URMC / Labs / MacLean Lab / Publications

Recent Publications

1. Arige V
2. MacLean DM
3. Yule DI
Inositol 1,4,5-Trisphosphate Receptor Mutations Associated with Human Disease: Insights into Receptor Function and Dysfunction.; Annual review of physiology. 2024 Nov 26.
1. Rook ML
2. McCullock TW
3. Couch T
4. Lueck JD
5. MacLean DM
Photomodulation of the ASIC1a acidic pocket destabilizes the open state.; Protein science : a publication of the Protein Society. 2023 Jan 08.
1. Allen JP
2. Garber KB
3. Perszyk R
4. Khayat CT
5. Kell SA
6. Kaneko M
7. Quindipan C
8. Saitta S
9. Ladda RL
10. Hewson S
11. Inbar-Feigenberg M
12. Prasad C
13. Prasad AN
14. Olewiler L
15. Mu W
16. Rosenthal LS
17. Scala M
18. Striano P
19. Zara F
20. McCullock TW
21. Jauss RT
22. Lemke JR
23. MacLean DM
24. Zhu C
25. Yuan H
26. Myers SJ
27. Traynelis SF
Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants.; Human molecular genetics. 2023 Jan 07.
1. Rook ML
2. Miaro M
3. Couch T
4. Kneisley DL
5. Musgaard M
6. MacLean DM
Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1.; The Journal of general physiology; Vol 153(8). 2021 Aug 02.
1. Couch T
2. Berger K
3. Kneisley DL
4. McCullock TW
5. Kammermeier P
6. Maclean DM
Topography and motion of the acid-sensing ion channel intracellular domains.; eLife; Vol 10. 2021 Jul 22.
1. Rook ML
2. Ananchenko A
3. Musgaard M
4. MacLean DM
Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 β11-12 Linker Isomerization and Channel Kinetics.; Frontiers in cellular neuroscience; Vol 15. 2021.
1. Rook ML
2. Musgaard M
3. MacLean DM
Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors.; The Journal of physiology. 2020 Apr 19.
1. Durham RJ
2. Paudyal N
3. Carrillo E
4. Bhatia NK
5. Maclean DM
6. Berka V
7. Dolino DM
8. Gorfe AA
9. Jayaraman V
Conformational spread and dynamics in allostery of NMDA receptors.; Proceedings of the National Academy of Sciences of the United States of America; Vol 117(7). 2020 Feb 18.
1. Rook ML
2. Williamson A
3. Lueck JD
4. Musgaard M
5. Maclean DM
β11-12 linker isomerization governs acid-sensing ion channel desensitization and recovery.; eLife; Vol 9. 2020 Feb 07.
1. Carrillo E
2. Shaikh SA
3. Berka V
4. Durham RJ
5. Litwin DB
6. Lee G
7. MacLean DM
8. Nowak LM
9. Jayaraman V
Mechanism of modulation of AMPA receptors by TARP-γ8.; The Journal of general physiology; Vol 152(1). 2020 Jan 06.
1. McCullock TW
2. MacLean DM
3. Kammermeier PJ
Comparing the performance of mScarlet-I, mRuby3, and mCherry as FRET acceptors for mNeonGreen.; PloS one; Vol 15(2). 2020.
1. MacLean DM
2. Durham RJ
3. Jayaraman V
Mapping the Conformational Landscape of Glutamate Receptors Using Single Molecule FRET.; Trends in neurosciences; Vol 42(2). 2019 Feb.
1. Chen J
2. Li L
3. Chen SR
4. Chen H
5. Xie JD
6. Sirrieh RE
7. MacLean DM
8. Zhang Y
9. Zhou MH
10. Jayaraman V
11. Pan HL
The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions.; Cell reports; Vol 22(9). 2018 Feb 27.
1. Dolino DM
2. Chatterjee S
3. MacLean DM
4. Flatebo C
5. Bishop LDC
6. Shaikh SA
7. Landes CF
8. Jayaraman V
The structure-energy landscape of NMDA receptor gating.; Nature chemical biology. 2017 Oct 09.
1. Coombs ID
2. MacLean DM
3. Jayaraman V
4. Farrant M
5. Cull-Candy SG
Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation.; Cell reports; Vol 20(5). 2017 Aug 01.
