Gail Johnson Lab
Welcome to the Gail Johnson Lab
The primary focus of Dr. Gail Johnson’s research group is on the molecular mechanisms of neurodegeneration. The lab has a longstanding interest in the pathogenic processes in Alzheimer disease, and more recently in stroke and spinal cord injury (SCI). For their studies they use a wide variety of different approaches from in vitro enzyme assays with purified proteins, to studies in whole animals. This broad-based approach allows them to translate what they learn about a process or signaling pathway at the molecular level to the in vivo situation. Each of these 2 areas of research that are ongoing in the lab are discussed briefly below.
Gail V W Johnson, Ph.D.
Principal Investigator
Publications
View All Publications- Mitochondrial Quality Control in Alzheimer's Disease: Insights from Caenorhabditis elegans Models.; Antioxidants (Basel, Switzerland); Vol 13(11). 2024 Nov 01.
- Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.; Acta neuropathologica; Vol 148(1), pp. 52. 2024 Oct 11.
- Tau phosphorylation suppresses oxidative stress-induced mitophagy via FKBP8 receptor modulation.; bioRxiv : the preprint server for biology. 2024 Jul 09.
- Stabilizing transglutaminase 2 in the open conformation results in reactive astrocytes being more neurosupportive.; bioRxiv : the preprint server for biology. 2024 Apr 19.
- Mitochondria-tau association promotes cognitive decline and hippocampal bioenergetic deficits during the aging.; Free radical biology & medicine. 2024 Mar 27.
Contact Us
Gail Johnson Lab
601 Elmwood Ave, Box 604
Rochester, NY 14642