URMC / Cardiovascular Research Institute / Research / Yan Lab / Publications

Recent Publications

1. Komatsu K
2. Nam DH
3. Lee JY
4. Yoneda G
5. Yan C
6. Li JD
Vinpocetine Suppresses Streptococcus pneumoniae-Induced Inflammation via Inhibition of ERK1 by CYLD.; Journal of immunology (Baltimore, Md. : 1950); Vol 204(4). 2020 Feb 15.
1. Chen S
2. Zhang Y
3. Lighthouse JK
4. Mickelsen DM
5. Wu J
6. Yao P
7. Small EM
8. Yan C
A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.; Circulation. 2019 Dec 05.
1. Dugbartey GJ
2. Quinn B
3. Luo L
4. Mickelsen DM
5. Ture SK
6. Morrell CN
7. Czyzyk J
8. Doyley MM
9. Yan C
10. Berk BC
11. Korshunov VA
The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.; The American journal of pathology. 2019 Jun 17.
1. Alvarado FJ
2. Bos JM
3. Yuchi Z
4. Valdivia CR
5. Hernández JJ
6. Zhao YT
7. Henderlong DS
8. Chen Y
9. Booher TR
10. Marcou CA
11. Van Petegem F
12. Ackerman MJ
13. Valdivia HH
Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2.; JCI insight; Vol 5. 2019 Mar 05.
1. Liu R
2. Wang M
3. Zhang L
4. Zhou W
5. Huang Y
6. Guo H
7. Gu Y
8. Chen Y
9. Li Y
10. Chen C
11. Wang Y
12. Rong L
13. Li J
14. Xu J
15. Cao Q
16. Jiang Z
The clinicopathologic features of chronic active Epstein-Barr virus infective enteritis.; Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc; Vol 32(3). 2019 Mar.
1. Su Q
2. Chen S
3. Wu L
4. Tian R
5. Yang X
6. Huang X
7. Chen Y
8. Peng Z
9. Chen J
Severe Thalassemia Caused by Hb Zunyi [β147(HC3)Stop→Gln; HBB: c.442T>C)] on the β-Globin Gene.; Hemoglobin; Vol 43(1). 2019 Jan.
1. Lee BC
2. Susuki-Miyata S
3. Yan C
4. Li JD
Dexamethasone Inhibits Synergistic Induction of PDE4B Expression by Roflumilast and Bacterium NTHi.; International journal of molecular sciences; Vol 19(11). 2018 Nov 08.
1. Zhang Y
2. Knight W
3. Chen S
4. Mohan A
5. Yan C
A Multi-Protein Complex with TRPC, PDE1C, and A2R Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival.; Circulation. 2018 Jun 05.
1. Chen W
2. Anokhina V
3. Dieudonne G
4. Abramowitz MK
5. Kashyap R
6. Yan C
7. Wu TT
8. de Mesy Bentley KL
9. Miller BL
10. Bushinsky DA
Patients with advanced chronic kidney disease and vascular calcification have a large hydrodynamic radius of secondary calciprotein particles.; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2018 May 16.
1. Yu F
2. Chen Y
3. Mathiason MA
4. Wan Q
5. Lin FV
Cognitive and physical factors affecting daily function in Alzheimer's disease: A cross-sectional analysis.; Nursing & health sciences. 2018 May 07.
1. Chen S
2. Knight WE
3. Yan C
Roles of PDE1 in Pathological Cardiac Remodeling and Dysfunction.; Journal of cardiovascular development and disease; Vol 5(2). 2018 Apr 23.
1. Zhang F
2. Yan C
3. Wei C
4. Yao Y
5. Ma X
6. Gong Z
7. Liu S
8. Zang D
9. Chen J
10. Shi FD
11. Hao J
Vinpocetine Inhibits NF-κB-Dependent Inflammation in Acute Ischemic Stroke Patients.; Translational stroke research; Vol 9(2). 2018 Apr.
1. Zuo C
2. Li X
3. Huang J
4. Chen D
5. Ji K
6. Yang Y
7. Xu T
8. Zhu D
9. Yan C
10. Gao P
Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling.; Cardiovascular research; Vol 114(5). 2018 Apr 01.
