URMC conducts research on possible COVID-19 nasal booster

Monday, December 2, 2024

David Topham, PhD, director of the Translational Immunology and Infectious Disease Institute, spoke to Rochester First (Dec. 2) about a potential alternative to COVID booster shots: a nasal puff. Researchers are working on this new type of booster that can elicit a different body response. “The idea is that if you have an immune response that’s local to the tissue where the pathogens are entering the body, then it’s going to be more effective. And we have lots of research that supports that idea,” Topham said.

Future COVID Boosters Could Be Nasal: URMC Researchers Lead Study on Next-Gen Vaccines

Wednesday, October 16, 2024

Sore arms may soon rejoice—future COVID boosters could be delivered as a puff instead of a jab. Vaccine researchers at the University of Rochester Medical Center (URMC) are investigating whether nasal vaccines, already available for the flu, can be effective against COVID-19.

"Most of the time, the strains we select for vaccines aren't a perfect match, because the virus evolves faster than we can keep up," said David Topham, PhD, founding director of the University of Rochester’s Translational Immunology and Infectious Disease Institute and principal investigator of the new study. "We need vaccines that elicit cross-reactive immunity—immunity that doesn’t rely on which strain is circulating but still offers protection and prevents severe illness or hospitalization."

This study aims to set important benchmarks that could guide the development of COVID-19 nasal vaccines, which have the potential to strengthen the immune response in the respiratory system, where the virus initially attacks. A COVID-19 nasal vaccine is currently being tested in an early-stage clinical trial sponsored by the National Institute of Allergy and Infectious Diseases (NIAID).

The new study will use data previously collected by a consortium that included Angela Branche, MD, co-director of the URMC Vaccine and Treatment and Evaluation Unit. This prior study, called COVAIL, compared single- and multi-strain COVID vaccines. Results published in Nature Medicine in 2023 showed that boosters don’t need to match a specific strain to provide protection.

Antibodies in mom’s breast milk are protecting babies

Thursday, October 3, 2024

“We would expect to find differences in antibody levels in different countries, due to different diseases circulating among areas of the world, but this is one of the first times that there’s been a head-to-head comparison for dozens of pathogens across several continents,” says lead author Kirsi Jarvinen-Seppo, a professor of pediatrics, of medicine, and of microbiology and immunology.

Read the full article in US News and World Report

Research: How the Immune System Fails as Cancer Arises

Wednesday, September 11, 2024

Cancer has been described as “a wound that does not heal,” implying that the immune system is unable to wipe out invading tumor cells. A new discovery confirms that a key molecule can reprogram immune cells that normally protect against infection and cancer, turning them into bad guys that promote cancer growth.

Studying the behavior of these “pro-tumor” immune cells is important because they could be targets for therapies that block their harmful activity, said Minsoo Kim, PhD, corresponding author of the study and a research leader at the Wilmot Cancer Institute.

The Proceedings of the National Academy of Sciences (PNAS) published the discovery.

Kim led a team of scientists investigating the dynamic interactions that occur between cells in the tumor environment, and the underlying factors that cause the harmful transformation of immune cells from good to bad.

They found that PAF (platelet-activating factor) is the key molecule that controls the destiny of the immune cells. PAF not only recruits cancer-promoting cells, but it also suppresses the immune system’s ability to fight back. In addition, they found that multiple cancers rely on the same PAF signals.

What Is H5N1 Bird Flu, How it Spreads to Humans, and Safety Concerns

Thursday, June 20, 2024

The H5N1 virus, also known as avian or bird flu, is once again in the news and on the radar of scientists and public health officials as a growing number of infections have been found in dairy cattle and farm workers.

David Topham, PhD, a professor of Microbiology and Immunology and director of the University of Rochester Translational Immunology and Infectious Disease Institute, has been studying the H5N1 and other influenza viruses for 27 years.