Recent Publications

• 1. Liu X
  2. Burke RM
  3. Lighthouse JK
  4. Baker CD
  5. Dirkx RA
  6. Kang B
  7. Chakraborty Y
  8. Mickelsen DM
  9. Twardowski J
  10. Mello SS
  11. Ashton JM
  12. Small EM
  P53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload.; Circulation research. 2023 Jul 06.
• 1. Quijada P
  2. Park S
  3. Zhao P
  4. Kolluri KS
  5. Wong D
  6. Shih KD
  7. Fang K
  8. Pezhouman A
  9. Wang L
  10. Daraei A
  11. Tran MD
  12. Rathbun EM
  13. Burgos Villar KN
  14. Garcia-Hernandez ML
  15. Pham TT
  16. Lowenstein CJ
  17. Iruela-Arispe ML
  18. Carmichael ST
  19. Small EM
  20. Ardehali R
  Cardiac pericytes mediate the remodeling response to myocardial infarction.; The Journal of clinical investigation; Vol 133(10). 2023 May 15.
• 1. Lighthouse JK
  2. Small EM
  Cell-Based Phenotypic Screen for Antifibrotic Compounds Targets Eicosanoid Metabolism.; Circulation research; Vol 132(1), pp. 30-33. 2023 Jan 05.
• 1. Pérez-Hernández M
  2. van Opbergen CJM
  3. Bagwan N
  4. Vissing CR
  5. Marrón-Liñares GM
  6. Zhang M
  7. Torres Vega E
  8. Sorrentino A
  9. Drici L
  10. Sulek K
  11. Zhai R
  12. Hansen FB
  13. Christensen AH
  14. Boesgaard S
  15. Gustafsson F
  16. Rossing K
  17. Small EM
  18. Davies MJ
  19. Rothenberg E
  20. Sato PY
  21. Cerrone M
  22. Jensen THL
  23. Qvortrup K
  24. Bundgaard H
  25. Delmar M
  26. Lundby A
  Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC.; Circulation; Vol 146(11), pp. 851-867. 2022 Aug 12.
• 1. Burgos Villar KN
  2. Liu X
  3. Small EM
  Transcriptional regulation of cardiac fibroblast phenotypic plasticity.; Current opinion in physiology; Vol 28. 2022 Jun 03.
• 1. Wu X
  2. Liu H
  3. Brooks A
  4. Xu S
  5. Luo J
  6. Steiner R
  7. Mickelsen DM
  8. Moravec CS
  9. Jeffrey AD
  10. Small EM
  11. Jin ZG
  SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes.; Circulation research; Vol 131(11), pp. 926-943. 2022 Jan 24.
• 1. Misra A
  2. Baker CD
  3. Pritchett EM
  4. Burgos Villar KN
  5. Ashton JM
  6. Small EM
  Characterizing Neonatal Heart Maturation, Regeneration, and Scar Resolution Using Spatial Transcriptomics.; Journal of cardiovascular development and disease; Vol 9(1). 2021 Dec 21.
• 1. Quijada P
  2. Trembley MA
  3. Misra A
  4. Myers JA
  5. Baker CD
  6. Pérez-Hernández M
  7. Myers JR
  8. Dirkx RA
  9. Cohen ED
  10. Delmar M
  11. Ashton JM
  12. Small EM
  Coordination of endothelial cell positioning and fate specification by the epicardium.; Nature communications; Vol 12(1). 2021 Jul 06.
• 1. Burke RM
  2. Dirkx RA
  3. Quijada P
  4. Lighthouse JK
  5. Mohan A
  6. O'Brien M
  7. Wojciechowski W
  8. Woeller C
  9. Phipps RP
  10. Alexis JD
  11. Ashton J
  12. Small EM
  Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin.; Circulation research. 2021 Apr 07.
• 1. Guo Y
  2. Cao Y
  3. Jardin BD
  4. Sethi I
  5. Ma Q
  6. Moghadaszadeh B
  7. Troiano EC
  8. Mazumdar N
  9. Trembley MA
  10. Small EM
  11. Yuan GC
  12. Beggs AH
  13. Pu WT
  Sarcomeres regulate murine cardiomyocyte maturation through MRTF-SRF signaling.; Proceedings of the National Academy of Sciences of the United States of America; Vol 118(2). 2021 Jan 12.