1. Li Y
2. Liu C
3. Tang K
4. Chen Y
5. Tian K
6. Feng Z
7. Chen J
Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer.; Molecular medicine reports; Vol 17(2). 2018 Feb.
1. Zhang YS
2. Li JD
3. Yan C
An update on vinpocetine: New discoveries and clinical implications.; European journal of pharmacology; Vol 819. 2018 Jan 15.
1. Li Y
2. Ren M
3. Wang X
4. Cui X
5. Zhao H
6. Zhao C
7. Zhou J
8. Guo Y
9. Hu Y
10. Yan C
11. Berk B
12. Wang J
Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting Bim.; Scientific reports; Vol 7(1). 2017 Nov 14.
1. Wu L
2. Peng Z
3. Lu S
4. Tan M
5. Rong Y
6. Tian R
7. Yang Y
8. Chen Y
9. Chen J
β‑thalassemia caused by compound heterozygous mutations and cured by bone marrow transplantation: A case report.; Molecular medicine reports; Vol 16(5). 2017 Nov.
1. Korshunov VA
2. Wang H
3. Ahmed R
4. Mickelsen DM
5. Zhou Q
6. Yan C
7. Doyley MM
Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice.; Scientific reports; Vol 7(1). 2017 Sep 21.
1. Ransford B
2. Kramer DB
3. Foo Kune D
4. Auto de Medeiros J
5. Yan C
6. Xu W
7. Crawford T
8. Fu K
Cybersecurity and medical devices: A practical guide for cardiac electrophysiologists.; Pacing and clinical electrophysiology : PACE; Vol 40(8). 2017 Aug.
1. Jiang D
2. Zhuang J
3. Peng W
4. Lu Y
5. Liu H
6. Zhao Q
7. Chi C
8. Li X
9. Zhu G
10. Xu X
11. Yan C
12. Xu Y
13. Ge J
14. Pang J
Phospholipase Cγ1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity.; Journal of the American Heart Association; Vol 6(7). 2017 Jul 11.
1. Jiang D
2. Zhuang J
3. Peng W
4. Lu Y
5. Liu H
6. Zhao Q
7. Chi C
8. Li X
9. Zhu G
10. Xu X
11. Yan C
12. Xu Y
13. Ge J
14. Pang J
Phospholipase Cg1 mediates intima formation through Akt-Notch1 signaling independent of the phospholipase activity; J Am Heart Assoc. pii: e005537. PMCID: PMC5663637. 2017 Jan 01.
1. Wu MP
2. Zhang YS
3. Xu X
4. Zhou Q
5. Li JD
6. Yan C
Vinpocetine Attenuates Pathological Cardiac Remodeling by Inhibiting Cardiac Hypertrophy and Fibrosis.; Cardiovascular drugs and therapy; Vol 31(2). 2017 Apr.
1. Wu M
2. Zhang Y
3. Xu X
4. Zhou Q
5. Li JD
6. Yan C
Vinpocetine Attenuates Pathological Cardiac Remodeling by inhibiting Cardiac Hypertrophy and Fibrosis.; Cardiovascular Drugs & Therapy.; Vol 31, pp. 157-166. 2017 Jan 01.
1. Li J
2. Chen Y
3. Zhang L
4. Xing L
5. Xu H
6. Wang Y
7. Shi Q
8. Liang Q
Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.; Journal of ethnopharmacology; Vol 193. 2016 Dec 04.
1. Knight WE
2. Chen S
3. Zhang Y
4. Oikawa M
5. Wu M
6. Zhou Q
7. Miller CL
8. Cai Y
9. Mickelsen DM
10. Moravec C
11. Small EM
12. Abe J
13. Yan C
PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.; Proceedings of the National Academy of Sciences of the United States of America. 2016 Oct 20.
1. Liang Q
2. Ju Y
3. Chen Y
4. Wang W
5. Li J
6. Zhang L
7. Xu H
8. Wood RW
9. Schwarz EM
10. Boyce BF
11. Wang Y
12. Xing L
Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice.; Arthritis research & therapy; Vol 18. 2016 Mar 12.
1. Shi X
2. O'Neill MM
3. MacDonnell S
4. Brookes PS
5. Yan C
6. Berk BC
The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.; Journal of cardiovascular pharmacology and therapeutics; Vol 21(2). 2016 Mar.
