URMC / Labs / Deane Lab / Publications

Publications

1. Bell RD
2. Winkler EA
3. Singh I
4. Sagare AP
5. Deane R
6. Wu Z
7. Holtzman DM
8. Betsholtz C
9. Armulik A
10. Sallstrom J
11. Berk BC
12. Zlokovic BV
Author Correction: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.; Nature. 2023 May 05.
1. McQuaid C
2. Solorzano A
3. Dickerson I
4. Deane R
Uptake of severe acute respiratory syndrome coronavirus 2 spike protein mediated by angiotensin converting enzyme 2 and ganglioside in human cerebrovascular cells.; Frontiers in neuroscience; Vol 17, pp. 1117845. 2023 Feb 16.
1. Brady M
2. McQuaid C
3. Solorzano A
4. Johnson A
5. Combs A
6. Venkatraman C
7. Rahman A
8. Leyva H
9. Kwok WE
10. Wood RW
11. Deane R
Spike protein multiorgan tropism suppressed by antibodies targeting SARS-CoV-2.; Communications biology; Vol 4(1). 2021 Nov 22.
1. Deane R
Response to the letter, entitled "Role of hemagglutinin esterase protein in neurological manifestation of COVID-19".; Fluids and barriers of the CNS; Vol 18(1). 2021 Sep 03.
1. McQuaid C
2. Brady M
3. Deane R
SARS-CoV-2: is there neuroinvasion?; Fluids and barriers of the CNS; Vol 18(1). 2021 Jul 14.
1. Brady M
2. Rahman A
3. Combs A
4. Venkatraman C
5. Kasper RT
6. McQuaid C
7. Kwok WE
8. Wood RW
9. Deane R
Cerebrospinal fluid drainage kinetics across the cribriform plate are reduced with aging.; Fluids and barriers of the CNS; Vol 17(1). 2020 Nov 30.
1. Achariyar TM
2. Li B
3. Peng W
4. Verghese PB
5. Shi Y
6. McConnell E
7. Benraiss A
8. Kasper T
9. Song W
10. Takano T
11. Holtzman DM
12. Nedergaard M
13. Deane R
Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.; Molecular neurodegeneration; Vol 12(1). 2017 Jan 12.
1. Achariyar TM
2. Li B
3. Peng W
4. Verghese PB
5. Shi Y
6. McConnell E
7. Benraiss A
8. Kasper T
9. Song W
10. Takana T
11. Holtzman DM
12. Nedergaard M
13. Deane R
Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.; Molecular neurodegeneration; Vol 11(1). 2016 Dec 08.
1. Lundgaard I
2. Lu ML
3. Yang E
4. Peng W
5. Mestre H
6. Hitomi E
7. Deane R
8. Nedergaard M
Glymphatic clearance controls state-dependent changes in brain lactate concentration.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Aug 1.
1. Peng W
2. Achariyar TM
3. Li B
4. Liao Y
5. Mestre H
6. Hitomi E
7. Regan S
8. Kasper T
9. Peng S
10. Ding F
11. Benveniste H
12. Nedergaard M
13. Deane R
Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease.; Neurobiology of disease. 2016 May 24.
1. Lee H
2. Xie L
3. Yu M
4. Kang H
5. Feng T
6. Deane R
7. Logan J
8. Nedergaard M
9. Benveniste H
The Effect of Body Posture on Brain Glymphatic Transport.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(31). 2015 Aug 5.
1. Plog BA
2. Dashnaw ML
3. Hitomi E
4. Peng W
5. Liao Y
6. Lou N
7. Deane R
8. Nedergaard M
Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(2). 2015 Jan 14.
1. Iliff JJ
2. Chen MJ
3. Plog BA
4. Zeppenfeld DM
5. Soltero M
6. Yang L
7. Singh I
8. Deane R
9. Nedergaard M
Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 34(49). 2014 Dec 03.
1. Kress BT
2. Iliff JJ
3. Xia M
4. Wang M
5. Wei HS
6. Zeppenfeld D
7. Xie L
8. Kang H
9. Xu Q
10. Liew JA
11. Plog BA
12. Ding F
13. Deane R
14. Nedergaard M
Impairment of paravascular clearance pathways in the aging brain.; Annals of neurology; Vol 76(6). 2014 Dec.
1. Petraglia AL
2. Plog BA
3. Dayawansa S
4. Chen M
5. Dashnaw ML
6. Czerniecka K
7. Walker CT
8. Viterise T
9. Hyrien O
10. Iliff JJ
11. Deane R
12. Nedergaard M
13. Huang JH
The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy.; Journal of neurotrauma; Vol 31(13). 2014 Jul 01.
1. Lundgaard I
2. Li B
3. Xie L
4. Kang H
5. Sanggaard S
6. Haswell JD
7. Sun W
8. Goldman S
9. Blekot S
10. Nielsen M
11. Takano T
12. Deane R
13. Nedergaard M
Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.; Nature communications; Vol 6. 2015.
