URMC / Cardiovascular Research Institute / Research / Yan Lab / Publications Recent Publications Komatsu KNam DHLee JYYoneda GYan CLi JD Vinpocetine Suppresses Streptococcus pneumoniae-Induced Inflammation via Inhibition of ERK1 by CYLD.; Journal of immunology (Baltimore, Md. : 1950); Vol 204(4). 2020 Feb 15. Chen SZhang YLighthouse JKMickelsen DMWu JYao PSmall EMYan C A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.; Circulation. 2019 Dec 05. Dugbartey GJQuinn BLuo LMickelsen DMTure SKMorrell CNCzyzyk JDoyley MMYan CBerk BCKorshunov VA The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla.; The American journal of pathology. 2019 Jun 17. Alvarado FJBos JMYuchi ZValdivia CRHernández JJZhao YTHenderlong DSChen YBooher TRMarcou CAVan Petegem FAckerman MJValdivia HH Cardiac hypertrophy and arrhythmia in mice induced by a mutation in ryanodine receptor 2.; JCI insight; Vol 5. 2019 Mar 05. Liu RWang MZhang LZhou WHuang YGuo HGu YChen YLi YChen CWang YRong LLi JXu JCao QJiang Z The clinicopathologic features of chronic active Epstein-Barr virus infective enteritis.; Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc; Vol 32(3). 2019 Mar. Su QChen SWu LTian RYang XHuang XChen YPeng ZChen J Severe Thalassemia Caused by Hb Zunyi [β147(HC3)Stop→Gln; HBB: c.442T>C)] on the β-Globin Gene.; Hemoglobin; Vol 43(1). 2019 Jan. Lee BCSusuki-Miyata SYan CLi JD Dexamethasone Inhibits Synergistic Induction of PDE4B Expression by Roflumilast and Bacterium NTHi.; International journal of molecular sciences; Vol 19(11). 2018 Nov 08. Zhang YKnight WChen SMohan AYan C A Multi-Protein Complex with TRPC, PDE1C, and A2R Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival.; Circulation. 2018 Jun 05. Chen WAnokhina VDieudonne GAbramowitz MKKashyap RYan CWu TTde Mesy Bentley KLMiller BLBushinsky DA Patients with advanced chronic kidney disease and vascular calcification have a large hydrodynamic radius of secondary calciprotein particles.; Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2018 May 16. Yu FChen YMathiason MAWan QLin FV Cognitive and physical factors affecting daily function in Alzheimer's disease: A cross-sectional analysis.; Nursing & health sciences. 2018 May 07. Chen SKnight WEYan C Roles of PDE1 in Pathological Cardiac Remodeling and Dysfunction.; Journal of cardiovascular development and disease; Vol 5(2). 2018 Apr 23. Zhang FYan CWei CYao YMa XGong ZLiu SZang DChen JShi FDHao J Vinpocetine Inhibits NF-κB-Dependent Inflammation in Acute Ischemic Stroke Patients.; Translational stroke research; Vol 9(2). 2018 Apr. Zuo CLi XHuang JChen DJi KYang YXu TZhu DYan CGao P Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling.; Cardiovascular research; Vol 114(5). 2018 Apr 01. Li YLiu CTang KChen YTian KFeng ZChen J Novel multi‑kinase inhibitor, T03 inhibits Taxol‑resistant breast cancer.; Molecular medicine reports; Vol 17(2). 2018 Feb. Zhang YSLi JDYan C An update on vinpocetine: New discoveries and clinical implications.; European journal of pharmacology; Vol 819. 2018 Jan 15. Li YRen MWang XCui XZhao HZhao CZhou JGuo YHu YYan CBerk BWang J Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting Bim.; Scientific reports; Vol 7(1). 2017 Nov 14. Wu LPeng ZLu STan MRong YTian RYang YChen YChen J β‑thalassemia caused by compound heterozygous mutations and cured by bone marrow transplantation: A case report.; Molecular medicine reports; Vol 16(5). 