1. Wu MP
2. Zhang YS
3. Zhou QM
4. Xiong J
5. Dong YR
6. Yan C
Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway.; Pharmacological research; Vol 104. 2016 Feb.
1. Chen Y
2. Li J
3. Li Q
4. Wang T
5. Xing L
6. Xu H
7. Wang Y
8. Shi Q
9. Zhou Q
10. Liang Q
Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function.; Evidence-based complementary and alternative medicine : eCAM; Vol 2016. 2016.
1. Knight W
2. Chen S
3. Zhang Y
4. Oikawa M
5. Wu M
6. Abe JI
7. Yan C
PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction; Proc. Nat. Acad. Sci., USA, pii: 201607728. PMCID: PMC5111646. 2016 Jan 01.
1. Wu MP
2. Zhang YS
3. Zhou QM
4. Xiong J
5. Dong YA
6. Yan C
Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of ?2-AR/PI3K/AKT signaling.; Pharmacological Research, PMCID: PMC4772856; Vol 104, pp. 115-123. 2016 Jan 01.
1. Knight W
2. Mickelsen DM
3. Moravec CS
4. Small EM
5. Abe JI
6. Yan C
PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.; Proc. Nat. Acad. Sci., USA, pii: 201607728. PMCID: PMC5111646.. 2016 Jan 01.
1. Yan C
Cyclic nucleotide phosphodiesterase 1 and vascular aging.; Clinical science (London, England : 1979); Vol 129(12). 2015 Dec.
1. Huang CK
2. Luo J
3. Lai KP
4. Wang R
5. Pang H
6. Chang E
7. Yan C
8. Sparks J
9. Lee SO
10. Cho J
11. Chang C
Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1α and transforming growth factor-β1 expression.; Hypertension; Vol 66(4). 2015 Oct.
1. Lee JY
2. Komatsu K
3. Lee BC
4. Miyata M
5. O'Neill Bohn A
6. Xu H
7. Yan C
8. Li JD
Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media.; Journal of immunology (Baltimore, Md. : 1950); Vol 194(12). 2015 Jun 15.
1. Susuki-Miyata S
2. Miyata M
3. Lee BC
4. Xu H
5. Kai H
6. Yan C
7. Li JD
Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi.; Proceedings of the National Academy of Sciences of the United States of America; Vol 112(14). 2015 Apr 07.
1. Cai Y
2. Nagel DJ
3. Zhou Q
4. Cygnar KD
5. Zhao H
6. Li F
7. Pi X
8. Knight PA
9. Yan C
Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.; Circulation research; Vol 116(7). 2015 Mar 27.
1. Ruan CC
2. Ge Q
3. Li Y
4. Li XD
5. Chen DR
6. Ji KD
7. Wu YJ
8. Sheng LJ
9. Yan C
10. Zhu DL
11. Gao PJ
Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.; Arteriosclerosis, thrombosis, and vascular biology; Vol 35(3). 2015 Mar.
1. Lee JY
2. Komatsu K
3. Lee BC
4. Miyata M
5. Bohn AO
6. Xu H
7. Yan C*
8. Li J
Vinpocetine inhibits Streptococcus pneumonia-induced up-regulation of mucin MUC5AC expression via induction of MKP-1 phosphatase. The Journal of Immunology, PMCID: PMC4456630. (* Co-corresponding authors).; ; Vol 194, pp. 5990-8. 2015 Jan 01.
1. Shi X
2. O'Neill MM
3. MacDonnell S
4. Brookes P
5. Yan C
6. Berk BC
The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury; Journal of Cardiovascular Pharmacology and Therapeutics, pii: 1074248415591700.. 2015 Jan 01.
1. Lin JR
2. Shen WL
3. Yan C
4. Gao PJ
Down regulation of Dynamin-related protein 1 (DRP1) contributes to impaired autophagic flux and angiogenic function in senescent endothelial cells.; Arterioscler Thromb Vasc Bio.; Vol 35, pp. 1413-22. 2015 Jan 01.
