Pang Lab
Welcome to the Pang Lab
Angiogenesis, the formation of new blood vessels from existing ones, is a critical event for tissue development and repair, as well as being associated with many diseases (e.g. bronchopulmonary dysplasia(BPD), pulmonary artery hypertension (PAH), ischemic cardiomyopathy, retinopathy and tumor growth). Newly formed and pre-existing vessels are continuously under dynamic remodeling (including vessel regression, neointima formation and artery-vein specification) to accustom to changes of mechanic force, oxygen level, metabolites and inflammatory factors et al. The long-term goal of Dr. Pang’s lab is to illustrate the molecular mechanisms of angiogenesis and vascular remodeling under physiological and pathological conditions.
Jinjiang Pang, B.Med., Ph.D.
Principal Investigator
Publications
View All Publications- Vessel tech: a high-accuracy pipeline for comprehensive mouse retinal vasculature characterization.; Angiogenesis. 2020 Oct 09.
- Endothelial-to-Mesenchymal Transition and Inflammation Play Key Roles in Cyclophilin A-Induced Pulmonary Arterial Hypertension.; Hypertension (Dallas, Tex. : 1979). 2020 Aug 24.
- Rare Pulmonary Connective Tissue Type Mast Cells Regulate Lung Endothelial Cell Angiogenesis.; The American journal of pathology. 2020 May 22.
- Dll4-Notch1 signaling but not VEGF-A is essential for hyperoxia induced vessel regression in retina.; Biochemical and biophysical research communications; Vol 507(1-4). 2018 Jan 09.
- Phospholipase Cγ1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity.; Journal of the American Heart Association; Vol 6(7). 2017 Jul 11.
- Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis.; eLife; Vol 6. 2017 Mar 31.
Contact Us
Pang Lab
601 Elmwood Ave
Box CVRI
Rochester, NY 14642