Epilepsy Imaging Phenotypes (Gugger) Lab
Welcome to the Epilepsy Imaging Phenotypes (Gugger) Lab
We are interested in quantitative brain imaging and its clinical applications in neuroscience, particularly in epilepsy and traumatic brain injury. Much of this work utilizes structural and diffusion MRI as well as functional imaging modalities such as arterial spin labeling, functional MRI, and FDG-PET. The overarching goal of our research is to develop neuroimaging-based biomarkers that can be rapidly translated to the clinic to better characterize neurological disorders, predict outcomes, and ultimately lead to more effective therapies.
James J. Gugger, M.D., Pharm.D..
Principal Investigator
Current Projects
The two major focus areas of the lab are:
- Identification of individuals at high risk for epilepsy after traumatic brain injury
- Characterization of epilepsy phenotypes.
Both areas utilize multimodal neuroimaging including structural and diffusion MRI as well as functional imaging.
Publications
- Neuroimaging Correlates of Traumatic Brain Injury in an Older Community-Dwelling Population: The Atherosclerosis Risk in Communities Study.; Neurology; Vol 104(8), pp. e213506. 2025 Apr 04.
- Mediators of epilepsy risk after traumatic brain injury: A 20-year U.S. veteran cohort study.; Epilepsia. 2024 Dec 27.
- Return of intracranial beta oscillations and traveling waves with recovery from traumatic brain injury.; bioRxiv : the preprint server for biology. 2024 Jul 23.
- Connectivity of the Piriform Cortex and its Implications in Temporal Lobe Epilepsy.; medRxiv : the preprint server for health sciences. 2024 Jul 22.
Affiliations
Contact Us
Gugger Lab
University of Rochester Center for Advanced Brain Imaging and Neurophysiology
430 Elmwood Ave
Room 2.B210
Rochester, NY 14642