News
Brown and Zhang lab are awarded NIH funding to apply optical techniques to understand the healing of bone
Sunday, May 1, 2016
The Brown Lab, in collaboration with the laboratory of Xinping Zhang of the URMC Center for Musculoskeletal Research, is excited to receive an NIH R21 award entitled “Understanding revascularization and repair of cranial bone grafts via intravital imaging.”
The goal of this proposal is to evaluate the role of hypoxia during revascularization of cranial bone grafts, using second harmonic generation imaging to assess the role of collagen in bone regrowth and phorophorescence decay methods to measure p02. This project builds upon Dr. Brown’s previous work with optical techniques to study collagen structure in tissue, as well as optical methods to quantify transport. It also builds upon Dr. Zhang’s exploration of the biology of bone healing, and her efforts to improve clinical outcomes in the healing of critical sized bone defects.