URMC / Labs / Glading Lab / Publications

Publications

1. Glading A
KRIT1 in Vascular Biology and Beyond.; Bioscience reports. 2024 Jul 09.
1. Perrelli A
2. Ferraris C
3. Berni E
4. Glading AJ
5. Retta SF
KRIT1: a traffic warden at the busy crossroads between redox signaling and the pathogenesis of Cerebral Cavernous Malformation disease.; Antioxidants & redox signaling. 2022 Sep 01.
1. Swamy H
2. Glading AJ
Is Location Everything? Regulation of the Endothelial CCM Signaling Complex.; Frontiers in cardiovascular medicine; Vol 9, pp. 954780. 2022 Jul 11.
1. Swamy H
2. Glading AJ
Contribution of protein-protein interactions to the endothelial barrier-stabilizing function of KRIT1.; Journal of cell science. 2021 Dec 17.
1. De Luca E
2. Perrelli A
3. Swamy H
4. Nitti M
5. Passalacqua M
6. Furfaro AL
7. Salzano AM
8. Scaloni A
9. Glading AJ
10. Retta SF
Protein kinase Cα (PKCα) regulates the nucleocytoplasmic shuttling of KRIT1.; Journal of cell science. 2020 Dec 21.
1. Khire TS
2. Salminen AT
3. Swamy H
4. Lucas KS
5. McCloskey MC
6. Ajalik RE
7. Chung HH
8. Gaborski TR
9. Waugh RE
10. Glading AJ
11. McGrath JL
Microvascular Mimetics for the Study of Leukocyte-Endothelial Interactions.; Cellular and molecular bioengineering; Vol 13(2). 2020 Apr.
1. Nobiletti N
2. Glading AJ
Isolation of Cerebral Endothelial Cells from CCM1/KRIT1 Null Mouse Brain.; Methods in molecular biology (Clifton, N.J.); Vol 2152. 2020.
1. DiStefano PV
2. Glading AJ
VEGF signalling enhances lesion burden in KRIT1 deficient mice.; Journal of cellular and molecular medicine; Vol 24(1). 2020 Jan.
1. Glading AJ
Measurement of Endothelial Barrier Function in Mouse Models of Cerebral Cavernous Malformations Using Intravital Microscopy.; Methods in molecular biology (Clifton, N.J.); Vol 2152. 2020.
1. De Luca E
2. Perrelli A
3. Swamy H
4. Nitti M
5. Passalacqua M
6. Furfaro AL
7. Salzano AM
8. Scaloni A
9. Glading AJ
10. Retta SF
Protein kinase Cα (PKCα) regulates the nucleocytoplasmic shuttling of KRIT1.; Journal of cell science. 2020 Jan 01.
1. Goitre L
2. DiStefano PV
3. Moglia A
4. Nobiletti N
5. Baldini E
6. Trabalzini L
7. Keubel J
8. Trapani E
9. Shuvaev VV
10. Muzykantov VR
11. Sarelius IH
12. Retta SF
13. Glading AJ
Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.; Scientific reports; Vol 7(1). 2017 Aug 15.
1. Retta SF
2. Glading AJ
Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.; The international journal of biochemistry & cell biology; Vol 81(Pt B). 2016 Jan.
1. DiStefano PV
2. Smrcka AV
3. Glading AJ
Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.; PloS one; Vol 11(9). 2016.
1. Sarelius IH
2. Glading AJ
Control of vascular permeability by adhesion molecules.; Tissue barriers; Vol 3(1-2). 2015.
1. DiStefano PV
2. Kuebel JM
3. Sarelius IH
4. Glading AJ
KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling.; The Journal of biological chemistry; Vol 289(47). 2014 Nov 21.
1. Corr M
2. Lerman I
3. Keubel JM
4. Ronacher L
5. Misra R
6. Lund F
7. Sarelius IH
8. Glading AJ
Decreased Krev interaction-trapped 1 expression leads to increased vascular permeability and modifies inflammatory responses in vivo.; Arteriosclerosis, thrombosis, and vascular biology; Vol 32(11). 2012 Nov.
1. Glading AJ
2. Ginsberg MH
Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling.; Disease models & mechanisms; Vol 3(1-2). 2010 Jan.
1. Glading A
2. Han J
3. Stockton RA
4. Ginsberg MH
KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions.; The Journal of cell biology; Vol 179(2). 2007 Oct 22.
1. Glading A
2. Koziol JA
3. Krueger J
4. Ginsberg MH
PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2.; Cancer research; Vol 67(4). 2007 Feb 15.
1. Krueger J
2. Chou FL
3. Glading A
4. Schaefer E
5. Ginsberg MH
Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation.; Molecular biology of the cell; Vol 16(8). 2005 Aug.
1. Satish L
2. Blair HC
3. Glading A
4. Wells A
Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain.; Molecular and cellular biology; Vol 25(5). 2005 Mar.
1. Glading A
2. Bodnar RJ
3. Reynolds IJ
4. Shiraha H
5. Satish L
6. Potter DA
7. Blair HC
8. Wells A
Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation.; Molecular and cellular biology; Vol 24(6). 2004 Mar.
1. Chou FL
2. Hill JM
3. Hsieh JC
4. Pouyssegur J
5. Brunet A
6. Glading A
7. Uberall F
8. Ramos JW
9. Werner MH
10. Ginsberg MH
PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation.; The Journal of biological chemistry; Vol 278(52). 2003 Dec 26.
1. Shiraha H
2. Glading A
3. Chou J
4. Jia Z
5. Wells A
Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain.; Molecular and cellular biology; Vol 22(8). 2002 Apr.
1. Glading A
2. Lauffenburger DA
3. Wells A
Cutting to the chase: calpain proteases in cell motility.; Trends in cell biology; Vol 12(1). 2002 Jan.
1. Glading A
2. Uberall F
3. Keyse SM
4. Lauffenburger DA
5. Wells A
Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.; The Journal of biological chemistry; Vol 276(26). 2001 Jun 29.
1. Glading A
2. Chang P
3. Lauffenburger DA
4. Wells A
Epidermal growth factor receptor activation of calpain is required for fibroblast motility and occurs via an ERK/MAP kinase signaling pathway.; The Journal of biological chemistry; Vol 275(4). 2000 Jan 28.
1. Shiraha H
2. Glading A
3. Gupta K
4. Wells A
IP-10 inhibits epidermal growth factor-induced motility by decreasing epidermal growth factor receptor-mediated calpain activity.; The Journal of cell biology; Vol 146(1). 1999 Jul 12.
1. Wells A
2. Gupta K
3. Chang P
4. Swindle S
5. Glading A
6. Shiraha H
Epidermal growth factor receptor-mediated motility in fibroblasts.; Microscopy research and technique; Vol 43(5). 1998 Dec 1.