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Kyu Kwang Kim, Ph.D.

Contact

Call Center (585) 276-3000

About Me

Faculty Appointments

Research Associate Professor - Department of Obstetrics and Gynecology (SMD)

Credentials

Post-doctoral Training & Residency

Brown University and Women and Infants Hospital of Rhode Island, Providence, RI 2006 - 2012

Education

PhD | Louisiana State University. Chemistry. 2005

Research

Patents

N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use

Issue date: August 11, 2015

N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use

Issue date: March 25, 2015

N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use

Issue date: June 05, 2012

N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use

Issue date: March 25, 2015

Publications

Journal Articles

AI is a viable alternative to high throughput screening: a 318-target study.

Scientific reports.. 2024 April 214 (1):7526. Epub 04/02/2024.

Forchlorfenuron-Induced Mitochondrial Respiration Inhibition and Metabolic Shifts in Endometrial Cancer.

Kim K, Khazan N, Rowswell-Turner RB, Singh RK, Moore T, Strawderman MS, Miller JP, Snyder CWA, Awada A, Moore RG

Cancers.. 2024 February 2816 (5)Epub 02/28/2024.

Analytical performance of the FDA-cleared Parsortix PC1 system.

Templeman A, Miller MC, Cooke MJ, O'Shannessy DJ, Gurung Y, Pereira T, Peters SG, Piano M, Teo M, Khazan N, Kim K, Cohen E, Lopez HB, Alvarez F, Ciccioli M, Pailhes-Jimenez AS

Journal of circulating biomarkers.. 2023 12 :26-33. Epub 08/07/2023.

A Multi-Center Clinical Study to Harvest and Characterize Circulating Tumor Cells from Patients with Metastatic Breast Cancer Using the Parsortix PC1 System.

Cohen EN, Jayachandran G, Moore RG, Cristofanilli M, Lang JE, Khoury JD, Press MF, Kim KK, Khazan N, Zhang Q, Zhang Y, Kaur P, Guzman R, Miller MC, Reuben JM, Ueno NT

Cancers.. 2022 October 2614 (21)Epub 10/26/2022.

Malignancy Assessment Using Gene Identification in Captured Cells Algorithm for the Prediction of Malignancy in Women With a Pelvic Mass.

Moore RG, Khazan N, Coulter MA, Singh R, Miller MC, Sivagnanalingam U, DuBeshter B, Angel C, Liu C, Seto K, Englert D, Meachem P, Kim KK

Obstetrics and gynecology.. 2022 October 1140 (4):631-642. Epub 09/07/2022.

Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors .

Khazan N, Kim KK, Hansen JN, Singh NA, Moore T, Snyder CWA, Pandita R, Strawderman M, Fujihara M, Takamura Y, Jian Y, Battaglia N, Yano N, Teramoto Y, Arnold LA, Hopson R, Kishor K, Nayak S, Ojha D, Sharon A, Ashton JM, Wang J, Milano MT, Miyamoto H, Linehan DC, Gerber SA, Kawar N, Singh AP, Tabdanov ED, Dokholyan NV, Kakuta H, Jurutka PW, Schor NF, Rowswell-Turner RB, Singh RK, Moore RG

Journal of medicinal chemistry.. 2022 April 2865 (8):6039-6055. Epub 04/11/2022.

HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression.

Rowswell-Turner RB, Singh RK, Urh A, Yano N, Kim KK, Khazan N, Pandita R, Sivagnanalingam U, Hovanesian V, James NE, Ribeiro JR, Kadambi S, Linehan DC, Moore RG

The Journal of immunology : official journal of the American Association of Immunologists.. 2021 May 15206 (10):2478-2488. Epub 04/26/2021.

Analysis of serum HE4 levels in various histologic subtypes of epithelial ovarian cancer and other malignant tumors.

Blackman A, Mitchell J, Rowswell-Turner R, Singh R, Kim KK, Eklund E, Skates S, Bast RC, Messerlian G, Miller MC, Moore RG

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.. 2021 43 (1):355-365. Epub 1900 01 01.

Development of Potent Forchlorfenuron Analogs and Their Cytotoxic Effect in Cancer Cell Lines.

Kim KK, Singh RK, Khazan N, Kodza A, Singh NA, Jones A, Sivagnanalingam U, Towner M, Itamochi H, Turner R, Moore RG

Scientific reports.. 2020 February 2410 (1):3241. Epub 02/24/2020.

Role of trypsin and protease-activated receptor-2 in ovarian cancer.

