URMC / Labs / Feng Earley Lab / Publications

Publications

1. Huang A
2. Yeum D
3. Sewaybricker LE
4. Aleksic S
5. Thomas M
6. Melhorn SJ
7. Earley YF
8. Schur EA
Update on Hypothalamic Inflammation and Gliosis: Expanding Evidence of Relevance Beyond Obesity.; Current obesity reports; Vol 14(1), pp. 6. 2025 Jan 08.
1. Zhang X
2. Shi J
3. Thakore P
4. Gonzales AL
5. Earley S
6. Chen Q
7. Zhou T
8. Earley YF
Mitochondrial small RNA alterations associated with increased lysosome activity in an Alzheimer's Disease Mouse Model uncovered by PANDORA-seq.; bioRxiv : the preprint server for biology. 2024 Oct 22.
1. Metwally E
2. Sanchez Solano A
3. Lavanderos B
4. Yamasaki E
5. Thakore P
6. McClenaghan C
7. Rios N
8. Radi R
9. Feng Earley Y
10. Nichols CG
11. Earley S
Mitochondrial Ca2+-coupled generation of reactive oxygen species, peroxynitrite formation, and endothelial dysfunction in Cantú syndrome.; JCI insight; Vol 9(17). 2024 Aug 01.
1. Pan S
2. A C Souza L
3. Worker CJ
4. Reyes Mendez ME
5. Gayban AJB
6. Cooper SG
7. Sanchez Solano A
8. Bergman RN
9. Stefanovski D
10. Morton GJ
11. Schwartz MW
12. Feng Earley Y
(Pro)renin receptor signaling in hypothalamic tyrosine hydroxylase neurons is required for obesity-associated glucose metabolic impairment.; JCI insight; Vol 9(6). 2024 Feb 13.
1. Michaely P
2. Bielinski SJ
3. Campbell K
4. D'Alessio F
5. Dean D
6. Earley YF
7. Paine R
8. Salama G
9. Peter I
Guide to assembling a successful K99/R00 application.; Journal of clinical and translational science; Vol 7(1), pp. e215. 2023 Sep 29.
1. Pan S
2. Worker CJ
3. Feng Earley Y
The hypothalamus as a key regulator of glucose homeostasis: emerging roles of the brain renin-angiotensin system.; American journal of physiology. Cell physiology; Vol 325(1), pp. C141-C154. 2023 Jun 05.
1. Sullivan MN
2. Thakore P
3. Krishnan V
4. Alphonsa S
5. Li W
6. Feng Earley Y
7. Earley S
Endothelial cell TRPA1 activity exacerbates cerebral hemorrhage during severe hypertension.; Frontiers in molecular biosciences; Vol 10, pp. 1129435. 2023 Jan 30.
1. Gayban AJB
2. Souza LAC
3. Cooper SG
4. Regalado E
5. Kleemann R
6. Feng Earley Y
(Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet-Induced Hepatic Steatosis.; Biomolecules; Vol 13(1). 2023 Jan 10.
1. Cooper SG
2. Souza LAC
3. Worker CJ
4. Gayban AJB
5. Buller S
6. Satou R
7. Feng Earley Y
Renin-a in the Subfornical Organ Plays a Critical Role in the Maintenance of Salt-Sensitive Hypertension.; Biomolecules; Vol 12(9). 2022 Aug 24.
1. Tran DT
2. Martinez I
3. Cross CL
4. Earley YF
MOBILE Intervention Pilot Study in College Students With Elevated Blood Pressure.; The Journal of cardiovascular nursing; Vol 38(3), pp. 256-261. 2022 Apr 19.
1. Souza LAC
2. Earley YF
(Pro)renin Receptor and Blood Pressure Regulation: A Focus on the Central Nervous System.; Current hypertension reviews; Vol 18(2), pp. 101-116. 2022.
1. Souza LA
2. Cooper SG
3. Worker CJ
4. Thakore P
5. Feng Earley Y
Use of chlorisondamine to assess the neurogenic contribution to blood pressure in mice: An evaluation of method.; Physiological reports; Vol 9(3), pp. e14753. 2021 Feb.
1. Mohsin M
2. Souza LAC
3. Aliabadi S
4. Worker CJ
5. Cooper SG
6. Afrin S
7. Murata Y
8. Xiong Z
9. Feng Earley Y
Increased (Pro)renin Receptor Expression in the Hypertensive Human Brain.; Frontiers in physiology; Vol 11, pp. 606811. 2020 Nov 19.
1. Zhang X
2. Trebak F
3. Souza LAC
4. Shi J
5. Zhou T
6. Kehoe PG
7. Chen Q
8. Feng Earley Y
Small RNA modifications in Alzheimer's disease.; Neurobiology of disease; Vol 145, pp. 105058. 2020 Aug 21.