1. MacLean DM
2. Jayaraman V
Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive.; Proceedings of the National Academy of Sciences of the United States of America; Vol 114(12). 2017 Mar 21.
1. Vitrac H
2. MacLean DM
3. Karlstaedt A
4. Taegtmeyer H
5. Jayaraman V
6. Bogdanov M
7. Dowhan W
Dynamic Lipid-dependent Modulation of Protein Topology by Post-translational Phosphorylation.; The Journal of biological chemistry; Vol 292(5). 2017 Feb 03.
1. Shaikh SA
2. Dolino DM
3. Lee G
4. Chatterjee S
5. MacLean DM
6. Flatebo C
7. Landes CF
8. Jayaraman V
Stargazin Modulation of AMPA Receptors.; Cell reports; Vol 17(2). 2016 Oct 04.
1. MacLean DM
2. Jayaraman V
Acid-sensing ion channels are tuned to follow high-frequency stimuli.; The Journal of physiology; Vol 594(10). 2016 May 15.
1. Vitrac H
2. MacLean DM
3. Jayaraman V
4. Bogdanov M
5. Dowhan W
Dynamic membrane protein topological switching upon changes in phospholipid environment.; Proceedings of the National Academy of Sciences of the United States of America; Vol 112(45). 2015 Nov 10.
1. Sirrieh RE
2. MacLean DM
3. Jayaraman V
A conserved structural mechanism of NMDA receptor inhibition: A comparison of ifenprodil and zinc.; The Journal of general physiology; Vol 146(2). 2015 Aug.
1. Sirrieh RE
2. MacLean DM
3. Jayaraman V
Subtype-dependent N-methyl-D-aspartate receptor amino-terminal domain conformations and modulation by spermine.; The Journal of biological chemistry; Vol 290(20). 2015 May 15.
1. MacLean DM
2. Ramaswamy SS
3. Du M
4. Howe JR
5. Jayaraman V
Stargazin promotes closure of the AMPA receptor ligand-binding domain.; The Journal of general physiology; Vol 144(6). 2014 Dec.
1. Lee G
2. MacLean DM
3. Ulrich H
4. Zhao X
5. Aronowski J
6. Jayaraman V
RNA based antagonist of NMDA receptors.; ACS chemical neuroscience; Vol 5(7). 2014 Jul 16.
1. Ramaswamy SS
2. MacLean DM
3. Gorfe AA
4. Jayaraman V
Proton-mediated conformational changes in an acid-sensing ion channel.; The Journal of biological chemistry; Vol 288(50). 2013 Dec 13.
1. Sirrieh RE
2. MacLean DM
3. Jayaraman V
Amino-terminal domain tetramer organization and structural effects of zinc binding in the N-methyl-D-aspartate (NMDA) receptor.; The Journal of biological chemistry; Vol 288(31). 2013 Aug 02.
1. MacLean DM
CrossTalk opposing view: TARPs modulate AMPA receptor conformations before the gating transitions.; The Journal of physiology; Vol 591(7). 2013 Apr 01.
1. Ramaswamy S
2. Cooper D
3. Poddar N
4. MacLean DM
5. Rambhadran A
6. Taylor JN
7. Uhm H
8. Landes CF
9. Jayaraman V
Role of conformational dynamics in α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor partial agonism.; The Journal of biological chemistry; Vol 287(52). 2012 Dec 21.
1. Maclean DM
2. Bowie D
Transmembrane AMPA receptor regulatory protein regulation of competitive antagonism: a problem of interpretation.; The Journal of physiology; Vol 589(Pt 22). 2011 Nov 15.
1. Maclean DM
2. Wong AY
3. Fay AM
4. Bowie D
Cations but not anions regulate the responsiveness of kainate receptors.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 31(6). 2011 Feb 09.
1. MacLean DM
The delta2 glutamate-like receptor undergoes similar conformational changes as other ionotropic glutamate receptors.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 29(21). 2009 May 27.
1. Wong AY
2. MacLean DM
3. Bowie D
Na+/Cl- dipole couples agonist binding to kainate receptor activation.; The Journal of neuroscience : the official journal of the Society for Neuroscience; Vol 27(25). 2007 Jun 20.
1. Kuang D
2. Yao Y
3. Maclean D
4. Wang M
5. Hampson DR
6. Chang BS
Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors.; Proceedings of the National Academy of Sciences of the United States of America; Vol 103(38). 2006 Sep 19.