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Publications, Patents, and Publicity

Publications

Patents

Chemical preconditioning as a preventative or treatment for excitotoxic synaptic damage. US Provisional Patent Application No. 60/731,742. International Patent Application No. PCT/US2006/042213. Inventors: M.J. Bellizzi, S.-M. Lu, H.A. Gelbard.
Treatment of NeuroAIDS using inhibitors of glycogen synthase kinase (GSK)-3. US Provisional Patent Application No. 60/753,614. International Patent Application No. PCT/US2006/009390. Inventors: H.A. Gelbard, S.B. Maggirwar, S. Dewhurst.
MLK inhibitors and methods of use. Composition of matter, attorney docket: URMC0001-101-US. International Patent Application No. PCT/065878 Inventors: H.A. Gelbard, S. Dewhurst, VS Goodfellow, T. Wiemann.

Publicity

Jamie Talan. Thinking could be harmful to people with brain diseases. Newsday, February 3, 2006

Jamie Talan. Stopping HIV dementia. Scientific American Mind, August 2006.

Scott P. Edwards. The other side of cytokines. The Dana Foundation News and Periodicals, September 1, 2006

Lauran Neergard. Surviving AIDS can wreak havoc on the brain – Associated Press, October 2, 2006

Chael Needle Brain Matter: Researchers look to adjunctive therapies to treat NeuroAIDS. A&U, November 2006, pp. 34-35

Laura Whitehorn and Rebecca Minnich. Dazed and Confused. POZ, April 2007, pp. 33-34.

Jamie Talan. Valproic acid is neuroprotective in a mouse model of Alzheimer’s disease. Neurology Today 18 December 2008 - Volume 8 - Issue 24 - p 17-18doi: 10.1097/01.NT.0000343222.76902.59

Elizabeth Norton Lasley. Researchers find new point of entry for HIV in brain cells. The Dana Foundation News and Periodicals January 5, 2009

Tom Rickey. Researchers target HIV-related brain difficulties. URMC Newsroom: October 7, 2010

