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Krishnan Padmanabhan, Ph.D.

Krishnan Padmanabhan, Ph.D.

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Office (585) 275-0698

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About Me

Dr. Padmanabhan received his BS in Biology and History and his MS in Physiological Sciences at the University of California, Los Angeles, his PhD at Carnegie Mellon University and was the Francis Crick-Irwin Jacobs Junior Fellow at the Salk Institute of Biological Studies before arriving at the Univ...
Dr. Padmanabhan received his BS in Biology and History and his MS in Physiological Sciences at the University of California, Los Angeles, his PhD at Carnegie Mellon University and was the Francis Crick-Irwin Jacobs Junior Fellow at the Salk Institute of Biological Studies before arriving at the University of Rochester.

Faculty Appointments

Associate Professor - Department of Neuroscience (SMD)

Associate Professor - Department of Biomedical Engineering (SMD) - Joint

Research

Dr. Padmanabhan's research aims to understand principles of neuronal function in the mammalian brain using experimental and computational methods with a focus on uncovering the biological bases of psychiatric disorders. Work in the Padmanabhan lab uses multi-electrode electrophysiology, induced-Plu...
Dr. Padmanabhan's research aims to understand principles of neuronal function in the mammalian brain using experimental and computational methods with a focus on uncovering the biological bases of psychiatric disorders. Work in the Padmanabhan lab uses multi-electrode electrophysiology, induced-Pluripotent Stem Cell (iPSC) technology, imaging, and theoretical models to address three outstanding questions in neuroscience.

1) How does the brain represents features of the world via patterns of neuronal activity?
2) How does memory and experience shape the process of sensory perception?
3) How are these functions disrupted in neurological and psychiatric disorders?

Publications

Journal Articles

Adult-neurogenesis allows for representational stability and flexibility in early olfactory system.

Chen Z, Padmanabhan K

bioRxiv : the preprint server for biology.. 2024 July 4 Epub 07/04/2024.

Rigor and reproducibility in human brain organoid research: Where we are and where we need to go.

Sandoval SO, Cappuccio G, Kruth K, Osenberg S, Khalil SM, Méndez-Albelo NM, Padmanabhan K, Wang D, Niciu MJ, Bhattacharyya A, Stein JL, Sousa AMM, Waxman EA, Buttermore ED, Whye D, Sirois CL, , Williams A, Maletic-Savatic M, Zhao X

Stem cell reports.. 2024 June 1119 (6):796-816. Epub 05/16/2024.

Differential disruptions in population coding along the dorsal-ventral axis of CA1 in the APP/PS1 mouse model of A? pathology.

Chockanathan U, Padmanabhan K

PLoS computational biology.. 2024 May 20 (5):e1012085. Epub 05/06/2024.

Network size affects the complexity of activity in human iPSC-derived neuronal populations.

Uzun YS, Santos R, Marchetto MC, Padmanabhan K

bioRxiv : the preprint server for biology.. 2023 November 2 Epub 11/02/2023.

Algebraic approach to spike-time neural codes in the hippocampus.

Pasini FW, Busch AN, Miná? J, Padmanabhan K, Muller L

Physical review. E.. 2023 November 108 (5-1):054404. Epub 1900 01 01.

High-resolution structural and functional retinal imaging in the awake behaving mouse.

Feng G, Joseph A, Dholakia K, Shang F, Pfeifer CW, Power D, Padmanabhan K, Schallek J

Communications biology.. 2023 May 296 (1):572. Epub 05/29/2023.

From synapses to circuits and back: Bridging levels of understanding in animal models of Alzheimer's disease.

Chockanthan U, Padmanabhan K

The European journal of neuroscience.. 2022 November 56 (9):5564-5586. Epub 03/14/2022.

Emerging Multiorgan Klebsiella pneumoniae Invasive Syndrome Leading to Septic Shock: A Case Report and Review of the Literature.

Villanueva DM, Taunk P, Krishnan P, Figueroa N

Cure?us.. 2022 July 14 (7):e26647. Epub 07/07/2022.

Top-down feedback enables flexible coding strategies in the olfactory cortex.

Chen Z, Padmanabhan K

Cell reports.. 2022 March 2238 (12):110545. Epub 1900 01 01.

Changes in pairwise correlations during running reshape global network state in the main olfactory bulb.

Chockanathan U, Crosier EJW, Waddle S, Lyman E, Gerkin RC, Padmanabhan K

Journal of neurophysiology.. 2021 May 1125 (5):1612-1623. Epub 03/03/2021.

Divergence in Population Coding for Space between Dorsal and Ventral CA1.