2017 Nov. Korshunov VAWang HAhmed RMickelsen DMZhou QYan CDoyley MM Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice.; Scientific reports; Vol 7(1). 2017 Sep 21. Ransford BKramer DBFoo Kune DAuto de Medeiros JYan CXu WCrawford TFu K Cybersecurity and medical devices: A practical guide for cardiac electrophysiologists.; Pacing and clinical electrophysiology : PACE; Vol 40(8). 2017 Aug. Jiang DZhuang JPeng WLu YLiu HZhao QChi CLi XZhu GXu XYan CXu YGe JPang J Phospholipase Cγ1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity.; Journal of the American Heart Association; Vol 6(7). 2017 Jul 11. Jiang DZhuang JPeng WLu YLiu HZhao QChi CLi XZhu GXu XYan CXu YGe JPang J Phospholipase Cg1 mediates intima formation through Akt-Notch1 signaling independent of the phospholipase activity; J Am Heart Assoc. pii: e005537. PMCID: PMC5663637. 2017 Jan 01. Wu MPZhang YSXu XZhou QLi JDYan C Vinpocetine Attenuates Pathological Cardiac Remodeling by Inhibiting Cardiac Hypertrophy and Fibrosis.; Cardiovascular drugs and therapy; Vol 31(2). 2017 Apr. Wu MZhang YXu XZhou QLi JDYan C Vinpocetine Attenuates Pathological Cardiac Remodeling by inhibiting Cardiac Hypertrophy and Fibrosis.; Cardiovascular Drugs & Therapy.; Vol 31, pp. 157-166. 2017 Jan 01. Li JChen YZhang LXing LXu HWang YShi QLiang Q Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.; Journal of ethnopharmacology; Vol 193. 2016 Dec 04. Knight WEChen SZhang YOikawa MWu MZhou QMiller CLCai YMickelsen DMMoravec CSmall EMAbe JYan C PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.; Proceedings of the National Academy of Sciences of the United States of America. 2016 Oct 20. Liang QJu YChen YWang WLi JZhang LXu HWood RWSchwarz EMBoyce BFWang YXing L Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice.; Arthritis research & therapy; Vol 18. 2016 Mar 12. Shi XO'Neill MMMacDonnell SBrookes PSYan CBerk BC The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.; Journal of cardiovascular pharmacology and therapeutics; Vol 21(2). 2016 Mar. Wu MPZhang YSZhou QMXiong JDong YRYan C Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway.; Pharmacological research; Vol 104. 2016 Feb. Chen YLi JLi QWang TXing LXu HWang YShi QZhou QLiang Q Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function.; Evidence-based complementary and alternative medicine : eCAM; Vol 2016. 2016. Knight WChen SZhang YOikawa MWu MAbe JIYan C PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction; Proc. Nat. Acad. Sci., USA, pii: 201607728. PMCID: PMC5111646. 2016 Jan 01. Wu MPZhang YSZhou QMXiong JDong YAYan C Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of ?2-AR/PI3K/AKT signaling.; Pharmacological Research, PMCID: PMC4772856; Vol 104, pp. 115-123. 2016 Jan 01. Knight WMickelsen DMMoravec CSSmall EMAbe JIYan C PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.; Proc. Nat. Acad. Sci., USA, pii: 201607728. PMCID: PMC5111646.. 2016 Jan 01. Yan C Cyclic nucleotide phosphodiesterase 1 and vascular aging.; Clinical science (London, England : 1979); Vol 129(12). 2015 Dec. Huang CKLuo JLai KPWang RPang HChang EYan CSparks JLee SOCho JChang C Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1α and transforming growth factor-β1 expression.; Hypertension; Vol 66(4). 2015 Oct. Lee JYKomatsu KLee BCMiyata MO'Neill Bohn AXu HYan CLi JD Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media.; Journal of immunology (Baltimore, Md. : 1950); Vol 194(12). 