URMC / Cardiovascular Research Institute / Research / Small Lab / Publications

Recent Publications

1. Liu X
2. Burke RM
3. Lighthouse JK
4. Baker CD
5. Dirkx RA
6. Kang B
7. Chakraborty Y
8. Mickelsen DM
9. Twardowski J
10. Mello SS
11. Ashton JM
12. Small EM
P53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload.; Circulation research. 2023 Jul 06.
1. Quijada P
2. Park S
3. Zhao P
4. Kolluri KS
5. Wong D
6. Shih KD
7. Fang K
8. Pezhouman A
9. Wang L
10. Daraei A
11. Tran MD
12. Rathbun EM
13. Burgos Villar KN
14. Garcia-Hernandez ML
15. Pham TT
16. Lowenstein CJ
17. Iruela-Arispe ML
18. Carmichael ST
19. Small EM
20. Ardehali R
Cardiac pericytes mediate the remodeling response to myocardial infarction.; The Journal of clinical investigation; Vol 133(10). 2023 May 15.
1. Lighthouse JK
2. Small EM
Cell-Based Phenotypic Screen for Antifibrotic Compounds Targets Eicosanoid Metabolism.; Circulation research; Vol 132(1), pp. 30-33. 2023 Jan 05.
1. Pérez-Hernández M
2. van Opbergen CJM
3. Bagwan N
4. Vissing CR
5. Marrón-Liñares GM
6. Zhang M
7. Torres Vega E
8. Sorrentino A
9. Drici L
10. Sulek K
11. Zhai R
12. Hansen FB
13. Christensen AH
14. Boesgaard S
15. Gustafsson F
16. Rossing K
17. Small EM
18. Davies MJ
19. Rothenberg E
20. Sato PY
21. Cerrone M
22. Jensen THL
23. Qvortrup K
24. Bundgaard H
25. Delmar M
26. Lundby A
Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC.; Circulation; Vol 146(11), pp. 851-867. 2022 Aug 12.
1. Burgos Villar KN
2. Liu X
3. Small EM
Transcriptional regulation of cardiac fibroblast phenotypic plasticity.; Current opinion in physiology; Vol 28. 2022 Jun 03.
1. Wu X
2. Liu H
3. Brooks A
4. Xu S
5. Luo J
6. Steiner R
7. Mickelsen DM
8. Moravec CS
9. Jeffrey AD
10. Small EM
11. Jin ZG
SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes.; Circulation research; Vol 131(11), pp. 926-943. 2022 Jan 24.
1. Misra A
2. Baker CD
3. Pritchett EM
4. Burgos Villar KN
5. Ashton JM
6. Small EM
Characterizing Neonatal Heart Maturation, Regeneration, and Scar Resolution Using Spatial Transcriptomics.; Journal of cardiovascular development and disease; Vol 9(1). 2021 Dec 21.
1. Quijada P
2. Trembley MA
3. Misra A
4. Myers JA
5. Baker CD
6. Pérez-Hernández M
7. Myers JR
8. Dirkx RA
9. Cohen ED
10. Delmar M
11. Ashton JM
12. Small EM
Coordination of endothelial cell positioning and fate specification by the epicardium.; Nature communications; Vol 12(1). 2021 Jul 06.
1. Burke RM
2. Dirkx RA
3. Quijada P
4. Lighthouse JK
5. Mohan A
6. O'Brien M
7. Wojciechowski W
8. Woeller C
9. Phipps RP
10. Alexis JD
11. Ashton J
12. Small EM
Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin.; Circulation research. 2021 Apr 07.
1. Guo Y
2. Cao Y
3. Jardin BD
4. Sethi I
5. Ma Q
6. Moghadaszadeh B
7. Troiano EC
8. Mazumdar N
9. Trembley MA
10. Small EM
11. Yuan GC
12. Beggs AH
13. Pu WT
Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling.; Proceedings of the National Academy of Sciences of the United States of America; Vol 118(2). 2021 Jan 12.
1. Burke RM
2. Burgos Villar KN
3. Small EM
Fibroblast contributions to ischemic cardiac remodeling.; Cellular signalling; Vol 77. 2021 Jan.
1. Small EM
2. Brooks AC
Cut the YAP: Limiting Fibrosis in Pathologic Cardiac Remodeling.; JACC. Basic to translational science; Vol 5(9). 2020 Sep.
1. Quijada P
2. Trembley MA
3. Small EM
The Role of the Epicardium During Heart Development and Repair.; Circulation research; Vol 126(3). 2020 Jan 31.
1. Chen S
2. Zhang Y
3. Lighthouse JK
4. Mickelsen DM
5. Wu J
6. Yao P
7. Small EM
8. Yan C
A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.; Circulation. 2019 Dec 05.
1. Liu H
2. Zhang S
3. Xu S
4. Koroleva M
5. Small EM
6. Jin ZG
Myofibroblast-specific YY1 promotes liver fibrosis.; Biochemical and biophysical research communications; Vol 514(3). 2019 Jun 30.
