Recent Publications

• 1. Joshi IM
  2. Mansouri M
  3. Ahmed A
  4. De Silva D
  5. Simon RA
  6. Esmaili P
  7. Desa DE
  8. Elias TM
  9. Brown EB
  10. Abhyankar VV
  Microengineering 3D Collagen Matrices with Tumor-Mimetic Gradients in Fiber Alignment.; Advanced functional materials; Vol 34(13). 2023 Dec 17.
• 1. Elias TM
  2. Brown EB
  3. Brown EB
  Expanding the applicability of multiphoton fluorescence recovery after photobleaching by incorporating shear stress in laminar flow.; Journal of biomedical optics; Vol 28(7), pp. 076502. 2023 Jul 21.
• 1. Joshi IM
  2. Mansouri M
  3. Ahmed A
  4. Simon RA
  5. Bambizi PE
  6. Desa DE
  7. Elias TM
  8. Brown EB
  9. Abhyankar VV
  Microengineering 3D Collagen Matrices with Tumor-Mimetic Gradients in Fiber Alignment.; bioRxiv : the preprint server for biology. 2023 Jul 10.
• 1. Dunn KJ
  2. Elias TM
  3. Brown EB
  4. Berger AJ
  Matching an immersion medium's refractive index to a cell's cytosol isolates organelle scattering.; Biomedical optics express; Vol 13(8), pp. 4236-4246. 2022 Jul 19.
• 1. Martin JD
  2. Lanning RM
  3. Chauhan VP
  4. Martin MR
  5. Mousa AS
  6. Kamoun WS
  7. Han HS
  8. Lee H
  9. Stylianopoulos T
  10. Bawendi MG
  11. Duda DG
  12. Brown EB
  13. Padera TP
  14. Fukumura D
  15. Jain RK
  Multiphoton phosphorescence quenching microscopy reveals kinetics of tumor oxygenation during anti-angiogenesis and angiotensin signaling inhibition.; Clinical cancer research : an official journal of the American Association for Cancer Research. 2022 May 18.
• 1. Desa DE
  2. Wu W
  3. Brown RM
  4. Brown EB
  5. Hill RL
  6. Turner BM
  7. Brown EB
  Second-Harmonic Generation Imaging Reveals Changes in Breast Tumor Collagen Induced by Neoadjuvant Chemotherapy.; Cancers; Vol 14(4). 2022 Feb 09.
• 1. Schilling K
  2. Zhai Y
  3. Zhou Z
  4. Zhou B
  5. Brown E
  6. Zhang X
  High resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy.; eLife; Vol 11. 2022 Jan 03.
• 1. Schilling K
  2. Brown E
  3. Zhang X
  NAD(P)H autofluorescence lifetime imaging enables single cell analyses of cellular metabolism of osteoblasts in vitro and in vivo via two-photon microscopy.; Bone. 2021 Nov 12.
• 1. Zhai Y
  2. Schilling K
  3. Wang T
  4. El Khatib M
  5. Vinogradov S
  6. Brown EB
  7. Zhang X
  Spatiotemporal blood vessel specification at the osteogenesis and angiogenesis interface of biomimetic nanofiber-enabled bone tissue engineering.; Biomaterials; Vol 276. 2021 Jul 26.
• 1. Desa DE
  2. Strawderman RL
  3. Wu W
  4. Hill RL
  5. Smid M
  6. Martens JWM
  7. Turner BM
  8. Brown EB
  Intratumoral heterogeneity of second-harmonic generation scattering from tumor collagen and its effects on metastatic risk prediction.; BMC cancer; Vol 20(1). 2020 Dec 10.
• 1. Shares BH
  2. Smith CO
  3. Sheu TJ
  4. Sautchuk R
  5. Schilling K
  6. Shum LC
  7. Paine A
  8. Huber A
  9. Gira E
  10. Brown E
  11. Awad H
  12. Eliseev RA
  Inhibition of the mitochondrial permeability transition improves bone fracture repair.; Bone. 2020 Apr 28.
