CLYM21071 / S2005 / Zent
Research Question:
cancer study
Basic Study Information
Purpose:
This phase II trial studies the effects of venetoclax and rituximab in comparison
to ibrutinib and rituximab in treating patients with previously untreated Waldenstrom's
macroglobulinemia/lymphoplasmacytic lymphoma. Ibrutinib may stop the growth of cancer
cells by blocking some of the enzymes needed for cell growth. Rituximab is a monoclonal
antibody. It binds to a protein called CD20, which is found on B cells (a type of
white blood cell) and some types of cancer cells. This may help the immune system
kill cancer cells. Venetoclax is in a class of medications called B-cell lymphoma-2
(BCL-2) inhibitors. It may stop the growth of cancer cells by blocking Bcl-2, a protein
needed for cancer cell survival. Giving venetoclax and rituximab may work better in
treating patients with previously untreated Waldenstrom's macroglobulinemia than ibrutinib
and rituximab alone.
Location: University of Rochester
Lead Researcher (Principal Investigator)
Lead Researcher:
Clive Zent
Study Contact Information
Study Contact: Clinical Trials Office
Study Location: Wilmot Cancer Institute, University of Rochester Medical Center
Study Email: WCICTOResearch@urmc.rochester.edu
Additional Study Details
Trial Not Found
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