• 1. Burke RM
  2. Burgos Villar KN
  3. Small EM
  Fibroblast contributions to ischemic cardiac remodeling.; Cellular signalling; Vol 77. 2021 Jan.
• 1. Small EM
  2. Brooks AC
  Cut the YAP: Limiting Fibrosis in Pathologic Cardiac Remodeling.; JACC. Basic to translational science; Vol 5(9). 2020 Sep.
• 1. Quijada P
  2. Trembley MA
  3. Small EM
  The Role of the Epicardium During Heart Development and Repair.; Circulation research; Vol 126(3). 2020 Jan 31.
• 1. Chen S
  2. Zhang Y
  3. Lighthouse JK
  4. Mickelsen DM
  5. Wu J
  6. Yao P
  7. Small EM
  8. Yan C
  A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.; Circulation. 2019 Dec 05.
• 1. Liu H
  2. Zhang S
  3. Xu S
  4. Koroleva M
  5. Small EM
  6. Jin ZG
  Myofibroblast-specific YY1 promotes liver fibrosis.; Biochemical and biophysical research communications; Vol 514(3). 2019 Jun 30.
• 1. Burke RM
  2. Lighthouse JK
  3. Mickelsen DM
  4. Small EM
  Sacubitril/Valsartan Decreases Cardiac Fibrosis in Left Ventricle Pressure Overload by Restoring PKG Signaling in Cardiac Fibroblasts.; Circulation. Heart failure; Vol 12(4). 2019 Apr.
• 1. Quijada P
  2. Misra A
  3. Velasquez LS
  4. Burke RM
  5. Lighthouse JK
  6. Mickelsen DM
  7. Dirkx RA
  8. Small EM
  Pre-existing fibroblasts of epicardial origin are the primary source of pathological fibrosis in cardiac ischemia and aging.; Journal of molecular and cellular cardiology; Vol 129. 2019 Feb 13.
• 1. Hilt ZT
  2. Pariser DN
  3. Ture SK
  4. Mohan A
  5. Quijada P
  6. Asante A
  7. Cameron SJ
  8. Sterling JA
  9. Merkel AR
  10. Johanson AL
  11. Jenkins JL
  12. Small EM
  13. McGrath KE
  14. Palis J
  15. Elliott MR
  16. Morrell CN
  Platelet-derived β2M regulates monocyte inflammatory responses.; JCI insight. 2019 Jan 31.
• 1. Lighthouse JK
  2. Burke RM
  3. Velasquez LS
  4. Dirkx RA
  5. Aiezza A
  6. Moravec CS
  7. Alexis JD
  8. Rosenberg A
  9. Small EM
  Exercise promotes a cardioprotective gene program in resident cardiac fibroblasts.; JCI insight; Vol 4(1). 2019 Jan 10.
• 1. Chi C
  2. Leonard A
  3. Knight WE
  4. Beussman KM
  5. Zhao Y
  6. Cao Y
  7. Londono P
  8. Aune E
  9. Trembley MA
  10. Small EM
  11. Jeong MY
  12. Walker LA
  13. Xu H
  14. Sniadecki NJ
  15. Taylor MR
  16. Buttrick PM
  17. Song K
  LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion.; Proceedings of the National Academy of Sciences of the United States of America; Vol 116(2). 2019 Jan 08.
• 1. Lacy SH
  2. Woeller CF
  3. Thatcher TH
  4. Pollock SJ
  5. Small EM
  6. Sime PJ
  7. Phipps RP
  Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Anti-Fibrotic Prostaglandins.; American journal of respiratory cell and molecular biology. 2018 Sep 28.
• 1. Trembley MA
  2. Quijada P
  3. Agullo-Pascual E
  4. Tylock KM
  5. Colpan M
  6. Dirkx RA
  7. Myers JR
  8. Mickelsen DM
  9. de Mesy Bentley K
  10. Rothenberg E
  11. Moravec CS
  12. Alexis JD
  13. Gregorio CC
  14. Dirksen RT
  15. Delmar M
  16. Small EM
  Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy.; Circulation. 2018 May 01.
