Mitochondrial Research and Innovation Group
Integrative Mitochondrial Physiology
The University of Rochester Mitochondrial Research and Innovation Group (MRIG) brings together laboratories with the common goal of understanding mitochondrial function to impact human disease. Our group studies mitochondria from all angles, bridging biophysics and biochemistry to integrative physiology and clinical outcomes.
We critically discuss the research from graduate students, postdoctoral associates and visiting scholars. We also discuss recent journal articles and conferences. MRIG is an excellent environment for trainees that is both rigorous and friendly to build the essential skills to carry out and present world-class mitochondrial research.
The models employed in our laboratories range from tissue culture and animal models (C. elegans, zebrafish, mouse, etc.) to clinical trials/human research.
Join us every Thursday, 9:00 am in the Fenn Room (URMC 4.6325). Our laboratories are always looking for new mitochondriacs!
Contact us for more information.
Publications
- Misconduct Detection - Evolving Methods & Lessons from 15 Years of Scientific Image Sleuthing.; The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics. 2025 Mar 27.
- Cyclophilin D (CypD) ablation prevents neurodegenerative and cognitive damage induced by caspase-3 cleaved tau.; Free radical biology & medicine. 2025 Feb 27.
- An Extensive Gap Junction Neural Network Modulates Caenorhabditis elegans Aversive Behavior.; Genes; Vol 16(3). 2025 Feb 23.
- Reevaluating Anti-Inflammatory Therapy: Targeting Senescence to Balance Anti-Cancer Efficacy and Vascular Disease.; Arteriosclerosis, thrombosis, and vascular biology. 2025 Jan 16.
- One BAG doesn't fit all: the differences and similarities of BAG family members in mediating CNS homeostasis.; Biological psychiatry. 2025 Jan 08.
- Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation.; PloS one; Vol 20(1), pp. e0307358. 2025 Jan 03.
- Transitioning From Nusinersen to Risdiplam for Spinal Muscular Atrophy in Clinical Practice: A Single-Center Experience.; Muscle & nerve. 2025 Jan 02.
- Post-burns persistent inflammation leads to kidney PANoptosis with Caspases pathway activation.; Heliyon; Vol 11(1), pp. e41485. 2024 Dec 28.
- Pharmacological Inhibition of Astrocytic Transglutaminase 2 Facilitates the Expression of a Neurosupportive Astrocyte Reactive Phenotype in Association with Increased Histone Acetylation.; Biomolecules; Vol 14(12). 2024 Dec 13.
- Interactive effects of temperature, cadmium, and hypoxia on rainbow trout (Oncorhynchus mykiss) liver mitochondrial bioenergetics.; Ecotoxicology and environmental safety; Vol 289, pp. 117450. 2024 Dec 03.
Affiliations
- Department of Anesthesiology and Perioperative Medicine
- Department of Pharmacology & Physiology
- Nephrology
- Department of Pediatrics
- Department of Neuroscience
- Orthopedics
- Center for Musculoskeletal Research
- Department of Biomedical Genetics
- Department of Microbiology and Immunology
- Department of Biology
- Aab Cardiovascular Research Institute
News
October 7, 2024
TRiMAD Mitochondria Conference comes to Rochester
January 2, 2024
TriMAD 11 is coming to Rochester in 2024!
Contact Us
Wojtovich Lab
575 Elmwood Ave, Box 711/604
Rochester, NY 14642