1. Thakore P
2. Pritchard HAT
3. Griffin CS
4. Yamasaki E
5. Drumm BT
6. Lane C
7. Sanders KM
8. Feng Earley Y
9. Earley S
TRPML1 channels initiate Ca2+ sparks in vascular smooth muscle cells.; Science signaling; Vol 13(637). 2020 Jun 23.
1. Worker CJ
2. Li W
3. Feng CY
4. Souza LAC
5. Gayban AJB
6. Cooper SG
7. Afrin S
8. Romanick S
9. Ferguson BS
10. Feng Earley Y
The neuronal (pro)renin receptor and astrocyte inflammation in the central regulation of blood pressure and blood glucose in mice fed a high-fat diet.; American journal of physiology. Endocrinology and metabolism; Vol 318(5), pp. E765-E778. 2020 Mar 31.
1. Souza LAC
2. Trebak F
3. Kumar V
4. Satou R
5. Kehoe PG
6. Yang W
7. Wharton W
8. Feng Earley Y
Elevated cerebrospinal fluid sodium in hypertensive human subjects with a family history of Alzheimer's disease.; Physiological genomics; Vol 52(3), pp. 133-142. 2020 Jan 21.
1. Pitra S
2. Worker CJ
3. Feng Y
4. Stern JE
Exacerbated effects of prorenin on hypothalamic magnocellular neuronal activity and vasopressin plasma levels during salt-sensitive hypertension.; American journal of physiology. Heart and circulatory physiology; Vol 317(3), pp. H496-H504. 2019 Jul 05.
1. Liu J
2. Zhou Y
3. Liu Y
4. Li L
5. Chen Y
6. Liu Y
7. Feng Y
8. Yosypiv IV
9. Song R
10. Peng H
(Pro)renin receptor regulates lung development via the Wnt/β-catenin signaling pathway.; American journal of physiology. Lung cellular and molecular physiology; Vol 317(2), pp. L202-L211. 2019 May 01.
1. Souza LAC
2. Worker CJ
3. Li W
4. Trebak F
5. Watkins T
6. Gayban AJB
7. Yamasaki E
8. Cooper SG
9. Drumm BT
10. Feng Y
(Pro)renin receptor knockdown in the paraventricular nucleus of the hypothalamus attenuates hypertension development and AT1 receptor-mediated calcium events.; American journal of physiology. Heart and circulatory physiology; Vol 316(6), pp. H1389-H1405. 2019 Mar 29.
1. Romanick SS
2. Ulrich C
3. Schlauch K
4. Hostler A
5. Payne J
6. Woolsey R
7. Quilici D
8. Feng Y
9. Ferguson BS
Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry.; Bioscience reports; Vol 38(5). 2018 Sep 07.
1. Trebak F
2. Li W
3. Feng Y
Neuronal (pro)renin receptor regulates deoxycorticosterone-induced sodium intake.; Physiological genomics; Vol 50(10), pp. 904-912. 2018 Aug 24.
1. Cooper SG
2. Trivedi DP
3. Yamamoto R
4. Worker CJ
5. Feng CY
6. Sorensen JT
7. Yang W
8. Xiong Z
9. Feng Y
Increased (pro)renin receptor expression in the subfornical organ of hypertensive humans.; American journal of physiology. Heart and circulatory physiology; Vol 314(4), pp. H796-H804. 2017 Dec 22.
1. Peng H
2. Jensen DD
3. Li W
4. Sullivan MN
5. Buller SA
6. Worker CJ
7. Cooper SG
8. Zheng S
9. Earley S
10. Sigmund CD
11. Feng Y
Overexpression of the neuronal human (pro)renin receptor mediates angiotensin II-independent blood pressure regulation in the central nervous system.; American journal of physiology. Heart and circulatory physiology; Vol 314(3), pp. H580-H592. 2017 Dec 15.
1. Pitra S
2. Feng Y
3. Stern JE
Mechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic control.; Molecular metabolism; Vol 5(10), pp. 858-868. 2016 Aug 04.
1. Xu Q
2. Jensen DD
3. Peng H
4. Feng Y
The critical role of the central nervous system (pro)renin receptor in regulating systemic blood pressure.; Pharmacology & therapeutics; Vol 164, pp. 126-34. 2016 Apr 23.
1. Lu X
2. Wang F
3. Xu C
4. Soodvilai S
5. Peng K
6. Su J
7. Zhao L
8. Yang KT
9. Feng Y
10. Zhou SF
11. Gustafsson JÅ
12. Yang T
Soluble (pro)renin receptor via β-catenin enhances urine concentration capability as a target of liver X receptor.; Proceedings of the National Academy of Sciences of the United States of America; Vol 113(13), pp. E1898-906. 2016 Mar 16.