Kim KK, Turner R, Khazan N, Kodza A, Jones A, Singh RK, Moore RG

PloS one.. 2020 15 (5):e0232253. Epub 05/04/2020.

Novel Small Molecule MEK Inhibitor URML-3881 Enhances Cisplatin Sensitivity in Clear Cell Ovarian Cancer.

Rowswell-Turner RB, Rutishauser JA, Kim KK, Khazan N, Sivagnanalingam U, Jones AM, Singh RK, Moore RG

Translational oncology.. 2019 July 12 (7):917-924. Epub 05/10/2019.

Septin-2 is overexpressed in epithelial ovarian cancer and mediates proliferation via regulation of cellular metabolic proteins.

James NE, Cantillo E, Yano N, Chichester CO, DiSilvestro PA, Hovanesian V, Rao RSP, Kim KK, Moore RG, Ahsan N, Ribeiro JR

Oncotarget.. 2019 April 2610 (31):2959-2972. Epub 04/26/2019.

Human Epididymis Secretory Protein 4 (HE4) Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6.

James NE, Oliver MT, Ribeiro JR, Cantillo E, Rowswell-Turner RB, Kim KK, Chichester CO, DiSilvestro PA, Moore RG, Singh RK, Yano N, Zhao TC

Frontiers in pharmacology.. 2019 10 :216. Epub 03/19/2019.

HE4 suppresses the expression of osteopontin in mononuclear cells and compromises their cytotoxicity against ovarian cancer cells.

James NE, Cantillo E, Oliver MT, Rowswell-Turner RB, Ribeiro JR, Kim KK, Chichester CO, DiSilvestro PA, Moore RG, Singh RK, Yano N, Zhao TC

Clinical and experimental immunology.. 2018 September 193 (3):327-340. Epub 1900 01 01.

HE4 promotes collateral resistance to cisplatin and paclitaxel in ovarian cancer cells.

Ribeiro JR, Schorl C, Yano N, Romano N, Kim KK, Singh RK, Moore RG

Journal of ovarian research.. 2016 May 179 (1):28. Epub 05/17/2016.

Tetrathiomolybdate mediates cisplatin-induced p38 signaling and EGFR degradation and enhances response to cisplatin therapy in gynecologic cancers.

Kim KK, Han A, Yano N, Ribeiro JR, Lokich E, Singh RK, Moore RG

Scientific reports.. 2015 November 165 :15911. Epub 11/16/2015.

Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1? in cancer cells.

Kim KK, Abelman S, Yano N, Ribeiro JR, Singh RK, Tipping M, Moore RG

Scientific reports.. 2015 October 155 :14296. Epub 10/15/2015.

HE4 expression is associated with hormonal elements and mediated by importin-dependent nuclear translocation.

Lokich E, Singh RK, Han A, Romano N, Yano N, Kim K, Moore RG

Scientific reports.. 2014 June 304 :5500. Epub 06/30/2014.

HE4 (WFDC2) gene overexpression promotes ovarian tumor growth.

Moore RG, Hill EK, Horan T, Yano N, Kim K, MacLaughlan S, Lambert-Messerlian G, Tseng YD, Padbury JF, Miller MC, Lange TS, Singh RK

Scientific reports.. 2014 January 64 :3574. Epub 01/06/2014.

PT19c, Another Nonhypercalcemic Vitamin D2 Derivative, Demonstrates Antitumor Efficacy in Epithelial Ovarian and Endometrial Cancer Models.

Kawar N, Maclaughlan S, Horan TC, Uzun A, Lange TS, Kim KK, Hopson R, Singh AP, Sidhu PS, Glass KA, Shaw S, Padbury JF, Vorsa N, Arnold LA, Moore RG, Brard L, Singh RK

Genes & cancer.. 2013 November 4 (11-12):524-34. Epub 1900 01 01.

7 Methyl indole ethyl isothiocyanate causes ROS mediated apoptosis and cell cycle arrest in endometrial cancer cells.

Kristjansdottir K, Kim K, Choi JS, Horan TC, Brard L, Moore RG, Singh RK

Gynecologic oncology.. 2012 August 126 (2):252-8. Epub 05/02/2012.

Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C.

Kim KK, Lange TS, Singh RK, Brard L, Moore RG

BMC cancer.. 2012 April 1312 :147. Epub 04/13/2012.

Anti-angiogenic activity of cranberry proanthocyanidins and cytotoxic properties in ovarian cancer cells.