1. Cai Y
2. Nagel DJ
3. Zhou Q
4. Li F
5. Pi X
6. Knight PA
7. Yan C
Role of cAMP-Phosphodiesterase 1C Signaling in Regulating Growth Factor Receptor Stability, Vascular Smooth Muscle Cell Growth, and Neointimal Hyperplasia. Editorial Commentary: Satoh K, Kikuchi N, Kurosawa R, and Shimokawa H, PDE1C Negatively Regulates Growth Factor Receptor Degradation and Promotes VSMC Proliferation. Circulation Research, 116: 1098-1100; Circulation Research, PMCID: PMC4702253. 2015 Jan 01.
1. Ruan CC
2. Ge Q
3. Li Y
4. Li XD
5. Chen DR
6. Ji KD
7. Wu YJ
8. Sheng LJ
9. Yan C
10. Zhu DL
11. Gao PJ
Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.; Arterioscler Thromb Vasc Bio.; Vol 35, pp. 598-606. 2015 Jan 01.
1. Spindel ON
2. Burke RM
3. Yan C
4. Berk BC
Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation.; Circulation research; Vol 114(7). 2014 Mar 28.
1. Shi J
2. Liang Q
3. Zuscik M
4. Shen J
5. Chen D
6. Xu H
7. Wang YJ
8. Chen Y
9. Wood RW
10. Li J
11. Boyce BF
12. Xing L
Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice.; Arthritis & rheumatology (Hoboken, N.J.); Vol 66(3). 2014 Mar.
1. Yang YQ
2. Yan C
3. Branford-White CJ
4. Hou XY
Biological values of acupuncture and chinese herbal medicine: impact on the life science.; Evidence-based complementary and alternative medicine : eCAM; Vol 2014. 2014.
1. Iwaya S
2. Oikawa M
3. Yan C
4. Takeishi Y
Phosphodiesterase 3A1 protects the heart against angiotensin II-induced cardiac remodeling through regulating transforming growth factor-? expression.; International Heart Journal,; Vol 55, pp. 165-8. 2014 Jan 01.
1. Spindel ON
2. Burke RM
3. Yan C
4. Berk BC
Thioredoxin-interacting protein is a biomechanical regulator of SRC activity: key role in endothelial cell stress fiber formation.; Circulation Research PMCID: PMC3981969.; Vol 114, pp. 1125-32. 2014 Jan 01.
1. Yin G
2. Sheu TJ
3. Menon P
4. Pang J
5. Ho HC
6. Shi S
7. Xie C
8. Smolock E
9. Yan C
10. Zuscik MJ
11. Berk BC
Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT-1) knock out mice.; PLoS One, 9: e89127. 2014 Jan 01.
1. Yin G
2. Sheu TJ
3. Menon P
4. Pang J
5. Ho HC
6. Shi S
7. Xie C
8. Smolock E
9. Yan C
10. Zuscik MJ
11. Berk BC
Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice.; PloS one; Vol 9(2). 2014.
1. Oikawa M
2. Wu M
3. Lim S
4. Knight WE
5. Miller CL
6. Cai Y
7. Lu Y
8. Blaxall BC
9. Takeishi Y
10. Abe J
11. Yan C
Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.; Journal of molecular and cellular cardiology; Vol 64. 2013 Nov.
1. Knight W
2. Yan C
Therapeutic potential of PDE modulation in treating heart disease.; Future medicinal chemistry; Vol 5(14). 2013 Sep.
1. Cai Y
2. Li JD
3. Yan C
Vinpocetine attenuates lipid accumulation and atherosclerosis formation.; Biochemical and biophysical research communications; Vol 434(3). 2013 May 10.
1. Park SY
2. Shi X
3. Pang J
4. Yan C
5. Berk BC
Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis.; Arteriosclerosis, thrombosis, and vascular biology; Vol 33(4). 2013 Apr.
1. Oikawa M
2. Wu M
3. Lim S
4. Knight WE
5. Miller CL
6. Cai Y
7. Lu Y
8. Blaxall BC
9. Takeishi Y
10. Abe J
11. Yan C
Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.; J. Mol. Cell. Cardiol. PMCID: PMC3869570; Vol 64C:(11-19). 2013 Jan 01.
1. Cai Y
2. Li JD
3. Yan C
Vinpocetine Attenuates Lipid Accumulation and Atherosclerosis Formation.; Biochem. Biophys. Res. Commun., PMCID: PMC3682500.; Vol 434:, pp. 439-43. 2013 Jan 01.