• 1. Dawes RP
  2. Burke KA
  3. Byun DK
  4. Xu Z
  5. Stastka P
  6. Chan L
  7. Brown EB
  8. Madden KS
  Chronic Stress Exposure Suppresses Mammary Tumor Growth and Reduces Circulating Exosome TGF-β Content via β-Adrenergic Receptor Signaling in MMTV-PyMT Mice.; Breast cancer : basic and clinical research; Vol 14. 2020.
• 1. Stowell RD
  2. Sipe GO
  3. Dawes RP
  4. Batchelor HN
  5. Lordy KA
  6. Whitelaw BS
  7. Stoessel MB
  8. Bidlack JM
  9. Brown E
  10. Sur M
  11. Majewska AK
  Author Correction: Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex.; Nature neuroscience. 2019 Nov 27.
• 1. Stowell RD
  2. Sipe GO
  3. Dawes RP
  4. Batchelor HN
  5. Lordy KA
  6. Whitelaw BS
  7. Stoessel MB
  8. Bidlack JM
  9. Brown E
  10. Sur M
  11. Majewska AK
  Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex.; Nature neuroscience. 2019 Oct 21.
• 1. Schilling K
  2. El Khatib M
  3. Plunkett S
  4. Xue J
  5. Xia Y
  6. Vinogradov SA
  7. Brown E
  8. Zhang X
  Electrospun Fiber Mesh for High-Resolution Measurements of Oxygen Tension in Cranial Bone Defect Repair.; ACS applied materials & interfaces; Vol 11(37). 2019 Sep 18.
• 1. Desa DE
  2. Bhanote M
  3. Hill RL
  4. Majeski JB
  5. Buscaglia B
  6. D'Aguiar M
  7. Strawderman R
  8. Hicks DG
  9. Turner BM
  10. Brown EB
  Second-harmonic generation directionality is associated with neoadjuvant chemotherapy response in breast cancer core needle biopsies.; Journal of biomedical optics; Vol 24(8). 2019 Aug.
• 1. Yu D
  2. Brown EB
  3. Huxlin KR
  4. Knox WH
  Tissue effects of intra-tissue refractive index shaping (IRIS): insights from two-photon autofluorescence and second harmonic generation microscopy.; Biomedical optics express; Vol 10(2). 2019 Feb 01.
• 1. Pan XS
  2. Li J
  3. Brown EB
  4. Kuo CK
  Embryo movements regulate tendon mechanical property development.; Philosophical transactions of the Royal Society of London. Series B, Biological sciences; Vol 373(1759). 2018 Sep 24.
• 1. Paquette ST
  2. Dawes RP
  3. Sundar IK
  4. Rahman I
  5. Brown EB
  6. White PM
  Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice.; Scientific reports; Vol 8(1). 2018 Apr 10.
• 1. Ramirez G
  2. Proctor AR
  3. Jung KW
  4. Wu TT
  5. Han S
  6. Adams RR
  7. Ren J
  8. Byun DK
  9. Madden KS
  10. Brown EB
  11. Foster TH
  12. Farzam P
  13. Durduran T
  14. Choe R
  Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy.; Biomedical optics express; Vol 7(9). 2016 Sep 1.
• 1. Herr MM
  2. Mohile NA
  3. van Wijngaarden E
  4. Brown EB
  5. Rich DQ
  Antidepressant use and risk of central nervous system metastasis.; Journal of neuro-oncology. 2016 Jun 11.
• 1. Herr MM
  2. Mohile NA
  3. Barr PM
  4. van Wijngaarden E
  5. Brown EB
  6. Rich DQ
  Survival of Secondary Central Nervous System Lymphoma Patients in the Rituximab Era.; Clinical lymphoma, myeloma & leukemia. 2016 Jun 8.
