Mechanisms of ATP-dependent Chromatin Remodeling Complexes

Project Collaborators:

Dr. Robert Kingston

We have been investigating the mechanisms by which chromatin remodeling complexes use the energy of ATP hydrolysis to alter structure and accessibility in nucleosomes. Working with our collaborators has allowed us to investigate several aspects of the hSWI/SNF complex, as well as carrying out similar studies on the Xenopus Mi2 complex.

Mechanism of SWI/SNF and RSC remodeling. Crosslinking results indicate that DNA moves

about the surface of the nucleosome via a 'threading' mechanism. Taken from Liu et al. (2011),.

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