Publications

Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes. RM Irwin, MA Thomas, MJ Fahey, MD Mayán, JW Smyth, ML Delco. Stem Cell Research & Therapy 15 (1), 359. 2024.

Human mesenchymal stromal cells release functional mitochondria in extracellular vesicles. MA Thomas, MJ Fahey, BR Pugliese, RM Irwin, MA Antonyak, ML Delco. Frontiers in Bioengineering and Biotechnology 10, 870193. 2022.

A tale of two loads: modulation of IL-1 induced inflammatory responses of meniscal cells in two models of dynamic physiologic loading. BD Andress, RM Irwin, I Puranam, BD Hoffman, AL McNulty. Frontiers in Bioengineering and Biotechnology 10, 837619. 2022.

Biological mechanisms for cartilage repair using a BioCartilage scaffold: Cellular adhesion/migration and bioactive proteins. J Commins, R Irwin, A Matuska, M Goodale, M Delco, L Fortier. Cartilage 13 (1_suppl), 984S-992S. 2021.

Differential response of inner and outer zone meniscal cells to tensile load under non-inflammatory and inflammatory conditions. RM Irwin, I Puranam, BD Hoffman, AL McNulty. Osteoarthritis and Cartilage 29, S3-S4. 2021.

Microscale strain mapping demonstrates the importance of interface slope in the mechanics of cartilage repair. RM Irwin, T Gao, AJ Boys, K Ortved, I Cohen, LJ Bonassar. Journal of biomechanics 114, 110159. 2021.

Distinct tribological endotypes of pathological human synovial fluid reveal characteristic biomarkers and variation in efficacy of viscosupplementation at reducing local strains in articular cartilage. RM Irwin, E Feeney, C Secchieri, D Galesso, I Cohen, F Oliviero,  et al. Osteoarthritis and cartilage 28 (4), 492-501. 2020.

Imaging the Microscale Mechanical Response of Articular Cartilage in Early Stage Osteoarthritis Treatments. RM Irwin. Cornell University. 2020.

The clot thickens: Autologous and allogeneic fibrin sealants are mechanically equivalent in an ex vivo model of cartilage repair. RM Irwin, LJ Bonassar, I Cohen, AM Matuska, J Commins, B Cole, et al. PLoS One 14 (11), e0224756. 2019.

Distinct tribological phenotypes of arthritic synovial fluid reveal differences in viscosupplementation efficacy. RM Irwin, E Feeney, D Galesso, C Secchieri, R Ramonda, I Cohen, et al. Osteoarthritis and Cartilage 27, S165-S166. 2019.

The clot thickens: pooled plasma and autologous fibrin sealants' show equivalent failure mechanics and repair adhesion to articular cartilage. RM Irwin, L Bonassar, I Cohen, A Matuska, J Commins, B Cole, L Fortier. Osteoarthritis and Cartilage 27, S430-S432. 2019.

Incidence of coexisting talar and tibial osteochondral lesions correlates with patient age and lesion location. RM Irwin, Y Shimozono, Y Yasui, R Megill, TW Deyer, JG Kennedy. Orthopaedic journal of sports medicine 6 (8), 2325967118790965. 2018.

Removal of excess interfacial material from surface-modified emulsions using a microfluidic device with triangular post geometry. L Lu, RM Irwin, MA Coloma, JW Schertzer, PR Chiarot. Microfluidics and Nanofluidics 18, 1233-1246. 2015.

Particulate and Emulsion Sorting Using Microfluidics. L Lu, RM Irwin, JW Schertzer, PR Chiarot. ASME International Mechanical Engineering Congress and Exposition 46545. 2014.

Measurements of Local Strains Allows for Detection of Distinct Tribological Phenotypes of Arthritic Synovial Fluid and Efficacy of Viscosupplementation. RM Irwin, E Feeney, D Galesso, C Secchieri, R Ramonda, I Cohen,  et al.