25. Epub 10/03/2012.

Growth phase-dependent modulation of Rgg binding specificity in Streptococcus pyogenes.

Anbalagan S, Dmitriev A, McShan WM, Dunman PM, Chaussee MS

Journal of bacteriology.. 2012 August 194 (15):3961-71. Epub 05/25/2012.

Identification of two small regulatory RNAs linked to virulence in Brucella abortus 2308.

Caswell CC, Gaines JM, Ciborowski P, Smith D, Borchers CH, Roux CM, Sayood K, Dunman PM, Roop Ii RM

Molecular microbiology.. 2012 July 85 (2):345-60. Epub 06/12/2012.

Characterization of SSR42, a novel virulence factor regulatory RNA that contributes to the pathogenesis of a Staphylococcus aureus USA300 representative.

Morrison JM, Miller EW, Benson MA, Alonzo F, Yoong P, Torres VJ, Hinrichs SH, Dunman PM

Journal of bacteriology.. 2012 June 194 (11):2924-38. Epub 04/06/2012.

Characterization of the Acinetobacter baumannii growth phase-dependent and serum responsive transcriptomes.

Jacobs AC, Sayood K, Olmsted SB, Blanchard CE, Hinrichs S, Russell D, Dunman PM

FEMS immunology and medical microbiology.. 2012 April 64 (3):403-12. Epub 01/23/2012.

Genetic pathway in acquisition and loss of vancomycin resistance in a methicillin resistant Staphylococcus aureus (MRSA) strain of clonal type USA300.

Gardete S, Kim C, Hartmann BM, Mwangi M, Roux CM, Dunman PM, Chambers HF, Tomasz A

PLoS pathogens.. 2012 February 8 (2):e1002505. Epub 02/02/2012.

RNA decay: a novel therapeutic target in bacteria.

Eidem TM, Roux CM, Dunman PM

Wiley interdisciplinary reviews. RNA.. 2012 3 (3):443-54. Epub 02/28/2012.

The staphylococcal accessory regulator, SarA, is an RNA-binding protein that modulates the mRNA turnover properties of late-exponential and stationary phase Staphylococcus aureus cells.

Morrison JM, Anderson KL, Beenken KE, Smeltzer MS, Dunman PM

Frontiers in cellular and infection microbiology.. 2012 2 :26. Epub 03/08/2012.

Transcriptional profiling analysis of the global regulator NorG, a GntR-like protein of Staphylococcus aureus.

Truong-Bolduc QC, Dunman PM, Eidem T, Hooper DC

Journal of bacteriology.. 2011 November 193 (22):6207-14. Epub 09/09/2011.

Characterization of components of the Staphylococcus aureus mRNA degradosome holoenzyme-like complex.

Roux CM, Demuth JP, Dunman PM

Journal of bacteriology.. 2011 October 193 (19):5520-6. Epub 07/15/2011.

Rsp inhibits attachment and biofilm formation by repressing fnbA in Staphylococcus aureus MW2.

Lei MG, Cue D, Roux CM, Dunman PM, Lee CY

Journal of bacteriology.. 2011 October 193 (19):5231-41. Epub 07/29/2011.

The modulation of Staphylococcus aureus mRNA turnover.

Morrison JM, Dunman PM

Future microbiology.. 2011 October 6 (10):1141-50. Epub 1900 01 01.

Identification of Rgg binding sites in the Streptococcus pyogenes chromosome.

Anbalagan S, McShan WM, Dunman PM, Chaussee MS

Journal of bacteriology.. 2011 September 193 (18):4933-42. Epub 07/15/2011.

Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis.

Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, Dunman PM

PLoS pathogens.. 2011 February 107 (2):e1001287. Epub 02/10/2011.

Staphylococcus aureus ClpC divergently regulates capsule via sae and codY in strain newman but activates capsule via codY in strain UAMS-1 and in strain Newman with repaired saeS.

Luong TT, Sau K, Roux C, Sau S, Dunman PM, Lee CY

Journal of bacteriology.. 2011 February 193 (3):686-94. Epub 12/03/2010.