Chockanathan U, Padmanabhan K

eNeuro.. 2021 8 (5)Epub 09/07/2021.

Sex differences in head-fixed voluntary running behavior in C57BL/6J mice.

Warner EJ, Padmanabhan K

The European journal of neuroscience.. 2020 February 51 (3):721-730. Epub 12/30/2019.

Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer's disease.

Chockanathan U, Warner EJ, Turpin L, O'Banion MK, Padmanabhan K

Scientific reports.. 2020 January 2310 (1):1077. Epub 01/23/2020.

Top-Down Control of Inhibitory Granule Cells in the Main Olfactory Bulb Reshapes Neural Dynamics Giving Rise to a Diversity of Computations.

Chen Z, Padmanabhan K

Frontiers in computational neuroscience.. 2020 14 :59. Epub 07/13/2020.

Species-specific maturation profiles of human, chimpanzee and bonobo neural cells.

Marchetto MC, Hrvoj-Mihic B, Kerman BE, Yu DX, Vadodaria KC, Linker SB, Narvaiza I, Santos R, Denli AM, Mendes AP, Oefner R, Cook J, McHenry L, Grasmick JM, Heard K, Fredlender C, Randolph-Moore L, Kshirsagar R, Xenitopoulos R, Chou G, Hah N, Muotri AR, Padmanabhan K, Semendeferi K, Gage FH

eLife.. 2019 February 78 Epub 02/07/2019.

Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.

Sarkar A, Mei A, Paquola ACM, Stern S, Bardy C, Klug JR, Kim S, Neshat N, Kim HJ, Ku M, Shokhirev MN, Adamowicz DH, Marchetto MC, Jappelli R, Erwin JA, Padmanabhan K, Shtrahman M, Jin X, Gage FH

Cell stem cell.. 2018 May 322 (5):684-697.e9. Epub 1900 01 01.

Centrifugal Inputs to the Main Olfactory Bulb Revealed Through Whole Brain Circuit-Mapping.

Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ

Frontiers in neuroanatomy.. 2018 12 :115. Epub 01/07/2019.

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals.

Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR

Molecular psychiatry.. 2017 June 22 (6):820-835. Epub 07/05/2016.

Diverse Representations of Olfactory Information in Centrifugal Feedback Projections.

Padmanabhan K, Osakada F, Tarabrina A, Kizer E, Callaway EM, Gage FH, Sejnowski TJ

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2016 July 1336 (28):7535-45. Epub 1900 01 01.

An Empirical Model for Reliable Spiking Activity.

Wang W, Tripathy SJ, Padmanabhan K, Urban NN, Kass RE

Neural computation.. 2015 August 27 (8):1609-23. Epub 06/16/2015.

Disrupting information coding via block of 4-AP-sensitive potassium channels.

Padmanabhan K, Urban NN

Journal of neurophysiology.. 2014 September 1112 (5):1054-66. Epub 06/03/2014.

Intermediate intrinsic diversity enhances neural population coding.

Tripathy SJ, Padmanabhan K, Gerkin RC, Urban NN

Proceedings of the National Academy of Sciences of the United States of America.. 2013 May 14110 (20):8248-53. Epub 04/29/2013.

A novel algorithm for optimal image thresholding of biological data.

Padmanabhan K, Eddy WF, Crowley JC

Journal of neuroscience methods.. 2010 November 30193 (2):380-4. Epub 09/15/2010.

Intrinsic biophysical diversity decorrelates neuronal firing while increasing information content.

Padmanabhan K, Urban NN

Nature neuroscience.. 2010 October 13 (10):1276-82. Epub 08/29/2010.

Multi-photon imaging.

Padmanabhan K, Andrews SE, Fitzpatrick JA

Current protocols in cytometry. 2010 October Chapter 2 :Unit2.9. Epub 1900 01 01.

A simple method of in vitro electroporation allows visualization, recording, and calcium imaging of local neuronal circuits.

Hovis KR, Padmanabhan K, Urban NN

Journal of neuroscience methods.. 2010 August 15191 (1):1-10. Epub 1900 01 01.

Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.

Gräub R, Lancero H, Pedersen A, Chu M, Padmanabhan K, Xu XQ, Spitz P, Chalkley R, Burlingame AL, Stokoe D, Bernstein HS

Cell cycle.. 2008 June 157 (12):1795-803. Epub 06/25/2008.

E2F-1 regulates the expression of a subset of target genes during skeletal myoblast hypertrophy.

Hlaing M, Spitz P, Padmanabhan K, Cabezas B, Barker CS, Bernstein HS

The Journal of biological chemistry.. 2004 October 15279 (42):43625-33. Epub 08/09/2004.