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Recent Publications

1. Joshi IM
2. Mansouri M
3. Ahmed A
4. De Silva D
5. Simon RA
6. Esmaili P
7. Desa DE
8. Elias TM
9. Brown EB
10. Abhyankar VV
Microengineering 3D Collagen Matrices with Tumor-Mimetic Gradients in Fiber Alignment.; Advanced functional materials; Vol 34(13). 2023 Dec 17.
1. Elias TM
2. Brown EB
3. Brown EB
Expanding the applicability of multiphoton fluorescence recovery after photobleaching by incorporating shear stress in laminar flow.; Journal of biomedical optics; Vol 28(7), pp. 076502. 2023 Jul 21.
1. Joshi IM
2. Mansouri M
3. Ahmed A
4. Simon RA
5. Bambizi PE
6. Desa DE
7. Elias TM
8. Brown EB
9. Abhyankar VV
Microengineering 3D Collagen Matrices with Tumor-Mimetic Gradients in Fiber Alignment.; bioRxiv : the preprint server for biology. 2023 Jul 10.
1. Dunn KJ
2. Elias TM
3. Brown EB
4. Berger AJ
Matching an immersion medium's refractive index to a cell's cytosol isolates organelle scattering.; Biomedical optics express; Vol 13(8), pp. 4236-4246. 2022 Jul 19.
1. Martin JD
2. Lanning RM
3. Chauhan VP
4. Martin MR
5. Mousa AS
6. Kamoun WS
7. Han HS
8. Lee H
9. Stylianopoulos T
10. Bawendi MG
11. Duda DG
12. Brown EB
13. Padera TP
14. Fukumura D
15. Jain RK
Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition.; Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 May 18.
1. Desa DE
2. Wu W
3. Brown RM
4. Brown EB
5. Hill RL
6. Turner BM
7. Brown EB
Second-Harmonic Generation Imaging Reveals Changes in Breast Tumor Collagen Induced by Neoadjuvant Chemotherapy.; Cancers; Vol 14(4). 2022 Feb 09.
1. Schilling K
2. Zhai Y
3. Zhou Z
4. Zhou B
5. Brown E
6. Zhang X
High resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy.; eLife; Vol 11. 2022 Jan 03.
1. Schilling K
2. Brown E
3. Zhang X
NAD(P)H autofluorescence lifetime imaging enables single cell analyses of cellular metabolism of osteoblasts in vitro and in vivo via two-photon microscopy.; Bone. 2021 Nov 12.
1. Zhai Y
2. Schilling K
3. Wang T
4. El Khatib M
5. Vinogradov S
6. Brown EB
7. Zhang X
Spatiotemporal blood vessel specification at the osteogenesis and angiogenesis interface of biomimetic nanofiber-enabled bone tissue engineering.; Biomaterials; Vol 276. 2021 Jul 26.
1. Desa DE
2. Strawderman RL
3. Wu W
4. Hill RL
5. Smid M
6. Martens JWM
7. Turner BM
8. Brown EB
Intratumoral heterogeneity of second-harmonic generation scattering from tumor collagen and its effects on metastatic risk prediction.; BMC cancer; Vol 20(1). 2020 Dec 10.
1. Shares BH
2. Smith CO
3. Sheu TJ
4. Sautchuk R
5. Schilling K
6. Shum LC
7. Paine A
8. Huber A
9. Gira E
10. Brown E
11. Awad H
12. Eliseev RA
Inhibition of the mitochondrial permeability transition improves bone fracture repair.; Bone. 2020 Apr 28.
1. Dawes RP
2. Burke KA
3. Byun DK
4. Xu Z
5. Stastka P
6. Chan L
7. Brown EB
8. Madden KS
Chronic Stress Exposure Suppresses Mammary Tumor Growth and Reduces Circulating Exosome TGF-β Content via β-Adrenergic Receptor Signaling in MMTV-PyMT Mice.; Breast cancer : basic and clinical research; Vol 14. 2020.
1. Stowell RD
2. Sipe GO
3. Dawes RP
4. Batchelor HN
5. Lordy KA
6. Whitelaw BS
7. Stoessel MB
8. Bidlack JM
9. Brown E
10. Sur M
11. Majewska AK
Author Correction: Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex.; Nature neuroscience. 2019 Nov 27.