Kim KK, Singh AP, Singh RK, Demartino A, Brard L, Vorsa N, Lange TS, Moore RG

International journal of oncology.. 2012 January 40 (1):227-35. Epub 09/12/2011.

Cytotoxic properties of Adamantyl isothiocyanate and potential in vivo metabolite adamantyl-N-acetylcystein in gynecological cancer cells.

Lange TS, Horan TC, Kim KK, Singh AP, Vorsa N, Brard L, Moore RG, Singh RK

Chemical biology & drug design.. 2012 January 79 (1):92-103. Epub 11/04/2011.

Purified cranberry proanthocyanidines (PAC-1A) cause pro-apoptotic signaling, ROS generation, cyclophosphamide retention and cytotoxicity in high-risk neuroblastoma cells.

Singh AP, Lange TS, Kim KK, Brard L, Horan T, Moore RG, Vorsa N, Singh RK

International journal of oncology.. 2012 January 40 (1):99-108. Epub 10/06/2011.

Efficacy of a non-hypercalcemic vitamin-D2 derived anti-cancer agent (MT19c) and inhibition of fatty acid synthesis in an ovarian cancer xenograft model.

Moore RG, Lange TS, Robinson K, Kim KK, Uzun A, Horan TC, Kawar N, Yano N, Chu SR, Mao Q, Brard L, DePaepe ME, Padbury JF, Arnold LA, Brodsky A, Shen TL, Singh RK

PloS one.. 2012 7 (4):e34443. Epub 04/03/2012.

Evaluation of the first Ergocalciferol-derived, non hypercalcemic anti-cancer agent MT19c in ovarian cancer SKOV-3 cell lines.

Brard L, Lange TS, Robison K, Kim KK, Ara T, McCallum MM, Arnold LA, Moore RG, Singh RK

Gynecologic oncology.. 2011 November 123 (2):370-8. Epub 07/30/2011.

Integrated genomics of ovarian xenograft tumor progression and chemotherapy response.

Stuckey A, Fischer A, Miller DH, Hillenmeyer S, Kim KK, Ritz A, Singh RK, Raphael BJ, Brard L, Brodsky AS

BMC cancer.. 2011 July 2211 :308. Epub 07/22/2011.

Tetrathiomolybdate induces doxorubicin sensitivity in resistant tumor cell lines.

Kim KK, Kawar NM, Singh RK, Lange TS, Brard L, Moore RG

Gynecologic oncology.. 2011 July 122 (1):183-9. Epub 05/06/2011.

Oral RKS262 reduces tumor burden in a neuroblastoma xenograft animal model and mediates cytotoxicity through SAPK/JNK and ROS activation in vitro.

Singh RK, Dorf L, DeMartino A, Illenye S, Koto K, Currier EA, Ashikaga T, Kim KK, Brard L, Sholler GL

Cancer biology & therapy.. 2011 June 1511 (12):1036-45. Epub 06/15/2011.

Antitumor activity of nifurtimox is enhanced with tetrathiomolybdate in medulloblastoma.

Koto KS, Lescault P, Brard L, Kim K, Singh RK, Bond J, Illenye S, Slavik MA, Ashikaga T, Saulnier Sholler GL

International journal of oncology.. 2011 May 38 (5):1329-41. Epub 03/10/2011.

Organometallic iron(III)-salophene exerts cytotoxic properties in neuroblastoma cells via MAPK activation and ROS generation.

Kim KK, Singh RK, Strongin RM, Moore RG, Brard L, Lange TS

PloS one.. 2011 April 296 (4):e19049. Epub 04/29/2011.

A coumarin derivative (RKS262) inhibits cell-cycle progression, causes pro-apoptotic signaling and cytotoxicity in ovarian cancer cells.

Singh RK, Lange TS, Kim KK, Brard L

Investigational new drugs.. 2011 February 29 (1):63-72. Epub 10/29/2009.

Effect of a vitamin D(3) derivative (B3CD) with postulated anti-cancer activity in an ovarian cancer animal model.

Lange TS, Stuckey AR, Robison K, Kim KK, Singh RK, Raker CA, Brard L

Investigational new drugs.. 2010 October 28 (5):543-53. Epub 07/07/2009.

Chemotherapeutic effect of calcidiol derivative B3CD in a neuroblastoma xenograft model.

Lange TS, Zou Y, Singh RK, Kim KK, Kristjansdottir K, Sholler GL, Brard L

Chemical biology & drug design.. 2010 August 76 (2):164-73. Epub 05/11/2010.

