Mitochondrial Research and Innovation Group
Integrative Mitochondrial Physiology
The University of Rochester Mitochondrial Research and Innovation Group (MRIG) brings together laboratories with the common goal of understanding mitochondrial function to impact human disease. Our group studies mitochondria from all angles, bridging biophysics and biochemistry to integrative physiology and clinical outcomes.
We critically discuss the research from graduate students, postdoctoral associates and visiting scholars. We also discuss recent journal articles and conferences. MRIG is an excellent environment for trainees that is both rigorous and friendly to build the essential skills to carry out and present world-class mitochondrial research.
The models employed in our laboratories range from tissue culture and animal models (C. elegans, zebrafish, mouse, etc.) to clinical trials/human research.
Join us every Thursday, 9:00 am in the Fenn Room (URMC 4.6325). Our laboratories are always looking for new mitochondriacs!
Contact us for more information.
Publications
View All Publications- Interactive effects of temperature, cadmium, and hypoxia on rainbow trout (Oncorhynchus mykiss) liver mitochondrial bioenergetics.; Ecotoxicology and environmental safety; Vol 289, pp. 117450. 2024 Dec 03.
- Mitochondrial metabolism and redox signaling.; Redox biology. 2024 Nov 29.
- Energy metabolism in osteoprogenitors and osteoblasts: role of the Pentose Phosphate Pathway.; The Journal of biological chemistry. 2024 Nov 26.
- Mitochondrial Quality Control in Alzheimer's Disease: Insights from Caenorhabditis elegans Models.; Antioxidants (Basel, Switzerland); Vol 13(11). 2024 Nov 01.
- Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.; Acta neuropathologica; Vol 148(1), pp. 52. 2024 Oct 11.
- DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid β proteotoxicity.; Free radical biology & medicine. 2024 Sep 22.
- Cyclophilin D, regulator of the mitochondrial permeability transition, impacts bone development and fracture repair.; Bone. 2024 Sep 18.
- PPARγ drives mitochondrial stress signaling and the loss of atrial cardiomyocytes in newborn mice exposed to hyperoxia.; Redox biology; Vol 76, pp. 103351. 2024 Sep 12.
- DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid β proteotoxicity.; bioRxiv : the preprint server for biology. 2024 Aug 09.
- A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria.; eLife; Vol 12. 2024 Jul 31.
Affiliations
- Department of Anesthesiology and Perioperative Medicine
- Department of Pharmacology & Physiology
- Nephrology
- Department of Pediatrics
- Department of Neuroscience
- Orthopedics
- Center for Musculoskeletal Research
- Department of Biomedical Genetics
- Department of Microbiology and Immunology
- Department of Biology
- Aab Cardiovascular Research Institute
News
October 7, 2024
TRiMAD Mitochondria Conference comes to Rochester
January 2, 2024
TriMAD 11 is coming to Rochester in 2024!
Contact Us
Wojtovich Lab
575 Elmwood Ave, Box 711/604
Rochester, NY 14642