1. Stowell RD
2. Sipe GO
3. Dawes RP
4. Batchelor HN
5. Lordy KA
6. Whitelaw BS
7. Stoessel MB
8. Bidlack JM
9. Brown E
10. Sur M
11. Majewska AK
Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex.; Nature neuroscience. 2019 Oct 21.
1. Schilling K
2. El Khatib M
3. Plunkett S
4. Xue J
5. Xia Y
6. Vinogradov SA
7. Brown E
8. Zhang X
Electrospun Fiber Mesh for High-Resolution Measurements of Oxygen Tension in Cranial Bone Defect Repair.; ACS applied materials & interfaces; Vol 11(37). 2019 Sep 18.
1. Desa DE
2. Bhanote M
3. Hill RL
4. Majeski JB
5. Buscaglia B
6. D'Aguiar M
7. Strawderman R
8. Hicks DG
9. Turner BM
10. Brown EB
Second-harmonic generation directionality is associated with neoadjuvant chemotherapy response in breast cancer core needle biopsies.; Journal of biomedical optics; Vol 24(8). 2019 Aug.
1. Yu D
2. Brown EB
3. Huxlin KR
4. Knox WH
Tissue effects of intra-tissue refractive index shaping (IRIS): insights from two-photon autofluorescence and second harmonic generation microscopy.; Biomedical optics express; Vol 10(2). 2019 Feb 01.
1. Pan XS
2. Li J
3. Brown EB
4. Kuo CK
Embryo movements regulate tendon mechanical property development.; Philosophical transactions of the Royal Society of London. Series B, Biological sciences; Vol 373(1759). 2018 Sep 24.
1. Paquette ST
2. Dawes RP
3. Sundar IK
4. Rahman I
5. Brown EB
6. White PM
Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice.; Scientific reports; Vol 8(1). 2018 Apr 10.
1. Ramirez G
2. Proctor AR
3. Jung KW
4. Wu TT
5. Han S
6. Adams RR
7. Ren J
8. Byun DK
9. Madden KS
10. Brown EB
11. Foster TH
12. Farzam P
13. Durduran T
14. Choe R
Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy.; Biomedical optics express; Vol 7(9). 2016 Sep 1.
1. Herr MM
2. Mohile NA
3. van Wijngaarden E
4. Brown EB
5. Rich DQ
Antidepressant use and risk of central nervous system metastasis.; Journal of neuro-oncology. 2016 Jun 11.
1. Herr MM
2. Mohile NA
3. Barr PM
4. van Wijngaarden E
5. Brown EB
6. Rich DQ
Survival of Secondary Central Nervous System Lymphoma Patients in the Rituximab Era.; Clinical lymphoma, myeloma & leukemia. 2016 Jun 8.
1. Van Hove AH
2. Burke K
3. Antonienko E
4. Brown E
5. Benoit DS
Enzymatically-responsive pro-angiogenic peptide-releasing poly(ethylene glycol) hydrogels promote vascularization in vivo.; Journal of controlled release : official journal of the Controlled Release Society; Vol 217. 2015 Nov 10.
1. Van Hove AH
2. Antonienko E
3. Burke K
4. Brown E
5. Benoit DS
Temporally Tunable, Enzymatically Responsive Delivery of Proangiogenic Peptides from Poly(ethylene glycol) Hydrogels.; Advanced healthcare materials. 2015 Jul 7.
1. Kottmann RM
2. Sharp J
3. Owens K
4. Salzman P
5. Xiao GQ
6. Phipps RP
7. Sime PJ
8. Brown EB
9. Perry SW
Second harmonic generation microscopy reveals altered collagen microstructure in usual interstitial pneumonia versus healthy lung.; Respiratory research; Vol 16(1). 2015 May 27.
1. Burke KA
2. Dawes RP
3. Cheema MK
4. Van Hove A
5. Benoit DS
6. Perry SW
7. Brown E
Second-harmonic generation scattering directionality predicts tumor cell motility in collagen gels.; Journal of biomedical optics; Vol 20(5). 2015 May.
1. Haynes-Gimore N
2. Banach M
3. Brown E
4. Dawes R
5. Edholm ES
6. Kim M
7. Robert J
Semi-solid tumsor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration.; Developmental biology. 2015 Jan 16.