• 1. Burke RM
  2. Lighthouse JK
  3. Quijada P
  4. Dirkx RA
  5. Rosenberg A
  6. Moravec CS
  7. Alexis JD
  8. Small EM
  Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure.; Proceedings of the National Academy of Sciences of the United States of America; Vol 115(15). 2018 Apr 10.
• 1. Guo B
  2. Lyu Q
  3. Slivano OJ
  4. Dirkx R
  5. Christie CK
  6. Czyzyk J
  7. Hezel AF
  8. Gharavi AG
  9. Small EM
  10. Miano JM
  Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.; Journal of the American Society of Nephrology : JASN. 2017 Nov 07.
• 1. Cao J
  2. Wang J
  3. Jackman CP
  4. Cox AH
  5. Trembley MA
  6. Balowski JJ
  7. Cox BD
  8. De Simone A
  9. Dickson AL
  10. Di Talia S
  11. Small EM
  12. Kiehart DP
  13. Bursac N
  14. Poss KD
  Tension Creates an Endoreplication Wavefront that Leads Regeneration of Epicardial Tissue.; Developmental cell; Vol 42(6). 2017 Sep 25.
• 1. Small EM
  2. Burke RM
  β-Adrenergic Blockade in Ischemia-Reperfusion Injury: βARKing Up a New Tree.; Journal of the American College of Cardiology; Vol 70(8). 2017 Aug 22.
• 1. Knight WE
  2. Chen S
  3. Zhang Y
  4. Oikawa M
  5. Wu M
  6. Zhou Q
  7. Miller CL
  8. Cai Y
  9. Mickelsen DM
  10. Moravec C
  11. Small EM
  12. Abe J
  13. Yan C
  PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.; Proceedings of the National Academy of Sciences of the United States of America. 2016 Oct 20.
• 1. Luna-Zurita L
  2. Stirnimann CU
  3. Glatt S
  4. Kaynak BL
  5. Thomas S
  6. Baudin F
  7. Samee MA
  8. He D
  9. Small EM
  10. Mileikovsky M
  11. Nagy A
  12. Holloway AK
  13. Pollard KS
  14. Müller CW
  15. Bruneau BG
  Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.; Cell; Vol 164(5). 2016 Feb 25.
• 1. Lighthouse JK
  2. Small EM
  Transcriptional control of cardiac fibroblast plasticity.; Journal of molecular and cellular cardiology; Vol 91. 2016 Feb.
• 1. Trembley MA
  2. Velasquez LS
  3. Small EM
  Epicardial Outgrowth Culture Assay and Ex Vivo Assessment of Epicardial-derived Cell Migration.; Journal of visualized experiments : JoVE. 2016.
• 1. Trembley MA
  2. Velasquez LS
  3. de Mesy Bentley KL
  4. Small EM
  Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels.; Development (Cambridge, England); Vol 142(1). 2015 Jan 1.
• 1. Rodés-Cabau J
  2. Dauerman HL
  3. Cohen MG
  4. Mehran R
  5. Small EM
  6. Smyth SS
  7. Costa MA
  8. Mega JL
  9. O'Donoghue ML
  10. Ohman EM
  11. Becker RC
  Antithrombotic treatment in transcatheter aortic valve implantation: insights for cerebrovascular and bleeding events.; Journal of the American College of Cardiology; Vol 62(25). 2013 Dec 24.
• 1. Velasquez LS
  2. Sutherland LB
  3. Liu Z
  4. Grinnell F
  5. Kamm KE
  6. Schneider JW
  7. Olson EN
  8. Small EM
  Activation of MRTF-A-dependent gene expression with a small molecule promotes myofibroblast differentiation and wound healing.; Proceedings of the National Academy of Sciences of the United States of America; Vol 110(42). 2013 Oct 15.
• 1. Small EM
  The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation.; Journal of cardiovascular translational research; Vol 5(6). 2012 Dec.
• 1. Miano JM
  2. Small EM
  MicroRNA133a: a new variable in vascular smooth muscle cell phenotypic switching.; Circulation research; Vol 109(8). 2011 Sep 30.
• 1. Small EM
  2. Olson EN
  Pervasive roles of microRNAs in cardiovascular biology.; Nature; Vol 469(7330). 2011 Jan 20.
