Faculty
Primary Faculty
Structural dynamics of the ribosome and ribosomal ligands during proteins synthesis, regulation of protein synthesis by mRNA structure in normal and diseased cells, and mechanisms of antibiotic action.
Crystallography and structural chemistry of enzyme-ligand interactions.
Investigating membranes and membrane proteins via computer simulation
X-ray crystallography and cryo-electron microscopy analysis of RNA and protein-RNA complexes
RNA metabolism in human cells (nonsense-mediated mRNA decay/mRNA surveillance); influence of pre-mRNA splicing on mRNA translation; Staufen-mediated mRNA decay and Staufen-regulated RNA metabolism; post-transcriptional gene control via lncRNAs and SINEs; miRNA metabolism; Fragile X Mental Retardation Syndrome/Autism; therapeutics of nonsense diseases.
Structural and functional investigation of the molecular mechanisms, dynamics, cellular organization, and spatiotemporal aspects of G protein and cyclase signaling pathways. Cryo-EM; GPCRs; membrane proteins; signal transduction.
Computational protein biophysics, bioinformatic approaches to protein folding and dynamics, development of novel methods of biomolecular sequence and structure comparison and analysis.
Mechanism and physiological importance of alternative polyadenylation; Integrator Complex and transcriptional control, development and application of next-generation sequencing technologies
Research Faculty
Secondary Faculty
Carbohydrate and protein recognition, molecular design, and biomolecular sensing
Pathophysiological function and molecular mechanism of new non-coding RNAs and RNA-binding proteins and translational control in cardiac system and cardiovascular disease
Emeritus Faculty
Hormone action in mammary cancer; Photodynamic therapy of neoplasia
Heme oxygenases and second messenger gases: CO and NO.
Molecular mechanisms of gene expression; transcription termination and mRNA 3' and formation in Escherichia coli and yeast; protein-nucleic acid.