Characterizing the effects of inorganic acid and alkaline shock on the Staphylococcus aureus transcriptome and messenger RNA turnover.

Anderson KL, Roux CM, Olson MW, Luong TT, Lee CY, Olson R, Dunman PM

FEMS immunology and medical microbiology.. 2010 December 60 (3):208-50. Epub 10/06/2010.

Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence.

Wyatt MA, Wang W, Roux CM, Beasley FC, Heinrichs DE, Dunman PM, Magarvey NA

Science.. 2010 July 16329 (5989):294-6. Epub 06/03/2010.

Direct targets of CodY in Staphylococcus aureus.

Majerczyk CD, Dunman PM, Luong TT, Lee CY, Sadykov MR, Somerville GA, Bodi K, Sonenshein AL

Journal of bacteriology.. 2010 June 192 (11):2861-77. Epub 04/02/2010.

Golden pigment production and virulence gene expression are affected by metabolisms in Staphylococcus aureus.

Lan L, Cheng A, Dunman PM, Missiakas D, He C

Journal of bacteriology.. 2010 June 192 (12):3068-77. Epub 04/16/2010.

Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis.

Jacobs AC, Hood I, Boyd KL, Olson PD, Morrison J, Carson S, Sayood K, Iwen PC, Skaar EP, Dunman PM

Infection and immunity.. 2010 May 78 (5):1952-62. Epub 03/01/2010.

Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia.

Torres VJ, Attia AS, Mason WJ, Hood MI, Corbin BD, Beasley FC, Anderson KL, Stauff DL, McDonald WH, Zimmerman LJ, Friedman DB, Heinrichs DE, Dunman PM, Skaar EP

Infection and immunity.. 2010 April 78 (4):1618-28. Epub 01/25/2010.

Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations.

Hood MI, Jacobs AC, Sayood K, Dunman PM, Skaar EP

Antimicrobial agents and chemotherapy.. 2010 March 54 (3):1029-41. Epub 12/22/2009.

Comparative genomics of epidemic versus sporadic Staphylococcus aureus strains does not reveal molecular markers for epidemicity.

Kuhn G, Koessler T, Melles DC, Francois P, Huyghe A, Dunman P, Vos MC, Zanetti G, Schrenzel J, van Belkum A, Blanc DS

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.. 2010 January 10 (1):89-96. Epub 10/31/2009.

Improved hydrophobicity of carbon nanotube arrays with micropatterning.

Lu SH, Ni Tun MH, Mei ZJ, Chia GH, Lim X, Sow CH

Langmuir : the ACS journal of surfaces and colloids.. 2009 November 325 (21):12806-11. Epub 1900 01 01.

Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC.

Cue D, Lei MG, Luong TT, Kuechenmeister L, Dunman PM, O'Donnell S, Rowe S, O'Gara JP, Lee CY

Journal of bacteriology.. 2009 October 191 (20):6363-73. Epub 08/14/2009.

The Staphylococcus aureus LytSR two-component regulatory system affects biofilm formation.

Sharma-Kuinkel BK, Mann EE, Ahn JS, Kuechenmeister LJ, Dunman PM, Bayles KW

Journal of bacteriology.. 2009 August 191 (15):4767-75. Epub 06/05/2009.

Comparative genomic analysis of European and Middle Eastern community-associated methicillin-resistant Staphylococcus aureus (CC80:ST80-IV) isolates by high-density microarray.

Goering RV, Larsen AR, Skov R, Tenover FC, Anderson KL, Dunman PM

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.. 2009 August 15 (8):748-55. Epub 06/11/2009.

Regulation of mprF in daptomycin-nonsusceptible Staphylococcus aureus strains.

Yang SJ, Xiong YQ, Dunman PM, Schrenzel J, François P, Peschel A, Bayer AS

Antimicrobial agents and chemotherapy.. 2009 June 53 (6):2636-7. Epub 03/16/2009.

The use of molecular beacons to directly measure bacterial mRNA abundances and transcript degradation.