1. Huang C
2. Ness VP
3. Yang X
4. Chen H
5. Luo J
6. Brown EB
7. Zhang X
Spatiotemporal Analyses of Osteogenesis and Angiogenesis via Intravital Imaging in Cranial Bone Defect Repair.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015 Jan 15.
1. Bouta EM
2. Li J
3. Ju Y
4. Brown EB
5. Ritchlin CT
6. Xing L
7. Schwarz EM
The Role of the Lymphatic System in Inflammatory-Erosive Arthritis.; Seminars in cell & developmental biology. 2015 Jan 15.
1. Burke K
2. Brown E
The Use of Second Harmonic Generation to Image the Extracellular Matrix During Tumor Progression.; Intravital; Vol 3(3). 2014 Dec.
1. Bouta EM
2. Wood RW
3. Brown EB
4. Rahimi H
5. Ritchlin CT
6. Schwarz EM
In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice.; The Journal of physiology; Vol 592(Pt 6). 2014 Mar 15.
1. Sullivan KD
2. Majewska AK
3. Brown EB
Single- and two-photon fluorescence recovery after photobleaching.; Cold Spring Harbor protocols; Vol 2015(1). 2015.
1. Shapovalov Y
2. Zettel M
3. Spielman SC
4. Amico-Ruvio SA
5. Kelly EA
6. Sipe GO
7. Dickerson IM
8. Majewska AK
9. Brown EB
Fluoxetine modulates breast cancer metastasis to the brain in a murine model.; BMC cancer; Vol 14. 2014.
1. Szpunar MJ
2. Burke KA
3. Dawes RP
4. Brown EB
5. Madden KS
The antidepressant desipramine and α2-adrenergic receptor activation promote breast tumor progression in association with altered collagen structure.; Cancer prevention research (Philadelphia, Pa.); Vol 6(12). 2013 Dec.
1. Arendt O
2. Schwaller B
3. Brown EB
4. Eilers J
5. Schmidt H
Restricted diffusion of calretinin in cerebellar granule cell dendrites implies Ca²⁺-dependent interactions via its EF-hand 5 domain.; The Journal of physiology; Vol 591(Pt 16). 2013 Aug 15.
1. Burke RM
2. Madden KS
3. Perry SW
4. Zettel ML
5. Brown EB
Tumor-associated macrophages and stromal TNF-α regulate collagen structure in a breast tumor model as visualized by second harmonic generation.; Journal of biomedical optics; Vol 18(8). 2013 Aug.
1. Chen T
2. Hilton MJ
3. Brown EB
4. Zuscik MJ
5. Awad HA
Engineering superficial zone features in tissue engineered cartilage.; Biotechnology and bioengineering; Vol 110(5). 2013 May.
1. Burke K
2. Tang P
3. Brown E
Second harmonic generation reveals matrix alterations during breast tumor progression.; Journal of biomedical optics; Vol 18(3). 2013 Mar.
1. Madden KS
2. Szpunar MJ
3. Brown EB
Early impact of social isolation and breast tumor progression in mice.; Brain, behavior, and immunity; Vol 30 Suppl. 2013 Mar.
1. Madden KS
2. Zettel ML
3. Majewska AK
4. Brown EB
Brain tumor imaging: imaging brain metastasis using a brain-metastasizing breast adenocarcinoma.; Cold Spring Harbor protocols; Vol 2013(3). 2013 Mar.
1. Madden KS
2. Zettel ML
3. Majewska AK
4. Brown EB
Brain tumor imaging: live imaging of glioma by two-photon microscopy.; Cold Spring Harbor protocols; Vol 2013(3). 2013 Mar.
1. Perry SW
2. Schueckler JM
3. Burke K
4. Arcuri GL
5. Brown EB
Stromal matrix metalloprotease-13 knockout alters Collagen I structure at the tumor-host interface and increases lung metastasis of C57BL/6 syngeneic E0771 mammary tumor cells.; BMC cancer; Vol 13. 2013.
1. Perry SW
2. Burke RM
3. Brown EB
Two-photon and second harmonic microscopy in clinical and translational cancer research.; Annals of biomedical engineering; Vol 40(2). 2012 Feb.
1. Bouta EM
2. Wood RW
3. Perry SW
4. Brown EB
5. Ritchlin CT
6. Xing L
7. Schwarz EM
Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes.; Annals of the New York Academy of Sciences; Vol 1240. 2011 Dec.
