Faculty
Affiliated Faculty
Microbiology & Immunology
Medicine
Research Interest: The role of B cells in the pathophysiology of human systemic lupus and rheumatoid arthritis and the study of new immuno-modulatory treatments
Pharmacology & Physiology
Neurosurgery
Research Interest: Cellular and Molecular Mechanisms of Microenvironmental Regulation of Hematopoietic Stem Cells in the Bone Marrow
Environmental Medicine
Neuroscience
Research Interest: Defining the impact of environmental chemicals (e.g., metals and air pollution) on brain development and behavior, with emphasis on attributable risk to neurodevelopmental disorders.
Dermatology
Electrical & Computer Engineering
Research Interest: Understanding the toxicological and biochemical properties of nanomaterial interactions with skin and the immune system; develop in vivo models to investigate nanoparticle skin penetration mechanisms, and develop novel biosensors to improve transdermal drug delivery and tissue engineering approaches.
Biomedical Engineering
Pediatrics
Research Interest: Molecular mechanisms of gene delivery and development of gene therapies for lung disease
Research Interest: Toxicology of inhaled ultrafine particles (UFPs) on the lung, cardiovascular and central nervous system
Pediatrics
Research Interest:
Understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition
Program for Advanced Immune Bioimaging
Microbiology & ImmunologyEnvironmental Medicine
Medicine
Research Interest:
Defining molecular pathways by which allergens and particulates activate epithelia and dendritic cells in the lung immune system
Rochester Environment and Child Health (REACH) Laboratory
Public Health SciencesPediatrics
Environmental Medicine
Research Interest: Environmental and Maternal and Child Health Epidemiology: Defining the impact of environmental chemicals on immunity and immune-mediated diseases and as a mechanism for susceptibility to other disease outcomes, such as neurobehavioral disorders.
Pediatrics
Research Interest:
Development of the infant microbiome and immune system, and how that relates to development of allergic diseases
Research Interest: Investigating how novel receptor-based therapeutics modify cytokine production to mitigate lung injury and fibrosis
Microbiology & Immunology
Research Interest:
Delineating mechanisms by which environmental exposures during different life stages alter immune function
Research Interest: Glia-neuron interactions during synaptic plasticity in health and disease
Biomedical Genetics
Research Interest: Identification of different stem and precursor cell pools in CNS that may be critical for cell replacement therapies or are targets of insults that lead to developmental pathologies.
Research Interest:
The genetics, genomics, and chromatin biochemistry of cell state transitions that occur during embryonic development and carcinogenesis.
Research Interest: Defining neuro-inflammatory processes that contribute to pathology and disease progression in Alzheimer's disease, as well as late CNS effects following radiation exposure
Wynne Center for Family Research
NeurosciencePsychiatry
Obstetrics & Gynecology
Research Interest: The mechanisms by which early stress exposures, including prenatal maternal anxiety and caregiving stress, may persistently shape children's behavioral and biological health
Environmental Medicine
Research Interest:
Defining how an aberrant oxygen environment and oxygen-induced DNA damage signaling alter distal lung development, the host response to respiratory viral infections, and promotes cardiovascular disease later in life
Mitochondrial Research and Innovation Group
Pharmacology & PhysiologyResearch Interest:
Elucidate the molecular mechanisms of divalent metal neurotoxicity and mitochondrial dysfunction in Alzheimer's disease pathogenesis
Research Interest:
Identify new targets susceptible to environmental perturbation in relevance with neurodevelopment or neurodegenerative diseases by utilizing functional genetics/genomics (RNAi and CRISPR screens and Next-Generation sequencing), and molecular benchwork. Discover the link between genetic polymorphism of the targets and neurological diseases. Explore novel roles of extracellular vesicles (EV) in receptor signaling and cell communication. Identify EV-encapsulated biomolecules released by the placenta in response to environmental perturbation. Explore the roles of placenta-derived EVs on neurodevelopment or neurodegeneration
Environmental Medicine
Research Interest:
Chronic lung disease of prematurity and lung development
Research Interest:
Using primarily human pluripotent stem cell models, we examine astrocyte development in normal and pathological conditions, the role of astrocytes in modulating response to injury or stress, the role of altered RNA processing and translation in neural development, and the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy.
Pediatrics
Research Interest:
The mechanisms of lung vascular endothelial cell dysfunction in acute lung injury
Medicine
Public Health Sciences
Dentistry
Research Interest:
Redox signaling mechanism of Proinflammatory gene expression in pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants
Research Interest: Mechanisms of toxicity of the environmental contaminant and neurotoxicant methylmercury (MeHg), defining MeHg effects on early life development of neural and muscular systems at the molecular, cellular, and organismal levels using invertebrate and mammalian models, and detailed characterization of MeHg metabolism and elimination kinetics in humans.
Public Health Sciences
Research Interest:
Cardiovascular, respiratory, and perinatal/reproductive health effects of exposure to environmental agents, including ambient air pollution
Environmental Medicine
Research Interest: Experimental platform using the amphibian Xenopus for research in immunotoxicology, fundamental and medical immunology
Research Interest:
Innate cell antiviral responses, allergic inflammation, mucosal/airway immunity, vaccine responses
Neuroscience
Research Interest:
Develop a research program concentrating on identifying genetic modifiers of environmental factors in disease etiology using a combination of Drosophila genetics, cell culture, and rodent models
Neuroscience
Research Interest:
Neurotoxicology, Etiology of neurobehavioral disease, Endocrine dysfunction, Synergistic Toxicity.
Research Interest:
Our research program focuses on mechanisms underlying gene environment interaction in pregnancy. We are interested in elucidating how environmental factors influence epigenetic regulation of developmental-relevant genes including imprinted genes, and how exposure modulates maternal-fetal health.
Program for Advanced Immune Bioimaging
Microbiology & ImmunologyResearch Interest:
Immune responses to respiratory viruses and experimental vaccines
Mitochondrial Research and Innovation Group
Pharmacology & PhysiologyAnesthesiology and Perioperative Medicine
Research Interest: Optogenetics to study the roles of Reactive Oxygen Species (ROS) in mitochondrial physiology and stress signaling.
Neuroscience
Research Interest: Molecular and signaling mechanisms of synaptic plasticity in memory formation and mental health
Public Health Sciences
Environmental Medicine
Research Interest: Environmental and Neurologic Epidemiology: Defining influences of environmental exposures, in particular toxic metals, on cognitive outcomes in children and adults.