Like thousands of medicinal chemists across the world I frequently spin my magnetic bars overnight, scratch round bottom flasks next morning as if the molecules are hiding somewhere in the flask walls and look at my harvest anxiously standing around my dirty and disorganized chemical hood hoping tha...
Like thousands of medicinal chemists across the world I frequently spin my magnetic bars overnight, scratch round bottom flasks next morning as if the molecules are hiding somewhere in the flask walls and look at my harvest anxiously standing around my dirty and disorganized chemical hood hoping that NMR and Mass will be okay and my hunt for that elusive molecule which is going to help someone rid of his/her disease to some extent is finally complete. In this tryst, I combine alphabets of cancer biology, tumor immunology, medicinal chemistry and some rudimentary pharmacology and drug design concepts and in vitro and in vivo models of tumors for screening; and seek guidance from molecular modeling/virtual screening experts and most recently with some extraterrestrial artificial intelligence (AI) nerds to design a drug-like molecule against a protein target which physicians or researchers believe has gone awry (based on their trust in p values) and is making some one sick.
Faculty Appointments
Research Associate Professor
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Department of Obstetrics and Gynecology (SMD)
M.Phil | India-Birla Institute of Tech and Science.Medicinal Chemistry.1996
Awards
Ranbaxy Research Fellowship.1999 - 2001
Senior Research Fellowship.1997 - 1998
Research
In team with renowned physicians, immunologists, cancer biologists and molecular modelling colleagues sitting in different continents and those extraterrestrial AI nerds situated somewhere on the west coast I currently focus on developing small molecule based immunotherapeutics for treatment of high...
In team with renowned physicians, immunologists, cancer biologists and molecular modelling colleagues sitting in different continents and those extraterrestrial AI nerds situated somewhere on the west coast I currently focus on developing small molecule based immunotherapeutics for treatment of high-risk malignancies such as but not limited to:
• Ovarian cancer • Neuroblastoma • Medulloblastoma • Pancreatic cancer • Melanoma • Colorectal cancer
Complexities of drug-discovery commerce aside, small molecule based immunotherapeutics can be a viable alternative or a great complementary armamentarium to antibody based immunotherapies for treatment of high-risk malignancies or diseases.
Patents
Derivatives of Vitamin D and Therapeutic Use Thereof
Issue date: May 11, 2011
Patent #: 1968383
Country: Europe
Inventors: Laurent Brard, Satyan Kalkunte, Rakesh K Singh
Heterocycles and Derivatives Thereof and Methods of Manufacture and Therapeutic Use
Issue date: May 05, 2015
Patent #: 9,024,039
Country: United States
Inventors: Laurent Brard, Satyan Kalkunte, Rakesh K Singh
N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Issue date: August 11, 2015
Patent #: 2,676,527
Country: Canada
Inventors: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh
N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Issue date: March 25, 2015
Patent #: 2114410
Country: Europe
Inventors: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh
N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Issue date: June 05, 2012
Patent #: 8,193,180
Country: United States
Inventors: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh
Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Issue date: June 02, 2021
Patent #: 3128996
Country: Europe
Inventors: Richard G Moore, Rakesh K Singh
Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Issue date: May 29, 2018
Patent #: 9,982,010
Country: United States
Inventors: Richard G Moore, Rakesh K Singh
Therapy for Malignant Disease Comprising the Inhibition of Human Epididymal Secretory Protein E4 and Immune Checkpoint Inhibitors
Issue date: December 14, 2021
Patent #: 2,981,068
Country: Canada
Inventors: Richard G Moore, Rakesh K Singh, Naohiro Yano
Therapy for Malignant Disease
Issue date: August 13, 2019