1. Komatsu K
2. Lee JY
3. Miyata M
4. Hyang LJ
5. Jono H
6. Koga T
7. Xu H
8. Yan C
9. Kai H
10. Li JD
Inhibition of PDE4B suppressed inflammation by increasing expression of the deubiquitinase CYLD.; Nat. Commun. PMCID: PMC3644066; Vol 4:. 2013 Jan 01.
1. Park SY
2. Shi X
3. Pang J
4. Yan C
5. Berk BC
Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis.; Arterioscler Thromb Vasc Biol. PMCID: PMC3629821.; Vol 33:, pp. 737-43. 2013 Jan 01.
1. Cai Y
2. Knight WE
3. Guo S
4. Li JD
5. Knight PA
6. Yan C
Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration.; The Journal of pharmacology and experimental therapeutics; Vol 343(2). 2012 Nov.
1. Xu X
2. Woo CH
3. Steere RR
4. Lee BC
5. Huang Y
6. Wu J
7. Pang J
8. Lim JH
9. Xu H
10. Zhang W
11. Konduru AS
12. Yan C
13. Cheeseman MT
14. Brown SD
15. Li JD
EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation.; Journal of immunology (Baltimore, Md. : 1950); Vol 188(12). 2012 Jun 15.
1. Spindel ON
2. Yan C
3. Berk BC
Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling.; Arteriosclerosis, thrombosis, and vascular biology; Vol 32(5). 2012 May.
1. Wang XQ
2. Nigro P
3. World C
4. Fujiwara K
5. Yan C
6. Berk BC
Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.; Circulation research; Vol 110(4). 2012 Feb 17.
1. Le NT
2. Takei Y
3. Shishido T
4. Woo CH
5. Chang E
6. Heo KS
7. Lee H
8. Lu Y
9. Morrell C
10. Oikawa M
11. McClain C
12. Wang X
13. Tournier C
14. Molina CA
15. Taunton J
16. Yan C
17. Fujiwara K
18. Patterson C
19. Yang J
20. Abe J
p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.; Circulation research; Vol 110(4). 2012 Feb 17.
1. Silva J
2. Polesskaya O
3. Knight WE
4. Zheng JT
5. Granger M
6. Ontiveros F
7. Feng C
8. Yan C
9. Dewhurst S
Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.; Journal of Neuroinflammation PMCID: PMC3526511.; Vol 9:. 2012 Jan 01.
1. Ghigo A
2. Perino A
3. Mehel H
4. Zahradnlkova AJ
5. Morello F
6. Leroy J
7. Nikolaev VO
8. Damilano F
9. Cimino J
10. De Luca E
11. Richter W
12. Westenbroek R
13. Catterall WA
14. Zhang J
15. Yan C
16. Conti M
17. Gomez AM
18. Vandecasteele G
19. Hirsch E
20. Fischmeister R
Phosphoinositide 3-Kinase ? Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A-Mediated Regulation of Distinct Phosphodiesterases.; CirculationPMCID: PMC3913165.; Vol 126:, pp. 2073-83. 2012 Jan 01.
1. Cai Y
2. Knight W
3. Guo S
4. Li J
5. Knight P
6. Yan C
Vinpocetine suppresses pathological vascular remodeling through inhibiting vascular smooth muscle cell proliferation and migration.; Journal of Pharmacology and Experimental Therapy. PMID: 22915768; PMCID: PMC3477207.; Vol 343, pp. 479-88. 2012 Jan 01.
1. Xu X
2. Woo CH
3. Steere RR
4. Lee BC
5. Huang Y
6. Wu J
7. Pang J
8. Lim JH
9. Xu H
10. Zhang W
11. Konduru AS
12. Yan C
13. Cheeseman MT
14. Brown SD
15. Li JD
EVI1 acts as an Inducible Negative-Feedback Regulator of NF-?B by Inhibiting p65 Acetylation. J Immunol. PMCID: PMC3370108.; ; Vol 188(12):, pp. 6371-80. 2012 Jan 01.
1. Wang X
2. Nigro P
3. World C
4. Fujiwara K
5. Yan C
6. BC B
Thioredoxin Interacting Protein Promotes Endothelial Cell Inflammation in Response to Disturbed Flow by Increasing Leukocyte Adhesion and Repressing Kruppel-Like Factor 2.; Circulation Research. PMCID: PMC3333844; Vol 110:, pp. 560-8. 2012 Jan 01.