2015 Jun 15. Susuki-Miyata SMiyata MLee BCXu HKai HYan CLi JD Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi.; Proceedings of the National Academy of Sciences of the United States of America; Vol 112(14). 2015 Apr 07. Cai YNagel DJZhou QCygnar KDZhao HLi FPi XKnight PAYan C Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.; Circulation research; Vol 116(7). 2015 Mar 27. Ruan CCGe QLi YLi XDChen DRJi KDWu YJSheng LJYan CZhu DLGao PJ Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.; Arteriosclerosis, thrombosis, and vascular biology; Vol 35(3). 2015 Mar. Lee JYKomatsu KLee BCMiyata MBohn AOXu HYan C*Li J Vinpocetine inhibits Streptococcus pneumonia-induced up-regulation of mucin MUC5AC expression via induction of MKP-1 phosphatase. The Journal of Immunology, PMCID: PMC4456630. (* Co-corresponding authors).; ; Vol 194, pp. 5990-8. 2015 Jan 01. Shi XO'Neill MMMacDonnell SBrookes PYan CBerk BC The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury; Journal of Cardiovascular Pharmacology and Therapeutics, pii: 1074248415591700.. 2015 Jan 01. Lin JRShen WLYan CGao PJ Down regulation of Dynamin-related protein 1 (DRP1) contributes to impaired autophagic flux and angiogenic function in senescent endothelial cells.; Arterioscler Thromb Vasc Bio.; Vol 35, pp. 1413-22. 2015 Jan 01. Cai YNagel DJZhou QLi FPi XKnight PAYan C Role of cAMP-Phosphodiesterase 1C Signaling in Regulating Growth Factor Receptor Stability, Vascular Smooth Muscle Cell Growth, and Neointimal Hyperplasia. Editorial Commentary: Satoh K, Kikuchi N, Kurosawa R, and Shimokawa H, PDE1C Negatively Regulates Growth Factor Receptor Degradation and Promotes VSMC Proliferation. Circulation Research, 116: 1098-1100; Circulation Research, PMCID: PMC4702253. 2015 Jan 01. Ruan CCGe QLi YLi XDChen DRJi KDWu YJSheng LJYan CZhu DLGao PJ Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.; Arterioscler Thromb Vasc Bio.; Vol 35, pp. 598-606. 2015 Jan 01. Spindel ONBurke RMYan CBerk BC Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation.; Circulation research; Vol 114(7). 2014 Mar 28. Shi JLiang QZuscik MShen JChen DXu HWang YJChen YWood RWLi JBoyce BFXing L Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice.; Arthritis & rheumatology (Hoboken, N.J.); Vol 66(3). 2014 Mar. Yang YQYan CBranford-White CJHou XY Biological values of acupuncture and chinese herbal medicine: impact on the life science.; Evidence-based complementary and alternative medicine : eCAM; Vol 2014. 2014. Iwaya SOikawa MYan CTakeishi Y Phosphodiesterase 3A1 protects the heart against angiotensin II-induced cardiac remodeling through regulating transforming growth factor-? expression.; International Heart Journal,; Vol 55, pp. 165-8. 2014 Jan 01. Spindel ONBurke RMYan CBerk BC Thioredoxin-interacting protein is a biomechanical regulator of SRC activity: key role in endothelial cell stress fiber formation.; Circulation Research PMCID: PMC3981969.; Vol 114, pp. 1125-32. 2014 Jan 01. Yin GSheu TJMenon PPang JHo HCShi SXie CSmolock EYan CZuscik MJBerk BC Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT-1) knock out mice.; PLoS One, 9: e89127. 2014 Jan 01. Yin GSheu TJMenon PPang JHo HCShi SXie CSmolock EYan CZuscik MJBerk BC Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice.; PloS one; Vol 9(2). 2014. Oikawa MWu MLim SKnight WEMiller CLCai YLu YBlaxall BCTakeishi YAbe JYan C Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.; Journal of molecular and cellular cardiology; Vol 64. 