Patent #: 10,376,535
Country: United States
Inventors: Richard G Moore, Rakesh K Singh, Naohiro Yano
Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers
Issue date: December 09, 2020
Patent #: 3311165
Country: Europe
Inventors: Richard G Moore, Rakesh K Singh
Derivatives of Vitamin D and Therapeutic Use Thereof
Issue date: May 11, 2011
Patent #: FR1968383
Country: France
Inventors: Laurent Brard, Satyan Kalkunte, Rakesh K Singh
Derivatives of Vitamin D and Therapeutic Use Thereof
Issue date: May 11, 2011
Patent #: DE1968383
Country: Germany
Inventors: Laurent Brard, Satyan Kalkunte, Rakesh K Singh
N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Issue date: March 25, 2015
Patent #: FR2114410
Country: France
Inventors: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh
7-Dehydrocholesterol Derivatives and Methods Using Same
Issue date: June 16, 2020
Patent #: 10,683,324
Country: United States
Inventors: Richard G Moore, Rakesh K Singh
Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Issue date: June 15, 2021
Patent #: 11,034,719
Country: United States
Inventors: Richard G Moore, Rakesh K Singh
Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers
Issue date: December 09, 2020
Patent #: FR3311165
Country: France
Inventors: Richard G Moore, Rakesh K Singh
Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers
Issue date: December 09, 2020
Patent #: DE3311165
Country: Germany
Inventors: Richard G Moore, Rakesh K Singh
Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers
Issue date: December 09, 2020
Patent #: GB3311165
Country: United Kingdom
Inventors: Richard G Moore, Rakesh K Singh
Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Issue date: June 02, 2021
Patent #: FR3128996
Country: France
Inventors: Richard G Moore, Rakesh K Singh
Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Issue date: June 02, 2021
Patent #: DE3128996
Country: Germany
Inventors: Richard G Moore, Rakesh K Singh
Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Sahasrabudhe DM, Liesveld JL, Minhajuddin M, Singh NA, Nath S, Kumar VM, Balys M, Evans AG, Azadniv M, Hansen JN, Becker MW, Sharon A, Thomas VK, Moore RG, Khera MK, Jordan CT, Singh RK
Scientific reports.. 2024 June 414 (1):12868. Epub 06/04/2024.
Khazan N, Quarato ER, Singh NA, Snyder CWA, Moore T, Miller JP, Yasui M, Teramoto Y, Goto T, Reshi S, Hong J, Zhang N, Pandey D, Srivastava P, Morell A, Kawano H, Kawano Y, Conley T, Sahasrabudhe DM, Yano N, Miyamoto H, Aljitawi O, Liesveld J, Becker MW, Calvi LM, Zhovmer AS, Tabdanov ED, Dokholyan NV, Linehan DC, Hansen JN, Gerber SA, Sharon A, Khera MK, Jurutka PW, Rochel N, Kim KK, Rowswell-Turner RB, Singh RK, Moore RG
Khazan N, Kim KK, Hansen JN, Singh NA, Moore T, Snyder CWA, Pandita R, Strawderman M, Fujihara M, Takamura Y, Jian Y, Battaglia N, Yano N, Teramoto Y, Arnold LA, Hopson R, Kishor K, Nayak S, Ojha D, Sharon A, Ashton JM, Wang J, Milano MT, Miyamoto H, Linehan DC, Gerber SA, Kawar N, Singh AP, Tabdanov ED, Dokholyan NV, Kakuta H, Jurutka PW, Schor NF, Rowswell-Turner RB, Singh RK, Moore RG
Journal of medicinal chemistry.. 2022 April 2865 (8):6039-6055. Epub 04/11/2022.
Rowswell-Turner RB, Singh RK, Urh A, Yano N, Kim KK, Khazan N, Pandita R, Sivagnanalingam U, Hovanesian V, James NE, Ribeiro JR, Kadambi S, Linehan DC, Moore RG
The Journal of immunology : official journal of the American Association of Immunologists.. 2021 May 15206 (10):2478-2488. Epub 04/26/2021.
Kawar N, Maclaughlan S, Horan TC, Uzun A, Lange TS, Kim KK, Hopson R, Singh AP, Sidhu PS, Glass KA, Shaw S, Padbury JF, Vorsa N, Arnold LA, Moore RG, Brard L, Singh RK
Moore RG, Lange TS, Robinson K, Kim KK, Uzun A, Horan TC, Kawar N, Yano N, Chu SR, Mao Q, Brard L, DePaepe ME, Padbury JF, Arnold LA, Brodsky A, Shen TL, Singh RK
Lange TS, Singh RK, Kim KK, Zou Y, Kalkunte SS, Sholler GL, Swamy N, Brard L
Chemical biology & drug design.. 2007 October 70 (4):302-10. Epub 1900 01 01.
A simple and efficient synthesis of 8-methyl-3, 8-diazabicyclo[3.2.1]octane (azatropane) and 3-substituted azatropanes therefrom using pyroglutamic acid.
Singh RK, Jain S, Sinha N, Mehta A, Naqvi F, Agarwal AK and Anand N.