• 1. Van Hove AH
  2. Burke K
  3. Antonienko E
  4. Brown E
  5. Benoit DS
  Enzymatically-responsive pro-angiogenic peptide-releasing poly(ethylene glycol) hydrogels promote vascularization in vivo.; Journal of controlled release : official journal of the Controlled Release Society; Vol 217. 2015 Nov 10.
• 1. Van Hove AH
  2. Antonienko E
  3. Burke K
  4. Brown E
  5. Benoit DS
  Temporally Tunable, Enzymatically Responsive Delivery of Proangiogenic Peptides from Poly(ethylene glycol) Hydrogels.; Advanced healthcare materials. 2015 Jul 7.
• 1. Kottmann RM
  2. Sharp J
  3. Owens K
  4. Salzman P
  5. Xiao GQ
  6. Phipps RP
  7. Sime PJ
  8. Brown EB
  9. Perry SW
  Second harmonic generation microscopy reveals altered collagen microstructure in usual interstitial pneumonia versus healthy lung.; Respiratory research; Vol 16(1). 2015 May 27.
• 1. Burke KA
  2. Dawes RP
  3. Cheema MK
  4. Van Hove A
  5. Benoit DS
  6. Perry SW
  7. Brown E
  Second-harmonic generation scattering directionality predicts tumor cell motility in collagen gels.; Journal of biomedical optics; Vol 20(5). 2015 May.
• 1. Haynes-Gimore N
  2. Banach M
  3. Brown E
  4. Dawes R
  5. Edholm ES
  6. Kim M
  7. Robert J
  Semi-solid tumsor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration.; Developmental biology. 2015 Jan 16.
• 1. Huang C
  2. Ness VP
  3. Yang X
  4. Chen H
  5. Luo J
  6. Brown EB
  7. Zhang X
  Spatiotemporal Analyses of Osteogenesis and Angiogenesis via Intravital Imaging in Cranial Bone Defect Repair.; Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015 Jan 15.
• 1. Bouta EM
  2. Li J
  3. Ju Y
  4. Brown EB
  5. Ritchlin CT
  6. Xing L
  7. Schwarz EM
  The Role of the Lymphatic System in Inflammatory-Erosive Arthritis.; Seminars in cell & developmental biology. 2015 Jan 15.
• 1. Burke K
  2. Brown E
  The Use of Second Harmonic Generation to Image the Extracellular Matrix During Tumor Progression.; Intravital; Vol 3(3). 2014 Dec.
• 1. Bouta EM
  2. Wood RW
  3. Brown EB
  4. Rahimi H
  5. Ritchlin CT
  6. Schwarz EM
  In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice.; The Journal of physiology; Vol 592(Pt 6). 2014 Mar 15.
• 1. Sullivan KD
  2. Majewska AK
  3. Brown EB
  Single- and two-photon fluorescence recovery after photobleaching.; Cold Spring Harbor protocols; Vol 2015(1). 2015.
• 1. Shapovalov Y
  2. Zettel M
  3. Spielman SC
  4. Amico-Ruvio SA
  5. Kelly EA
  6. Sipe GO
  7. Dickerson IM
  8. Majewska AK
  9. Brown EB
  Fluoxetine modulates breast cancer metastasis to the brain in a murine model.; BMC cancer; Vol 14. 2014.
• 1. Szpunar MJ
  2. Burke KA
  3. Dawes RP
  4. Brown EB
  5. Madden KS
  The antidepressant desipramine and α2-adrenergic receptor activation promote breast tumor progression in association with altered collagen structure.; Cancer prevention research (Philadelphia, Pa.); Vol 6(12). 2013 Dec.
• 1. Arendt O
  2. Schwaller B
  3. Brown EB
  4. Eilers J
  5. Schmidt H
  Restricted diffusion of calretinin in cerebellar granule cell dendrites implies Ca²⁺-dependent interactions via its EF-hand 5 domain.; The Journal of physiology; Vol 591(Pt 16). 2013 Aug 15.
