The Irwin Lab
Welcome to The Irwin Lab
The Irwin lab aims to address knowledge gaps in orthopaedic mechanobiology using biomaterials and intravital imaging approaches. Our goal is to develop mechano-targeted therapies to improve tissue healing and prevent joint deterioration after injury. We use a multi-scale approach (cells, tissues, whole-joint model systems) to investigate mechanotransduction mechanisms at different levels of resolution and complexity, and to evaluate therapeutic efficacy.
Projects
Identify Key Mechanotransducers to Promote Musculoskeletal Tissue Repair
Engineer Biomaterials for Mechano-Targeted Therapies
Role of Systemic Factors and Mechanics on Spine Health and Repair
Publications
Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes. RM Irwin, MA Thomas, MJ Fahey, MD Mayán, JW Smyth, ML Delco. Stem Cell Research & Therapy 15 (1), 359. 2024.
Human mesenchymal stromal cells release functional mitochondria in extracellular vesicles. MA Thomas, MJ Fahey, BR Pugliese, RM Irwin, MA Antonyak, ML Delco. Frontiers in Bioengineering and Biotechnology 10, 870193. 2022.
A tale of two loads: modulation of IL-1 induced inflammatory responses of meniscal cells in two models of dynamic physiologic loading. BD Andress, RM Irwin, I Puranam, BD Hoffman, AL McNulty. Frontiers in Bioengineering and Biotechnology 10, 837619. 2022.
Biological mechanisms for cartilage repair using a BioCartilage scaffold: Cellular adhesion/migration and bioactive proteins. J Commins, R Irwin, A Matuska, M Goodale, M Delco, L Fortier. Cartilage 13 (1_suppl), 984S-992S. 2021.
View All PublicationsContact Us
Rebecca Irwin, Ph.D.
Goergen Hall
480 Intercampus Drive
Rochester, NY 14620