1. Petraglia AL
2. Plog BA
3. Dayawansa S
4. Dashnaw ML
5. Czerniecka K
6. Walker CT
7. Chen M
8. Hyrien O
9. Iliff JJ
10. Deane R
11. Huang JH
12. Nedergaard M
The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy.; Surgical neurology international; Vol 5. 2014.
1. Iliff JJ
2. Wang M
3. Zeppenfeld DM
4. Venkataraman A
5. Plog BA
6. Liao Y
7. Deane R
8. Nedergaard M
Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 33(46). 2013 Nov 13.
1. Xie L
2. Kang H
3. Xu Q
4. Chen MJ
5. Liao Y
6. Thiyagarajan M
7. O'Donnell J
8. Christensen DJ
9. Nicholson C
10. Iliff JJ
11. Takano T
12. Deane R
13. Nedergaard M
Sleep drives metabolite clearance from the adult brain.; Science (New York, N.Y.); Vol 342(6156). 2013 Oct 18.
1. Singh I
2. Sagare AP
3. Coma M
4. Perlmutter D
5. Gelein R
6. Bell RD
7. Deane RJ
8. Zhong E
9. Parisi M
10. Ciszewski J
11. Kasper RT
12. Deane R
Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance.; Proceedings of the National Academy of Sciences of the United States of America; Vol 110(36). 2013 Sep 03.
1. Rangroo Thrane V
2. Thrane AS
3. Plog BA
4. Thiyagarajan M
5. Iliff JJ
6. Deane R
7. Nagelhus EA
8. Nedergaard M
Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain.; Scientific reports; Vol 3. 2013.
1. Iliff JJ
2. Wang M
3. Liao Y
4. Plogg BA
5. Peng W
6. Gundersen GA
7. Benveniste H
8. Vates GE
9. Deane R
10. Goldman SA
11. Nagelhus EA
12. Nedergaard M
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.; Science translational medicine; Vol 4(147). 2012 Aug 15.
1. Bell RD
2. Winkler EA
3. Singh I
4. Sagare AP
5. Deane R
6. Wu Z
7. Holtzman DM
8. Betsholtz C
9. Armulik A
10. Sallstrom J
11. Berk BC
12. Zlokovic BV
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.; Nature; Vol 485(7399). 2012 May 16.
1. Deane R
2. Singh I
3. Sagare AP
4. Bell RD
5. Ross NT
6. LaRue B
7. Love R
8. Perry S
9. Paquette N
10. Deane RJ
11. Thiyagarajan M
12. Zarcone T
13. Fritz G
14. Friedman AE
15. Miller BL
16. Zlokovic BV
A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.; The Journal of clinical investigation; Vol 122(4). 2012 Apr.
1. Polesskaya O
2. Silva J
3. Sanfilippo C
4. Desrosiers T
5. Sun A
6. Shen J
7. Feng C
8. Polesskiy A
9. Deane R
10. Zlokovic B
11. Kasischke K
12. Dewhurst S
Methamphetamine causes sustained depression in cerebral blood flow.; Brain research; Vol 1373. 2011 Feb 10.
1. Sagare AP
2. Deane R
3. Zetterberg H
4. Wallin A
5. Blennow K
6. Zlokovic BV
Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease.; Journal of Alzheimer's disease : JAD; Vol 24(1). 2011.
1. Zlokovic BV
2. Deane R
3. Sagare AP
4. Bell RD
5. Winkler EA
Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain.; Journal of neurochemistry; Vol 115(5). 2010 Dec.
1. Bell RD
2. Winkler EA
3. Sagare AP
4. Singh I
5. LaRue B
6. Deane R
7. Zlokovic BV
Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging.; Neuron; Vol 68(3). 2010 Nov 04.
1. Zhu D
2. Wang Y
3. Singh I
4. Bell RD
5. Deane R
6. Zhong Z
7. Sagare A
8. Winkler EA
9. Zlokovic BV
Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.; Blood; Vol 115(23). 2010 Jun 10.
1. Menon P
2. Deane R
3. Sagare A
4. Lane SM
5. Zarcone TJ
6. O'Dell MR
7. Yan C
8. Zlokovic BV
9. Berk BC
Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice.; Brain research; Vol 1317. 2010 Mar 4.
1. Zhong Z
2. Ilieva H
3. Hallagan L
4. Bell R
5. Singh I
6. Paquette N
7. Thiyagarajan M
8. Deane R
9. Fernandez JA
10. Lane S
11. Zlokovic AB
12. Liu T
13. Griffin JH
14. Chow N
15. Castellino FJ
16. Stojanovic K
17. Cleveland DW
18. Zlokovic BV
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.; The Journal of clinical investigation; Vol 119(11). 2009 Nov.