1. Spindel ON
2. Yan C
3. BC B
Thioredoxin Interacting Protein (TXNIP) mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 (VEGFR2) signaling.; Arterioscler Thromb Vasc Biol. PMCID: PMC3876410.; Vol 32:, pp. 1264-70. 2012 Jan 01.
1. Lim JH
2. Jono H
3. Komatsu K
4. Woo CH
5. Lee J
6. Miyata M
7. Matsuno T
8. Xu X
9. Huang Y
10. Zhang W
11. Park SH
12. Kim YI
13. Choi YD
14. Shen H
15. Heo KS
16. Xu H
17. Bourne P
18. Koga T
19. Xu H
20. Yan C
21. Wang B
22. Chen LF
23. Feng XH
24. Li JD
CYLD negatively regulates transforming growth factor-?-signaling via deubiquitinating Akt.; Nat Commun.PMCID: PMC3337989.; Vol 3:. 2012 Jan 01.
1. Lee J
2. Komatsu K
3. Lee BC
4. Lim JH
5. Jono H
6. Xu H
7. Kai H
8. Zhang ZJ
9. Yan C
10. Li JD
PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.; J Biol Chem. PMCID: PMC3391144.; Vol 287:, pp. 22799-811. 2012 Jan 01.
1. Le N
2. Takei Y
3. Shishido T
4. Woo CH
5. Chang E
6. Heo KS
7. Lee H
8. Lu Y
9. Morrell C
10. Oikawa M
11. McClain C
12. Wang X
13. Tournier C
14. Molina CA
15. Taunton J
16. Yan C
17. Fujiwara K
18. Patterson C
19. Yang J
20. Abe JI
p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.; Circulation Research. PMCID: PMC3306797; Vol 110:, pp. 536-50. 2012 Jan 01.
1. Silva J
2. Polesskaya O
3. Knight W
4. Zheng JT
5. Granger M
6. Lopez T
7. Ontiveros F
8. Feng C
9. Yan C
10. Kasischke KA
11. Dewhurst S
Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.; Journal of neuroinflammation; Vol 9. 2012.
1. Chan S
2. Yan C
PDE1 isozymes, key regulators of pathological vascular remodeling.; Current opinion in pharmacology; Vol 11(6). 2011 Dec.
1. Miller CL
2. Cai Y
3. Oikawa M
4. Thomas T
5. Dostmann WR
6. Zaccolo M
7. Fujiwara K
8. Yan C
Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.; Basic research in cardiology; Vol 106(6). 2011 Nov.
1. Shi X
2. Yan C
3. Nadtochiy SM
4. Abe J
5. Brookes PS
6. Berk BC
p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.; Journal of molecular and cellular cardiology; Vol 51(2). 2011 Aug.
1. Satoh K
2. Nigro P
3. Zeidan A
4. Soe NN
5. Jaffré F
6. Oikawa M
7. O'Dell MR
8. Cui Z
9. Menon P
10. Lu Y
11. Mohan A
12. Yan C
13. Blaxall BC
14. Berk BC
Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice.; Arteriosclerosis, thrombosis, and vascular biology; Vol 31(5). 2011 May.
1. Cai Y
2. Miller CL
3. Nagel DJ
4. Jeon KI
5. Lim S
6. Gao P
7. Knight PA
8. Yan C
Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells.; Arteriosclerosis, thrombosis, and vascular biology; Vol 31(3). 2011 Mar.
1. Miller CL
2. Cai Y
3. Oikawa M
4. Thomas T
5. Dostmann WR
6. Zaccolo M
7. Fujiwara K
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Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E-Deficient Mice.; Arterioscler Thromb Vasc Biol. PMCID: PMC3085960; Vol 31: 1, pp. 116-23. 2011 Jan 01.
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Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications.; Journal of cardiovascular translational research; Vol 3(5). 2010 Oct.
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GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass.; Journal of Cellular Physiology. PMCID: PMC2939960. 2010 Jan 01.
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G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development.; Circulation; Vol 119(11). 2009 Mar 24.
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GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma.; Arteriosclerosis, thrombosis, and vascular biology; Vol 29(2). 2009 Feb.