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Cesare Orlandi, Ph.D.

Cesare Orlandi, Ph.D.

he/him

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Office (585) 275-6613

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About Me

Faculty Appointments

Assistant Professor - Department of Pharmacology and Physiology (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral Research Associate
Department of Neuroscience; The Scripps Research Institute, Jupiter, FL
PI: Prof. Kirill Martemyanov
New mechanisms regulating G Protein Coupled Receptor (GPCR) signaling by orphan receptors GPR158/GPR179 in complex with R7-RGS proteins in mouse brain and retina. 2011 - 2018

Postdoctoral Research Associate
University of Brescia, Italy
Head Professors: Prof. Sergio Barlati and Prof. Alessandro Barbon
Analysis of the mechanisms that regulate the activity of Adenosine Deaminases Acting on RNA (ADAR), the enzymes responsible for the RNA editing reaction and their effect on glutamate and serotonin neurotransmission. 2010 - 2011

Research

The main focus of the lab research is to investigate the biology of a group of understudied G protein coupled receptors (GPCR) in brain and visual systems. Members of the large GPCR family are involved in the regulation of every aspect of human physiology. Because of their physiological relevance an...
The main focus of the lab research is to investigate the biology of a group of understudied G protein coupled receptors (GPCR) in brain and visual systems. Members of the large GPCR family are involved in the regulation of every aspect of human physiology. Because of their physiological relevance and localization at the plasma membrane GPCRs are ideal targets for drug development. Orphan GPCRs constitute a group of receptors whose endogenous ligands are still unknown. Nonetheless, the identification of disease-causing mutations in patients together with animal studies have established the involvement of orphan GPCRs in essential physiological processes. More broadly, the lab is interested in applying proteomics, biochemistry, microscopy imaging, and pharmacology to understand the role that orphan GPCRs play in shaping behavioral responses as well as the ways in which alterations in these complexes can lead to diseases.

Publications

Journal Articles

Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling.

Kwon J, Kawase H, Mattonet K, Guenther S, Hahnefeld L, Shamsara J, Heering J, Kurz M, Kirchhofer S, Krasel C, Ulrich M, Persechino M, Murthy S, Orlandi C, Sadik CD, Geisslinger G, Bünemann M, Kolb P, Offermanns S, Wettschureck N

Nature communications.. 2025 February 716 (1):1448. Epub 02/07/2025.

Gz Enhanced Signal Transduction assaY (GESTY) for GPCR deorphanization.

Franchini L, Porter JJ, Lueck JD, Orlandi C

bioRxiv : the preprint server for biology.. 2024 July 26 Epub 07/26/2024.

Deorphanization of G Protein Coupled Receptors: A Historical Perspective.

Franchini L, Orlandi C

Molecular pharmacology.. 2024 May 17105 (6):374-385. Epub 05/17/2024.

G Protein Signaling Bias at Serotonin 1A Receptor.

Alabdali R, Franchini L, Orlandi C

Molecular pharmacology.. 2023 November 104 (5):230-238. Epub 08/11/2023.

Probing the orphan receptors: Tools and directions.

Franchini L, Orlandi C

Progress in molecular biology and translational science.. 2023 195 :47-76. Epub 07/13/2022.

Comprehensive Spatial Profile of the Orphan G Protein Coupled Receptor GPRC5B Expression in Mouse Brain.

Fu W, Franchini L, Orlandi C

Frontiers in neuroscience.. 2022 16 :891544. Epub 06/23/2022.

In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity.

Watkins LR, Orlandi C

British journal of pharmacology.. 2021 August 178 (15):2963-2975. Epub 05/08/2021.

Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors.

Cao Y, Wang Y, Dunn HA, Orlandi C, Shultz N, Kamasawa N, Fitzpatrick D, Li W, Zeitz C, Hauswirth W, Martemyanov KA

Proceedings of the National Academy of Sciences of the United States of America.. 2020 September 22117 (38):23914-23924. Epub 09/02/2020.

Orphan G Protein Coupled Receptors in Affective Disorders.

Watkins LR, Orlandi C

Genes.. 2020 June 2411 (6)Epub 06/24/2020.