1. Burke RM
2. Lighthouse JK
3. Mickelsen DM
4. Small EM
Sacubitril/Valsartan Decreases Cardiac Fibrosis in Left Ventricle Pressure Overload by Restoring PKG Signaling in Cardiac Fibroblasts.; Circulation. Heart failure; Vol 12(4). 2019 Apr.
1. Quijada P
2. Misra A
3. Velasquez LS
4. Burke RM
5. Lighthouse JK
6. Mickelsen DM
7. Dirkx RA
8. Small EM
Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging.; Journal of molecular and cellular cardiology; Vol 129. 2019 Feb 13.
1. Hilt ZT
2. Pariser DN
3. Ture SK
4. Mohan A
5. Quijada P
6. Asante A
7. Cameron SJ
8. Sterling JA
9. Merkel AR
10. Johanson AL
11. Jenkins JL
12. Small EM
13. McGrath KE
14. Palis J
15. Elliott MR
16. Morrell CN
Platelet-derived β2M regulates monocyte inflammatory responses.; JCI insight. 2019 Jan 31.
1. Lighthouse JK
2. Burke RM
3. Velasquez LS
4. Dirkx RA
5. Aiezza A
6. Moravec CS
7. Alexis JD
8. Rosenberg A
9. Small EM
Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts.; JCI insight; Vol 4(1). 2019 Jan 10.
1. Chi C
2. Leonard A
3. Knight WE
4. Beussman KM
5. Zhao Y
6. Cao Y
7. Londono P
8. Aune E
9. Trembley MA
10. Small EM
11. Jeong MY
12. Walker LA
13. Xu H
14. Sniadecki NJ
15. Taylor MR
16. Buttrick PM
17. Song K
LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion.; Proceedings of the National Academy of Sciences of the United States of America; Vol 116(2). 2019 Jan 08.
1. Lacy SH
2. Woeller CF
3. Thatcher TH
4. Pollock SJ
5. Small EM
6. Sime PJ
7. Phipps RP
Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Anti-Fibrotic Prostaglandins.; American journal of respiratory cell and molecular biology. 2018 Sep 28.
1. Trembley MA
2. Quijada P
3. Agullo-Pascual E
4. Tylock KM
5. Colpan M
6. Dirkx RA
7. Myers JR
8. Mickelsen DM
9. de Mesy Bentley K
10. Rothenberg E
11. Moravec CS
12. Alexis JD
13. Gregorio CC
14. Dirksen RT
15. Delmar M
16. Small EM
Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy.; Circulation. 2018 May 01.
1. Burke RM
2. Lighthouse JK
3. Quijada P
4. Dirkx RA
5. Rosenberg A
6. Moravec CS
7. Alexis JD
8. Small EM
Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure.; Proceedings of the National Academy of Sciences of the United States of America; Vol 115(15). 2018 Apr 10.
1. Guo B
2. Lyu Q
3. Slivano OJ
4. Dirkx R
5. Christie CK
6. Czyzyk J
7. Hezel AF
8. Gharavi AG
9. Small EM
10. Miano JM
Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.; Journal of the American Society of Nephrology : JASN. 2017 Nov 07.
1. Cao J
2. Wang J
3. Jackman CP
4. Cox AH
5. Trembley MA
6. Balowski JJ
7. Cox BD
8. De Simone A
9. Dickson AL
10. Di Talia S
11. Small EM
12. Kiehart DP
13. Bursac N
14. Poss KD
Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue.; Developmental cell; Vol 42(6). 2017 Sep 25.
1. Small EM
2. Burke RM
β-Adrenergic Blockade in Ischemia-Reperfusion Injury: βARKing Up a New Tree.; Journal of the American College of Cardiology; Vol 70(8). 2017 Aug 22.
1. Knight WE
2. Chen S
3. Zhang Y
4. Oikawa M
5. Wu M
6. Zhou Q
7. Miller CL
8. Cai Y
9. Mickelsen DM
10. Moravec C
11. Small EM
12. Abe J
13. Yan C
PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.; Proceedings of the National Academy of Sciences of the United States of America. 2016 Oct 20.
1. Luna-Zurita L
2. Stirnimann CU
3. Glatt S
4. Kaynak BL
5. Thomas S
6. Baudin F
7. Samee MA
8. He D
9. Small EM
10. Mileikovsky M
11. Nagy A
12. Holloway AK
13. Pollard KS
14. Müller CW
15. Bruneau BG
Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.; Cell; Vol 164(5). 2016 Feb 25.
1. Lighthouse JK
2. Small EM
Transcriptional control of cardiac fibroblast plasticity.; Journal of molecular and cellular cardiology; Vol 91. 2016 Feb.
1. Trembley MA
2. Velasquez LS
3. Small EM
Epicardial Outgrowth Culture Assay and Ex Vivo Assessment of Epicardial-derived Cell Migration.; Journal of visualized experiments : JoVE. 2016.
1. Trembley MA
2. Velasquez LS
3. de Mesy Bentley KL
4. Small EM
Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels.; Development (Cambridge, England); Vol 142(1). 2015 Jan 1.