1. Deane R
2. Bell RD
3. Sagare A
4. Zlokovic BV
Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease.; CNS & neurological disorders drug targets; Vol 8(1). 2009 Mar.
1. Guo H
2. Singh I
3. Wang Y
4. Deane R
5. Barrett T
6. Fernández JA
7. Chow N
8. Griffin JH
9. Zlokovic BV
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity.; The European journal of neuroscience; Vol 29(6). 2009 Mar.
1. Bell RD
2. Deane R
3. Chow N
4. Long X
5. Sagare A
6. Singh I
7. Streb JW
8. Guo H
9. Rubio A
10. Van Nostrand W
11. Miano JM
12. Zlokovic BV
SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.; Nature cell biology; Vol 11(2). 2009 Feb.
1. Deane R
2. LaRue B
3. Sagare AP
4. Castellino FJ
5. Zhong Z
6. Zlokovic BV
Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism; Vol 29(1). 2009 Jan.
1. Deane R
2. Sagare A
3. Hamm K
4. Parisi M
5. Lane S
6. Finn MB
7. Holtzman DM
8. Zlokovic BV
apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.; The Journal of clinical investigation; Vol 118(12). 2008 Dec.
1. Zhong Z
2. Deane R
3. Ali Z
4. Parisi M
5. Shapovalov Y
6. O'Banion MK
7. Stojanovic K
8. Sagare A
9. Boillee S
10. Cleveland DW
11. Zlokovic BV
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.; Nature neuroscience; Vol 11(4). 2008 Apr.
1. Deane R
2. Sagare A
3. Zlokovic BV
The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease.; Current pharmaceutical design; Vol 14(16). 2008.
1. Sagare A
2. Deane R
3. Bell RD
4. Johnson B
5. Hamm K
6. Pendu R
7. Marky A
8. Lenting PJ
9. Wu Z
10. Zarcone T
11. Goate A
12. Mayo K
13. Perlmutter D
14. Coma M
15. Zhong Z
16. Zlokovic BV
Clearance of amyloid-beta by circulating lipoprotein receptors.; Nature medicine; Vol 13(9). 2007 Sep.
1. Bell RD
2. Sagare AP
3. Friedman AE
4. Bedi GS
5. Holtzman DM
6. Deane R
7. Zlokovic BV
Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system.; Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism; Vol 27(5). 2007 May.
1. Deane R
2. Zlokovic BV
Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease.; Current Alzheimer research; Vol 4(2). 2007 Apr.
1. Takano T
2. Han X
3. Deane R
4. Zlokovic B
5. Nedergaard M
Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease.; Annals of the New York Academy of Sciences; Vol 1097. 2007 Feb.
1. Chow N
2. Bell RD
3. Deane R
4. Streb JW
5. Chen J
6. Brooks A
7. Van Nostrand W
8. Miano JM
9. Zlokovic BV
Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.; Proceedings of the National Academy of Sciences of the United States of America; Vol 104(3). 2007 Jan 16.
1. Deane R
2. Zlokovic BV
Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease; Current Alzheimer's Research; Vol 4, pp. 191-197. 2007 Jan 01.
1. Sagare A
2. Friedman AE
3. Bedi G
4. Deane R
5. Zlokovic BV
Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J.; J Cerebral Blood flow and Metabolism; Vol 27, pp. 909-918. 2007 Jan 01.
1. Deane R
2. Zlokovic BV
Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease; Current Alzheimer's Research; Vol 4, pp. 191-197. 2007 Jan 01.
1. Kassem NA
2. Deane R
3. Segal MB
4. Preston JE
Role of transthyretin in thyroxine transfer from cerebrospinal fluid to brain and choroid plexus; American Journal of Physiology - Regulatory Integrative & Comparative Physiology; Vol 291(5), pp. 1310-1315. 2006 Jan 01.
1. Cheng T
2. Petraglia AL
3. Li Z
4. Thiyagarajan M
5. Zhong Z
6. Wu Z
7. Liu D
8. Maggirwar SB
9. Deane R
10. Fernández JA
11. LaRue B
12. Griffin JH
13. Chopp M
14. Zlokovic BV
Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.; Nature medicine; Vol 12(11). 2006 Nov.
1. Deane R
2. Sagare A
3. Hamm K
4. Parisi M
5. LaRue B
6. Guo H
7. Wu Z
8. Holtzman DM
9. Zlokovic BV
IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 25(50). 2005 Dec 14.
1. Cirrito JR
2. Deane R
3. Fagan AM
4. Spinner ML
5. Parsadanian M
6. Finn MB
7. Jiang H
8. Prior JL
9. Sagare A
10. Bales KR
11. Paul SM
12. Zlokovic BV
13. Piwnica-Worms D
14. Holtzman DM
P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model.; The Journal of clinical investigation; Vol 115(11). 2005 Nov.