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Martha Susiarjo, Ph.D.

Martha Susiarjo, Ph.D.

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Environmental Health Sciences Center

Epigenetics Facility

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About Me

Faculty Appointments

Professor - Department of Environmental Medicine (SMD)

Credentials

Post-doctoral Training & Residency

University of Pennsylvania
Mentor: Dr. Marisa Bartolomei
Project: Studying effects of environmental exposure on the mammalian epigenome and characterizing the relevant mechanisms leading to abnormal metabolic health in mice exposed to endocrine disrupting compounds 2008 - 2015

Education

PhD | Case Western Reserve University. Genetics. 2007

BA | Case Western Reserve University. Biology. 1999

Awards

Susan Heyner Award for Excellence in Research. 2013

Departmental Symposium Best Poster Award. 2003

Departmental and University Honors, magna cum laude. 1999

Russell M. Lawall Prize for Excellence in Biology. 1999

Phi Beta Kappa. 1998

ASEAN Student Research Award. 1998

University Dean's High Honor. 1995 - 1999

Research

Martha Susiarjo is an Associate Professor in the department of Environmental Medicine, and member of the Environmental Health Sciences Center. She received her PhD in Genetics from Case Western Reserve University School of Medicine and completed her postdoctoral fellowship at the Perelman School of ...
Martha Susiarjo is an Associate Professor in the department of Environmental Medicine, and member of the Environmental Health Sciences Center. She received her PhD in Genetics from Case Western Reserve University School of Medicine and completed her postdoctoral fellowship at the Perelman School of Medicine of the University of Pennsylvania. Research in the Susiarjo Lab investigates the underlying mechanisms of the developmental origin of health and disease focusing on how epigenetic mechanisms mediate gene-environment interaction. Her laboratory uses imprinted genes as epigenetic markers to test the effect of environmental exposure on DNA methylation regulation on fetal and placental development. Additional, she is also interested in elucidating the role of environmental exposure on maternal health during pregnancy and the potential beneficial role of nutritional supplementation. Her research is supported by R01 grants from NIH. The lab employs bisulfite sequencing analysis, mouse genetics and embryology, molecular biology, and next generation sequencing.

Publications

Journal Articles

Exercise and inflammatory cytokine regulation among older adults with myeloid malignancies.

Loh KP, Wang Y, Sanapala C, Gilmore N, Netherby-Winslow C, Mendler JH, Liesveld J, Huselton E, Williams AM, Klepin HD, Jensen-Battaglia M, Mustian K, Vertino P, Susiarjo M, Janelsins MC

Experimental gerontology.. 2024 March 187 :112364. Epub 01/25/2024.

Exposure to endocrine disrupting chemicals impacts immunological and metabolic status of women during pregnancy.

Merrill AK, Sobolewski M, Susiarjo M

Molecular and cellular endocrinology.. 2023 November 1577 :112031. Epub 07/26/2023.

Susceptibility to Low Vitamin B6 Diet-induced Gestational Diabetes Is Modulated by Strain Differences in Mice.

Spinelli P, Fields AM, Falcone S, Mesaros C, Susiarjo M

Endocrinology.. 2023 August 28164 (10)Epub 1900 01 01.

Exercise and epigenetic ages in older adults with myeloid malignancies.

Loh KP, Sanapala C, Jensen-Battaglia M, Rana A, Sohn MB, Watson E, Gilmore N, Klepin HD, Mendler JH, Liesveld J, Huselton E, LoCastro M, Susiarjo M, Netherby-Winslow C, Williams AM, Mustian K, Vertino P, Janelsins MC

European journal of medical research.. 2023 May 3028 (1):180. Epub 05/30/2023.

A single-arm pilot study of a mobile health exercise intervention (GO-EXCAP) in older patients with myeloid neoplasms.

Loh KP, Sanapala C, Watson EE, Jensen-Battaglia M, Janelsins MC, Klepin HD, Schnall R, Culakova E, Vertino P, Susiarjo M, Lin PJ, Mendler JH, Liesveld JL, Huselton EJ, Taberner K, Mohile SG, Mustian K

Blood advances.. 2022 July 126 (13):3850-3860. Epub 1900 01 01.

