Anolik Lab
B Cells and Immune Diseases
Defining the role of B cells in systemic autoimmunity has been instrumental in characterizing the impact of B cell depletion (BCD) on the human immune system and establishing B cell targeted therapies. This has been a major advance in the field of immunologic disease with broad implications in rheumatoid arthritis, lupus, diabetes, malignancy, and immune deficiency.
Findings demonstrating a link between the clinical response and the immunologic reconstitution with transitional B cells was the first delineation of a B regulatory cell population in humans, greatly advancing our understanding of BCD therapy and human B cell development pathways. A prominent publication defining new populations of human transitional B cells provided further fundamental insights into the developmental process followed by human B cells, identifying a new population of human transitional B cells. Recent work has elucidated a previously unrecognized cross-talk between the B cell compartment and neutrophil driven α interferon production in the bone marrow in systemic lupus erythematosus (SLE) that alters B cell development and selection, as well as a critical role for B cells in regulation of bone homeostasis in RA.
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Jennifer Howitt Anolik, M.D., Ph.D.
Principal Investigator
Projects
View All ProjectsPublications
- Granzyme K activates the entire complement cascade.; Nature. 2025 Feb 06.
- Interferon activation in bone marrow long-lived plasma cells in systemic lupus erythematosus.; Frontiers in immunology; Vol 15, pp. 1499551. 2025 Jan 10.
- Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis.; Nature communications; Vol 15(1), pp. 9859. 2024 Nov 14.
- Highlights from the 2024 Rheumatoid Arthritis Research Summit.; Seminars in arthritis and rheumatism. 2024 Nov 08.
Affiliations
In the News
January 6, 2025
Jennifer Anolik Named Chief of Allergy, Immunology and Rheumatology Division
December 11, 2024
AIR Faculty Shine at ACR Meeting
October 4, 2024
Dr. Jennifer Anolik Delivers Keynote Address
August 5, 2024
Katherine Escalera-Rivera Receives Awards
June 13, 2024
Drs. Korman and Garcia-Henandez Receive University Research Award
Contact Us
Anolik Lab
601 Elmwood Ave/Box 695
Rochester, NY 14642