2013 Nov. Knight WYan C Therapeutic potential of PDE modulation in treating heart disease.; Future medicinal chemistry; Vol 5(14). 2013 Sep. Cai YLi JDYan C Vinpocetine attenuates lipid accumulation and atherosclerosis formation.; Biochemical and biophysical research communications; Vol 434(3). 2013 May 10. Park SYShi XPang JYan CBerk BC Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis.; Arteriosclerosis, thrombosis, and vascular biology; Vol 33(4). 2013 Apr. Oikawa MWu MLim SKnight WEMiller CLCai YLu YBlaxall BCTakeishi YAbe JYan C Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury.; J. Mol. Cell. Cardiol. PMCID: PMC3869570; Vol 64C:(11-19). 2013 Jan 01. Cai YLi JDYan C Vinpocetine Attenuates Lipid Accumulation and Atherosclerosis Formation.; Biochem. Biophys. Res. Commun., PMCID: PMC3682500.; Vol 434:, pp. 439-43. 2013 Jan 01. Komatsu KLee JYMiyata MHyang LJJono HKoga TXu HYan CKai HLi JD Inhibition of PDE4B suppressed inflammation by increasing expression of the deubiquitinase CYLD.; Nat. Commun. PMCID: PMC3644066; Vol 4:. 2013 Jan 01. Park SYShi XPang JYan CBerk BC Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis.; Arterioscler Thromb Vasc Biol. PMCID: PMC3629821.; Vol 33:, pp. 737-43. 2013 Jan 01. Cai YKnight WEGuo SLi JDKnight PAYan C Vinpocetine suppresses pathological vascular remodeling by inhibiting vascular smooth muscle cell proliferation and migration.; The Journal of pharmacology and experimental therapeutics; Vol 343(2). 2012 Nov. Xu XWoo CHSteere RRLee BCHuang YWu JPang JLim JHXu HZhang WKonduru ASYan CCheeseman MTBrown SDLi JD EVI1 acts as an inducible negative-feedback regulator of NF-κB by inhibiting p65 acetylation.; Journal of immunology (Baltimore, Md. : 1950); Vol 188(12). 2012 Jun 15. Spindel ONYan CBerk BC Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling.; Arteriosclerosis, thrombosis, and vascular biology; Vol 32(5). 2012 May. Wang XQNigro PWorld CFujiwara KYan CBerk BC Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2.; Circulation research; Vol 110(4). 2012 Feb 17. Le NTTakei YShishido TWoo CHChang EHeo KSLee HLu YMorrell COikawa MMcClain CWang XTournier CMolina CATaunton JYan CFujiwara KPatterson CYang JAbe J p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.; Circulation research; Vol 110(4). 2012 Feb 17. Silva JPolesskaya OKnight WEZheng JTGranger MOntiveros FFeng CYan CDewhurst S Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.; Journal of Neuroinflammation PMCID: PMC3526511.; Vol 9:. 2012 Jan 01. Ghigo APerino AMehel HZahradnlkova AJMorello FLeroy JNikolaev VODamilano FCimino JDe Luca ERichter WWestenbroek RCatterall WAZhang JYan CConti MGomez AMVandecasteele GHirsch EFischmeister R Phosphoinositide 3-Kinase ? Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A-Mediated Regulation of Distinct Phosphodiesterases.; CirculationPMCID: PMC3913165.; Vol 126:, pp. 2073-83. 2012 Jan 01. Cai YKnight WGuo SLi JKnight PYan C Vinpocetine suppresses pathological vascular remodeling through inhibiting vascular smooth muscle cell proliferation and migration.; Journal of Pharmacology and Experimental Therapy. PMID: 22915768; PMCID: PMC3477207.; Vol 343, pp. 479-88. 2012 Jan 01. Xu XWoo CHSteere RRLee BCHuang YWu JPang JLim JHXu HZhang WKonduru ASYan CCheeseman MTBrown SDLi JD EVI1 acts as an Inducible Negative-Feedback Regulator of NF-?B by Inhibiting p65 Acetylation. J Immunol. PMCID: PMC3370108.; ; Vol 188(12):, pp. 6371-80. 