Kuechenmeister LJ, Anderson KL, Morrison JM, Dunman PM

Journal of microbiological methods.. 2009 February 76 (2):146-51. Epub 10/25/2008.

A new oxidative sensing and regulation pathway mediated by the MgrA homologue SarZ in Staphylococcus aureus.

Chen PR, Nishida S, Poor CB, Cheng A, Bae T, Kuechenmeister L, Dunman PM, Missiakas D, He C

Molecular microbiology.. 2009 January 71 (1):198-211. Epub 11/05/2008.

Messenger RNA Turnover Processes in Escherichia coli, Bacillus subtilis, and Emerging Studies in Staphylococcus aureus.

Anderson KL, Dunman PM

International journal of microbiology. 2009 2009 :525491. Epub 03/05/2009.

Staphylococcus aureus HrtA is an ATPase required for protection against heme toxicity and prevention of a transcriptional heme stress response.

Stauff DL, Bagaley D, Torres VJ, Joyce R, Anderson KL, Kuechenmeister L, Dunman PM, Skaar EP

Journal of bacteriology.. 2008 May 190 (10):3588-96. Epub 03/07/2008.

Metal chelation and inhibition of bacterial growth in tissue abscesses.

Corbin BD, Seeley EH, Raab A, Feldmann J, Miller MR, Torres VJ, Anderson KL, Dattilo BM, Dunman PM, Gerads R, Caprioli RM, Nacken W, Chazin WJ, Skaar EP

Science.. 2008 February 15319 (5865):962-5. Epub 1900 01 01.

Staphylococcus epidermidis saeR is an effector of anaerobic growth and a mediator of acute inflammation.

Handke LD, Rogers KL, Olson ME, Somerville GA, Jerrells TJ, Rupp ME, Dunman PM, Fey PD

Infection and immunity.. 2008 January 76 (1):141-52. Epub 10/22/2007.

Target-based antimicrobial drug discovery.

Alksne LE, Dunman PM

Methods in molecular biology.. 2008 431 :271-83. Epub 1900 01 01.

A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence.

Torres VJ, Stauff DL, Pishchany G, Bezbradica JS, Gordy LE, Iturregui J, Anderson KL, Dunman PM, Joyce S, Skaar EP

Cell host & microbe.. 2007 April 191 (2):109-19. Epub 1900 01 01.

Staphylococcal vaccines and immunotherapy: to dream the impossible dream?

Projan SJ, Nesin M, Dunman PM

Current opinion in pharmacology.. 2006 October 6 (5):473-9. Epub 07/25/2006.

Characterization of the Staphylococcus aureus heat shock, cold shock, stringent, and SOS responses and their effects on log-phase mRNA turnover.

Anderson KL, Roberts C, Disz T, Vonstein V, Hwang K, Overbeek R, Olson PD, Projan SJ, Dunman PM

Journal of bacteriology.. 2006 October 188 (19):6739-56. Epub 1900 01 01.

Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences in comparison to the laboratory strain RN6390.

Cassat J, Dunman PM, Murphy E, Projan SJ, Beenken KE, Palm KJ, Yang SJ, Rice KC, Bayles KW, Smeltzer MS

Microbiology.. 2006 October 152 (Pt 10):3075-3090. Epub 1900 01 01.

The nitrosative stress response of Staphylococcus aureus is required for resistance to innate immunity.

Richardson AR, Dunman PM, Fang FC

Molecular microbiology.. 2006 August 61 (4):927-39. Epub 07/12/2006.

Characterizing the effect of the Staphylococcus aureus virulence factor regulator, SarA, on log-phase mRNA half-lives.

Roberts C, Anderson KL, Murphy E, Projan SJ, Mounts W, Hurlburt B, Smeltzer M, Overbeek R, Disz T, Dunman PM

Journal of bacteriology.. 2006 April 188 (7):2593-603. Epub 1900 01 01.

Characterization of the Staphylococcus aureus CidR regulon: elucidation of a novel role for acetoin metabolism in cell death and lysis.

Yang SJ, Dunman PM, Projan SJ, Bayles KW

Molecular microbiology.. 2006 April 60 (2):458-68. Epub 1900 01 01.