• 1. Burke RM
  2. Madden KS
  3. Perry SW
  4. Zettel ML
  5. Brown EB
  Tumor-associated macrophages and stromal TNF-α regulate collagen structure in a breast tumor model as visualized by second harmonic generation.; Journal of biomedical optics; Vol 18(8). 2013 Aug.
• 1. Chen T
  2. Hilton MJ
  3. Brown EB
  4. Zuscik MJ
  5. Awad HA
  Engineering superficial zone features in tissue engineered cartilage.; Biotechnology and bioengineering; Vol 110(5). 2013 May.
• 1. Burke K
  2. Tang P
  3. Brown E
  Second harmonic generation reveals matrix alterations during breast tumor progression.; Journal of biomedical optics; Vol 18(3). 2013 Mar.
• 1. Madden KS
  2. Szpunar MJ
  3. Brown EB
  Early impact of social isolation and breast tumor progression in mice.; Brain, behavior, and immunity; Vol 30 Suppl. 2013 Mar.
• 1. Madden KS
  2. Zettel ML
  3. Majewska AK
  4. Brown EB
  Brain tumor imaging: imaging brain metastasis using a brain-metastasizing breast adenocarcinoma.; Cold Spring Harbor protocols; Vol 2013(3). 2013 Mar.
• 1. Madden KS
  2. Zettel ML
  3. Majewska AK
  4. Brown EB
  Brain tumor imaging: live imaging of glioma by two-photon microscopy.; Cold Spring Harbor protocols; Vol 2013(3). 2013 Mar.
• 1. Perry SW
  2. Schueckler JM
  3. Burke K
  4. Arcuri GL
  5. Brown EB
  Stromal matrix metalloprotease-13 knockout alters Collagen I structure at the tumor-host interface and increases lung metastasis of C57BL/6 syngeneic E0771 mammary tumor cells.; BMC cancer; Vol 13. 2013.
• 1. Perry SW
  2. Burke RM
  3. Brown EB
  Two-photon and second harmonic microscopy in clinical and translational cancer research.; Annals of biomedical engineering; Vol 40(2). 2012 Feb.
• 1. Bouta EM
  2. Wood RW
  3. Perry SW
  4. Brown EB
  5. Ritchlin CT
  6. Xing L
  7. Schwarz EM
  Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes.; Annals of the New York Academy of Sciences; Vol 1240. 2011 Dec.
• 1. Madden KS
  2. Szpunar MJ
  3. Brown EB
  β-Adrenergic receptors (β-AR) regulate VEGF and IL-6 production by divergent pathways in high β-AR-expressing breast cancer cell lines.; Breast cancer research and treatment; Vol 130(3). 2011 Dec.
• 1. Sullivan KD
  2. Brown EB
  Multiphoton fluorescence recovery after photobleaching in bounded systems.; Physical review. E, Statistical, nonlinear, and soft matter physics; Vol 83(5 Pt 1). 2011 May.
• 1. Perry SW
  2. Norman JP
  3. Barbieri J
  4. Brown EB
  5. Gelbard HA
  Mitochondrial membrane potential probes and the proton gradient: a practical usage guide.; BioTechniques; Vol 50(2). 2011 Feb.
• 1. Sullivan K
  2. Brown E
  Diffusion and multi-photon fluorescence recovery after photobleaching in bounded systems; Physical review E. In Press. 2011 Jan 01.
• 1. Perry S
  2. Norman J
  3. Barbieri J
  4. Brown E
  5. Gelbard H
  Mitochondrial membrane potential probes and the proton gradient: a practical usage guide; BioTechniques. In Press. 2011 Jan 01.
• 1. Kozai TD
  2. Marzullo TC
  3. Hooi F
  4. Langhals NB
  5. Majewska AK
  6. Brown EB
  7. Kipke DR
  Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in vivo two-photon mapping.; Journal of neural engineering; Vol 7(4). 2010 Aug.