2012 Jan 01. Wang XNigro PWorld CFujiwara KYan CBC B Thioredoxin Interacting Protein Promotes Endothelial Cell Inflammation in Response to Disturbed Flow by Increasing Leukocyte Adhesion and Repressing Kruppel-Like Factor 2.; Circulation Research. PMCID: PMC3333844; Vol 110:, pp. 560-8. 2012 Jan 01. Spindel ONYan CBC B Thioredoxin Interacting Protein (TXNIP) mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 (VEGFR2) signaling.; Arterioscler Thromb Vasc Biol. PMCID: PMC3876410.; Vol 32:, pp. 1264-70. 2012 Jan 01. Lim JHJono HKomatsu KWoo CHLee JMiyata MMatsuno TXu XHuang YZhang WPark SHKim YIChoi YDShen HHeo KSXu HBourne PKoga TXu HYan CWang BChen LFFeng XHLi JD CYLD negatively regulates transforming growth factor-?-signaling via deubiquitinating Akt.; Nat Commun.PMCID: PMC3337989.; Vol 3:. 2012 Jan 01. Lee JKomatsu KLee BCLim JHJono HXu HKai HZhang ZJYan CLi JD PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway.; J Biol Chem. PMCID: PMC3391144.; Vol 287:, pp. 22799-811. 2012 Jan 01. Le NTakei YShishido TWoo CHChang EHeo KSLee HLu YMorrell COikawa MMcClain CWang XTournier CMolina CATaunton JYan CFujiwara KPatterson CYang JAbe JI p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction.; Circulation Research. PMCID: PMC3306797; Vol 110:, pp. 536-50. 2012 Jan 01. Silva JPolesskaya OKnight WZheng JTGranger MLopez TOntiveros FFeng CYan CKasischke KADewhurst S Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5.; Journal of neuroinflammation; Vol 9. 2012. Chan SYan C PDE1 isozymes, key regulators of pathological vascular remodeling.; Current opinion in pharmacology; Vol 11(6). 2011 Dec. Miller CLCai YOikawa MThomas TDostmann WRZaccolo MFujiwara KYan C Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.; Basic research in cardiology; Vol 106(6). 2011 Nov. Shi XYan CNadtochiy SMAbe JBrookes PSBerk BC p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.; Journal of molecular and cellular cardiology; Vol 51(2). 2011 Aug. Satoh KNigro PZeidan ASoe NNJaffré FOikawa MO'Dell MRCui ZMenon PLu YMohan AYan CBlaxall BCBerk BC Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice.; Arteriosclerosis, thrombosis, and vascular biology; Vol 31(5). 2011 May. Cai YMiller CLNagel DJJeon KILim SGao PKnight PAYan C Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells.; Arteriosclerosis, thrombosis, and vascular biology; Vol 31(3). 2011 Mar. Miller CLCai YOikawa MThomas TDostmann WRZaccolo MFujiwara KYan C Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.; Basic Res. Cardiol. PMCID: PMC4114346.; Vol 106:, pp. 1023-39. 2011 Jan 01. Shi XYan CNadtochiy SMAbe JBrookes PSBerk BC p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury.; J Mol Cell Cardiol. PMCID: PMC3124613; Vol 51:, pp. 272-5. 2011 Jan 01. Cai YMiller CLNagel DJJeon KLim SGao PKinight PYan C Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen degradation in vascular smooth muscle cells.; Arterioscler Thromb Vasc Biol. PMCID: PMC4114343; Vol 31:, pp. 616-623. 2011 Jan 01. Satoh KNigro PZeidan ASoe NNJaffré FOikawa MO'Dell MRCui ZMenon PLu YMohan AYan CBlaxall BCBerk BC Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E-Deficient Mice.; Arterioscler Thromb Vasc Biol. PMCID: PMC3085960; Vol 31: 1, pp. 116-23. 2011 Jan 01. Jeon KIJono HMiller CLCai YLim SLiu XGao PAbe JLi JDYan C Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells.; The FEBS journal; Vol 277(24). 