URMC / Labs / Bohmann Lab / Publications

Recent Publications

1. Bohmann D
2. O'Connell M
3. Frendewey D
4. Gerber A
5. Hernandez N
6. Krämer A
7. Minvielle-Sebastia L
8. Shaw P
9. Wahle E
10. Zavolan M
Walter Keller (1938-2023): a tribute from his mentees.; RNA (New York, N.Y.); Vol 29(9), pp. v-xiii. 2023 Jun 27.
1. Cheng Y
2. Pitoniak A
3. Wang J
4. Bohmann D
Preserving transcriptional stress responses as an anti-aging strategy.; Aging cell. 2021 Jan 20.
1. Mello S
2. Bohmann D
Counting the Minutes.; eLife; Vol 9. 2020 Jan 07.
1. Tian X
2. Firsanov D
3. Zhang Z
4. Cheng Y
5. Luo L
6. Tombline G
7. Tan R
8. Simon M
9. Henderson S
10. Steffan J
11. Goldfarb A
12. Tam J
13. Zheng K
14. Cornwell A
15. Johnson A
16. Yang JN
17. Mao Z
18. Manta B
19. Dang W
20. Zhang Z
21. Vijg J
22. Wolfe A
23. Moody K
24. Kennedy BK
25. Bohmann D
26. Gladyshev VN
27. Seluanov A
28. Gorbunova V
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.; Cell; Vol 177(3). 2019 Apr 18.
1. Chatterjee N
2. Bohmann D
BET-ting on Nrf2: How Nrf2 Signaling can Influence the Therapeutic Activities of BET Protein Inhibitors.; BioEssays : news and reviews in molecular, cellular and developmental biology. 2018 Mar 30.
1. Li X
2. Eberhardt A
3. Hansen JN
4. Bohmann D
5. Li H
6. Schor NF
Methylation of the phosphatase-transcription activator EYA1 by protein arginine methyltransferase 1: mechanistic, functional, and structural studies.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017 Feb 17.
1. Chatterjee N
2. Tian M
3. Spirohn K
4. Boutros M
5. Bohmann D
Keap1-Independent Regulation of Nrf2 Activity by Protein Acetylation and a BET Bromodomain Protein.; PLoS genetics; Vol 12(5). 2016 May.
1. Li X
2. Chatterjee N
3. Spirohn K
4. Boutros M
5. Bohmann D
Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes.; Scientific reports; Vol 6. 2016.
1. Pitoniak A
2. Bohmann D
Mechanisms and functions of Nrf2 signaling in Drosophila.; Free radical biology & medicine; Vol 88(Pt B). 2015 Nov.
1. Bohmann D
2. Dhillon P
Towards a systems-level understanding of aging and cancer: an interview with Dirk Bohmann.; Disease models & mechanisms; Vol 7(5). 2014 May.
1. Tsakiri EN
2. Sykiotis GP
3. Papassideri IS
4. Terpos E
5. Dimopoulos MA
6. Gorgoulis VG
7. Bohmann D
8. Trougakos IP
Proteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging.; Aging cell; Vol 12(5). 2013 Oct.
1. Rahman MM
2. Sykiotis GP
3. Nishimura M
4. Bodmer R
5. Bohmann D
Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes.; Aging cell; Vol 12(4). 2013 Aug.
1. Tsakiri EN
2. Sykiotis GP
3. Papassideri IS
4. Gorgoulis VG
5. Bohmann D
6. Trougakos IP
Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 27(6). 2013 Jun.
1. Barone MC
2. Bohmann D
Assessing neurodegenerative phenotypes in Drosophila dopaminergic neurons by climbing assays and whole brain immunostaining.; Journal of visualized experiments : JoVE. 2013.
1. Chatterjee N
2. Bohmann D
A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture.; PloS one; Vol 7(4). 2012.
1. Barone MC
2. Sykiotis GP
3. Bohmann D
Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.; Disease models & mechanisms; Vol 4(5). 2011 Sep.
1. Kriete A
2. Lechner M
3. Clearfield D
4. Bohmann D
Computational systems biology of aging.; Wiley interdisciplinary reviews. Systems biology and medicine; Vol 3(4). 2011 Jul.
1. Schreck I
2. Al-Rawi M
3. Mingot JM
4. Scholl C
5. Diefenbacher ME
6. O'Donnell P
7. Bohmann D
8. Weiss C
c-Jun localizes to the nucleus independent of its phosphorylation by and interaction with JNK and vice versa promotes nuclear accumulation of JNK.; Biochemical and biophysical research communications; Vol 407(4). 2011 Apr 22.
1. Hochmuth CE
2. Biteau B
3. Bohmann D
4. Jasper H
Redox regulation by Keap1 and Nrf2 controls intestinal stem cell proliferation in Drosophila.; Cell stem cell; Vol 8(2). 2011 Feb 4.
1. Sykiotis GP
2. Habeos IG
3. Samuelson AV
4. Bohmann D
The role of the antioxidant and longevity-promoting Nrf2 pathway in metabolic regulation.; Current opinion in clinical nutrition and metabolic care; Vol 14(1). 2011 Jan.
1. Wang Q
2. Uhlirova M
3. Bohmann D
Spatial restriction of FGF signaling by a matrix metalloprotease controls branching morphogenesis.; Developmental cell; Vol 18(1). 2010 Jan 19.
1. Sekyrova P
2. Bohmann D
3. Jindra M
4. Uhlirova M
Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis.; Development (Cambridge, England); Vol 137(1). 2010 Jan.