1. Chiang W
2. Urban JM
3. Yanchik-Slade F
4. Stout A
5. Hammond JM
6. Nilsson BL
7. Gelbard HA
8. Krauss TD
Hybrid Amyloid Quantum Dot Nano-Bio Assemblies to Probe Neuroinflammatory Damage.; ACS chemical neuroscience. 2024 Aug 15.
1. Gelbard HA
2. Chiang W
SARS and synapses.; Nature microbiology. 2024 Apr 23.
1. Birbeck GL
2. Mwenechanya M
3. Ume-Ezeoke I
4. Mathews M
5. Bositis CM
6. Kalungwana L
7. Bearden D
8. Elafros M
9. Gelbard HA
10. Theodore WH
11. Koralnik IJ
12. Okulicz JF
13. Johnson BA
14. Musonda N
15. Siddiqi OK
16. Potchen MJ
17. Sikazwe I
Long-term outcomes after new onset seizure in children living with HIV: A cohort study.; Epilepsia open. 2024 Feb 17.
1. Li H
2. Terrando N
3. Gelbard HA
Infectious Diseases.; Advances in neurobiology; Vol 37, pp. 423-444. 2024.
1. Chiang W
2. Urban JM
3. Yanchik-Slade F
4. Stout A
5. Nilsson BL
6. Gelbard HA
7. Krauss TD
Hybrid Amyloid Quantum Dot Nanoassemblies to Probe Neuroinflammatory Damage.; bioRxiv : the preprint server for biology. 2023 Sep 01.
1. Chiang W
2. Stout A
3. Yanchik-Slade F
4. Li H
5. Terrando N
6. Nilsson BL
7. Gelbard HA
8. Krauss TD
Quantum Dot Biomimetic for SARS-CoV-2 to Interrogate Blood-Brain Barrier Damage Relevant to NeuroCOVID Brain Inflammation.; ACS applied nano materials; Vol 6(16), pp. 15094-15107. 2023 Aug 07.
1. Bearden DR
2. Mwanza-Kabaghe S
3. Bositis CM
4. Dallah I
5. Johnson BA
6. Siddiqi OK
7. Elafros MA
8. Gelbard HA
9. Okulicz JF
10. Kalungwana L
11. Musonda N
12. Theodore WH
13. Mwenechanya M
14. Mathews M
15. Sikazwe IT
16. Birbeck GL
Early Initiation of Antiretroviral Therapy is Protective Against Seizures in Children with HIV in Zambia: A Prospective Case-Control Study.; Journal of acquired immune deficiency syndromes (1999). 2023 Jan 28.
1. Li H
2. Le L
3. Marrero M
4. David-Bercholz J
5. Caceres AI
6. Lim C
7. Chiang W
8. Majewska A
9. Terrando N
10. Gelbard H
Neutrophilia with damage to the blood-brain barrier and neurovascular unit following acute lung injury.; Research square. 2023 Jan 23.
1. Li H
2. Le L
3. Marrero M
4. David-Bercholz J
5. Caceres AI
6. Lim C
7. Chiang W
8. Majewska AK
9. Terrando N
10. Gelbard HA
Neutrophilia with damage to the blood-brain barrier and neurovascular unit following acute lung injury.; bioRxiv : the preprint server for biology. 2023 Jan 17.
1. Miller-Rhodes P
2. Li H
3. Velagapudi R
4. Chiang W
5. Terrando N
6. Gelbard HA
URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia.; FASEB journal : official publication of the Federation of American Societies for Experimental Biology; Vol 36(6). 2022 Jun.
1. Zakusilo FT
2. Gelbard HA
3. Seluanov A
4. Kerry O'Banion M
5. Gorbunova V
Matters of size: Roles of hyaluronan in CNS aging and disease.; Ageing research reviews. 2021 Oct 08.
1. Urban JM
2. Chiang W
3. Hammond JW
4. Cogan NMB
5. Litzburg A
6. Burke R
7. Stern HA
8. Gelbard HA
9. Nilsson BL
10. Krauss TD
Quantum Dots for Improved Single-Molecule Localization Microscopy.; The journal of physical chemistry. B. 2021 Mar 08.
1. Qiu WQ
2. Luo S
3. Ma SA
4. Saminathan P
5. Li H
6. Gunnersen JM
7. Gelbard HA
8. Hammond JW
The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases.; Frontiers in immunology; Vol 12. 2021.
1. Miller-Rhodes P
2. Gelbard HA
The Cell Culture Environment Regulates the Transcription Factor MafB in BV-2 Microglia.; Matters; Vol 2021. 2021.
1. Navis A
2. Dallah I
3. Mabeta C
4. Musukuma K
5. Siddiqi OK
6. Bositis CM
7. Koralnik IJ
8. Gelbard HA
9. Theodore WH
10. Okulicz JF
11. Johnson BA
12. Sikazwe I
13. Bearden DR
14. Birbeck GL
Evaluating the impact of antiretroviral and antiseizure medication interactions on treatment effectiveness among outpatient clinic attendees with HIV in Zambia.; Epilepsia. 2020 Oct 21.
1. Nguyen L
2. Laboissonniere LA
3. Guo S
4. Pilotto F
5. Scheidegger O
6. Oestmann A
7. Hammond JW
8. Li H
9. Hyysalo A
10. Peltola R
11. Pattamatta A
12. Zu T
13. Voutilainen MH
14. Gelbard HA
15. Saxena S
16. Ranum LPW
Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs.; Neuron. 2020 Oct 01.
1. Miller-Rhodes P
2. Gelbard HA
3. Terrando N
This Is Your Brain on (Low) Glucose.; Trends in neurosciences. 2020 Sep 17.
1. Wang P
2. Velagapudi R
3. Kong C
4. Rodriguiz RM
5. Wetsel WC
6. Yang T
7. Berger M
8. Gelbard HA
9. Colton CA
10. Terrando N
Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.; Alzheimer's & dementia : the journal of the Alzheimer's Association; Vol 16(5). 2020 May.
1. Hammond JW
2. Bellizzi MJ
3. Ware C
4. Qiu WQ
5. Saminathan P
6. Li H
7. Luo S
8. Ma SA
9. Li Y
10. Gelbard HA
Complement-dependent synapse loss and microgliosis in a mouse model of multiple sclerosis.; Brain, behavior, and immunity. 2020 Mar 06.
1. Pavlakis S
2. Gelbard HA
The darker side of varicella zoster infection: Arterial ischemic stroke.; Neurology; Vol 94(5). 2020 Feb 04.
1. Miller-Rhodes P
2. Kong C
3. Baht GS
4. Saminathan P
5. Rodriguiz RM
6. Wetsel WC
7. Gelbard HA
8. Terrando N
The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders.; Journal of neuroinflammation; Vol 16(1). 2019 Oct 28.
1. Saminathan P
2. Kevadiya BD
3. Marker DF
4. Gendelman HE
5. Gorantla S
6. Gelbard HA
Broad Spectrum Mixed Lineage Kinase Type 3 Inhibition and HIV-1 Persistence in Macrophages.; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2019 Jan 07.
1. Bellizzi MJ
2. Hammond JW
3. Li H
4. Gantz Marker MA
5. Marker DF
6. Freeman RS
7. Gelbard HA
The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis.; eNeuro; Vol 5(6). 2018 Nov.
1. Hammond JW
2. Qiu WQ
3. Marker DF
4. Chamberlain JM
5. Greaves-Tunnell W
6. Bellizzi MJ
7. Lu SM
8. Gelbard HA
HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q.; Glia. 2018 Oct 16.
1. Kiyota T
2. Machhi J
3. Lu Y
4. Dyavarshetty B
5. Nemati M
6. Zhang G
7. Mosley RL
8. Gelbard HA
9. Gendelman HE
URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer's disease.; Journal of neuroinflammation; Vol 15(1). 2018 May 05.
1. Tomita K
2. Kohli R
3. MacLaurin BL
4. Hirsova P
5. Guo Q
6. Sanchez LHG
7. Gelbard HA
8. Blaxall BC
9. Ibrahim SH
Mixed-lineage kinase 3 pharmacological inhibition attenuates murine nonalcoholic steatohepatitis.; JCI insight; Vol 2(15). 2017 Aug 03.
1. Gelbard HA
Neuroimmune Pharmacology, 2nd Edition - A Perspective.; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology; Vol 12(2). 2017 Jun.
1. Dong W
2. Embury CM
3. Lu Y
4. Whitmire SM
5. Dyavarshetty B
6. Gelbard HA
7. Gendelman HE
8. Kiyota T
The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation.; Journal of neuroinflammation; Vol 13(1). 2016 Jul 11.
1. Bellizzi MJ
2. Geathers JS
3. Allan KC
4. Gelbard HA
Platelet-Activating Factor Receptors Mediate Excitatory Postsynaptic Hippocampal Injury in Experimental Autoimmune Encephalomyelitis.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 36(4). 2016 Jan 27.
1. Zhang G
2. Guo D
3. Dash PK
4. Araínga M
5. Wiederin JL
6. Haverland NA
7. Knibbe-Hollinger J
8. Martinez-Skinner A
9. Ciborowski P
10. Goodfellow VS
11. Wysocki TA
12. Wysocki BJ
13. Poluektova LY
14. Liu XM
15. McMillan JM
16. Gorantla S
17. Gelbard HA
18. Gendelman HE
The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy.; Nanomedicine : nanotechnology, biology, and medicine. 2015 Oct 22.
1. Hammond JW
2. Lu SM
3. Gelbard HA
Corrigendum: Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation.; Frontiers in cellular neuroscience; Vol 10. 2016.
1. Puccini JM
2. Marker DF
3. Fitzgerald T
4. Barbieri J
5. Kim CS
6. Miller-Rhodes P
7. Lu SM
8. Dewhurst S
9. Gelbard HA
Leucine-rich repeat kinase 2 modulates neuroinflammation and neurotoxicity in models of human immunodeficiency virus 1-associated neurocognitive disorders.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 35(13). 2015 Apr 1.
1. Hammond JW
2. Lu SM
3. Gelbard HA
Platelet Activating Factor Enhances Synaptic Vesicle Exocytosis Via PKC, Elevated Intracellular Calcium, and Modulation of Synapsin 1 Dynamics and Phosphorylation.; Frontiers in cellular neuroscience; Vol 9. 2015.
1. Gendelman HE
2. Gelbard HA
Adjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disorders.; Current opinion in HIV and AIDS. 2014 Sep 16.
1. Guo D
2. Zhang G
3. Wysocki TA
4. Wysocki BJ
5. Gelbard HA
6. Liu XM
7. McMillan JM
8. Gendelman HE
Endosomal Trafficking of Nanoformulated Antiretroviral Therapy Facilitates Drug Particle Carriage and HIV Clearance.; Journal of virology. 2014 Jun 11.
1. Dayawansa S
2. Wang EW
3. Liu W
4. Markman JD
5. Gelbard HA
6. Huang JH
Allotransplanted DRG neurons or Schwann cells affect functional recovery in a rodent model of sciatic nerve injury.; Neurological research. 2014 May 18.
1. Polesskaya O
2. Wong C
3. Lebron L
4. Chamberlain JM
5. Gelbard HA
6. Goodfellow V
7. Kim M
8. Daiss JL
9. Dewhurst S
MLK3 regulates fMLP-stimulated neutrophil motility.; Molecular immunology; Vol 58(2). 2014 Apr.
1. Kapetanovic S
2. Griner R
3. Zeldow B
4. Nichols S
5. Leister E
6. Gelbard HA
7. Miller TL
8. Hazra R
9. Mendez AJ
10. Malee K
11. Kammerer B
12. Williams PL
Biomarkers and neurodevelopment in perinatally HIV-infected or exposed youth: a structural equation model analysis.; AIDS (London, England); Vol 28(3). 2014 Jan 28.
1. Tremblay MÈ
2. Marker DF
3. Puccini JM
4. Muly EC
5. Lu SM
6. Gelbard HA
Ultrastructure of microglia-synapse interactions in the HIV-1 Tat-injected murine central nervous system.; Communicative & integrative biology; Vol 6(6). 2013 Nov 1.
1. Rhoo KH
2. Granger M
3. Sur J
4. Feng C
5. Gelbard HA
6. Dewhurst S
7. Polesskaya O
Pharmacologic Inhibition of MLK3 Kinase Activity Blocks the In Vitro Migratory Capacity of Breast Cancer Cells but Has No Effect on Breast Cancer Brain Metastasis in a Mouse Xenograft Model.; PloS one; Vol 9(9). 2014.
1. Goodfellow VS
2. Loweth CJ
3. Ravula SB
4. Wiemann T
5. Nguyen T
6. Xu Y
7. Todd DE
8. Sheppard D
9. Pollack S
10. Polesskaya O
11. Marker DF
12. Dewhurst S
13. Gelbard HA
Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.; Journal of medicinal chemistry; Vol 56(20). 2013 Oct 24.
1. Gelbard HA
2. Gendelman HE
Lipids and cognition make good bedfellows for neuroAIDS.; Neurology; Vol 81(17). 2013 Oct 22.
1. Marker DF
2. Tremblay MÈ
3. Puccini JM
4. Barbieri J
5. Gantz Marker MA
6. Loweth CJ
7. Muly EC
8. Lu SM
9. Goodfellow VS
10. Dewhurst S
11. Gelbard HA
The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 33(24). 2013 Jun 12.
1. Ma Q
2. Gelbard HA
3. Maggirwar SB
4. Dewhurst S
5. Gendelman HE
6. Peterson DR
7. DiFrancesco R
8. Hochreiter JS
9. Morse GD
10. Schifitto G
Pharmacokinetic interactions of CEP-1347 and atazanavir in HIV-infected patients.; Journal of neurovirology; Vol 19(3). 2013 Jun.
1. Marker DF
2. Puccini JM
3. Mockus TE
4. Barbieri J
5. Lu SM
6. Gelbard HA
LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein.; Journal of neuroinflammation; Vol 9. 2012 Nov 29.
1. Dash PK
2. Gendelman HE
3. Roy U
4. Balkundi S
5. Alnouti Y
6. Mosley RL
7. Gelbard HA
8. McMillan J
9. Gorantla S
10. Poluektova LY
Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice.; AIDS (London, England); Vol 26(17). 2012 Nov 13.
1. Lapin ZJ
2. Höppener C
3. Gelbard HA
4. Novotny L
Near-field quantification of complement receptor 1 (CR1/CD35) protein clustering in human erythrocytes.; Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology; Vol 7(3). 2012 Sep.
1. Liu W
2. Ren Y
3. Bossert A
4. Wang X
5. Dayawansa S
6. Tong J
7. He X
8. Smith DH
9. Gelbard HA
10. Huang JH
Allotransplanted neurons used to repair peripheral nerve injury do not elicit overt immunogenicity.; PloS one; Vol 7(2). 2012.
1. Dash PK
2. Gorantla S
3. Gendelman HE
4. Knibbe J
5. Casale GP
6. Makarov E
7. Epstein AA
8. Gelbard HA
9. Boska MD
10. Poluektova LY
Loss of neuronal integrity during progressive HIV-1 infection of humanized mice.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 31(9). 2011 Mar 2.
1. Perry SW
2. Norman JP
3. Barbieri J
4. Brown EB
5. Gelbard HA
Mitochondrial membrane potential probes and the proton gradient: a practical usage guide.; BioTechniques; Vol 50(2). 2011 Feb.