ELFN2 is a postsynaptic cell adhesion molecule with essential roles in controlling group III mGluRs in the brain and neuropsychiatric behavior.

Dunn HA, Zucca S, Dao M, Orlandi C, Martemyanov KA

Molecular psychiatry.. 2019 December 24 (12):1902-1919. Epub 09/04/2019.

Beyond the Ligand: Extracellular and Transcellular G Protein-Coupled Receptor Complexes in Physiology and Pharmacology.

Dunn HA, Orlandi C, Martemyanov KA

Pharmacological reviews.. 2019 October 71 (4):503-519. Epub 1900 01 01.

NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control.

Sutton LP, Muntean BS, Ostrovskaya O, Zucca S, Dao M, Orlandi C, Song C, Xie K, Martemyanov KA

PLoS biology.. 2019 October 17 (10):e3000477. Epub 10/10/2019.

Genetic behavioral screen identifies an orphan anti-opioid system.

Wang D, Stoveken HM, Zucca S, Dao M, Orlandi C, Song C, Masuho I, Johnston C, Opperman KJ, Giles AC, Gill MS, Lundquist EA, Grill B, Martemyanov KA

Science.. 2019 September 20365 (6459):1267-1273. Epub 08/15/2019.

The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex.

Song C, Orlandi C, Sutton LP, Martemyanov KA

The Journal of biological chemistry.. 2019 August 30294 (35):13145-13157. Epub 07/16/2019.

Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors.

Orlandi C, Sutton LP, Muntean BS, Song C, Martemyanov KA

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 2019 February 44 (3):642-653. Epub 10/11/2018.

Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is Differentially Regulated by Alternative Macromolecular Complexes of RGS7.

Ostrovskaya OI, Orlandi C, Fajardo-Serrano A, Young SM, Lujan R, Martemyanov KA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2018 November 1438 (46):10002-10015. Epub 10/12/2018.

An Input-Specific Orphan Receptor GPR158-HSPG Interaction Organizes Hippocampal Mossy Fiber-CA3 Synapses.

Condomitti G, Wierda KD, Schroeder A, Rubio SE, Vennekens KM, Orlandi C, Martemyanov KA, Gounko NV, Savas JN, de Wit J

Neuron.. 2018 October 10100 (1):201-215.e9. Epub 10/02/2018.

Transsynaptic Binding of Orphan Receptor GPR179 to Dystroglycan-Pikachurin Complex Is Essential for the Synaptic Organization of Photoreceptors.

Orlandi C, Omori Y, Wang Y, Cao Y, Ueno A, Roux MJ, Condomitti G, de Wit J, Kanagawa M, Furukawa T, Martemyanov KA

Cell reports.. 2018 October 225 (1):130-145.e5. Epub 1900 01 01.

Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors .

Dunn HA, Patil DN, Cao Y, Orlandi C, Martemyanov KA

Proceedings of the National Academy of Sciences of the United States of America.. 2018 May 8115 (19):5022-5027. Epub 04/23/2018.

LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors.

Sarria I, Cao Y, Wang Y, Ingram NT, Orlandi C, Kamasawa N, Kolesnikov AV, Pahlberg J, Kefalov VJ, Sampath AP, Martemyanov KA

Cell reports.. 2018 March 2722 (13):3562-3573. Epub 1900 01 01.

Orphan receptor GPR158 controls stress-induced depression.

Sutton LP, Orlandi C, Song C, Oh WC, Muntean BS, Xie K, Filippini A, Xie X, Satterfield R, Yaeger JDW, Renner KJ, Young SM, Xu B, Kwon H, Martemyanov KA

eLife.. 2018 February 87 Epub 02/08/2018.

NF1 Is a Direct G Protein Effector Essential for Opioid Signaling to Ras in the Striatum.

Xie K, Colgan LA, Dao MT, Muntean BS, Sutton LP, Orlandi C, Boye SL, Boye SE, Shih CC, Li Y, Xu B, Smith RG, Yasuda R, Martemyanov KA

Current biology : CB.. 2016 November 2126 (22):2992-3003. Epub 10/20/2016.

Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum.