• 1. Han X
  2. Brown E
  Measurement of the ratio of forward-propagating to back-propagating second harmonic signal using a single objective.; Optics express; Vol 18(10). 2010 May 10.
• 1. Sullivan KD
  2. Brown EB
  Measuring diffusion coefficients via two-photon fluorescence recovery after photobleaching.; Journal of visualized experiments : JoVE. 2010.
• 1. Li J
  2. Sullivan K
  3. Brown E
  4. Anthamatten M
  Thermally activated diffusion in reversibly associating polymers; Soft matter; Vol 6, pp. 235-238. 2010 Jan 01.
• 1. Sullivan K
  2. Brown E
  Measuring Diffusion Coefficients via Two-Photon Fluorescence Recovery After Photobleaching; Journal of visualized experiments; Vol 36. 2010 Jan 01.
• 1. Chauhan VP
  2. Lanning RM
  3. Diop-Frimpong B
  4. Mok W
  5. Brown EB
  6. Padera TP
  7. Boucher Y
  8. Jain RK
  Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.; Biophysical journal; Vol 97(1). 2009 Jul 8.
• 1. Sullivan KD
  2. Sipprell WH
  3. Brown EB
  4. Brown EB
  Improved model of fluorescence recovery expands the application of multiphoton fluorescence recovery after photobleaching in vivo.; Biophysical journal; Vol 96(12). 2009 Jun 17.
• 1. Han X
  2. Burke RM
  3. Zettel ML
  4. Tang P
  5. Brown EB
  Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma.; Optics express; Vol 16(3). 2008 Feb 4.
• 1. Schmidt H
  2. Arendt O
  3. Brown EB
  4. Schwaller B
  5. Eilers J
  Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones.; Journal of neurochemistry; Vol 100(3). 2007 Feb.
• 1. Tyrrell JA
  2. Mahadevan V
  3. Tong RT
  4. Brown EB
  5. Jain RK
  6. Roysam B
  A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy.; Microvascular research; Vol 70(3). 2005 Nov.
• 1. Stroh M
  2. Zimmer JP
  3. Duda DG
  4. Levchenko TS
  5. Cohen KS
  6. Brown EB
  7. Scadden DT
  8. Torchilin VP
  9. Bawendi MG
  10. Fukumura D
  11. Jain RK
  Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.; Nature medicine; Vol 11(6). 2005 Jun.
• 1. Duda DG
  2. Fukumura D
  3. Munn LL
  4. Booth MF
  5. Brown EB
  6. Huang P
  7. Seed B
  8. Jain RK
  Differential transplantability of tumor-associated stromal cells.; Cancer research; Vol 64(17). 2004 Sep 1.
• 1. Brown EB
  2. Boucher Y
  3. Nasser S
  4. Jain RK
  Measurement of macromolecular diffusion coefficients in human tumors.; Microvascular research; Vol 67(3). 2004 May.
• 1. Garkavtsev I
  2. Kozin SV
  3. Chernova O
  4. Xu L
  5. Winkler F
  6. Brown E
  7. Barnett GH
  8. Jain RK
  The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.; Nature; Vol 428(6980). 2004 Mar 18.
• 1. Alexandrakis G
  2. Brown EB
  3. Tong RT
  4. McKee TD
  5. Campbell RB
  6. Boucher Y
  7. Jain RK
  Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.; Nature medicine; Vol 10(2). 2004 Feb.
• 1. Znati CA
  2. Rosenstein M
  3. McKee TD
  4. Brown E
  5. Turner D
  6. Bloomer WD
  7. Watkins S
  8. Jain RK
  9. Boucher Y
  Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.; Clinical cancer research : an official journal of the American Association for Cancer Research; Vol 9(15). 2003 Nov 15.
• 1. Abdul-Karim MA
  2. Al-Kofahi K
  3. Brown EB
  4. Jain RK
  5. Roysam B
  Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series.; Microvascular research; Vol 66(2). 2003 Sep.
