Majewska Lab
The Functional Synapse Group
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Specialized junctions between neurons (synapses)
that lead to changes in brain function.
Image courtesy of Serkan Oray
Our brains constantly remodel to adapt to a changing environment. The focus of our group is to understand the structural and functional changes that occur at the specialized junctions between neurons (synapses) that lead to changes in brain function. Our group uses advanced imaging techniques to study the structure and function of single synapses in networks in the intact brain. Although a vast literature describes the development and function of neuronal connectivity, most of this work has been carried out in culture and excised or fixed tissue, where dynamic processes are inferred from static images compared across animals. Little is known about the function of subcellular compartments in the computations carried out by neurons in vivo. The goal of our work is to understand structural and functional changes occurring at synapses during plasticity elicited by sensory stimuli.

Anna Majewska, Ph.D.
Principal Investigator
Projects
View All ProjectsPublications
- The microglial response to inhibition of Colony-stimulating-factor-1 receptor by PLX3397 differs by sex in adult mice.; Cell reports. 2025 Jan 09.
- Microglia morphology in the developing primate amygdala and effects of early life stress.; eNeuro. 2025 Jan 03.
- Partial microglial depletion and repopulation exert subtle but differential effects on amyloid pathology at different disease stages.; Scientific reports; Vol 14(1), pp. 30912. 2024 Dec 28.
- Basic Science and Pathogenesis.; Alzheimer's & dementia : the journal of the Alzheimer's Association; Vol 20 Suppl 1, pp. e090717. 2024 Dec.
Affiliations
News
January 21, 2025
Brain Immune Cells May also be From Mars and Venus
May 9, 2024
Majewska Lab Member Shares How Figures Help Effectively Communicate Science
April 24, 2023
Halting the Rise of Parkinson’s
Contact Us
Majewska Lab
601 Elmwood Ave,
Rochester, NY 14642