2010 Dec. Woo CHLe NTShishido TChang ELee HHeo KSMickelsen DMLu YMcClain CSpangenberg TYan CMolina CAYang JPatterson CAbe J Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 24(12). 2010 Dec. Menon PYin GSmolock EMZuscik MJYan CBerk BC GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass.; Journal of cellular physiology; Vol 225(3). 2010 Nov. Wang JYin GMenon PPang JSmolock EMYan CBerk BC Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells.; Arteriosclerosis, thrombosis, and vascular biology; Vol 30(10). 2010 Oct. Miller CLYan C Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications.; Journal of cardiovascular translational research; Vol 3(5). 2010 Oct. Jeon KIXu XAizawa TLim JHJono HKwon DSAbe JBerk BCLi JDYan C Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism.; Proceedings of the National Academy of Sciences of the United States of America; Vol 107(21). 2010 May 25. Abe JYan C CCN notch signaling in vascular smooth muscle cells: good or bad?; Arteriosclerosis, thrombosis, and vascular biology; Vol 30(4). 2010 Apr. Menon PDeane RSagare ALane SMZarcone TJO'Dell MRYan CZlokovic BVBerk BC Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice.; Brain research; Vol 1317. 2010 Mar 4. Jeon KJono HCai YLim SLiu XGao PAbe JLi JYan C Ca2+/calmodulin-stimulated Phosphodiesterase 1A regulates the beta-catenin/TCF signal pathway through PP2A B56 gamma subunit in vascular smooth muscle cells.; FEBS Journal PMCID: PMC3059601; Vol 277:, pp. 5026-39. 2010 Jan 01. Woo CHLe NTShishido TChang ELee HHeo KSMichelsen DMLu YMcClain CSpangenberg TYan CMolina CAYang JPatterson CAbe JI Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor.; FASEB J. PMCID: PMC2992371; Vol 24:, pp. 4917-28. 2010 Jan 01. Jeon KXu XAizawa TLim JHJono HKwoen DAbe JBerk BCLi JYan C Vinpocetine inhibits NF-?B-dependent inflammation via an IKK-dependent but PDE-independent mechanism. Editorial Commentary: Alexandre E. Medina (2010). Vinpocetine as a potent anti-inflammatory agent Proc. Nat. Acad. Sci., USA. 107:9921-2.; Proc. Nat. Acad. Sci., USA, PMCID: PMC2906898; Vol 107, pp. 9795-9800. 2010 Jan 01. Wang JYin GMenon PPang JSmolock EYan Cand BB Phosphorylation of GIT1 tyrosine-392 is required for PLC??activation and podosome formation in vascular smooth muscle cells.; Arterioscler Thromb Vasc Biol. PMCID: PMC2941990; Vol 30:, pp. 1976-82. 2010 Jan 01. Menon PYin GSmolock EZuscik MYan CBerk BC GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass.; Journal of Cellular Physiology. PMCID: PMC2939960. 2010 Jan 01. Menon PDeane RSagare ALane SMZarcone TJO'Dell MRYan CZlokovic BVBerk BC Impaired spine formation and learning in GPCR kinase interacting protein-1 (GIT1) deficient mice.; Brain Research PMCID: PMC2861918; Vol 1317:2, pp. 18-26. 2010 Jan 01. Miller CLOikawa MCai YWojtovich APNagel DJXu XXu HFlorio VRybalkin SDBeavo JAChen YFLi JDBlaxall BCAbe JYan C Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy.; Circulation research; Vol 105(10). 2009 Nov 06. Satoh KNigro PMatoba TO'Dell MRCui ZShi XMohan AYan CAbe JIllig KABerk BC Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms.; Nature medicine; Vol 15(6). 2009 Jun. Pang JHoefen RPryhuber GSWang JYin GWhite RJXu XO'Dell MRMohan AMichaloski HMassett MPYan CBerk BC G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development.; Circulation; Vol 119(11). 2009 Mar 24. Wang JTaba YPang JYin GYan CBerk BC GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma.; Arteriosclerosis, thrombosis, and vascular biology; Vol 29(2). 2009 Feb.