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Research Interest: Environmental epidemiology of the effect of air polution on respiratory health
Research Interest: Molecular mechanisms of gene delivery and development of gene therapies for lung disease
Research Interest: Toxicology of inhaled ultrafine particles (UFPs) on the lung, cardiovascular and central nervous system
Research Interest: Understanding the pathogenesis of Acute Lung Injury (ALI), a life threatening pulmonary inflammatory condition
Research Interest: Delineating the role of alveolar epithelium in modulating the pulmonary injury response to physiological and toxicological stimuli, including oxidant induced signaling in the pulmonary epithelium and macrophages, and epithelial production of mediators that regulate inflammatory functions of macrophages.
Research Interest: Defining molecular pathways by which allergens and particulates activate epithelia and dendritic cells in the lung immune system
Research Interest: Molecular regulation of vascular endothelial function
Research Interest: Community outreach and engagement, role of science in public decision-making
Research Interest: Delineating mechanisms by which environmental exposures during different life stages alter immune function
Research Interest: Extracellular vesicles (Evs), Exosomes, for their roles in cancer development, progression and response to treatment in Urology cancers.
Research Interest: Investigating factors that both increase and decrease the risk of developing asthma, wheezing, and allergic disorders in childhood
Research Interest: Genetic and environmental susceptibility to developmental lung injury
Research Interest: Developing and coordinating a wide variety of science education and outreach programs for students (elementary through high school), teachers, and the general community.
Research Interest: Airway epithelial stem cells in chemical inhalation exposures
Research Interest: Smoking Cessation in special populations, Technology/Web Assisted Risk Behavior Intervention and Dissemination of effective interventions to physician practices
Research Interest: Understanding mechanisms of pathology in common inflammatory conditions of children
Research Interest: Defining how an aberrant oxygen environment and oxygen-induced DNA damage signaling alter distal lung development, the host response to respiratory viral infections, and promotes cardiovascular disease later in life
Research Interest: Biokinetics, Effects and Mechanisms of Inhaled Micro- and Nano- Particles: Dosimetry, Risk Extrapolation and Risk Assessment
Research Interest: Behavioral medicine and outcomes management include tobacco use and smoking interventions, obesity prevention and exercise
Research Interest: The use of nutritional supplementation and exercise to treat the symptoms and side effects of cancer and its related treatment
Research Interest: The mechanisms of lung vascular endothelial cell dysfunction in acute lung injury
Research Interest: Redox signaling mechanism of Proinflammatory gene expression in pathogenesis of chronic inflammatory lung diseases caused by environmental toxicants
Research Interest: Mechanisms of toxicity of the environmental contaminant and neurotoxicant methylmercury (MeHg), defining MeHg effects on early life development of neural and muscular systems at the molecular, cellular, and organismal levels using invertebrate and mammalian models, and detailed characterization of MeHg metabolism and elimination kinetics in humans.
Research Interest: Our research program focuses on mechanisms underlying gene environment interaction in pregnancy. We are interested in elucidating how environmental factors influence epigenetic regulation of developmental-relevant genes including imprinted genes, and how exposure modulates maternal-fetal health.
Research Interest: Behavioral Pharmacology and Toxicology; Substance Abuse; Inhalation Toxicology; Medications for Urologic Disorders (urge incontinence, interstitial cystitis, pain)
Research Interest: Innovations in mass spectrometry assay design and implementation as it pertains to toxicology, personalized medicine, and health disparities.
Research Interest: Molecular mechanisms of skeletal repair in bone loss due to traumatic injury, tumor and bone graft.