Protocol for a pilot randomized controlled trial of a mobile health exercise intervention for older patients with myeloid neoplasms (GO-EXCAP 2).

Loh KP, Sanapala C, Janelsins M, Klepin HD, Schnall R, Culakova E, Sohn MB, Vertino P, Susiarjo M, Jensen-Battaglia M, Becker MW, Liesveld J, Mendler JH, Huselton E, Lin PJ, Mustian K

Journal of geriatric oncology.. 2022 May 13 (4):545-553. Epub 12/21/2021.

Evaluating the Effects of BPA and TBBPA Exposure on Pregnancy Loss and Maternal-Fetal Immune Cells in Mice.

Reed JM, Spinelli P, Falcone S, He M, Goeke CM, Susiarjo M

Environmental health perspectives.. 2022 March 130 (3):37010. Epub 03/28/2022.

Characterization of the temporal, cell-specific and interferon-inducible patterns of indoleamine 2,3 dioxygenase 1 (IDO1) expression in the human placenta across gestation.

Murthy GG, Prideaux MA, Armstrong M, Kenney HM, Latchney SE, Susiarjo M, Murphy SP

Placenta.. 2021 November 115 :129-138. Epub 09/14/2021.

Developing and adapting a mobile health exercise intervention for older patients with myeloid neoplasms: A qualitative study.

Loh KP, Sanapala C, Di Giovanni G, Klepin HD, Janelsins M, Schnall R, Culakova E, Vertino P, Susiarjo M, Mendler JH, Liesveld JL, Lin PJ, Dunne RF, Kleckner I, Mustian K, Mohile SG

Journal of geriatric oncology.. 2021 July 12 (6):909-914. Epub 03/04/2021.

Vitamin B6 deficiency disrupts serotonin signaling in pancreatic islets and induces gestational diabetes in mice.

Fields AM, Welle K, Ho ES, Mesaros C, Susiarjo M

Communications biology.. 2021 March 264 (1):421. Epub 03/26/2021.

Lineage- and Sex-Dependent Behavioral and Biochemical Transgenerational Consequences of Developmental Exposure to Lead, Prenatal Stress, and Combined Lead and Prenatal Stress in Mice.

Sobolewski M, Abston K, Conrad K, Marvin E, Harvey K, Susiarjo M, Cory-Slechta DA

Environmental health perspectives.. 2020 February 128 (2):27001. Epub 02/05/2020.

Epigenetic Suppression of SERPINB1 Promotes Inflammation-Mediated Prostate Cancer Progression.

Lerman I, Ma X, Seger C, Maolake A, Garcia-Hernandez ML, Rangel-Moreno J, Ackerman J, Nastiuk KL, Susiarjo M, Hammes SR

Molecular cancer research : MCR.. 2019 April 17 (4):845-859. Epub 01/04/2019.

Thy1 (CD90) expression is regulated by DNA methylation during adipogenesis.

Flores EM, Woeller CF, Falsetta ML, Susiarjo M, Phipps RP

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2019 March 33 (3):3353-3363. Epub 10/30/2018.

Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss.

Spinelli P, Latchney SE, Reed JM, Fields A, Baier BS, Lu X, McCall MN, Murphy SP, Mak W, Susiarjo M

Human molecular genetics.. 2019 February 1528 (4):662-674. Epub 1900 01 01.

Endocrine-disrupting chemicals, epigenetics, and skeletal system dysfunction: exploration of links using bisphenol A as a model system.

Xin F, Smith LM, Susiarjo M, Bartolomei MS, Jepsen KJ

Environmental epigenetics.. 2018 April 4 (2):dvy002. Epub 04/26/2018.

Linking inter-individual variability to endocrine disruptors: insights for epigenetic inheritance.

Latchney SE, Fields AM, Susiarjo M

Mammalian genome : official journal of the International Mammalian Genome Society.. 2018 February 29 (1-2):141-152. Epub 12/07/2017.