• 1. Small EM
  2. Sutherland LB
  3. Rajagopalan KN
  4. Wang S
  5. Olson EN
  MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling.; Circulation research; Vol 107(11). 2010 Nov 26.
• 1. Small EM
  2. Thatcher JE
  3. Sutherland LB
  4. Kinoshita H
  5. Gerard RD
  6. Richardson JA
  7. Dimaio JM
  8. Sadek H
  9. Kuwahara K
  10. Olson EN
  Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction.; Circulation research; Vol 107(2). 2010 Jul 23.
• 1. Small EM
  2. O'Rourke JR
  3. Moresi V
  4. Sutherland LB
  5. McAnally J
  6. Gerard RD
  7. Richardson JA
  8. Olson EN
  Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486.; Proceedings of the National Academy of Sciences of the United States of America; Vol 107(9). 2010 Mar 2.
• 1. Small EM
  2. Frost RJ
  3. Olson EN
  MicroRNAs add a new dimension to cardiovascular disease.; Circulation; Vol 121(8). 2010 Mar 2.
• 1. Xin M
  2. Small EM
  3. Sutherland LB
  4. Qi X
  5. McAnally J
  6. Plato CF
  7. Richardson JA
  8. Bassel-Duby R
  9. Olson EN
  MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury.; Genes & development; Vol 23(18). 2009 Sep 15.
• 1. Meadows SM
  2. Warkman AS
  3. Salanga MC
  4. Small EM
  5. Krieg PA
  The myocardin-related transcription factor, MASTR, cooperates with MyoD to activate skeletal muscle gene expression.; Proceedings of the National Academy of Sciences of the United States of America; Vol 105(5). 2008 Feb 5.
• 1. Xin M
  2. Small EM
  3. van Rooij E
  4. Qi X
  5. Richardson JA
  6. Srivastava D
  7. Nakagawa O
  8. Olson EN
  Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function.; Proceedings of the National Academy of Sciences of the United States of America; Vol 104(19). 2007 May 8.
• 1. Small EM
  2. Warkman AS
  3. Wang DZ
  4. Sutherland LB
  5. Olson EN
  6. Krieg PA
  Myocardin is sufficient and necessary for cardiac gene expression in Xenopus.; Development (Cambridge, England); Vol 132(5). 2005 Mar.
• 1. Small EM
  2. Krieg PA
  Molecular regulation of cardiac chamber-specific gene expression.; Trends in cardiovascular medicine; Vol 14(1). 2004 Jan.
• 1. Small EM
  2. Krieg PA
  Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF.; Developmental biology; Vol 261(1). 2003 Sep 1.
• 1. Small EM
  2. Krieg PA
  Molecular mechanisms of chamber-specific myocardial gene expression: transgenic analysis of the ANF promoter.; Cold Spring Harbor symposia on quantitative biology; Vol 67. 2002.
• 1. Wang D
  2. Passier R
  3. Liu ZP
  4. Shin CH
  5. Wang Z
  6. Li S
  7. Sutherland LB
  8. Small E
  9. Krieg PA
  10. Olson EN
  Regulation of cardiac growth and development by SRF and its cofactors.; Cold Spring Harbor symposia on quantitative biology; Vol 67. 2002.
• 1. Wang D
  2. Chang PS
  3. Wang Z
  4. Sutherland L
  5. Richardson JA
  6. Small E
  7. Krieg PA
  8. Olson EN
  Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor.; Cell; Vol 105(7). 2001 Jun 29.
• 1. Garriock RJ
  2. Vokes SA
  3. Small EM
  4. Larson R
  5. Krieg PA
  Developmental expression of the Xenopus Iroquois-family homeobox genes, Irx4 and Irx5.; Development genes and evolution; Vol 211(5). 2001 May.
• 1. Small EM
  2. Krieg PA
  Expression of atrial natriuretic factor (ANF) during Xenopus cardiac development.; Development genes and evolution; Vol 210(12). 2000 Dec.
• 1. Small EM
  2. Vokes SA
  3. Garriock RJ
  4. Li D
  5. Krieg PA
  Developmental expression of the Xenopus Nkx2-1 and Nkx2-4 genes.; Mechanisms of development; Vol 96(2). 2000 Sep.