Transcription Profiling of the mgrA Regulon in Staphylococcus aureus.

Luong TT, Dunman PM, Murphy E, Projan SJ, Lee CY

Journal of bacteriology.. 2006 March 188 (5):1899-910. Epub 1900 01 01.

Characterization of a strain of community-associated methicillin-resistant Staphylococcus aureus widely disseminated in the United States.

Tenover FC, McDougal LK, Goering RV, Killgore G, Projan SJ, Patel JB, Dunman PM

Journal of clinical microbiology.. 2006 January 44 (1):108-18. Epub 1900 01 01.

Use of ribotyping to retrospectively identify methicillin-resistant Staphylococcus aureus isolates from phase 3 clinical trials for tigecycline that are genotypically related to community-associated isolates.

McAleese F, Murphy E, Babinchak T, Singh G, Said-Salim B, Kreiswirth B, Dunman P, O'Connell J, Projan SJ, Bradford PA

Antimicrobial agents and chemotherapy.. 2005 November 49 (11):4521-9. Epub 1900 01 01.

Improving the treatment of musculoskeletal infections with molecular diagnostics.

Tarkin IS, Dunman PM, Garvin KL

Clinical orthopaedics and related research.. 2005 August (437):83-8. Epub 1900 01 01.

A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline.

McAleese F, Petersen P, Ruzin A, Dunman PM, Murphy E, Projan SJ, Bradford PA

Antimicrobial agents and chemotherapy.. 2005 May 49 (5):1865-71. Epub 1900 01 01.

MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus.

Truong-Bolduc QC, Dunman PM, Strahilevitz J, Projan SJ, Hooper DC

Journal of bacteriology.. 2005 April 187 (7):2395-405. Epub 1900 01 01.

Role of sigmaB in the expression of Staphylococcus aureus cell wall adhesins ClfA and FnbA and contribution to infectivity in a rat model of experimental endocarditis.

Entenza JM, Moreillon P, Senn MM, Kormanec J, Dunman PM, Berger-Bächi B, Projan S, Bischoff M

Infection and immunity.. 2005 February 73 (2):990-8. Epub 1900 01 01.

Comparative genomics of Staphylococcus aureus musculoskeletal isolates.

Cassat JE, Dunman PM, McAleese F, Murphy E, Projan SJ, Smeltzer MS

Journal of bacteriology.. 2005 January 187 (2):576-92. Epub 1900 01 01.

Effect of mild acid on gene expression in Staphylococcus aureus.

Weinrick B, Dunman PM, McAleese F, Murphy E, Projan SJ, Fang Y, Novick RP

Journal of bacteriology.. 2004 December 186 (24):8407-23. Epub 1900 01 01.

Uses of Staphylococcus aureus GeneChips in genotyping and genetic composition analysis.

Dunman PM, Mounts W, McAleese F, Immermann F, Macapagal D, Marsilio E, McDougal L, Tenover FC, Bradford PA, Petersen PJ, Projan SJ, Murphy E

Journal of clinical microbiology.. 2004 September 42 (9):4275-83. Epub 1900 01 01.

Microarray-based analysis of the Staphylococcus aureus sigmaB regulon.

Bischoff M, Dunman P, Kormanec J, Macapagal D, Murphy E, Mounts W, Berger-Bächi B, Projan S

Journal of bacteriology.. 2004 July 186 (13):4085-99. Epub 1900 01 01.

Global gene expression in Staphylococcus aureus biofilms.

Beenken KE, Dunman PM, McAleese F, Macapagal D, Murphy E, Projan SJ, Blevins JS, Smeltzer MS

Journal of bacteriology.. 2004 July 186 (14):4665-84. Epub 1900 01 01.

Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon.

Utaida S, Dunman PM, Macapagal D, Murphy E, Projan SJ, Singh VK, Jayaswal RK, Wilkinson BJ

Microbiology.. 2003 October 149 (Pt 10):2719-2732. Epub 1900 01 01.

Passive immunization as prophylaxis: when and where will this work?

