Gowrishankar Muthukrishnan earned his Ph.D. in Biomedical Sciences. He is a microbial immunologist with expertise in host-microbe interactions, bacterial pathogenesis, and immunobiology of Staphylococcus aureus infections. His graduate work aimed at understanding the S. aureus nasal carriage dynamic...
Gowrishankar Muthukrishnan earned his Ph.D. in Biomedical Sciences. He is a microbial immunologist with expertise in host-microbe interactions, bacterial pathogenesis, and immunobiology of Staphylococcus aureus infections. His graduate work aimed at understanding the S. aureus nasal carriage dynamics, in addition to identifying important host and microbial determinants that influence S. aureus nasal colonization in humans. His postdoctoral studies at the University of Rochester Medical Center involved numerous basic research projects related to human immune mechanisms and the development of supporting immunological methods for viral and bacterial vaccine research. He also worked on assessing functional humoral and cell-mediated responses in patients with S. aureus osteomyelitis, diabetic foot ulcer infections, and spine infections. As a faculty member within the Center for Musculoskeletal Research (CMSR), his research group is focused on understanding host-pathogen interactions and the osteoimmunology of orthopaedic infections. His research group also develops novel small animal models (humanized mice) to study bone infections.
Faculty Appointments
Assistant Professor
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Department of Orthopaedics, Center for Musculoskeletal Research (SMD)
Assistant Professor
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Department of Microbiology and Immunology (SMD) - Joint
Credentials
Post-doctoral Training & Residency
Center for Musculoskeletal Research, Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center 2017 - 2019
Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center 2015 - 2017
Education
PhD | University of Central Florida College of Medicine.Biomedical Sciences.2014
MS | University of Central Florida.Molecular Biology and Microbiology.2010
Masters in Engineering | Birla Institute of Technology and Science, Pilani, India.Biotechnology.2007
Awards
AO Research Institute Fellowship (Davos, Switzerland).2019 - 2021
Great Lakes International Imaging and Flow Cytometry Association (GLIIFCA 2016) Travel Award.2016
Great Lakes International Imaging and Flow Cytometry Association (GLIIFCA 2016) Best Poster Award.2016
Rudy Wodzinski Memorial Scholarship.2011 - 2012
Research
The research program in the Muthukrishnan Laboratory aims to understand the immunobiology of musculoskeletal infections, which remains among the most severe and devastating risk associated with orthopaedic surgery. Currently, there are no available immunotherapies to combat these debilitating infect...
The research program in the Muthukrishnan Laboratory aims to understand the immunobiology of musculoskeletal infections, which remains among the most severe and devastating risk associated with orthopaedic surgery. Currently, there are no available immunotherapies to combat these debilitating infections. Our lab is focused on uncovering host-pathogen interactions and the osteoimmunology of orthopaedic infections to aid in novel immunotherapy development. We utilize humanized mouse models, genetic mouse models of human disease, primary human patient samples, high dimensional flow cytometry, next-generation sequencing (scRNAseq, single cell immune profiling), and in vivo imaging techniques to study bone infections.
Saito M, McDonald KA, Grier AK, Meghwani H, Rangel-Moreno J, Becerril-Villanueva E, Gamboa-Dominguez A, Bruno J, Beck CA, Proctor RA, Kates SL, Schwarz EM, Muthukrishnan G
bioRxiv : the preprint server for biology.. 2024 December 31 Epub 12/31/2024.
Xie C, Ren Y, Weeks J, Rainbolt J, Mark Kenney H, Xue T, Allen F, Shu Y, Tay AJH, Lekkala S, Yeh SA, Muthukrishnan G, Gill AL, Gill SR, Kim M, Kates SL, Schwarz EM
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2024 March 42 (3):531-538. Epub 10/17/2023.
Kenney HM, Rangel-Moreno J, Peng Y, Chen KL, Bruno J, Embong A, Pritchett E, Fox JI, Becerril-Villanueva E, Gamboa-Domínguez A, Quataert S, Muthukrishnan G, Wood RW, Korman BD, Anolik JH, Xing L, Ritchlin CT, Schwarz EM, Wu CL
Frontiers in immunology.. 2023 14 :1237498. Epub 08/25/2023.
Adjei-Sowah E, Peng Y, Weeks J, Jonason JH, de Mesy Bentley KL, Masters E, Morita Y, Muthukrishnan G, Cherian P, Hu XE, McKenna CE, Ebetino FH, Sun S, Schwarz EM, Xie C