Bile Acids and Tryptophan Metabolism Are Novel Pathways Involved in Metabolic Abnormalities in BPA-Exposed Pregnant Mice and Male Offspring.

Susiarjo M, Xin F, Stefaniak M, Mesaros C, Simmons RA, Bartolomei MS

Endocrinology.. 2017 August 1158 (8):2533-2542. Epub 1900 01 01.

DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD.

Sundar IK, Yin Q, Baier BS, Yan L, Mazur W, Li D, Susiarjo M, Rahman I

Clinical epigenetics.. 2017 9 :38. Epub 04/14/2017.

Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation?

Xin F, Susiarjo M, Bartolomei MS

Seminars in cell & developmental biology.. 2015 July 43 :66-75. Epub 05/28/2015.

Bisphenol a exposure disrupts metabolic health across multiple generations in the mouse.

Susiarjo M, Xin F, Bansal A, Stefaniak M, Li C, Simmons RA, Bartolomei MS

Endocrinology.. 2015 June 156 (6):2049-58. Epub 03/25/2015.

Epigenetics. You are what you eat, but what about your DNA?

Susiarjo M, Bartolomei MS

Science.. 2014 August 15345 (6198):733-4. Epub 1900 01 01.

Bisphenol a exposure disrupts genomic imprinting in the mouse.

Susiarjo M, Sasson I, Mesaros C, Bartolomei MS

PLoS genetics.. 2013 April 9 (4):e1003401. Epub 04/04/2013.

A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes.

Choufani S, Shapiro JS, Susiarjo M, Butcher DT, Grafodatskaya D, Lou Y, Ferreira JC, Pinto D, Scherer SW, Shaffer LG, Coullin P, Caniggia I, Beyene J, Slim R, Bartolomei MS, Weksberg R

Genome research.. 2011 March 21 (3):465-76. Epub 02/07/2011.

The bisphenol A experience: a primer for the analysis of environmental effects on mammalian reproduction.

Hunt PA, Susiarjo M, Rubio C, Hassold TJ

Biology of reproduction.. 2009 November 81 (5):807-13. Epub 05/20/2009.

Bisphenol A effects on the growing mouse oocyte are influenced by diet.

Muhlhauser A, Susiarjo M, Rubio C, Griswold J, Gorence G, Hassold T, Hunt PA

Biology of reproduction.. 2009 May 80 (5):1066-71. Epub 01/21/2009.

Analyzing mammalian female meiosis.

Susiarjo M, Rubio C, Hunt P

Methods in molecular biology.. 2009 558 :339-54. Epub 1900 01 01.

Imprinting and epigenetic changes in the early embryo.

Weaver JR, Susiarjo M, Bartolomei MS

Mammalian genome : official journal of the International Mammalian Genome Society.. 2009 20 (9-10):532-43. Epub 09/16/2009.

Evaluation of aneugenic effects of bisphenol A in somatic and germ cells of the mouse.

Pacchierotti F, Ranaldi R, Eichenlaub-Ritter U, Attia S, Adler ID

Mutation research.. 2008 March 12651 (1-2):64-70. Epub 11/04/2007.

Bisphenol A exposure disrupts egg development in the mouse.

Susiarjo M, Hunt P

Fertility and sterility.. 2008 February 89 (2 Suppl):e97. Epub 1900 01 01.

Bisphenol A exposure in utero disrupts early oogenesis in the mouse.

Susiarjo M, Hassold TJ, Freeman E, Hunt PA

PLoS genetics.. 2007 January 123 (1):e5. Epub 1900 01 01.

Bisphenol a exposure causes meiotic aneuploidy in the female mouse.

Hunt PA, Koehler KE, Susiarjo M, Hodges CA, Ilagan A, Voigt RC, Thomas S, Thomas BF, Hassold TJ

Current biology : CB.. 2003 April 113 (7):546-53. Epub 1900 01 01.

Books

The Epigenome and Developmental Origins of Health and Disease (2015)

Chapter: Introduction to Epigenetic Mechanisms: The Probable Common Thread for Various Developmental Origin of Health and Diseases Effects