1. Madden KS
2. Szpunar MJ
3. Brown EB
β-Adrenergic receptors (β-AR) regulate VEGF and IL-6 production by divergent pathways in high β-AR-expressing breast cancer cell lines.; Breast cancer research and treatment; Vol 130(3). 2011 Dec.
1. Sullivan KD
2. Brown EB
Multiphoton fluorescence recovery after photobleaching in bounded systems.; Physical review. E, Statistical, nonlinear, and soft matter physics; Vol 83(5 Pt 1). 2011 May.
1. Perry SW
2. Norman JP
3. Barbieri J
4. Brown EB
5. Gelbard HA
Mitochondrial membrane potential probes and the proton gradient: a practical usage guide.; BioTechniques; Vol 50(2). 2011 Feb.
1. Sullivan K
2. Brown E
Diffusion and multi-photon fluorescence recovery after photobleaching in bounded systems; Physical review E. In Press. 2011 Jan 01.
1. Perry S
2. Norman J
3. Barbieri J
4. Brown E
5. Gelbard H
Mitochondrial membrane potential probes and the proton gradient: a practical usage guide; BioTechniques. In Press. 2011 Jan 01.
1. Kozai TD
2. Marzullo TC
3. Hooi F
4. Langhals NB
5. Majewska AK
6. Brown EB
7. Kipke DR
Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in vivo two-photon mapping.; Journal of neural engineering; Vol 7(4). 2010 Aug.
1. Han X
2. Brown E
Measurement of the ratio of forward-propagating to back-propagating second harmonic signal using a single objective.; Optics express; Vol 18(10). 2010 May 10.
1. Sullivan KD
2. Brown EB
Measuring diffusion coefficients via two-photon fluorescence recovery after photobleaching.; Journal of visualized experiments : JoVE. 2010.
1. Li J
2. Sullivan K
3. Brown E
4. Anthamatten M
Thermally activated diffusion in reversibly associating polymers; Soft matter; Vol 6, pp. 235-238. 2010 Jan 01.
1. Sullivan K
2. Brown E
Measuring Diffusion Coefficients via Two-Photon Fluorescence Recovery After Photobleaching; Journal of visualized experiments; Vol 36. 2010 Jan 01.
1. Chauhan VP
2. Lanning RM
3. Diop-Frimpong B
4. Mok W
5. Brown EB
6. Padera TP
7. Boucher Y
8. Jain RK
Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.; Biophysical journal; Vol 97(1). 2009 Jul 8.
1. Sullivan KD
2. Sipprell WH
3. Brown EB
4. Brown EB
Improved model of fluorescence recovery expands the application of multiphoton fluorescence recovery after photobleaching in vivo.; Biophysical journal; Vol 96(12). 2009 Jun 17.
1. Han X
2. Burke RM
3. Zettel ML
4. Tang P
5. Brown EB
Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma.; Optics express; Vol 16(3). 2008 Feb 4.
1. Schmidt H
2. Arendt O
3. Brown EB
4. Schwaller B
5. Eilers J
Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones.; Journal of neurochemistry; Vol 100(3). 2007 Feb.
1. Tyrrell JA
2. Mahadevan V
3. Tong RT
4. Brown EB
5. Jain RK
6. Roysam B
A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy.; Microvascular research; Vol 70(3). 2005 Nov.
1. Stroh M
2. Zimmer JP
3. Duda DG
4. Levchenko TS
5. Cohen KS
6. Brown EB
7. Scadden DT
8. Torchilin VP
9. Bawendi MG
10. Fukumura D
11. Jain RK
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.; Nature medicine; Vol 11(6). 2005 Jun.
1. Duda DG
2. Fukumura D
3. Munn LL
4. Booth MF
5. Brown EB
6. Huang P
7. Seed B
8. Jain RK
Differential transplantability of tumor-associated stromal cells.; Cancer research; Vol 64(17). 2004 Sep 1.
1. Brown EB
2. Boucher Y
3. Nasser S
4. Jain RK
Measurement of macromolecular diffusion coefficients in human tumors.; Microvascular research; Vol 67(3). 2004 May.
1. Garkavtsev I
2. Kozin SV
3. Chernova O
4. Xu L
5. Winkler F
6. Brown E
7. Barnett GH
8. Jain RK
The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.; Nature; Vol 428(6980). 2004 Mar 18.