Lipophilic aroylhydrazone chelator HNTMB and its multiple effects on ovarian cancer cells.

Kim KK, Lange TS, Singh RK, Brard L

BMC cancer.. 2010 February 2510 :72. Epub 02/25/2010.

Apoptotic and chemotherapeutic properties of iron (III)-salophene in an ovarian cancer animal model.

Lange TS, McCourt C, Singh RK, Kim KK, Singh AP, Luisi BS, Alptürk O, Strongin RM, Brard L

Drug design, development and therapy.. 2009 September 213 :17-26. Epub 09/21/2009.

Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin.

Singh AP, Singh RK, Kim KK, Satyan KS, Nussbaum R, Torres M, Brard L, Vorsa N

Phytotherapy research : PTR.. 2009 August 23 (8):1066-74. Epub 1900 01 01.

Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells.

Brard L, Singh RK, Kim KK, Lange TS, Sholler GL

Drug design, development and therapy.. 2009 February 62 :61-9. Epub 02/06/2009.

Isothiocyanate NB7M causes selective cytotoxicity, pro-apoptotic signalling and cell-cycle regression in ovarian cancer cells.

Singh RK, Lange TS, Kim KK, Singh AP, Vorsa N, Brard L

British journal of cancer.. 2008 December 299 (11):1823-31. Epub 11/11/2008.

Iron(III)-salophene: an organometallic compound with selective cytotoxic and anti-proliferative properties in platinum-resistant ovarian cancer cells.

Lange TS, Kim KK, Singh RK, Strongin RM, McCourt CK, Brard L

PloS one.. 2008 May 283 (5):e2303. Epub 05/28/2008.

A novel indole ethyl isothiocyanate (7Me-IEITC) with anti-proliferative and pro-apoptotic effects on platinum-resistant human ovarian cancer cells.

Singh RK, Lange TS, Kim KK, Shaw SK, Brard L

Gynecologic oncology.. 2008 May 109 (2):240-9. Epub 03/07/2008.

Synthesis of Bicyclic Aryl Thiazolines with Selective Anti-Proliferative Effects on Human Cancer Cell Lines

Brard L.; Singh R.K.; Lange T.S.; Kim K.; Singh A.P.; Hopson R.; Vorsa N.

Letters in organic chemistry. 2008; 5(2): 103-109.

Effect of indole ethyl isothiocyanates on proliferation, apoptosis, and MAPK signaling in neuroblastoma cell lines.

Singh RK, Lange TS, Kim K, Zou Y, Lieb C, Sholler GL, Brard L

Bioorganic & medicinal chemistry letters.. 2007 November 117 (21):5846-52. Epub 08/19/2007.

Anti-proliferative and pro-apoptotic properties of 3-bromoacetoxy calcidiol in high-risk neuroblastoma.

Lange TS, Singh RK, Kim KK, Zou Y, Kalkunte SS, Sholler GL, Swamy N, Brard L

Chemical biology & drug design.. 2007 October 70 (4):302-10. Epub 1900 01 01.

Stereochemical and regiochemical trends in the selective detection of saccharides.

Jiang S, Escobedo JO, Kim KK, Alptürk O, Samoei GK, Fakayode SO, Warner IM, Rusin O, Strongin RM

Journal of the American Chemical Society.. 2006 September 20128 (37):12221-8. Epub 1900 01 01.

Detection of homocysteine and cysteine.

Wang W, Rusin O, Xu X, Kim KK, Escobedo JO, Fakayode SO, Fletcher KA, Lowry M, Schowalter CM, Lawrence CM, Fronczek FR, Warner IM, Strongin RM

Journal of the American Chemical Society.. 2005 November 16127 (45):15949-58. Epub 1900 01 01.

Postcolumn HPLC detection of mono- and oligosaccharides with a chemosensor.

Kim KK, Escobedo JO, St Luce NN, Rusin O, Wong D, Strongin RM

Organic letters.. 2003 December 255 (26):5007-10. Epub 1900 01 01.

Chromophore formation in resorcinarene solutions and the visual detection of mono- and oligosaccharides.

He M, Johnson RJ, Escobedo JO, Beck PA, Kim KK, St Luce NN, Davis CJ, Lewis PT, Fronczek FR, Melancon BJ, Mrse AA, Treleaven WD, Strongin RM

Journal of the American Chemical Society.. 2002 May 8124 (18):5000-9. Epub 1900 01 01.

Books

Reviews in Fluorescence 2006 (2006)

Chapter: Detection of biological thiols