1. Sykiotis GP
2. Bohmann D
Stress-activated cap'n'collar transcription factors in aging and human disease.; Science signaling; Vol 3(112). 2010.
1. Wu H
2. Wang MC
3. Bohmann D
JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy.; Mechanisms of development; Vol 126(8-9). 2009 Aug.
1. Sykiotis GP
2. Bohmann D
Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila.; Developmental cell; Vol 14(1). 2008 Jan.
1. Luo X
2. Puig O
3. Hyun J
4. Bohmann D
5. Jasper H
Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation.; The EMBO journal; Vol 26(2). 2007 Jan 24.
1. Sykiotis GP
2. Bohmann D
Stress-Activated Protein Kinase Signaling in Drosophila; Topics in Current Genetics. 2007 Jan 01.
1. Uhlirova M
2. Bohmann D
JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila.; The EMBO journal; Vol 25(22). 2006 Nov 15.
1. Hyun J
2. Bécam I
3. Yanicostas C
4. Bohmann D
Control of G2/M transition by Drosophila Fos.; Molecular and cellular biology; Vol 26(22). 2006 Nov.
1. Homsy JG
2. Jasper H
3. Peralta XG
4. Wu H
5. Kiehart DP
6. Bohmann D
JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.; Developmental dynamics : an official publication of the American Association of Anatomists; Vol 235(2). 2006 Feb.
1. Miotto B
2. Sagnier T
3. Berenger H
4. Bohmann D
5. Pradel J
6. Graba Y
Chameau HAT and DRpd3 HDAC function as antagonistic cofactors of JNK/AP-1-dependent transcription during Drosophila metamorphosis.; Genes & development; Vol 20(1). 2006 Jan 1.
1. Uhlirova M
2. Jasper H
3. Bohmann D
Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model.; Proceedings of the National Academy of Sciences of the United States of America; Vol 102(37). 2005 Sep 13.
1. Hyun J
2. Jasper H
3. Bohmann D
DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs.; Molecular and cellular biology; Vol 25(13). 2005 Jul.
1. Wang MC
2. Bohmann D
3. Jasper H
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling.; Cell; Vol 121(1). 2005 Apr 08.
1. Letsou A
2. Bohmann D
Small flies--big discoveries: nearly a century of Drosophila genetics and development.; Developmental dynamics : an official publication of the American Association of Anatomists; Vol 232(3). 2005 Mar.
1. Etter PD
2. Narayanan R
3. Navratilova Z
4. Patel C
5. Bohmann D
6. Jasper H
7. Ramaswami M
Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons.; BMC neuroscience; Vol 6. 2005.
1. Portman DS
2. Bohmann D
Toward the computable transcriptome.; Molecular cell; Vol 14(6). 2004 Jun 18.
1. Su C
2. Gao G
3. Schneider S
4. Helt C
5. Weiss C
6. O'Reilly MA
7. Bohmann D
8. Zhao J
DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway.; The EMBO journal; Vol 23(5). 2004 Mar 10.
1. Weiss C
2. Bohmann D
Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis.; Cell cycle (Georgetown, Tex.); Vol 3(2). 2004 Feb.
1. Wang MC
2. Bohmann D
3. Jasper H
JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.; Developmental cell; Vol 5(5). 2003 Nov.
1. Weiss C
2. Schneider S
3. Wagner EF
4. Zhang X
5. Seto E
6. Bohmann D
JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun.; The EMBO journal; Vol 22(14). 2003 Jul 15.
1. Jasper H
2. Bohmann D
Drosophila innate immunity: a genomic view of pathogen defense.; Molecular cell; Vol 10(5). 2002 Nov.
1. Jasper H
2. Benes V
3. Atzberger A
4. Sauer S
5. Ansorge W
6. Bohmann D
A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye.; Developmental cell; Vol 3(4). 2002 Oct.
1. Gallo A
2. Cuozzo C
3. Esposito I
4. Maggiolini M
5. Bonofiglio D
6. Vivacqua A
7. Garramone M
8. Weiss C
9. Bohmann D
10. Musti AM
Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation.; Oncogene; Vol 21(42). 2002 Sep 19.
1. Lafarga M
2. Berciano MT
3. Pena E
4. Mayo I
5. Castaño JG
6. Bohmann D
7. Rodrigues JP
8. Tavanez JP
9. Carmo-Fonseca M
Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.; Molecular biology of the cell; Vol 13(8). 2002 Aug.
1. Ciapponi L
2. Bohmann D
An essential function of AP-1 heterodimers in Drosophila development.; Mechanisms of development; Vol 115(1-2). 2002 Jul.
1. Gritzan U
2. Weiss C
3. Brennecke J
4. Bohmann D
Transrepression of AP-1 by nuclear receptors in Drosophila.; Mechanisms of development; Vol 115(1-2). 2002 Jul.
1. Westermarck J
2. Weiss C
3. Saffrich R
4. Kast J
5. Musti AM
6. Wessely M
7. Ansorge W
8. Séraphin B
9. Wilm M
10. Valdez BC
11. Bohmann D
The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription.; The EMBO journal; Vol 21(3). 2002 Feb 1.
1. Jasper H
2. Benes V
3. Schwager C
4. Sauer S
5. Clauder-Münster S
6. Ansorge W
7. Bohmann D
The genomic response of the Drosophila embryo to JNK signaling.; Developmental cell; Vol 1(4). 2001 Oct.
1. Leppä S
2. Eriksson M
3. Saffrich R
4. Ansorge W
5. Bohmann D
Complex functions of AP-1 transcription factors in differentiation and survival of PC12 cells.; Molecular and cellular biology; Vol 21(13). 2001 Jul.