1. Alexandrakis G
2. Brown EB
3. Tong RT
4. McKee TD
5. Campbell RB
6. Boucher Y
7. Jain RK
Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.; Nature medicine; Vol 10(2). 2004 Feb.
1. Znati CA
2. Rosenstein M
3. McKee TD
4. Brown E
5. Turner D
6. Bloomer WD
7. Watkins S
8. Jain RK
9. Boucher Y
Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.; Clinical cancer research : an official journal of the American Association for Cancer Research; Vol 9(15). 2003 Nov 15.
1. Abdul-Karim MA
2. Al-Kofahi K
3. Brown EB
4. Jain RK
5. Roysam B
Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series.; Microvascular research; Vol 66(2). 2003 Sep.
1. Brown E
2. McKee T
3. diTomaso E
4. Pluen A
5. Seed B
6. Boucher Y
7. Jain RK
Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.; Nature medicine; Vol 9(6). 2003 Jun.
1. Schmidt H
2. Brown EB
3. Schwaller B
4. Eilers J
Diffusional mobility of parvalbumin in spiny dendrites of cerebellar Purkinje neurons quantified by fluorescence recovery after photobleaching.; Biophysical journal; Vol 84(4). 2003 Apr.
1. Wei X
2. Henke VG
3. Strübing C
4. Brown EB
5. Clapham DE
Real-time imaging of nuclear permeation by EGFP in single intact cells.; Biophysical journal; Vol 84(2 Pt 1). 2003 Feb.
1. Campbell RB
2. Fukumura D
3. Brown EB
4. Mazzola LM
5. Izumi Y
6. Jain RK
7. Torchilin VP
8. Munn LL
Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.; Cancer research; Vol 62(23). 2002 Dec 1.
1. Migliorini C
2. Qian Y
3. Chen H
4. Brown EB
5. Jain RK
6. Munn LL
Red blood cells augment leukocyte rolling in a virtual blood vessel.; Biophysical journal; Vol 83(4). 2002 Oct.
1. Ramanujan S
2. Pluen A
3. McKee TD
4. Brown EB
5. Boucher Y
6. Jain RK
Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.; Biophysical journal; Vol 83(3). 2002 Sep.
1. Padera TP
2. Kadambi A
3. di Tomaso E
4. Carreira CM
5. Brown EB
6. Boucher Y
7. Choi NC
8. Mathisen D
9. Wain J
10. Mark EJ
11. Munn LL
12. Jain RK
Lymphatic metastasis in the absence of functional intratumor lymphatics.; Science (New York, N.Y.); Vol 296(5574). 2002 Jun 7.
1. Brown EB
2. Campbell RB
3. Tsuzuki Y
4. Xu L
5. Carmeliet P
6. Fukumura D
7. Jain RK
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.; Nature medicine; Vol 7(7). 2001 Jul.
1. Pluen A
2. Boucher Y
3. Ramanujan S
4. McKee TD
5. Gohongi T
6. di Tomaso E
7. Brown EB
8. Izumi Y
9. Campbell RB
10. Berk DA
11. Jain RK
Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.; Proceedings of the National Academy of Sciences of the United States of America; Vol 98(8). 2001 Apr 10.
1. Majewska A
2. Brown E
3. Ross J
4. Yuste R
Mechanisms of calcium decay kinetics in hippocampal spines: role of spine calcium pumps and calcium diffusion through the spine neck in biochemical compartmentalization.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 20(5). 2000 Mar 1.
1. Brown EB
2. Wu ES
3. Zipfel W
4. Webb WW
Measurement of molecular diffusion in solution by multiphoton fluorescence photobleaching recovery.; Biophysical journal; Vol 77(5). 1999 Nov.
1. Brown EB
2. Shear JB
3. Adams SR
4. Tsien RY
5. Webb WW
Photolysis of caged calcium in femtoliter volumes using two-photon excitation.; Biophysical journal; Vol 76(1 Pt 1). 1999 Jan.
1. Brown EB
2. Webb WW
Two-photon activation of caged calcium with submicron, submillisecond resolution.; Methods in enzymology; Vol 291. 1998.
1. Shear JB
2. Brown EB
3. Webb WW
Multiphoton-excited fluorescence of fluorogen-labeled neurotransmitters.; Analytical chemistry; Vol 68(10). 1996 May 15.