1. Rodés-Cabau J
2. Dauerman HL
3. Cohen MG
4. Mehran R
5. Small EM
6. Smyth SS
7. Costa MA
8. Mega JL
9. O'Donoghue ML
10. Ohman EM
11. Becker RC
Antithrombotic treatment in transcatheter aortic valve implantation: insights for cerebrovascular and bleeding events.; Journal of the American College of Cardiology; Vol 62(25). 2013 Dec 24.
1. Velasquez LS
2. Sutherland LB
3. Liu Z
4. Grinnell F
5. Kamm KE
6. Schneider JW
7. Olson EN
8. Small EM
Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing.; Proceedings of the National Academy of Sciences of the United States of America; Vol 110(42). 2013 Oct 15.
1. Small EM
The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation.; Journal of cardiovascular translational research; Vol 5(6). 2012 Dec.
1. Miano JM
2. Small EM
MicroRNA133a: a new variable in vascular smooth muscle cell phenotypic switching.; Circulation research; Vol 109(8). 2011 Sep 30.
1. Small EM
2. Olson EN
Pervasive roles of microRNAs in cardiovascular biology.; Nature; Vol 469(7330). 2011 Jan 20.
1. Small EM
2. Sutherland LB
3. Rajagopalan KN
4. Wang S
5. Olson EN
MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling.; Circulation research; Vol 107(11). 2010 Nov 26.
1. Small EM
2. Thatcher JE
3. Sutherland LB
4. Kinoshita H
5. Gerard RD
6. Richardson JA
7. Dimaio JM
8. Sadek H
9. Kuwahara K
10. Olson EN
Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction.; Circulation research; Vol 107(2). 2010 Jul 23.
1. Small EM
2. O'Rourke JR
3. Moresi V
4. Sutherland LB
5. McAnally J
6. Gerard RD
7. Richardson JA
8. Olson EN
Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486.; Proceedings of the National Academy of Sciences of the United States of America; Vol 107(9). 2010 Mar 2.
1. Small EM
2. Frost RJ
3. Olson EN
MicroRNAs add a new dimension to cardiovascular disease.; Circulation; Vol 121(8). 2010 Mar 2.
1. Xin M
2. Small EM
3. Sutherland LB
4. Qi X
5. McAnally J
6. Plato CF
7. Richardson JA
8. Bassel-Duby R
9. Olson EN
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury.; Genes & development; Vol 23(18). 2009 Sep 15.
1. Meadows SM
2. Warkman AS
3. Salanga MC
4. Small EM
5. Krieg PA
The myocardin-related transcription factor, MASTR, cooperates with MyoD to activate skeletal muscle gene expression.; Proceedings of the National Academy of Sciences of the United States of America; Vol 105(5). 2008 Feb 5.
1. Xin M
2. Small EM
3. van Rooij E
4. Qi X
5. Richardson JA
6. Srivastava D
7. Nakagawa O
8. Olson EN
Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function.; Proceedings of the National Academy of Sciences of the United States of America; Vol 104(19). 2007 May 8.
1. Small EM
2. Warkman AS
3. Wang DZ
4. Sutherland LB
5. Olson EN
6. Krieg PA
Myocardin is sufficient and necessary for cardiac gene expression in Xenopus.; Development (Cambridge, England); Vol 132(5). 2005 Mar.
1. Small EM
2. Krieg PA
Molecular regulation of cardiac chamber-specific gene expression.; Trends in cardiovascular medicine; Vol 14(1). 2004 Jan.
1. Small EM
2. Krieg PA
Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF.; Developmental biology; Vol 261(1). 2003 Sep 1.
1. Small EM
2. Krieg PA
Molecular mechanisms of chamber-specific myocardial gene expression: transgenic analysis of the ANF promoter.; Cold Spring Harbor symposia on quantitative biology; Vol 67. 2002.
1. Wang D
2. Passier R
3. Liu ZP
4. Shin CH
5. Wang Z
6. Li S
7. Sutherland LB
8. Small E
9. Krieg PA
10. Olson EN
Regulation of cardiac growth and development by SRF and its cofactors.; Cold Spring Harbor symposia on quantitative biology; Vol 67. 2002.
1. Wang D
2. Chang PS
3. Wang Z
4. Sutherland L
5. Richardson JA
6. Small E
7. Krieg PA
8. Olson EN
Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor.; Cell; Vol 105(7). 2001 Jun 29.
1. Garriock RJ
2. Vokes SA
3. Small EM
4. Larson R
5. Krieg PA
Developmental expression of the Xenopus Iroquois-family homeobox genes, Irx4 and Irx5.; Development genes and evolution; Vol 211(5). 2001 May.
1. Small EM
2. Krieg PA
Expression of atrial natriuretic factor (ANF) during Xenopus cardiac development.; Development genes and evolution; Vol 210(12). 2000 Dec.
1. Small EM
2. Vokes SA
3. Garriock RJ
4. Li D
5. Krieg PA
Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes.; Mechanisms of development; Vol 96(2). 2000 Sep.