1. Wang F
2. Lu X
3. Liu M
4. Feng Y
5. Zhou SF
6. Yang T
Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin-angiotensin system.; BMC medicine; Vol 13, pp. 278. 2015 Nov 10.
1. Feng Y
ANG II-independent prorenin/(pro)renin receptor signaling pathways in the central nervous system.; American journal of physiology. Heart and circulatory physiology; Vol 309(5), pp. H731-3. 2015 Jul 24.
1. Li W
2. Liu J
3. Hammond SL
4. Tjalkens RB
5. Saifudeen Z
6. Feng Y
Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein.; American journal of physiology. Regulatory, integrative and comparative physiology; Vol 309(2), pp. R138-47. 2015 May 20.
1. Li Y
2. Liu J
3. Li W
4. Brown A
5. Baddoo M
6. Li M
7. Carroll T
8. Oxburgh L
9. Feng Y
10. Saifudeen Z
p53 Enables metabolic fitness and self-renewal of nephron progenitor cells.; Development (Cambridge, England); Vol 142(7), pp. 1228-41. 2015 Apr 01.
1. Sullivan MN
2. Gonzales AL
3. Pires PW
4. Bruhl A
5. Leo MD
6. Li W
7. Oulidi A
8. Boop FA
9. Feng Y
10. Jaggar JH
11. Welsh DG
12. Earley S
Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation.; Science signaling; Vol 8(358), pp. ra2. 2015 Jan 06.
1. Xia H
2. de Queiroz TM
3. Sriramula S
4. Feng Y
5. Johnson T
6. Mungrue IN
7. Lazartigues E
Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress.; American journal of physiology. Regulatory, integrative and comparative physiology; Vol 308(5), pp. R370-8. 2014 Dec 17.
1. Li W
2. Sullivan MN
3. Zhang S
4. Worker CJ
5. Xiong Z
6. Speth RC
7. Feng Y
Intracerebroventricular infusion of the (Pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate-salt-induced hypertension.; Hypertension (Dallas, Tex. : 1979); Vol 65(2), pp. 352-61. 2014 Nov 24.
1. Zubcevic J
2. Jun JY
3. Kim S
4. Perez PD
5. Afzal A
6. Shan Z
7. Li W
8. Santisteban MM
9. Yuan W
10. Febo M
11. Mocco J
12. Feng Y
13. Scott E
14. Baekey DM
15. Raizada MK
Altered inflammatory response is associated with an impaired autonomic input to the bone marrow in the spontaneously hypertensive rat.; Hypertension (Dallas, Tex. : 1979); Vol 63(3), pp. 542-50. 2013 Dec 23.
1. Li W
2. Peng H
3. Mehaffey EP
4. Kimball CD
5. Grobe JL
6. van Gool JM
7. Sullivan MN
8. Earley S
9. Danser AH
10. Ichihara A
11. Feng Y
Neuron-specific (pro)renin receptor knockout prevents the development of salt-sensitive hypertension.; Hypertension (Dallas, Tex. : 1979); Vol 63(2), pp. 316-23. 2013 Nov 18.
1. Yoshida T
2. Tabony AM
3. Galvez S
4. Mitch WE
5. Higashi Y
6. Sukhanov S
7. Delafontaine P
Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia.; The international journal of biochemistry & cell biology; Vol 45(10), pp. 2322-32. 2013 Jun 13.
1. Cao T
2. Feng Y
The (pro)renin receptor and body fluid homeostasis.; American journal of physiology. Regulatory, integrative and comparative physiology; Vol 305(2), pp. R104-6. 2013 May 15.
1. Peng H
2. Li W
3. Seth DM
4. Nair AR
5. Francis J
6. Feng Y
(Pro)renin receptor mediates both angiotensin II-dependent and -independent oxidative stress in neuronal cells.; PloS one; Vol 8(3), pp. e58339. 2013 Mar 14.
1. Li W
2. Peng H
3. Seth DM
4. Feng Y
The Prorenin and (Pro)renin Receptor: New Players in the Brain Renin-Angiotensin System?; International journal of hypertension; Vol 2012, pp. 290635. 2012 Dec 18.
1. Feng Y
2. Hans C
3. McIlwain E
4. Varner KJ
5. Lazartigues E
Angiotensin-converting enzyme 2 over-expression in the central nervous system reduces angiotensin-II-mediated cardiac hypertrophy.; PloS one; Vol 7(11), pp. e48910. 2012 Nov 14.
1. Li W
2. Peng H
3. Cao T
4. Sato R
5. McDaniels SJ
6. Kobori H
7. Navar LG
8. Feng Y
Brain-targeted (pro)renin receptor knockdown attenuates angiotensin II-dependent hypertension.; Hypertension (Dallas, Tex. : 1979); Vol 59(6), pp. 1188-94. 2012 Apr 23.