Sutton LP, Ostrovskaya O, Dao M, Xie K, Orlandi C, Smith R, Wee S, Martemyanov KA

Biological psychiatry.. 2016 August 180 (3):235-45. Epub 08/14/2015.

Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by G?o and R7-binding Protein.

Tayou J, Wang Q, Jang GF, Pronin AN, Orlandi C, Martemyanov KA, Crabb JW, Slepak VZ

The Journal of biological chemistry.. 2016 April 22291 (17):9133-47. Epub 02/19/2016.

Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons.

Sarria I, Orlandi C, McCall MA, Gregg RG, Martemyanov KA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2016 March 936 (10):2915-25. Epub 1900 01 01.

The TRPM1 channel in ON-bipolar cells is gated by both the ? and the ?? subunits of the G-protein Go.

Xu Y, Orlandi C, Cao Y, Yang S, Choi CI, Pagadala V, Birnbaumer L, Martemyanov KA, Vardi N

Scientific reports.. 2016 February 176 :20940. Epub 02/17/2016.

Cellular and Subcellular Localization of the RGS7/G?5/R7BP Complex in the Cerebellar Cortex.

Aguado C, Orlandi C, Fajardo-Serrano A, Gil-Minguez M, Martemyanov KA, Luján R

Frontiers in neuroanatomy.. 2016 10 :114. Epub 11/30/2016.

Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision.

Cao Y, Sarria I, Fehlhaber KE, Kamasawa N, Orlandi C, James KN, Hazen JL, Gardner MR, Farzan M, Lee A, Baker S, Baldwin K, Sampath AP, Martemyanov KA

Neuron.. 2015 September 2387 (6):1248-1260. Epub 1900 01 01.

Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain.

Orlandi C, Xie K, Masuho I, Fajardo-Serrano A, Lujan R, Martemyanov KA

The Journal of biological chemistry.. 2015 May 29290 (22):13622-39. Epub 03/19/2015.

Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons.

Orlandi C, Cao Y, Martemyanov KA

Investigative ophthalmology & visual science.. 2013 October 2954 (10):7153-61. Epub 10/29/2013.

Modulation of dendritic AMPA receptor mRNA trafficking by RNA splicing and editing.

La Via L, Bonini D, Russo I, Orlandi C, Barlati S, Barbon A

Nucleic acids research.. 2013 January 741 (1):617-31. Epub 11/19/2012.

GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes.

Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA

The Journal of cell biology.. 2012 June 11197 (6):711-9. Epub 1900 01 01.

Activity regulation of adenosine deaminases acting on RNA (ADARs).

Orlandi C, Barbon A, Barlati S

Molecular neurobiology.. 2012 February 45 (1):61-75. Epub 11/20/2011.

Chronic antidepressant treatments induce a time-dependent up-regulation of AMPA receptor subunit protein levels.

Barbon A, Caracciolo L, Orlandi C, Musazzi L, Mallei A, La Via L, Bonini D, Mora C, Tardito D, Gennarelli M, Racagni G, Popoli M, Barlati S

Neurochemistry international.. 2011 November 59 (6):896-905. Epub 08/03/2011.

Antidepressant treatments change 5-HT2C receptor mRNA expression in rat prefrontal/frontal cortex and hippocampus.

Barbon A, Orlandi C, La Via L, Caracciolo L, Tardito D, Musazzi L, Mallei A, Gennarelli M, Racagni G, Popoli M, Barlati S

Neuropsychobiology. 2011 63 (3):160-8. Epub 01/13/2011.

AMPA receptor regulation at the mRNA and protein level in rat primary cortical cultures.

Orlandi C, La Via L, Bonini D, Mora C, Russo I, Barbon A, Barlati S

PloS one.. 2011 6 (9):e25350. Epub 09/22/2011.

Human GluR6c, a functional splicing variants of GluR6, is mainly expressed in non-nervous cells.

Barbon A, Gervasoni A, LaVia L, Orlandi C, Jaskolski F, Perrais D, Barlati S

Neuroscience letters.. 2008 March 21434 (1):77-82. Epub 02/02/2008.

Books

Progress in Molecular Biology and Translational Science (2022)

Chapter: Probing the orphan receptors: Tools and directions