Dunman PM, Nesin M

Current opinion in pharmacology.. 2003 October 3 (5):486-96. Epub 1900 01 01.

Global regulation of Staphylococcus aureus genes by Rot.

Saïd-Salim B, Dunman PM, McAleese FM, Macapagal D, Murphy E, McNamara PJ, Arvidson S, Foster TJ, Projan SJ, Kreiswirth BN

Journal of bacteriology.. 2003 January 185 (2):610-9. Epub 1900 01 01.

Genomics in anti-infective drug discovery--getting to endgame.

Haney SA, Alksne LE, Dunman PM, Murphy E, Projan SJ

Current pharmaceutical design.. 2002 8 (13):1099-118. Epub 1900 01 01.

Transcription profiling-based identification of Staphylococcus aureus genes regulated by the agr and/or sarA loci.

Dunman PM, Murphy E, Haney S, Palacios D, Tucker-Kellogg G, Wu S, Brown EL, Zagursky RJ, Shlaes D, Projan SJ

Journal of bacteriology.. 2001 December 183 (24):7341-53. Epub 1900 01 01.

Antibiotic resistance in bacteria from magpies (Pica pica) and rabbits (Oryctolagus cuniculus) from west Wales.

Livermore DM, Warner M, Hall LM, Enne VI, Projan SJ, Dunman PM, Wooster SL, Harrison G

Environmental microbiology.. 2001 October 3 (10):658-61. Epub 1900 01 01.

Transcriptional profile analysis of the Staphylococcus aureus agr and sarA virulence loci.

Dunman, P.M., Murphy, E., Haney, S., Palacios, D., Brown, E.L., Wu, S., Tucker-Kellog, G., Zagursky, R., Shlaes, D., and S. Projan.

J Bact. 2001; 183(24):7341-53.

Escherichia coli cells defective for the recN gene display constitutive elevation of mutagenesis at 3,N(4)-ethenocytosine via an SOS-induced mechanism.

Dunman PM, Ren L, Rahman MS, Palejwala VA, Murphy HS, Volkert MR, Humayun MZ

Molecular microbiology.. 2000 August 37 (3):680-6. Epub 1900 01 01.

Replication of M13 single-stranded DNA bearing a site-specific ethenocytosine lesion by Escherichia coil cell extracts.

Wang G, Dunman PM, Humayun MZ

Cell research.. 1997 June 7 (1):1-12. Epub 1900 01 01.

Role of mismatch repair in the Escherichia coli UVM response.

Murphy HS, Palejwala VA, Rahman MS, Dunman PM, Wang G, Humayun MZ

Journal of bacteriology.. 1996 December 178 (23):6651-7. Epub 1900 01 01.

Effect of UVM induction on mutation fixation at non-pairing and mispairing DNA lesions.

Rahman MS, Dunman PM, Wang G, Murphy HS, Humayun MZ

Molecular microbiology.. 1996 November 22 (4):747-55. Epub 1900 01 01.

Alkylating agents induce UVM, a recA-independent inducible mutagenic phenomenon in Escherichia coli.

Wang G, Palejwala VA, Dunman PM, Aviv DH, Murphy HS, Rahman MS, Humayun MZ

Genetics.. 1995 November 141 (3):813-23. Epub 1900 01 01.

UVM, an ultraviolet-inducible RecA-independent mutagenic phenomenon in Escherichia coli.

Palejwala VA, Pandya GA, Bhanot OS, Solomon JJ, Murphy HS, Dunman PM, Humayun MZ

The Journal of biological chemistry.. 1994 November 4269 (44):27433-40. Epub 1900 01 01.

Books

Microbial Genomics and Drug Discovery. (2003)

Chapter: Expression Profiling Uses in Antibacterial Chemotherapy Development.

Authors: Dunman, P.M. and S.J. Projan.

Publisher: Marcel Dekker Inc. New York. 2003

Staphylococcal infection a (2001)

Chapter: The regulation of virulence in the Staphylococci.

Authors: Dunman, P.M. and S.J. Projan.

Publisher: Kluwer Academic/Plenum Publishers, New York. 2001