• 1. Brown E
  2. McKee T
  3. diTomaso E
  4. Pluen A
  5. Seed B
  6. Boucher Y
  7. Jain RK
  Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.; Nature medicine; Vol 9(6). 2003 Jun.
• 1. Schmidt H
  2. Brown EB
  3. Schwaller B
  4. Eilers J
  Diffusional mobility of parvalbumin in spiny dendrites of cerebellar Purkinje neurons quantified by fluorescence recovery after photobleaching.; Biophysical journal; Vol 84(4). 2003 Apr.
• 1. Wei X
  2. Henke VG
  3. Strübing C
  4. Brown EB
  5. Clapham DE
  Real-time imaging of nuclear permeation by EGFP in single intact cells.; Biophysical journal; Vol 84(2 Pt 1). 2003 Feb.
• 1. Campbell RB
  2. Fukumura D
  3. Brown EB
  4. Mazzola LM
  5. Izumi Y
  6. Jain RK
  7. Torchilin VP
  8. Munn LL
  Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.; Cancer research; Vol 62(23). 2002 Dec 1.
• 1. Migliorini C
  2. Qian Y
  3. Chen H
  4. Brown EB
  5. Jain RK
  6. Munn LL
  Red blood cells augment leukocyte rolling in a virtual blood vessel.; Biophysical journal; Vol 83(4). 2002 Oct.
• 1. Ramanujan S
  2. Pluen A
  3. McKee TD
  4. Brown EB
  5. Boucher Y
  6. Jain RK
  Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.; Biophysical journal; Vol 83(3). 2002 Sep.
• 1. Padera TP
  2. Kadambi A
  3. di Tomaso E
  4. Carreira CM
  5. Brown EB
  6. Boucher Y
  7. Choi NC
  8. Mathisen D
  9. Wain J
  10. Mark EJ
  11. Munn LL
  12. Jain RK
  Lymphatic metastasis in the absence of functional intratumor lymphatics.; Science (New York, N.Y.); Vol 296(5574). 2002 Jun 7.
• 1. Brown EB
  2. Campbell RB
  3. Tsuzuki Y
  4. Xu L
  5. Carmeliet P
  6. Fukumura D
  7. Jain RK
  In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.; Nature medicine; Vol 7(7). 2001 Jul.
• 1. Pluen A
  2. Boucher Y
  3. Ramanujan S
  4. McKee TD
  5. Gohongi T
  6. di Tomaso E
  7. Brown EB
  8. Izumi Y
  9. Campbell RB
  10. Berk DA
  11. Jain RK
  Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.; Proceedings of the National Academy of Sciences of the United States of America; Vol 98(8). 2001 Apr 10.
• 1. Majewska A
  2. Brown E
  3. Ross J
  4. Yuste R
  Mechanisms of calcium decay kinetics in hippocampal spines: role of spine calcium pumps and calcium diffusion through the spine neck in biochemical compartmentalization.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 20(5). 2000 Mar 1.
• 1. Brown EB
  2. Wu ES
  3. Zipfel W
  4. Webb WW
  Measurement of molecular diffusion in solution by multiphoton fluorescence photobleaching recovery.; Biophysical journal; Vol 77(5). 1999 Nov.
• 1. Brown EB
  2. Shear JB
  3. Adams SR
  4. Tsien RY
  5. Webb WW
  Photolysis of caged calcium in femtoliter volumes using two-photon excitation.; Biophysical journal; Vol 76(1 Pt 1). 1999 Jan.
• 1. Brown EB
  2. Webb WW
  Two-photon activation of caged calcium with submicron, submillisecond resolution.; Methods in enzymology; Vol 291. 1998.
• 1. Shear JB
  2. Brown EB
  3. Webb WW
  Multiphoton-excited fluorescence of fluorogen-labeled neurotransmitters.; Analytical chemistry; Vol 68(10). 1996 May 15.