1. Xia H
2. Suda S
3. Bindom S
4. Feng Y
5. Gurley SB
6. Seth D
7. Navar LG
8. Lazartigues E
ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function.; PloS one; Vol 6(7), pp. e22682. 2011 Jul 27.
1. Prieto MC
2. González-Villalobos RA
3. Botros FT
4. Martin VL
5. Pagán J
6. Satou R
7. Lara LS
8. Feng Y
9. Fernandes FB
10. Kobori H
11. Casarini DE
12. Navar LG
Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats.; American journal of physiology. Renal physiology; Vol 300(3), pp. F749-55. 2011 Jan 05.
1. Hans CP
2. Feng Y
3. Naura AS
4. Troxclair D
5. Zerfaoui M
6. Siddiqui D
7. Jihang J
8. Kim H
9. Kaye AD
10. Matrougui K
11. Lazartigues E
12. Boulares AH
Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy.; Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology; Vol 20(2), pp. e57-68. 2010 May 07.
1. Feng Y
2. Xia H
3. Cai Y
4. Halabi CM
5. Becker LK
6. Santos RA
7. Speth RC
8. Sigmund CD
9. Lazartigues E
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension.; Circulation research; Vol 106(2), pp. 373-82. 2009 Nov 19.
1. Feng Y
2. Xia H
3. Santos RA
4. Speth R
5. Lazartigues E
Angiotensin-converting enzyme 2: a new target for neurogenic hypertension.; Experimental physiology; Vol 95(5), pp. 601-6. 2009 Nov 18.
1. Hans CP
2. Feng Y
3. Naura AS
4. Zerfaoui M
5. Rezk BM
6. Xia H
7. Kaye AD
8. Matrougui K
9. Lazartigues E
10. Boulares AH
Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE mice: effects on eNOS and oxidative stress.; PloS one; Vol 4(10), pp. e7430. 2009 Oct 13.
1. Zhang X
2. Wang G
3. Dupré DJ
4. Feng Y
5. Robitaille M
6. Lazartigues E
7. Feng YH
8. Hébert TE
9. Wu G
Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor.; The Journal of pharmacology and experimental therapeutics; Vol 330(1), pp. 109-17. 2009 Apr 08.
1. Xu W
2. Yi L
3. Feng Y
4. Chen L
5. Liu J
Structural insight into the activation mechanism of human pancreatic prophospholipase A2.; The Journal of biological chemistry; Vol 284(24), pp. 16659-16666. 2009 Mar 18.
1. Xia H
2. Feng Y
3. Obr TD
4. Hickman PJ
5. Lazartigues E
Angiotensin II type 1 receptor-mediated reduction of angiotensin-converting enzyme 2 activity in the brain impairs baroreflex function in hypertensive mice.; Hypertension (Dallas, Tex. : 1979); Vol 53(2), pp. 210-6. 2009 Jan 05.
1. Park S
2. Bivona BJ
3. Feng Y
4. Lazartigues E
5. Harrison-Bernard LM
Intact renal afferent arteriolar autoregulatory responsiveness in db/db mice.; American journal of physiology. Renal physiology; Vol 295(5), pp. F1504-11. 2008 Aug 27.
1. Feng Y
2. Yue X
3. Xia H
4. Bindom SM
5. Hickman PJ
6. Filipeanu CM
7. Wu G
8. Lazartigues E
Angiotensin-converting enzyme 2 overexpression in the subfornical organ prevents the angiotensin II-mediated pressor and drinking responses and is associated with angiotensin II type 1 receptor downregulation.; Circulation research; Vol 102(6), pp. 729-36. 2008 Feb 07.
1. Lazartigues E
2. Feng Y
3. Lavoie JL
The two fACEs of the tissue renin-angiotensin systems: implication in cardiovascular diseases.; Current pharmaceutical design; Vol 13(12), pp. 1231-45. 2007.
1. Feng Y
2. Feng Y
3. Liao X
4. Zhu X
5. Zhou Q
6. Zeng Z
7. Ma Q
Characterization of a monoclonal antibody that antagonizes the function of human endostatin.; Hybridoma (2005); Vol 24(1), pp. 42-9. 2005 Feb.
1. Feng Y
2. Feng Y
3. Zhu X
4. Dang Y
5. Ma Q
Alkali burn causes aldehyde dehydrogenase 3A1 (ALDH3A1) decrease in mouse cornea.; Molecular vision; Vol 10, pp. 845-50. 2004 Nov 08.
1. Feng YM
2. Feng Y
3. Zhang YH
4. Ren L
5. Zeng ZC
6. Ma QJ
[Preparation and identification of the monoclonal antibody against human endostatin].; Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology; Vol 19(6), pp. 580-1. 2003 Nov.

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